simrisc-16.02.00/agegroupvsd/0000775000175000017500000000000014665030471014733 5ustar frankfranksimrisc-16.02.00/agegroupvsd/fmt.cc0000664000175000017500000000044114665030471016027 0ustar frankfrank//#define XERR #include "agegroupvsd.ih" // static void AgeGroupVSD::fmt(unsigned indent, unsigned mIntWidth, unsigned mPrec, unsigned sdIntWidth, unsigned sdPrec) { s_indent = indent; VSD::fmt(mIntWidth, mPrec, sdIntWidth, sdPrec); } simrisc-16.02.00/agegroupvsd/data.cc0000664000175000017500000000011214665030471016145 0ustar frankfrank//#define XERR #include "agegroupvsd.ih" unsigned AgeGroupVSD::s_indent; simrisc-16.02.00/agegroupvsd/ln.cc0000664000175000017500000000023714665030471015655 0ustar frankfrank//#define XERR #include "agegroupvsd.ih" void AgeGroupVSD::ln() { d_vsd.ln(); if (d_stdDev > 0) d_stdDev = log(d_stdDev); d_exp = true; } simrisc-16.02.00/agegroupvsd/vary2.cc0000664000175000017500000000077514665030471016316 0ustar frankfrank//#define XERR #include "agegroupvsd.ih" // hdr should end in ':' void AgeGroupVSD::vary(ostream &out, unsigned indent, char const *hdr, AgeGroupVSDvect &vect) { out << setw(indent) << ' ' << hdr << '\n'; indent += 2; for (auto &ag: vect) { ag.vary(); out << setw(indent) << ' ' << "ageGroup: " << ag.d_group << " "; ag.d_vsd.showVary(out); } out.put('\n'); } simrisc-16.02.00/agegroupvsd/agegroupvsd.h0000664000175000017500000000433214665030471017434 0ustar frankfrank#ifndef INCLUDED_AGEGROUPVSD_ #define INCLUDED_AGEGROUPVSD_ #include #include #include "../group/group.h" #include "../vsd/vsd.h" class AgeGroupVSD { friend std::istream &operator>>(std::istream &in, AgeGroupVSD &group); friend std::ostream &operator<<(std::ostream &out, std::vector const &vect); friend std::ostream &operator<<(std::ostream &out, AgeGroupVSD const &group); bool d_extractGroup; Group d_group; VSD d_vsd; double d_stdDev; // if negative: std dev not used static unsigned s_indent; bool d_exp; public: AgeGroupVSD(VaryType varyType, bool useStdDev, bool etractGroup = true); Group const &group() const; // .f uint16_t beginAge() const; // .f uint16_t endAge() const; // .f double value() const; // .f double stdDev() const; // .f void ln(); void vary(); // 1 static void fmt(unsigned valueIntWidth, unsigned valuePrec, // inl unsigned distValueWdith, unsigned distPrec); static void fmt(unsigned indent, // indentation below topLabel unsigned mIntWidth, unsigned mPrec, unsigned sdIntWidth, unsigned sdPrec); // hdr should end in ':' static void vary(std::ostream &out, unsigned indent, // 2 char const *hdr, std::vector &vect); private: std::ostream &insert(std::ostream &out) const; // 1 static std::ostream &insert(std::ostream &out, // 2 std::vector const &vect); std::istream &extract(std::istream &in); }; using AgeGroupVSDvect = std::vector; #include "agegroupvsd.f" #endif simrisc-16.02.00/agegroupvsd/insert1.cc0000664000175000017500000000065214665030471016632 0ustar frankfrank//#define XERR #include "agegroupvsd.ih" std::ostream &AgeGroupVSD::insert(std::ostream &out) const { out << d_group << ", "; // insert the age group if (d_stdDev >= 0) // then the sd.dev (if available) Globals::setPrecision(out, 3) << "std.dev: " << (d_exp ? exp(d_stdDev) : d_stdDev) << "; "; return out << d_vsd; // then the VSD } simrisc-16.02.00/agegroupvsd/agegroupvsd.ih0000664000175000017500000000025214665030471017602 0ustar frankfrank#include "agegroupvsd.h" #include "../xerr/xerr.ih" #include #include "../globals/globals.h" #include "../err/err.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/agegroupvsd/vary1.cc0000664000175000017500000000020714665030471016303 0ustar frankfrank//#define XERR #include "agegroupvsd.ih" void AgeGroupVSD::vary() { d_vsd.vary(); // vary the parameter if applicable } simrisc-16.02.00/agegroupvsd/insert2.cc0000664000175000017500000000043514665030471016632 0ustar frankfrank//#define XERR #include "agegroupvsd.ih" // static ostream &AgeGroupVSD::insert(ostream &out, AgeGroupVSDvect const &vect) { for (unsigned idx = 0, end = vect.size(); idx != end; ++idx) out << setw(s_indent) << ' ' << "ageGroup: " << vect[idx] << '\n'; return out; } simrisc-16.02.00/agegroupvsd/icmconf0000664000175000017500000000010214665030471016265 0ustar frankfrank#define LIBRARY "agegroupvsd" #include "../icmconf.lib" simrisc-16.02.00/agegroupvsd/extract.cc0000664000175000017500000000125614665030471016720 0ustar frankfrank#define XERR #include "agegroupvsd.ih" // e.g., 1 - 50 .61 4.38 .43 Normal // or: 1 - 50 4.38 .43 Normal // // or (lung): .21 4.59 .74 Normal std::istream &AgeGroupVSD::extract(std::istream &in) { if (d_extractGroup) in >> d_group; if (d_stdDev < 0) { string value; in >> value; istringstream in{ value }; in >> d_vsd; } else { in >> d_stdDev >> d_vsd; // the default Distribution setting is VARY_OK: OK for AgeGroupVSD if (d_stdDev < 0) Err::msg(Err::NEGATIVE) << "(final std. dev.)" << endl; } return in; } simrisc-16.02.00/agegroupvsd/agegroupvsd1.cc0000664000175000017500000000037414665030471017655 0ustar frankfrank//#define XERR #include "agegroupvsd.ih" AgeGroupVSD::AgeGroupVSD(VaryType varyType, bool useStdDev, bool extractGroup) : d_extractGroup(extractGroup), d_group(RANGE), d_vsd(varyType), d_stdDev(useStdDev ? 0 : -1), d_exp(false) {} simrisc-16.02.00/agegroupvsd/frame0000664000175000017500000000007414665030471015751 0ustar frankfrank//#define XERR #include "agegroupvsd.ih" AgeGroupVSD:: { } simrisc-16.02.00/agegroupvsd/agegroupvsd.f0000664000175000017500000000205014665030471017425 0ustar frankfrank//inline Group const &AgeGroupVSD::ageGroup() const inline Group const &AgeGroupVSD::group() const { return d_group; } inline uint16_t AgeGroupVSD::beginAge() const { return d_group.begin(); } inline uint16_t AgeGroupVSD::endAge() const { return d_group.end(); } inline double AgeGroupVSD::value() const { return d_vsd.value(); } inline double AgeGroupVSD::stdDev() const { return d_stdDev; } // static inline void fmt(unsigned valueIntWidth, unsigned valuePrec, unsigned distValueWdith, unsigned distPrec) { VSD::fmt(valueIntWidth, valuePrec, distValueWdith, distPrec); } inline std::istream &operator>>(std::istream &in, AgeGroupVSD &ageGroupVSD) { return ageGroupVSD.extract(in); } inline std::ostream &operator<<(std::ostream &out, AgeGroupVSD const &ageGroupVSD) { return ageGroupVSD.insert(out); } inline std::ostream &operator<<(std::ostream &out, AgeGroupVSDvect const &vect) { return AgeGroupVSD::insert(out, vect); } simrisc-16.02.00/analysis/0000775000175000017500000000000014665030471014230 5ustar frankfranksimrisc-16.02.00/analysis/analysis.ih0000664000175000017500000000055714665030471016404 0ustar frankfrank#include "analysis.h" #include "../xerr/xerr.ih" #include #include #include #include #include "../options/options.h" #include "../loop/loop.h" extern FBB::Arg::LongOption const g_longOpts[]; extern FBB::Arg::LongOption const *g_longEnd; #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/analysis/run.cc0000664000175000017500000000056714665030471015353 0ustar frankfrank#define XERR #include "analysis.ih" //extern Parser *pPtr; void Analysis::run() { requireBase(); // the base directory must be (made) available Loop loop{ d_labels }; // errors may be set at Options, ConfFile if (emsg.count() != 0) // construction, or Loop construction return; loop.iterate(); } simrisc-16.02.00/analysis/requirebase.cc0000664000175000017500000000050214665030471017043 0ustar frankfrank//#define XERR #include "analysis.ih" void Analysis::requireBase() const { error_code ec; auto const &base = Options::instance().base(); if ( not filesystem::create_directory(base, ec) and ec.value() != 0 ) throw Exception{} << "Cannot create base directory " << base; } simrisc-16.02.00/analysis/actualize.cc0000664000175000017500000000242014665030471016516 0ustar frankfrank#define XERR #include "analysis.ih" void Analysis::actualize(Parser::OptionsVect const &optionsVect) { auto &options = Options::instance(); options.activate(); // activate the startup // (default/command-line) // options for (auto const &spec: optionsVect) // visit all options specified { // in this analysis // visit all long options for (auto const *ptr = g_longOpts; ptr != g_longEnd; ++ptr) { string const &name = ptr->longName(); if (name == spec.name) // found an option to alter { // try to change it if (not options.alter(ptr->optionChar(), spec.value)) wmsg << "ignored analysis option specification " << spec.name << " (line " << spec.lineNr << ')' << endl; break; // done with this option } } } options.actualize(); // obtain the actual options } simrisc-16.02.00/analysis/analysis.h0000664000175000017500000000074514665030471016232 0ustar frankfrank#ifndef INCLUDED_ANALYSIS_ #define INCLUDED_ANALYSIS_ #include #include "../parser/parser.h" #include "../typedefs/typedefs.h" class Analysis { StringVect d_labels; Parser d_parser; public: // stream: the analysis: secifications Analysis(std::istream &&stream, uint16_t lineNr); void run(); private: void actualize(Parser::OptionsVect const &specs); void requireBase() const; }; #endif simrisc-16.02.00/analysis/icmconf0000664000175000017500000000007714665030471015575 0ustar frankfrank#define LIBRARY "analysis" #include "../icmconf.lib" simrisc-16.02.00/analysis/analysis1.cc0000664000175000017500000000105114665030471016440 0ustar frankfrank#define XERR #include "analysis.ih" // the error count is reset by the Simulator Analysis::Analysis(std::istream &&stream, uint16_t lineNr) { Parser::OptionsVect optionsVect; // read the analysis specs d_parser.load(stream, lineNr, d_labels, optionsVect); // set the options used actualize(optionsVect); // for this analysis d_parser.load(Options::instance().configFile()); // read the config file } simrisc-16.02.00/analysis/frame0000664000175000017500000000006614665030471015247 0ustar frankfrank//#define XERR #include "analysis.ih" Analysis:: { } simrisc-16.02.00/beir7/0000775000175000017500000000000014665030471013415 5ustar frankfranksimrisc-16.02.00/beir7/vary.cc0000664000175000017500000000030214665030471014700 0ustar frankfrank//#define XERR #include "beir7.ih" void Beir7::vary(ostream &out) { d_vsd.vary(); out << " Beir7:\n" " " << Globals::simTypeLabel(LC) << " "; d_vsd.showVary(out); } simrisc-16.02.00/beir7/beir7.f0000664000175000017500000000041614665030471014575 0ustar frankfrankinline double Beir7::beta() const { return d_vsd.value(); } inline double Beir7::eta() const { return d_eta; } inline DistType Beir7::distType() const { return d_vsd.distType(); } //inline double Beir7::spread() const //{ // return d_vsd.spread(); //} simrisc-16.02.00/beir7/icmconf0000664000175000017500000000007414665030471014757 0ustar frankfrank#define LIBRARY "beir5" #include "../icmconf.lib" simrisc-16.02.00/beir7/writeparameters.cc0000664000175000017500000000057414665030471017150 0ustar frankfrank//#define XERR #include "beir7.ih" void Beir7::writeParameters(ostream &out) const { VSD::fmt(1, 2, 1, 2); Globals::setWidthPrec(out, 3, 3) << " Beir7:\n" " " << Globals::simTypeLabel(LC) << (Globals::simulationType() == MALE ? " " : "") << " eta = " << d_eta << ", beta = " << d_vsd << "\n\n"; } simrisc-16.02.00/beir7/beir7.h0000664000175000017500000000200414665030471014572 0ustar frankfrank#ifndef INCLUDED_BEIR7_ #define INCLUDED_BEIR7_ //Tumor: // # eta beta spread dist // Beir7: -2.0 .51 .32 Normal // Tumor: // Beir7: // # eta beta spread dist. // breast: -2.0 0.51 0.32 Normal // // # LC: // male: -1.4 .32 Beta // female: -1.4 1.40 Beta #include #include "../typedefs/typedefs.h" #include "../vsd/vsd.h" class Beir7 { double d_eta; // eta; VSD d_vsd; // contains beta and spread/distribution public: Beir7(); double beta() const; // .f double eta() const; // .f DistType distType() const; // .f void vary(std::ostream &out); void writeParameters(std::ostream &out) const; // double spread() const; }; #include "beir7.f" #endif simrisc-16.02.00/beir7/beir7.ih0000664000175000017500000000025414665030471014750 0ustar frankfrank#include "beir7.h" #include "../xerr/xerr.ih" #include #include "../globals/globals.h" #include "../parser/parser.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/beir7/beir71.cc0000664000175000017500000000206414665030471015017 0ustar frankfrank#define XERR #include "beir7.ih" //#Tumor: // Beir7: // # eta beta spread dist. // breast: -2.0 0.51 0.32 Normal // //#Beir7 // Read by BetaDist (./betadist) // >>> dist: not used unless spread == true // # LC: eta beta dist constant factor aParam bParam // male: -1.4 .32 Beta .234091 1.72727 2.664237 5.184883 // female: -1.4 1.40 Beta .744828 .818966 3.366115 4.813548 Beir7::Beir7() : d_vsd(VARY_NONNEG) { switch (Globals::simulationType()) { case BREAST: Parser::extract( Parser::one({ "Beir7:", "breast:" }), d_eta, d_vsd); break; case MALE: Parser::extract( Parser::one({ "Beir7:", "male:" }), d_eta, d_vsd); break; case FEMALE: Parser::extract( Parser::one({ "Beir7:", "female:" }), d_eta, d_vsd); break; } } simrisc-16.02.00/beir7/frame0000664000175000017500000000006014665030471014426 0ustar frankfrank//#define XERR #include "beir7.ih" Beir7:: { } simrisc-16.02.00/betadist/0000775000175000017500000000000014665030471014204 5ustar frankfranksimrisc-16.02.00/betadist/betadist.ih0000664000175000017500000000015614665030471016327 0ustar frankfrank#include "betadist.h" #include #include "../err/err.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/betadist/betadist1.cc0000664000175000017500000000053514665030471016376 0ustar frankfrank//#define XERR #include "betadist.ih" BetaDist::BetaDist(istream &in) { for (size_t idx = 0; idx != size(d_param); ++idx) in >> d_param[idx]; if (not in) { Err::msgTxt(Err::SPEC_ERROR); return; } d_xGamma = gamma_distribution<>{ d_param[2], 1 }; d_yGamma = gamma_distribution<>{ d_param[3], 1 }; } simrisc-16.02.00/betadist/reset.cc0000664000175000017500000000015614665030471015637 0ustar frankfrank//#define XERR #include "betadist.ih" void BetaDist::reset() { d_xGamma.reset(); d_yGamma.reset(); } simrisc-16.02.00/betadist/icmconf0000664000175000017500000000007714665030471015551 0ustar frankfrank#define LIBRARY "betadist" #include "../icmconf.lib" simrisc-16.02.00/betadist/frame0000664000175000017500000000006614665030471015223 0ustar frankfrank//#define XERR #include "betadist.ih" BetaDist:: { } simrisc-16.02.00/betadist/betadist.h0000664000175000017500000000160114665030471016152 0ustar frankfrank#ifndef INCLUDED_BETADIST_ #define INCLUDED_BETADIST_ #include #include // 'Beta' has just been read | read from here // # LC: eta beta dist constant factor aParam bParam // male: -1.4 .32 Beta .234091 1.72727 2.664237 5.184883 // female: -1.4 1.40 Beta .744828 .818966 3.366115 4.813548 class BetaDist { double d_param[4]; // 0: constant, 1: factor, 2: aParam, 3: bParam std::gamma_distribution<> d_xGamma; std::gamma_distribution<> d_yGamma; public: BetaDist(std::istream &in); // extracts params from the config file void reset(); double operator()(std::mt19937 &engine); std::pair parameters() const; }; inline std::pair BetaDist::parameters() const { return {std::size(d_param), d_param}; } #endif simrisc-16.02.00/betadist/operatorfun.cc0000664000175000017500000000032314665030471017055 0ustar frankfrank//#define XERR #include "betadist.ih" double BetaDist::operator()(mt19937 &engine) { double xValue = d_xGamma(engine); return (xValue / (xValue + d_yGamma(engine)) + d_param[0]) / d_param[1]; } simrisc-16.02.00/bisonc++parser/0000775000175000017500000000000014665030471015225 5ustar frankfranksimrisc-16.02.00/bisonc++parser/parser.h0000664000175000017500000000232414665030471016673 0ustar frankfrank// Generated by Bisonc++ V6.04.00 on Fri, 20 Mar 2020 16:07:08 +0100 #ifndef Parser_h_included #define Parser_h_included // $insert baseclass #include "parserbase.h" // $insert scanner.h #include "../scanner/scanner.h" // $insert undefparser #undef Parser // CAVEAT: between the baseclass-include directive and the // #undef directive in the previous line references to Parser // are read as ParserBase. // If you need to include additional headers in this file // you should do so after these comment-lines. class Parser: public ParserBase { // $insert scannerobject Scanner d_scanner; public: Parser(char const *infile); int parse(); private: void error(); // called on (syntax) errors int lex(); // returns the next token from the // lexical scanner. void print(); // use, e.g., d_token, d_loc void exceptionHandler(std::exception const &exc); // support functions for parse(): void executeAction_(int ruleNr); void errorRecovery_(); void nextCycle_(); void nextToken_(); void print_(); }; #endif simrisc-16.02.00/bisonc++parser/parser1.cc0000664000175000017500000000013114665030471017104 0ustar frankfrank#include "parser.ih" Parser::Parser(char const *infile) : d_scanner(infile, "-") {} simrisc-16.02.00/bisonc++parser/parser.ih0000664000175000017500000000103114665030471017036 0ustar frankfrank// Generated by Bisonc++ V6.04.00 on Fri, 20 Mar 2020 16:07:08 +0100 // Include this file in the sources of the class Parser. // $insert class.h #include "parser.h" inline void Parser::error() { std::cerr << "Syntax error\n"; } // $insert lex inline int Parser::lex() { return d_scanner.lex(); } inline void Parser::print() { } inline void Parser::exceptionHandler(std::exception const &exc) { throw; // re-implement to handle exceptions thrown by actions } #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/bisonc++parser/inc/0000775000175000017500000000000014665030471015776 5ustar frankfranksimrisc-16.02.00/bisonc++parser/inc/survival0000664000175000017500000000023014665030471017567 0ustar frankfranksurvivalSpec: TYPE number optDistribution ; survivalSpecs: survivalSpecs survivalSpec | // empty ; survival: SURVIVAL survivalSpecs ; simrisc-16.02.00/bisonc++parser/inc/scenario0000664000175000017500000000032114665030471017520 0ustar frankfrankscenarioSpec: CASES NR | SPREAD BOOL | GENERATOR GENTYPE | SEED NR | ITERATIONS NR ; scenarioSpecs: scenarioSpecs scenarioSpec | // empty ; scenario: SCENARIO scenarioSpecs ; simrisc-16.02.00/bisonc++parser/inc/costs0000664000175000017500000000062214665030471017054 0ustar frankfrankcostsDiscount: AGE NR | PROP NR ; costsDiscounts: costsDiscounts costsDiscount | costsDiscount ; costsDiameter: NR ':' NR ; costsDiameters: costsDiameters costsDiameter | costsDiameter ; costsSpec: BIOP NR | DIAMETERS costsDiameters | DISCOUNT costsDiscounts ; costsSpecs: costsSpecs costsSpec | // empty ; costs: COSTS costsSpecs ; simrisc-16.02.00/bisonc++parser/inc/agerange0000664000175000017500000000015014665030471017466 0ustar frankfranklastAge: NR | '*' ; ageRange: NR '-' lastAge ':' ; ageGroupRange: AGEGROUP ageRange ; simrisc-16.02.00/bisonc++parser/inc/mri0000664000175000017500000000022014665030471016502 0ustar frankfrankmriSpec: cost | SENSITIVITY REAL | SPECIFICITY REAL ; mriSpecs: mriSpecs mriSpec | // empty ; mri: MRI mriSpecs ; simrisc-16.02.00/bisonc++parser/inc/number0000664000175000017500000000003414665030471017206 0ustar frankfranknumber: NR | REAL ; simrisc-16.02.00/bisonc++parser/inc/carrierspecs0000664000175000017500000000032614665030471020407 0ustar frankfrankcarrierSpec: PROB number | LIFETIMERISK number optDistribution | MEANAGE number optDistribution | STDDEV number optDistribution ; carrierSpecs: carrierSpecs carrierSpec | carrierSpec ; simrisc-16.02.00/bisonc++parser/inc/breastdensities0000664000175000017500000000021514665030471021107 0ustar frankfrankbDAgeGroup: ageGroupRange biRads ; bDSpecs: bDSpecs bDAgeGroup | // empty ; breastDensities: BREASTDENSITIES bDSpecs ; simrisc-16.02.00/bisonc++parser/inc/dose0000664000175000017500000000003314665030471016647 0ustar frankfrankdose: DOSE biRads ; simrisc-16.02.00/bisonc++parser/inc/mammo0000664000175000017500000000031014665030471017021 0ustar frankfrankmammoSpec: cost | dose | specificity | BETA distributions | SYSERR distribution ; mammoSpecs: mammoSpecs mammoSpec | // empty ; mammo: MAMMO mammoSpecs ; simrisc-16.02.00/bisonc++parser/inc/distributions0000664000175000017500000000033114665030471020620 0ustar frankfrankdistribution: REAL NORMAL ; optDistribution: distribution | // empty ; optParenDistribution: '(' distribution ')' | // empty ; distributions: distributions distribution | distribution ; simrisc-16.02.00/bisonc++parser/inc/modalities0000664000175000017500000000034014665030471020050 0ustar frankfrank%include inc/mammo %include inc/tomo %include inc/mri modalitiesSpec: mammo | tomo | mri ; modalitiesSpecs: modalitiesSpecs modalitiesSpec | // empty ; modalities: MODALITIES modalitiesSpecs ; simrisc-16.02.00/bisonc++parser/inc/tumor0000664000175000017500000000036214665030471017070 0ustar frankfrank%include inc/beir7 %include inc/incidence %include inc/growth %include inc/survival tumorSpec: beir7 | incidence | growth | survival ; tumorSpecs: tumorSpecs tumorSpec | // empty ; tumor: TUMOR tumorSpecs ; simrisc-16.02.00/bisonc++parser/inc/tokens0000664000175000017500000000062314665030471017225 0ustar frankfrank%token SCENARIO BOOL SPREAD ITERATIONS NR GENERATOR GENTYPE SEED CASES COSTS BIOP DIAMETERS DISCOUNT AGE PROP REAL BREASTDENSITIES AGEGROUP MODALITIES MAMMO COST DOSE SPECIFICITY BETA NORMAL SYSERR TOMO SENSITIVITY MRI SCREENING ATTENDANCERATE ROUND TUMOR BEIR7 ETA INCIDENCE PROB LIFETIMERISK MEANAGE STDDEV BRCA1 BRCA2 GROWTH START SELFDETECTMU SELFDETECTSIGMA DOUBLINGTIME SURVIVAL TYPE simrisc-16.02.00/bisonc++parser/inc/screening0000664000175000017500000000053214665030471017676 0ustar frankfrankscreeningModality: MAMMO | TOMO | MRI ; screeningModalities: screeningModalities screeningModality | screeningModality ; screeningSpec: ROUND number screeningModalities | ATTENDANCERATE distribution ; screeningSpecs: screeningSpecs screeningSpec | // empty ; screening: SCREENING screeningSpecs ; simrisc-16.02.00/bisonc++parser/inc/agerangeprobs0000664000175000017500000000014614665030471020541 0ustar frankfrankageRangeProb: ageRange REAL ; ageRangeProbs: ageRangeProbs ageRangeProb | ageRangeProb ; simrisc-16.02.00/bisonc++parser/inc/doublingtime0000664000175000017500000000034614665030471020406 0ustar frankfrankdoublingTimeSpec: ageGroupRange number optParenDistribution number optParenDistribution ; doublingTimeSpecs: doublingTimeSpecs doublingTimeSpec | doublingTimeSpec ; doublingTime: DOUBLINGTIME doublingTimeSpecs ; simrisc-16.02.00/bisonc++parser/inc/tomo0000664000175000017500000000023714665030471016701 0ustar frankfranktomoSpec: cost | dose | specificity | SENSITIVITY biRads ; tomoSpecs: tomoSpecs tomoSpec | // empty ; tomo: TOMO tomoSpecs ; simrisc-16.02.00/bisonc++parser/inc/incidence0000664000175000017500000000034414665030471017643 0ustar frankfrank%include inc/carrierspecs incidenceSpec: NORMAL carrierSpecs | BRCA1 carrierSpecs | BRCA2 carrierSpecs ; incidenceSpecs: incidenceSpecs incidenceSpec | // empty ; incidence: INCIDENCE incidenceSpecs ; simrisc-16.02.00/bisonc++parser/inc/birads0000664000175000017500000000005114665030471017161 0ustar frankfrankbiRads: biRads number | number ; simrisc-16.02.00/bisonc++parser/inc/beir70000664000175000017500000000023414665030471016730 0ustar frankfrankbeir7Spec: BETA REAL | ETA REAL | SPREAD distribution ; beir7Specs: beir7Specs beir7Spec | // empty ; beir7: BEIR7 beir7Specs ; simrisc-16.02.00/bisonc++parser/inc/cost0000664000175000017500000000002414665030471016665 0ustar frankfrankcost: COST NR ; simrisc-16.02.00/bisonc++parser/inc/specificity0000664000175000017500000000005514665030471020234 0ustar frankfrankspecificity: SPECIFICITY ageRangeProbs ; simrisc-16.02.00/bisonc++parser/inc/growth0000664000175000017500000000042014665030471017227 0ustar frankfrank%include inc/doublingtime growthSpec: START number optDistribution | SELFDETECTMU number optDistribution | SELFDETECTSIGMA number optDistribution | doublingTime ; growthSpecs: growthSpecs growthSpec | // empty ; growth: GROWTH growthSpecs ; simrisc-16.02.00/bisonc++parser/inc/normal0000664000175000017500000000004214665030471017205 0ustar frankfranknormal: NORMAL carrierSpecs ; simrisc-16.02.00/bisonc++parser/grammar0000664000175000017500000000133314665030471016576 0ustar frankfrank%default-actions quiet %filenames parser %scanner ../scanner/scanner.h %token-path tokens.h // %print-tokens %baseclass-preinclude ../info/info.h %include inc/tokens %% // Define the start-rule below (the name `startrule' may be altered) startrule: startrule keywords | // empty ; %include inc/agerange %include inc/agerangeprobs %include inc/number %include inc/birads %include inc/distributions %include inc/cost %include inc/dose %include inc/specificity %include inc/scenario %include inc/costs %include inc/breastdensities %include inc/modalities %include inc/screening %include inc/tumor keywords: scenario | costs | breastDensities | modalities | screening | tumor | error ; simrisc-16.02.00/build0000775000175000017500000000752014665030471013436 0ustar frankfrank#!/usr/bin/icmake -t. #define LOGENV "SIMRISC" #include "icmconf" string g_logPath = getenv(LOGENV)[1], g_cwd = chdir(""); // initial working directory, ends in / int g_echo = ON; #include "icmake/cuteoln" #include "icmake/backtick" #include "icmake/setopt" #include "icmake/beep" // beep if /usr/local/bin/beep exists and exit #include "icmake/run" #include "icmake/md" #include "icmake/pathfile" #include "icmake/findall" #include "icmake/loginstall" #include "icmake/logzip" #include "icmake/logfile" #include "icmake/uninstall" #include "icmake/special" #include "icmake/clean" #include "icmake/manpage" #include "icmake/latexdoc" #include "icmake/pdf" #include "icmake/manual" #include "icmake/install" #include "icmake/gitlab" void main(int argc, list argv) { string option; int idx; for (idx = listlen(argv); idx--; ) { if (argv[idx] == "-q") { g_echo = OFF; argv -= (list)"-q"; } } echo(g_echo); option = argv[1]; if (option == "clean") clean(0); if (option == "distclean") clean(1); if (option != "") special(); if (option == "install") install(argv[2], argv[3]); if (option == "uninstall") uninstall(argv[2]); if (option == "gitlab") gitlab(); if (option == "man") manpage(); if (option == "manual") manual(); if (option == "pdf") // creates the pdf version of the pdf(); // tech manual if (option == "library") { system("icmbuild library"); beep(); } if (option == "program") { system("icmbuild program"); if (argv[2] == "strip") system("strip " TMP_DIR "/bin/binary"); beep(); } if (option == "xref") { system("icmbuild program"); run("oxref -t main -r replacements -fxs tmp/main.o tmp/lib" LIBRARY ".a > " PROGRAM ".xref"); if (argv[2] == "strip") system("strip " TMP_DIR "/bin/binary"); beep(); } printf("Usage: build [-q] what\n" "Where\n" " [-q]: run quietly, do not show executed commands\n" "`what' is one of:\n" " clean - clean up remnants of previous " "compilations\n" " distclean - clean + fully remove tmp/\n" " library - build " PROGRAM "'s library\n" " man - build the man-page (requires Yodl)\n" " manual - build the html manual (requires Yodl)\n" " pdf - build the pdf manual (requires Yodl)\n" " program [strip] - build " PROGRAM " (optionally strip the\n" " executable)\n" " xref [strip] - same a `program', also builds xref file\n" " using oxref\n" " install selection [base] - to install the software in the \n" " locations defined in the INSTALL.im file,\n" " optionally below base\n" " selection can be\n" " x, to install all components,\n" " or a combination of:\n" " b (binary program),\n" " d (documentation),\n" " m (man-page)\n" " uninstall logfile - remove files and empty directories listed\n" " in the file 'logfile'\n" " gitlab - prepare gitlab's web-pages update\n" " (internal use only)\n" "\n" ); } simrisc-16.02.00/changelog0000664000175000017500000003636214665030471014271 0ustar frankfranksimrisc (16.02.00) * Natural deaths occurring before tumor onsets are no longer using 'UNDETECTED_XXX' exit codes but 'NATURAL_XXX' exit codes. * In those cases 'Yes' status flags are changed to 'No' -- Frank B. Brokken Thu, 15 Jun 2024 11:33:25 +0200 simrisc (16.01.00) * The lung cancer survival parameters (i.e., table S4) received an e (quality of medical support) parameter, like the BC e-parameter. * The simriscparams(7) man-page was updated accordingly -- Frank B. Brokken Wed, 05 Jun 2024 09:35:24 +0200 simrisc (16.00.00) * Reimplemented major elements of the simulation algorithm: elements of the pre-screening, intervals between screening rounds and post-screening are not separately defined anymore, but all call the same implementation components. * Simplified handling of the screening rounds and the post-screening step. Pre-screen now superfluous. For details: sse README.loop-tests * Simrisc's organization was reorganized avoiding multiply implemented elements deriving from versions before simrisc 12.00.00. * The organization of the configuration file and of Analysis specifications was simplified. * Screening::writeParameters reports the attendanceRate in 2 decimals * Growth parameters are specified using millimeters, not anymore using ln(millimeters) * In the data*txt files case indices use natural numbers (starting at 1) * The data*txt files show the death status legend below the time-stamp and analysis label * Type e (quality of the medical care) was added to the survival: type: specifications. * Tumor incidence parameters (probabilities) can also be specified using a table, in addition to using distribution parameters (cf. Incidence in the simriscparams(7) man-page). * Man-pages were updated. -- Frank B. Brokken Wed, 29 May 2024 17:37:41 +0200 simrisc (15.05.00) * natural death ages < tumor death ages are no longer reported as death by tumors * repaired sudden increases in # tumor cases * avoiding tumor sizes < growth.start sizes * the name 'detectableAge' is confusing: renamed to 'onset', indicating the tumor's start * interval cancers prevent exact 5mm tumor occurrences, caused by spurious onset values -- Frank B. Brokken Mon, 29 Jan 2024 12:40:08 +0100 simrisc (15.04.00) * The params.txt file also contains the cumulative death-proportions if specified (currently: with lung-cancer simulations) -- Frank B. Brokken Thu, 07 Dec 2023 21:10:54 +0100 simrisc (15.03.01) * When reading the cumulative death proportions errors in the specification of the cumulative death proportions are checked (like lines broken at a final '='-character). * Changed the copyright to the Gnu GPL * Cosmetics on the simrisc.xref * The c++std file is no longer used. Instead the ICMAKE_CXXFLAGS environment variable is inspected. -- Frank B. Brokken Sat, 28 Oct 2023 15:08:19 +0200 simrisc (15.03.00) * Repaired survival/cptvsdrow: d_vsdRow was set to S3's row instead of S4's element index, which also resulted in errors in computing, e.g., the number of interval cancers. Because of this bug Simrisc before 15.03.00 should not anymore be used for lung cancer simulations. Using Simrisc for breast cancer simulations is OK. * When using lung cancer simulations the parameters written to file now correctly report the lung cancer parameters. -- Frank B. Brokken Sat, 01 Jul 2023 15:34:15 +0200 simrisc (15.02.00) * Costs values are now stored in size_t instead of in uint16_t variables -- Frank B. Brokken Wed, 14 Jun 2023 16:22:36 +0200 simrisc (15.01.00) * Added a column TNM to the data file containing the TNM categories per case. With breast cancer the 2nd value carries no meaning and is set to 0. * Added specification 'bc:' to the default configuration file defining the tumor diameter boundaries when using breast cancer simulations. * The S3 table in the default configuration specifies increasing (inclusive) boundaries for lung cancer tumer diameters. * Added option --tnm inserting -1,0 in the TNM column of the data file for cases not having tumors. * Fixed handling CT sensitivity computations (in the simulations percentages instead of proportions were used). * Fixed the CT specificity mean (was 99.2, changed to .992). * Added the class Log producing extensive logging when handling cases. * Added option --log "begin end logfile [set] " to log process information for the selected case-index ranges. * Fixed a boundary bug in probgroup/indexof.cc causing indexOf() to return an index value exceeding the width of a cumulative probability vector if the generated probability equals 1. -- Frank B. Brokken Mon, 08 May 2023 10:33:36 +0200 simrisc (15.00.00) * Added option --cancer (-c) which is used to specify the simulation type. By default '--cancer breast' is used, in which case breast cancer simulations are performed. Alternatively, '--cancer female' can be specified in which case lung cancer simulations are performed for women, and '--cancer male' can be specified in which case lung cancer simulations are performed for men. * When performing lung-cancer simulations modality CT must be used (default costs, dose, sensitivity and specificity parameters are defined in the default configuration file in section 'Modalities:' 'CT:'). * Added option --cum-death (-d) which is used to specify the name of a file containing the 101 cumulative death proportions. * Default proportions are provided in the default configuration file at the 'death:' parameter specification of the section 'Scenario:'. * Option --err is still present, but is removed in a future version. It is not mentioned in the current man-page and in simrisc's usage information anymore. * The default configuration file contains parameters used with lung cancer simulations for Costs: Discount: proportion:, Tumor: Growth: start:, Tumor: Growth: lung: (used to specify the selfDetect parameters, for breast cancer simulations Tumor: Growth: breast: is used) Tumor: Growth: DoublingTime: lung: And separate Male: and Female: subsections for Tumor: Incidence: (for breast cancer simulation Tumor: Incidence: Breast: is used) Survival: lung[0-3]: sections to determine the survival parameters, in combination with the new section Tumor: S3: (see the simriscparams(7) man-page for details). * The simrisc(1) and simriscparams(7) manpages were updated. -- Frank B. Brokken Sat, 10 Dec 2022 12:25:10 +0100 simrisc (14.05.01) * Ready for libbobcat6 * Added 'c++std' defining the c++ standard to use for compilation. Compilation commands also use -Werror * Renamed the 'oxref' option in the 'build' script to 'xref' -- Frank B. Brokken Sat, 17 Sep 2022 16:07:04 +0200 simrisc (14.05.00) * Added option --err (-e) to select the previously used but inorrect algorithm for computing the Beir7 risk vector, instead of using the (now default) correct algorithm for computing the risk vector. -- Frank B. Brokken Sat, 22 May 2021 22:09:08 +0200 simrisc (14.04.00) * Modalities support spread-variation. See the simriscparams(7) man-page for a description of how the configuration file was extended wrt the Modality-specifications. When 'spead: true' is specified then Loop::iterate() now calls d_modalities.vary(), calling ModBase vary for the various Modalities. Previously defined 'double' Modality values now use VSDs * Age range specifications do not end in ':'s anymore. E.g., ageGroup: 1 - 50 * Beir7's parameter specification first specifies eta, then beta. * The Case-specific data matrix defines an extra (18th) colum, showing the results of the screening rounds for each simulated case. * When 'spread: true' is specified the actually used and original parameter values are listed in a file, by default 'spread-$.txt', where $ is replaced by the loop iteration index. Use the option '-s' to specify a non-default filename (cf. simrisc(1)); * The man-pages were update -- Frank B. Brokken Sun, 11 Apr 2021 11:00:58 +0200 simrisc (14.03.00) * To specify no screening round ages 'round: none' should be specified. When 'round: none' is specified then the rounds file is not written. -- Frank B. Brokken Sun, 21 Feb 2021 13:30:38 +0100 simrisc (14.02.00) * Option --cases was renamed to --last-case (-l) to avoid confusion with the cases: specification in the configuration file * Default option values are reset at each Analysis: specification. * Analysis files now use (capitalized) Analysis: specifications. * Fixed some specification errors in the simriscparams(7) man-page * Updated the simrisc(1) man-page * Updated the usage info -- Frank B. Brokken Wed, 27 Jan 2021 16:39:02 +0100 simrisc (14.01.00) * 'm:' parameter specifications for the four bi-rad categories were added to the Mammo specifications in the default configuration file * The 'm:' parameter corresponding to the cases bi-rad category given the case's age is used when computing the sensitivity associated with the Mammo modality * The simriscparams(7) man-page was updated accordingly * The simrisc --help info lists the --cases (-c) option instead of --nCases (-n). -- Frank B. Brokken Fri, 22 Jan 2021 11:14:22 +0100 simrsic (14.00.00) * Case-specific data are reproducible when specifying 'generator: fixed' or 'generator: increasing' * Parameter variation when specifying 'spread: true' is available * The organization of the configuration file was drastically modified * The validity of parameter value specifications is checked -- Frank B. Brokken Wed, 20 Jan 2021 20:43:53 +0100 simrsic (13.03.00) * Redefined variables in the Costs class: the discount percentage in fact is a proportion, and its type was adapted accordingly * MRI simulation was incorrectly implemented in the original program. After fixing this error handling False Negatives is now using a standard procedure for all Modalities * The configuration file and the simriscparams man-page were adapted accordingly. * The classes Options, Random, and Error are now singletons. -- Frank B. Brokken Tue, 27 Oct 2020 19:56:12 +0100 simrsic (13.02.01) * Added a Copyright-notice file -- Frank B. Brokken Mon, 12 Oct 2020 09:34:04 +0200 simrsic (13.02.00) * Specifications using multiple analyses no longer overwrite existing files * Added specification 'generator' to the scenario specifications to specify the way the random number generator is initialized * The classes Pool, IDpool, and RandomPool are superfluous * MRI handling is activated. * The loop Status enum now uses 'PRESENT' instead of 'ALIVE' and Status enum values beginning with 'LEFT_' instead of 'NATURAL_' -- Frank B. Brokken Tue, 29 Sep 2020 16:04:26 +0200 simrsic (13.01.00) * Added missing registration of d_roundDetected to loop/maybedetect.cc * loop/selfdetected.cc and loop/treatmentdeath.cc are identical except for used Status values: now inline, calling new function in loop/characteristics.cc * Added a new section OUTPUT to the simrisc(3) man-page, containing descriptions of the content of generated files * By default the id-base option uses value 1 simrsic (13.00.00-pre) * Reorganized config/simrisc, costs associated with Modalities are now defined by the individual modality-specifications * Repaired the computation of d_prePeriod in tumor/reset.cc * Implemented Danielle's code and modified the handling of multiple modalities * Standardized the handling of Modalities by defining one standard interface * Updated the man-pages -- Frank B. Brokken Thu, 16 Jul 2020 13:45:32 +0200 simrsic (12.03.01) * Dropped 'oneAnalysis' and 'showAll' from Options, added specificAges(), fixing a bug in handling specific ages / N-cases specifications -- Frank B. Brokken Fri, 29 May 2020 15:52:30 +0200 simrsic (12.03.00) * Fixed handling of filename specifications in analysis: sections * The --one-analysis option no longer requires command-line arguments * Analysis: specifications may be empty * Minor update of the man-page -- Frank B. Brokken Fri, 29 May 2020 13:39:29 +0200 simrsic (12.02.02) * Changed the content of /usr/share/doc/simrisc: it now contains the README.hierarchy file and the default configuration file (simrisc.gz) -- Frank B. Brokken Tue, 26 May 2020 13:38:10 +0200 simrsic (12.02.01) * Updated the short option letters of the program's usage info -- Frank B. Brokken Tue, 26 May 2020 11:14:14 +0200 simrsic (12.02.00) * Added option --id-base to use id-based random numbers instead of random-pool based random numbers. * All options referring to filesystem entries use capitalized single letter options; all other options are lowercase * Updated the man-pages. * The default parameter specification file is available as the file 'simrisc' in the distribution's .config/ directory -- Frank B. Brokken Mon, 25 May 2020 15:48:49 +0200 simrsic (12.01.01) * New sub-minor release due to a man-page bug. -- Frank B. Brokken Sat, 23 May 2020 21:20:04 +0200 simrsic (12.01.00) * Reorganized the class hierarchy, preparing for multi-threading: see README.hierarcy. * Base directories are created if not available * Output files are provided with a timestamp and optionally analysis labels * Output files are cleaned up: improved table formats, and CSVs for the data files * The file echoing the used parameters is by default not produced. The --parameters option is used to specify the name of that file if requested. * When specifying configuration parameters in the context of an analysis either all, or none of the parameters of a category must be provided. This procedure is used to allow reduction of, e.g., screening rounds. -- Frank B. Brokken Sat, 23 May 2020 19:26:48 +0200 simrsic (12.00.00) * Following a request by Marcel Greuter (m.j.w.greuter@umcg.nl) SimRiSc was completely rewrittin in this release. Earlier specific changelog version information is not available. In the distribution earlier changelog info is available under 'legacy' * This is the initial conversion, offering the basic facilities. The current program produces the same results as the original program, for a single scenario, but specifying 100'000 women is OK. * Lots of work is still required to update the man-pages, and to completely generalize the program. * Debian package construction is (locally) operational. -- Frank B. Brokken Sun, 17 May 2020 17:47:06 +0200 simrisc-16.02.00/CLASSES0000664000175000017500000000047414665030471013432 0ustar frankfranksimulator analysis loop scenario tumor tumorinfo growth survival params vsdparams tableparams incidence beir7 costs modalities screening round densities configlines vsd distribution options random globals err ct tomo mammo mri modbase configlines group probgroup agegroupvsd parser betadist log //typedefs //enums simrisc-16.02.00/compsens/0000775000175000017500000000000014665030471014234 5ustar frankfranksimrisc-16.02.00/compsens/compsense.cc0000664000175000017500000000153614665030471016544 0ustar frankfrank#include #include #include using namespace std; int main() { ifstream in{"../org/simrisc/test3/sensitivity.txt"}; in.ignore(1000, '\n'); double orgYears; double orgCosts; in >> orgYears >> orgYears >> orgCosts; cout << "Originally:\n" << orgYears << ' ' << orgCosts << '\n'; in.close(); in.open("../output/sensitivity.txt"); in.ignore(1000, '\n'); in.ignore(1000, '\n'); in.ignore(1000, '\n'); double simYears; double simCosts; char comma; in >> simYears >> comma >> simYears >> comma >> simCosts; cout << "New simrisc:\n" << simYears << ' ' << simCosts << '\n'; double q1 = orgYears / simYears; double q2 = orgCosts / simCosts; if (q1 < 1) q1 = 1 / q1; if (q2 < 1) q2 = 1 / q2; cout << q1 << " " << q2 << '\n'; } simrisc-16.02.00/compsens.bim0000664000175000017500000000025714665030471014731 0ustar frankfrank9.03z££t" ÿ¿þ¿ÿ¿ þ¿þ¿ÿ¿ þ¿"þ¿ & þ¿'þ¿ %þ¿ #!$org/simrisc/test3/sensitivity.txt compsens.im simrisc-16.02.00/configlines/0000775000175000017500000000000014665030471014705 5ustar frankfranksimrisc-16.02.00/configlines/configlines2.cc0000664000175000017500000000023714665030471017600 0ustar frankfrank//#define XERR #include "configlines.ih" ConfigLines::ConfigLines(istream &in, uint16_t lineNr) : d_config(in, lineNr) { d_iter = d_config.begin(); } simrisc-16.02.00/configlines/get.cc0000664000175000017500000000150014665030471015767 0ustar frankfrank//#define XERR #include "configlines.ih" bool ConfigLines::get() { if (d_redo) { d_redo = false; return d_iter != d_config.end(); } while (d_iter != d_config.end()) { string const &line = d_iter->line(); if (line.empty() or isspace(line.front())) // skip empty lines { ++d_iter; continue; } d_line = d_iter->line(); d_lineNr = d_iter->lineNr(); d_tail = d_iter->tail(); d_value = d_iter->value(); d_key = d_iter->key(); if (d_key.empty()) // no key -> store d_key = d_line; // the line as key ++d_iter; return true; } return false; // end of file } simrisc-16.02.00/configlines/configlines1.cc0000664000175000017500000000022114665030471017570 0ustar frankfrank//#define XERR #include "configlines.ih" ConfigLines::ConfigLines(string const &fname) : d_config(fname) { d_iter = d_config.begin(); } simrisc-16.02.00/configlines/insert.cc0000664000175000017500000000032614665030471016521 0ustar frankfrank//#define XERR #include "configlines.ih" ostream &ConfigLines::insert(ostream &out) const { for (auto iter = d_iter, end = d_config.end(); iter != end; ++iter) out << *iter << '\n'; return out; } simrisc-16.02.00/configlines/key1.cc0000664000175000017500000000024714665030471016070 0ustar frankfrank//#define XERR #include "configlines.ih" void ConfigLines::key(string const &newKey) { d_tail = d_line; d_key = newKey; d_line = newKey + ' ' + d_tail; } simrisc-16.02.00/configlines/configlines.h0000664000175000017500000000361014665030471017356 0ustar frankfrank#ifndef INCLUDED_CONFIGLINES_ #define INCLUDED_CONFIGLINES_ #include #include #include "../options/options.h" class ConfigLines { friend std::ostream &operator<<(std::ostream &out, ConfigLines const &configLines); typedef FBB::Config::const_iterator const_iterator; typedef FBB::CF_Line CF_Line; FBB::Config d_config; uint16_t d_lineNr; std::string d_key; std::string d_tail; std::string d_line; std::string d_value; const_iterator d_iter; // iterator to Config lines bool d_redo = false; // next get() returns d_line public: ConfigLines(std::string const &fname); ConfigLines(std::istream &in, uint16_t lineNr); // void load(); void redo(); bool get(); void key(std::string const &newKey); // 1 std::string const &line() const; // only after get() returns true std::string const &tail() const; std::string const &value() const; // 1st word of the key's value std::string const &key() const; // h uint16_t lineNr() const; private: std::ostream &insert(std::ostream &out) const; }; inline uint16_t ConfigLines::lineNr() const { return d_lineNr; } inline void ConfigLines::redo() { d_redo = true; } inline std::string const &ConfigLines::key() const { return d_key; } inline std::string const &ConfigLines::line() const { return d_line; } inline std::string const &ConfigLines::value() const { return d_value; } inline std::string const &ConfigLines::tail() const { return d_tail; } inline std::ostream &operator<<(std::ostream &out, ConfigLines const &configLines) { return configLines.insert(out); } #endif simrisc-16.02.00/configlines/icmconf0000664000175000017500000000010214665030471016237 0ustar frankfrank#define LIBRARY "configlines" #include "../icmconf.lib" simrisc-16.02.00/configlines/configlines.ih0000664000175000017500000000020014665030471017517 0ustar frankfrank#include "configlines.h" #include "../xerr/xerr.ih" #include "../options/options.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/configlines/frame0000664000175000017500000000007414665030471015723 0ustar frankfrank//#define XERR #include "configlines.ih" ConfigLines:: { } simrisc-16.02.00/configlines/load.cc0000664000175000017500000000025614665030471016136 0ustar frankfrank////#define XERR //#include "configlines.ih" // //void ConfigLines::load() //{ // d_config.load(Options::instance().configFile()); // d_iter = d_config.begin(); //} // simrisc-16.02.00/Copyright-notice0000664000175000017500000000305514665030471015562 0ustar frankfrank-----BEGIN PGP SIGNED MESSAGE----- Hash: SHA256 Simrisc is a program simulating the effects of cancer and cancer treatments. The program is a complete rewrite of the original simrisc program developed at the University Medical Center Groningen (UMCG) by a research group around Truuske de Bock and Marcel Greuter. The current program is developed in close collaboration with Truuske and Marcel. Copyright (C) 2020-now Frank B. Brokken (f.b.brokken@rug.nl) This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version. This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details. A copy of the GNU General Public License can be retrieved from http://www.gnu.org/licenses/. -----BEGIN PGP SIGNATURE----- iQEzBAEBCAAdFiEE3zIT3rFWdzLmXjtNfbKovurk2KoFAl+EBmMACgkQfbKovurk 2Ko+MwgAh6Z8SnvsasIF15lfxkeqSx2x8EGwb6Wz0fFVfbd6nl4kbcidZZcWHtok bd526YR/Py24cXfcMfkf4+NlB9tnaeHTyBleDCBJEh1L3MUDZdUzI4jN7UsLTjF8 VCxTCMbhqS0VBGGmvQ9ZZ8AOuRzzTK93Fi2IXa2g55PAINlCDFzmHOnKQ4j8vl3X bmFZoNfkKfypYD9XZkhURnZdMTc9athaGb+A5Ju3E2lt3ozeu5joCKYeOvlkFodX X4AQiqkwuzRnSK9oXat09h2xkII8pPJxnJBWrtYkzU834cn2WwXc9q0c7F+EUp51 lCcXFyr/POylSW0aoQHV60alq89NLw== =QWjm -----END PGP SIGNATURE----- simrisc-16.02.00/costs/0000775000175000017500000000000014665030471013540 5ustar frankfranksimrisc-16.02.00/costs/setage.cc0000664000175000017500000000021214665030471015312 0ustar frankfrank//#define XERR #include "costs.ih" void Costs::setAge() { d_base.back() = "age:"; Parser::nonNegative(d_base, d_referenceAge); } simrisc-16.02.00/costs/costs.ih0000664000175000017500000000052114665030471015213 0ustar frankfrank#include "costs.h" #include "../xerr/xerr.ih" #include #include #include #include #include #include #include "../globals/globals.h" //#include "../options/options.h" #include "../scenario/scenario.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/costs/setproportion.cc0000664000175000017500000000146614665030471017005 0ustar frankfrank#define XERR #include "costs.ih" void Costs::setProportion(bool lungCancer) { d_base.back() = "proportion:"; LineInfo const *lineInfo = Parser::one(d_base).get(); istringstream in{ lineInfo->tail }; // get the line's tail if (not (in >> d_discountProportion)) { Err::msg(Err::SPEC_ERROR) << "[Costs:] proportion: must specify at least one value" << endl; return; } // at LC simulations: if (lungCancer) // maybe a 2nd proportion? { double prop2; if (in >> prop2) // if so, use it d_discountProportion = prop2; } if (not Globals::proportion(d_discountProportion)) Err::range(); } simrisc-16.02.00/costs/setdiameters.cc0000664000175000017500000000026514665030471016543 0ustar frankfrank#define XERR #include "costs.ih" void Costs::setDiameters() { d_base.back() = "diameters:"; if (not extractDiameters(Parser::one(d_base))) Err::specification(); } simrisc-16.02.00/costs/setdiscount.cc0000664000175000017500000000017414665030471016415 0ustar frankfrank#define XERR #include "costs.ih" void Costs::setDiscount(bool lungCancer) { setAge(); setProportion(lungCancer); } simrisc-16.02.00/costs/costs.f0000664000175000017500000000105014665030471015036 0ustar frankfrankinline double Costs::usingAt(double age) const { return discount(age, d_usingCosts); } inline double Costs::screening(double age, size_t cost) const { return discount(age, cost); } inline double Costs::treatment(double age, double diameter, bool metastasis) const { // calls lcTreatment with lung cancer, otherwise: otherTreatment return (this->*d_treatment)(age, diameter, metastasis); } // return (this->*d_using)(age, d_usingCosts); // return (this->*d_screening)(age, cost); simrisc-16.02.00/costs/setlungcancer.cc0000664000175000017500000000051714665030471016707 0ustar frankfrank#define XERR #include "costs.ih" void Costs::setLungCancer() { size_t unused; // = modbase->cost(), extracted by ModBase if (not Parser::extract(Parser::one(d_base), unused, d_usingCosts, d_treatmentCosts[0], d_treatmentCosts[1])) Err::atLeast(0); } simrisc-16.02.00/costs/extractdiameters.cc0000664000175000017500000000164314665030471017423 0ustar frankfrank#define XERR #include "costs.ih" bool Costs::extractDiameters(Parser::Lines &&lines) { if (not lines) return false; istringstream in{ lines.get()->tail }; // extract the diameters double lastAge = -1; // ages must increase CostPair spec; while (in >> spec.first) // begin diameter { if (spec.first <= lastAge) // not increasing return false; // ignore the : if (not (in.ignore() >> spec.second)) // followed by treatment return false; // cost. Ends at an // incomplete entry d_treatmntPair.push_back(spec); lastAge = spec.first; } return d_treatmntPair.size() > 0 and Globals::isPositiveZero(d_treatmntPair.front().first); } simrisc-16.02.00/costs/othertreatment.cc0000664000175000017500000000034414665030471017115 0ustar frankfrank#define XERR #include "costs.ih" //code double Costs::otherTreatment(double age, double diameter, bool metastasis) const { return discount(age, usingAt(age) + cost(diameter)); } //= simrisc-16.02.00/costs/costs.h0000664000175000017500000000514614665030471015052 0ustar frankfrank#ifndef INCLUDED_COSTS_ #define INCLUDED_COSTS_ // Costs: // biop: 176 // diameters: 0: 6438 20: 7128 50: 7701 // Discount: // age: 50 // # breast lung // proportion: 0 4 // CT: // # screening diagnosis M0 M1 (M0, M1: Table S3) // costs: 176 1908 37909 56556 // ^^^ // | // extracted by ModBase::costBase #include "../typedefs/typedefs.h" #include "../parser/parser.h" class Costs { // lower diam., cost typedef std::pair CostPair; StringVect d_base; // costs of treatments given std::vector d_treatmntPair; // tumor diam. double d_referenceAge; // discount reference age double d_discountProportion; size_t d_biopCosts; // set by usingCosts size_t d_usingCosts; // for lungCancer: diagnosis, // otherwise biopsy cost std::vector d_treatmentCosts; // for lungCancer: M0/M1 states // lcTreatment or otherTreatment double (Costs::*d_treatment)(double age, double diameter, bool metastasis) const; public: Costs(); double usingAt(double age) const; // .f double screening(double age, size_t cost) const; // .f double treatment(double age, double diameter, bool metastasis) const; // .f void writeParameters(std::ostream &out) const; private: bool extractDiameters(Parser::Lines &&lines); void setAge(); void setDiameters(); void setDiscount(bool lungCancer); void setLungCancer(); // sets LC diagnosis costs // as d_usingCosts void setProportion(bool lungCancer); void setVariables(bool lungCancer); size_t cost(double diameter) const; // for LungCancer double lcTreatment(double age, double diameter, // @ treatment bool metastasis) const; double otherTreatment(double age, double diameter, // @ treatment bool metastasis) const; double discount(double age, size_t cost) const; // otherwise }; #include "costs.f" #endif simrisc-16.02.00/costs/icmconf0000664000175000017500000000007414665030471015102 0ustar frankfrank#define LIBRARY "costs" #include "../icmconf.lib" simrisc-16.02.00/costs/writeparameters.cc0000664000175000017500000000134514665030471017270 0ustar frankfrank//#define XERR #include "costs.ih" void Costs::writeParameters(ostream &out) const { Globals::setWidthPrec(out, 2, 1) << "Costs:\n" " biopsy: " << setw(4) << d_usingCosts << "\n" " Discount:\n" " reference age: " << setw(4) << d_referenceAge << '\n'; Globals::setWidthPrec(out, 4, 3) << " proportion: " << setw(5) << d_discountProportion << "\n" " diameters:\n"; Globals::setWidthPrec(out, 2, 0); for (size_t idx = 0; idx != d_treatmntPair.size(); ++idx) out << " diameter >= " << setw(6) << d_treatmntPair[idx].first << " mm: " << setw(4) << d_treatmntPair[idx].second << '\n'; out.put('\n'); } simrisc-16.02.00/costs/discount.cc0000664000175000017500000000025614665030471015702 0ustar frankfrank#define XERR #include "costs.ih" //code double Costs::discount(double age, size_t cost) const { return cost * pow(1 + d_discountProportion, d_referenceAge - age); } //= simrisc-16.02.00/costs/costs1.cc0000664000175000017500000000045114665030471015263 0ustar frankfrank#define XERR #include "costs.ih" Costs::Costs() : d_base{ ""} { bool lungCancer = not Globals::isBreast(); setDiameters(); setDiscount(lungCancer); setVariables(lungCancer); // d_base, d_using, d_screening, // d_treatment } simrisc-16.02.00/costs/frame0000664000175000017500000000006014665030471014551 0ustar frankfrank//#define XERR #include "costs.ih" Costs:: { } simrisc-16.02.00/costs/setvariables.cc0000664000175000017500000000126114665030471016533 0ustar frankfrank#define XERR #include "costs.ih" void Costs::setVariables(bool lungCancer) { if (not lungCancer) { d_base.back() = "biop:"; Parser::nonNegative(d_base, d_usingCosts); d_treatment = &Costs::otherTreatment; return; } // below: ony used for LC simulations // reset d_base to read the CT: costs d_base.back() = "CT:"; d_base.push_back("costs:"); d_treatmentCosts.resize(2); d_treatment = &Costs::lcTreatment; setLungCancer(); } // d_using = &Costs::lcUsing; // d_screening = &Costs::lcScreening; // d_using = &Costs::otherUsing; // d_screening = &Costs::otherScreening; simrisc-16.02.00/costs/cost.cc0000664000175000017500000000066314665030471015024 0ustar frankfrank#define XERR #include "costs.ih" size_t Costs::cost(double diameter) const { // reversed search: start at the max. diameter return find_if(d_treatmntPair.rbegin(), d_treatmntPair.rend(), [&](CostPair const &costPair) { return diameter >= costPair.first; } )->second; } // xerr("cost with diam. " << diameter << " = " << ret); simrisc-16.02.00/costs/lctreatment.cc0000664000175000017500000000026714665030471016376 0ustar frankfrank#define XERR #include "costs.ih" //code double Costs::lcTreatment(double age, double diameter, bool metastasis) const { return discount(age, d_treatmentCosts[metastasis]); } //= simrisc-16.02.00/ct/0000775000175000017500000000000014665030471013013 5ustar frankfranksimrisc-16.02.00/ct/vspecificity.cc0000664000175000017500000000016114665030471016021 0ustar frankfrank//#define XERR #include "ct.ih" double CT::vSpecificity(double age) const { return d_specificity.value(); } simrisc-16.02.00/ct/setdose.cc0000664000175000017500000000027114665030471014770 0ustar frankfrank#define XERR #include "ct.ih" void CT::setDose() { base().back() = "dose:"; if (not Parser::one(base(), d_dose) or d_dose < 0) Err::msg(Err::SPEC_ERROR) << "dose:"; } simrisc-16.02.00/ct/setspecificity.cc0000664000175000017500000000015314665030471016350 0ustar frankfrank//#define XERR #include "ct.ih" void CT::setSpecificity() { extract("specificity:", d_specificity); } simrisc-16.02.00/ct/setsensitivity.cc0000664000175000017500000000121514665030471016427 0ustar frankfrank//#define XERR #include "ct.ih" void CT::setSensitivity() { auto lines = Parser::any({ "CT:", "sensitivity:" }); bool checkRange = true; while (true) { LineInfo const *line = lines.get(); if (line == 0) break; add(&checkRange, *line); // some failure: don't check ranges } if (d_sensitivity.size()) // sensitivity groups { // must cover 0..* if (d_sensitivity.front().group.begin() != 0 or not d_sensitivity.back().group.maxEnd() ) Err::msgTxt(Err::CT_SENS_RANGE); } } simrisc-16.02.00/ct/ct1.cc0000664000175000017500000000040014665030471014003 0ustar frankfrank#define XERR #include "ct.ih" // configfile lines: CT::CT(Tumor const &tumor) : ModBase("CT"), d_tumor(tumor), d_specificity(VARY_NONNEG) { if (not defined()) return; setDose(); setSpecificity(); setSensitivity(); } simrisc-16.02.00/ct/ct.ih0000664000175000017500000000044714665030471013750 0ustar frankfrank#include "ct.h" #include "../xerr/xerr.ih" #include #include "../globals/globals.h" #include "../tumor/tumor.h" #include "../parser/parser.h" // static inline double CT::sensFun(double diameter) { return 100 * (.5 * diameter - 1.5); } #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/ct/ct.h0000664000175000017500000000301014665030471013564 0ustar frankfrank#ifndef INCLUDED_CT_ #define INCLUDED_CT_ #include #include "../vsd/vsd.h" #include "../modbase/modbase.h" // ModBase uses CT: costs: to read the 'screening' costs. // CT reads // // CT: // # screening diagnosis M0 M1 (M0, M1: Table S3) // costs: 176 1908 37909 56556 // // dose: 1 // # diam. // sensitivity: 0 - 3: 0 // sensitivity: 3 - 5: -1 # formula: (.5 * diam - 1.5) * 100 // sensitivity: 5 - *: 100 // // # mean stddev dist // specificity: 99.2 .076 Normal class Tumor; class CT: public ModBase { struct Sensitivity { Group group; int sens; }; double d_dose; Tumor const &d_tumor; VSD d_specificity; std::vector d_sensitivity; public: CT(Tumor const &tumor); ~CT() override; // currently empty private: void add(bool *checkRange, LineInfo const &line); static double sensFun(double diameter); // .ih void setDose(); void setSensitivity(); void setSpecificity(); double vDose(uint16_t) const override; void vInsert(std::ostream &out) const override; double vSensitivity(size_t idx) const override; double vSpecificity(double age) const override; void vVary(std::ostream &out) override; void extract(char const *keyword, VSD &dest); }; #endif simrisc-16.02.00/ct/icmconf0000664000175000017500000000007114665030471014352 0ustar frankfrank#define LIBRARY "ct" #include "../icmconf.lib" simrisc-16.02.00/ct/extract.cc0000664000175000017500000000021214665030471014767 0ustar frankfrank//#define XERR #include "ct.ih" void CT::extract(char const *keyword, VSD &dest) { base().back() = keyword; extractBase(dest); } simrisc-16.02.00/ct/destructor.cc0000664000175000017500000000005614665030471015521 0ustar frankfrank//#define XERR #include "ct.ih" CT::~CT() {} simrisc-16.02.00/ct/vinsert.cc0000664000175000017500000000072514665030471015020 0ustar frankfrank//#define XERR #include "ct.ih" void CT::vInsert(ostream &out) const { VSD::fmt(0, 2, 0, 3); for (Sensitivity const &sens: d_sensitivity) { out << setw(4) << ' ' << "sensitivity: " << sens.group << ": "; if (sens.sens == -1) out << "f(diameter), cf. configuration file\n"; else out << sens.sens << '\n'; } out << setw(4) << ' ' << "specificity: " << d_specificity << '\n'; } simrisc-16.02.00/ct/vdose.cc0000664000175000017500000000015614665030471014444 0ustar frankfrank//#define XERR #include "ct.ih" double CT::vDose([[maybe_unused]] uint16_t idx) const { return d_dose; } simrisc-16.02.00/ct/frame0000664000175000017500000000005214665030471014025 0ustar frankfrank//#define XERR #include "ct.ih" CT:: { } simrisc-16.02.00/ct/add.cc0000664000175000017500000000132214665030471014050 0ustar frankfrank//#define XERR #include "ct.ih" // sensitivity: 0 - 3 0 # sensFixed // sensitivity: 3 - 5 -1 # sensFun: formula: (.5 * diam - 1.5) * 100 // sensitivity: 5 - * 100 # sensFixed void CT::add(bool *checkRange, LineInfo const &line) { Sensitivity sensitivity{ Group{ RANGE } }; if (not Parser::extract(line, sensitivity.group, sensitivity.sens)) { *checkRange = false; return; } if ( // invalid sens. value not (0 <= sensitivity.sens and sensitivity.sens <= 100) and sensitivity.sens != -1 ) { Err::msgTxt(Err::CT_SENS); return; } d_sensitivity.push_back(move(sensitivity)); } simrisc-16.02.00/ct/vsensitivity.cc0000664000175000017500000000056014665030471016103 0ustar frankfrank#define XERR #include "ct.ih" double CT::vSensitivity(size_t idx) const { double diameter = d_tumor.diameter(); for (Sensitivity const &sens: d_sensitivity) { if (sens.group.contains(diameter)) return (sens.sens != -1 ? sens.sens : sensFun(diameter)) / 100; } Err::msg(Err::CT_NO_SENS) << diameter << '\n'; return 100; } simrisc-16.02.00/ct/vvary.cc0000664000175000017500000000044014665030471014467 0ustar frankfrank//#define XERR #include "ct.ih" // override void CT::vVary(ostream &out) { d_specificity.vary(); out << " CT:\n" " sensitivity: f(diam), cf. config. file\n"; //d_sensitivity.showVary(out); out << " specificity: "; d_specificity.showVary(out); } simrisc-16.02.00/densities/0000775000175000017500000000000014665030471014374 5ustar frankfranksimrisc-16.02.00/densities/xerr/0000775000175000017500000000000014665030471015354 5ustar frankfranksimrisc-16.02.00/densities/xerr/xerr.ih0000664000175000017500000000131414665030471016655 0ustar frankfrank// define XERR to activate the xerr/xerr(2) macros: // xerr(insertion) // inserts the '<<' concatenated elements into std::cerr // preceded by the name of the source file, and ended by ' ' // xerr2(insertion, code) // performs the insertion if X is defined, and (unconditionally) // executes the statement(s) in `code'. `code' must be valid // C(++) code. // #ifdef XERR #include #define xerr(insertion) std::cerr << __FILE__": " << insertion << ' ' #define xerr2(insertion, code) { std::cerr << __FILE__": " << insertion << ' '; code; } #else #define xerr(insertion) #define xerr2(insertion, code) code #endif simrisc-16.02.00/densities/densities1.cc0000664000175000017500000000104514665030471016753 0ustar frankfrank//#define XERR #include "densities.ih" Densities::Densities() : d_base{ "BreastDensities:", "ageGroup:" } { if (Globals::simulationType() != BREAST) return; // retrieve the Densities: ageGroup: lines auto lines = Parser::any(d_base); bool checkRange = true; // check whether age ranges connect. while (true) { LineInfo const *line = lines.get(); if (line == 0) break; add(&checkRange, *line); // some failure: don't check ranges } } simrisc-16.02.00/densities/densities.h0000664000175000017500000000272514665030471016542 0ustar frankfrank#ifndef INCLUDED_DENSITIES_ #define INCLUDED_DENSITIES_ // example config spec.: // BreastDensities: // // # bi-rad: a b c d // ageGroup: 0 - 40 .05 .30 .48 .17 // ageGroup: 40 - 50 .06 .34 .47 .13 // ageGroup: 50 - 60 .08 .50 .37 .05 // ageGroup: 60 - 70 .15 .53 .29 .03 // ageGroup: 70 - * .18 .54 .26 .02 #include #include "../probgroup/probgroup.h" #include "../typedefs/typedefs.h" class Densities { StringVect d_base; ProbGroup::Vector d_densities; // contains the ageGroup data public: Densities(); ProbGroup::Vector const *biRad() const; void writeParameters(std::ostream &out) const; private: void add(bool *checkRange, LineInfo const &ageGroup); bool nextRange(ProbGroup const &next) const; static bool percentages(std::vector const &vect); }; inline ProbGroup::Vector const *Densities::biRad() const { return &d_densities; } // birad idx for age, given // its probability // uint16_t biradIdx(double age, double prob) const; // randomly determined bi-rad indices // for screening round ages // Uint16Vect biRadIndices(DoubleVect const &ages) const; #endif simrisc-16.02.00/densities/icmconf0000664000175000017500000000010014665030471015724 0ustar frankfrank#define LIBRARY "densities" #include "../icmconf.lib" simrisc-16.02.00/densities/densities.ih0000664000175000017500000000040214665030471016701 0ustar frankfrank#include "densities.h" #include "../xerr/xerr.ih" #include #include #include "../random/random.h" #include "../parser/parser.h" #include "../globals/globals.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/densities/writeparameters.cc0000664000175000017500000000045414665030471020124 0ustar frankfrank//#define XERR #include "densities.ih" void Densities::writeParameters(std::ostream &out) const { out << "BreastDensities:\n"; Globals::setWidthPrec(out, 4, 3); for (ProbGroup const &density: d_densities) out << setw(2) << ' ' << density << '\n'; out.put('\n'); } simrisc-16.02.00/densities/proportions.cc0000664000175000017500000000070414665030471017302 0ustar frankfrank//#define XERR #include "densities.ih" // static bool Densities::percentages(vector const &vect) { return find_if(vect.begin(), vect.end(), [&](double value) { return value < 0 or 1 < value; // if not in [0..1] then } // not a percentage -> ) // vect.end() is not returned == vect.end(); } simrisc-16.02.00/densities/frame0000664000175000017500000000007014665030471015406 0ustar frankfrank//#define XERR #include "densities.ih" Densities:: { } simrisc-16.02.00/densities/add.cc0000664000175000017500000000162014665030471015432 0ustar frankfrank#define XERR #include "densities.ih" // # bi-rad: a b c d // ageGroup: 0 - 40: .05 .30 .48 .17 void Densities::add(bool *checkRange, LineInfo const &line) { ProbGroup density{ RANGE }; if (not Parser::extract(line, density)) // density spec. error { *checkRange = false; return; } //xerr("ProbGroup: " << density); Err::Context context; if (not percentages(density.prob())) context = Err::RANGE_0_1; else if (not density.sumOne()) context = Err::PROB_SUM; else // so far all's OK { if (*checkRange) { if (density.group().nextRange(d_densities)) d_densities.push_back(density); else *checkRange = false; } return; } Err::msgTxt(context); } simrisc-16.02.00/distribution/0000775000175000017500000000000014665030471015124 5ustar frankfranksimrisc-16.02.00/distribution/fmt.cc0000664000175000017500000000031214665030471016215 0ustar frankfrank//#define XERR #include "distribution.ih" // static void Distribution::fmt(unsigned intWidth, unsigned precision) { s_width = intWidth + precision + (precision > 0); s_precision = precision; } simrisc-16.02.00/distribution/find.cc0000664000175000017500000000034714665030471016357 0ustar frankfrank#define XERR #include "distribution.ih" // static DistType Distribution::find(string const &name) { return static_cast( std::find(s_name.begin(), s_name.end(), name) - s_name.begin() ); } simrisc-16.02.00/distribution/insert.cc0000664000175000017500000000200714665030471016736 0ustar frankfrank//#define XERR #include "distribution.ih" std::ostream &Distribution::insert(std::ostream &out) const { switch (d_distType) { case N_DISTRIBUTIONS: out << setw(12) << ' '; break; case BETA_VARY: { out << '\n' << setw(15) << ' ' << "Beta: constant " " factor " " aParam " " bParam\n" << setw(20) << ' '; auto pair = Random::instance().betaParameters(); Globals::setPrecision(out, 5); for (size_t idx = 0, end = pair.first; idx != end; ++idx) out << setw(10) << pair.second[idx]; } break; default: Globals::setWidthPrec(out, s_width, s_precision) << (d_exp ? exp(d_confValue) : d_confValue) << " (" << s_name[d_distType] << ')'; break; } return out; } simrisc-16.02.00/distribution/data.cc0000664000175000017500000000165514665030471016353 0ustar frankfrank//#define XERR #include "distribution.ih" StringVect Distribution::s_name // see enums.h { "Uniform" , // UNIFORM "Uniform" , // UNIFORM_CASE "LogNormal" , // LOGNORMAL "Normal", // NORMAL_VARY "Uniform" , // UNIFORM_VARY "LogNormal" , // LOGNORMAL_VARY "Beta" , // BETA_VARY }; // the beta distribution have been initialized for male/female simulations // so only one varyBeta can be used. double (Distribution::*Distribution::s_varyParam[])(double orgValue) const = { &Distribution::varyMean, // VARY_MEAN, all OK &Distribution::varyNonNeg, // VARY_NONNEG, values must be >= 0 &Distribution::varyProb, // VARY_PROB, values must be probabilities &Distribution::varyBeta, // VARY_BETA, the Beta distributions }; unsigned Distribution::s_width = 0; unsigned Distribution::s_precision = 0; simrisc-16.02.00/distribution/accept.cc0000664000175000017500000000016514665030471016674 0ustar frankfrank#define XERR #include "distribution.ih" double Distribution::accept(double orgValue) const { return orgValue; } simrisc-16.02.00/distribution/varybeta.cc0000664000175000017500000000021414665030471017245 0ustar frankfrank#define XERR #include "distribution.ih" double Distribution::varyBeta(double orgValue) const { return Random::instance().betaVary(); } simrisc-16.02.00/distribution/ln.cc0000664000175000017500000000017614665030471016050 0ustar frankfrank//#define XERR #include "distribution.ih" void Distribution::ln() { d_confValue = log(d_confValue); d_exp = true; } simrisc-16.02.00/distribution/xlat.cc0000664000175000017500000000042214665030471016401 0ustar frankfrank//#define XERR #include "distribution.ih" // static DistType Distribution::xlat(LineInfo const &info, string const &name) { auto ret = find(name); if (ret == N_DISTRIBUTIONS) Err::msg(Err::UNDEFINED_DIST) << '`' << name << '\'' << endl; return ret; } simrisc-16.02.00/distribution/distribution1.cc0000664000175000017500000000027514665030471020237 0ustar frankfrank//#define XERR #include "distribution.ih" Distribution::Distribution(VaryType varyType) : d_value(Globals::vary() ? s_varyParam[varyType] : &Distribution::accept), d_exp(false) {} simrisc-16.02.00/distribution/varynonneg.cc0000664000175000017500000000102514665030471017617 0ustar frankfrank#define XERR #include "distribution.ih" double Distribution::varyNonNeg(double orgValue) const { for (unsigned count = 0; count != MAX_VARY_TRIES; ++count) { // try to obtain a valid spreaded SD if (double ret = varyMean(orgValue); ret >= 0) return ret; } throw Exception{} << "failed to obtain non-negative spread value for " << orgValue << " (spread = " << d_confValue << ", distribution: " << name(d_distType) << ')'; } simrisc-16.02.00/distribution/icmconf0000664000175000017500000000010314665030471016457 0ustar frankfrank#define LIBRARY "distribution" #include "../icmconf.lib" simrisc-16.02.00/distribution/extract.cc0000664000175000017500000000403214665030471017104 0ustar frankfrank#define XERR #include "distribution.ih" // So far the extraction has extracted the mean. Next comes the stddev and // dist, but stddev may not be present -> dist is not present // # mean stddev dist // specificity: 99.2 .076 Normal // // for Beta destributions, used with LC, the name and parameters of the // Beta distribution are provided, which are used when parameter spread // is configured // // # LC: eta beta dist constant factor aParam bParam // male: -1.4 .32 Beta .234091 1.72727 2.664237 5.184883 // female: -1.4 1.40 Beta .744828 .818966 3.366115 4.813548 // the Distribution is extracted if d_confValue is present. // if present it must be >= 0 istream &Distribution::extract(istream &in) { if (not Globals::vary()) // no parameter variation -> no return in; // distribution extraction string next; // inspect the next field on 'in' // try extracting the SD parameter if (not (in >> next)) // nothing is extracted, so this is not { // a Beta dist. spec, or a dist. w/o SD d_distType = NORMAL_VARY; prepareVary(in); // in: unused here in.clear(); return in; } if (next == "Beta") // this is a Beta distribution { d_distType = BETA_VARY; Random::instance().prepareBeta(in); d_value = &Distribution::varyBeta; return in; } d_confValue = stod(next); // no beta, so it must be a value if (d_confValue < 0) { Err::msgTxt(Err::NEGATIVE); in.fail(); return in; } // value was extracted: the distribtion name must be next if (in >> next and (d_distType = find(next)) != N_DISTRIBUTIONS) { prepareVary(in); return in; } Err::msgTxt(Err::UNDEFINED_DIST); in.fail(); return in; } simrisc-16.02.00/distribution/distribution.f0000664000175000017500000000074614665030471020021 0ustar frankfrank// static inline std::string const &Distribution::name(DistType dist) { return s_name[dist]; } inline std::istream &operator>>(std::istream &in, Distribution &dist) { return dist.extract(in); } inline std::ostream &operator<<(std::ostream &out, Distribution const &dist) { return dist.insert(out); } inline DistType Distribution::type() const { return d_distType; } inline double Distribution::value(double orgValue) const { return (this->*d_value)(orgValue); } simrisc-16.02.00/distribution/preparevary.cc0000664000175000017500000000076514665030471020003 0ustar frankfrank//#define XERR #include "distribution.ih" // Beta distribution is handled by extract() void Distribution::prepareVary(istream &in) { if (not Globals::vary()) // no parameter spreading is used return; switch (d_distType) { case NORMAL_VARY: break; case UNIFORM: d_distType = UNIFORM_VARY; break; case LOGNORMAL: d_distType = LOGNORMAL_VARY; break; default: return; } } simrisc-16.02.00/distribution/varymean.cc0000664000175000017500000000137514665030471017263 0ustar frankfrank#define XERR #include "distribution.ih" // in the original code refreshing is handled by reloading the complete config // file. So the argument passed to this member should be the initial value // and not the updated value. double Distribution::varyMean(double orgValue) const { Random &random = Random::instance(); switch (d_distType) { case NORMAL_VARY: return orgValue + random.normalVary() * d_confValue; case UNIFORM_VARY: return orgValue + d_confValue * (random.uniformVary() - .5); case LOGNORMAL_VARY: return random.logNormalVary(orgValue, d_confValue); default: return orgValue; } } // case EXPONENTIAL: // return orgValue + random.exponential(orgValue); simrisc-16.02.00/distribution/distribution.h0000664000175000017500000000557614665030471020031 0ustar frankfrank#ifndef INCLUDED_DISTRIBUTION_ #define INCLUDED_DISTRIBUTION_ #include #include #include "../typedefs/typedefs.h" // The Distribution receives the spread value and distribution name, // Either both or none most be specified. If none is specified then // spread = 0, and calling vary() simply returns the received argument class Distribution { enum { MAX_VARY_TRIES = 10, // max #attempts to obtain a valid varied value }; friend std::istream &operator>>(std::istream &in, Distribution &dist); friend std::ostream &operator<<(std::ostream &out, Distribution const &dist); double d_confValue = 0; // configured (e.g., SD) value DistType d_distType = N_DISTRIBUTIONS; // with, e.g., vectors // points to the function handling // the random value variation (the // vary*/accept functions below) double (Distribution::*d_value)(double orgValue) const; bool d_exp; static StringVect s_name; static unsigned s_width; static unsigned s_precision; static double (Distribution::*s_varyParam[])(double orgValue) const; public: Distribution(VaryType varyType); // returns N_DISTRIBUTIONS if // an undefined name is used static DistType find(std::string const &distName); // intWidth: width of the // integral part static void fmt(unsigned intWidth, unsigned precision); void ln(); // ln(d_confValue) .f DistType type() const; // .f double value(double orgValue) const; // return varied value (if .f // s_vary) or orgValue or // throw an exception // must succeed or err static DistType xlat(LineInfo const &lineInfo, std::string const &distName); static std::string const &name(DistType dist); private: std::istream &extract(std::istream &in); std::ostream &insert(std::ostream &out) const; void prepareVary(std::istream &in); // -> extract() double varyMean(double orgValue) const; // these members are double varyNonNeg(double orgValue) const; // called via d_value double varyProb(double orgValue) const; double varyBeta(double orgValue) const; double accept(double orgValue) const; // if not s_vary }; #include "distribution.f" #endif simrisc-16.02.00/distribution/frame0000664000175000017500000000007614665030471016144 0ustar frankfrank//#define XERR #include "distribution.ih" Distribution:: { } simrisc-16.02.00/distribution/distribution.ih0000664000175000017500000000046714665030471020174 0ustar frankfrank#include "distribution.h" #include "../xerr/xerr.ih" #include #include #include #include #include #include "../err/err.h" #include "../globals/globals.h" #include "../random/random.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/distribution/varyprob.cc0000664000175000017500000000077614665030471017311 0ustar frankfrank#define XERR #include "distribution.ih" double Distribution::varyProb(double orgValue) const { for (unsigned count = 0; count != MAX_VARY_TRIES; ++count) { if ( double ret = varyMean(orgValue); Globals::proportion(ret) ) return ret; } throw Exception{} << "failed to obtain spread proportion for " << orgValue << " (spread parameter = " << d_confValue << ", distribution: " << name(d_distType) << ')'; } simrisc-16.02.00/documentation/0000755000175000017500000000000014665030471015254 5ustar frankfranksimrisc-16.02.00/documentation/man/0000755000175000017500000000000014665030471016027 5ustar frankfranksimrisc-16.02.00/documentation/man/include/0000775000175000017500000000000014665030471017454 5ustar frankfranksimrisc-16.02.00/documentation/man/include/trailer.yo0000664000175000017500000000030314665030471021463 0ustar frankfrank manpagesection(COPYRIGHT) This is free software, distributed under the terms of the GNU General Public License (GPL). manpageauthor() Frank B. Brokken (bf(f.b.brokken@rug.nl)),nl() simrisc-16.02.00/documentation/man/include/configfiles.yo0000664000175000017500000000104014665030471022310 0ustar frankfrankbf(Configuration files) itemization( it() tt(~/.config/simrisc): the default location of the program's configuration file; it() the sr() distribution archive contains the default configuration file as tt(simrisc-VERSION/stdconfig/simrisc), where tt(VERSION) is replaced by sr()'s actual release version; it() when installing sr() using Linux distribution archives (e.g., tt(.deb) files) the default configuration file is commonly available as tt(/usr/shared/doc/simrisc/simrisc.gz) ) simrisc-16.02.00/documentation/man/include/header.yo0000664000175000017500000000143614665030471021261 0ustar frankfrankDEFINEMACRO(Manpage)(1)(\ whenman((Manpage: bf(man -e simrisc ARG1)))\ whenhtml((Manpage: url(ARG1(3simrisc))(ARG1.3.html)))\ ) DEFINEMACRO(itb)(1)(it() bf(ARG1):nl()) DEFINEMACRO(itt)(1)(it() tt(ARG1)) DEFINEMACRO(itrange)(2)(tt(CHAR(91)ARG1, ARG2+CHAR(41))) includefile(../../../release.yo) htmlbodyopt(text)(#27408B) htmlbodyopt(bgcolor)(#FFFAF0) whenhtml(mailto(Frank B. Brokken: f.b.brokken@rug.nl)) DEFINEMACRO(lsoption)(3)(\ bf(--ARG1)=tt(ARG3) (bf(-ARG2))\ ) DEFINEMACRO(laoption)(2)(\ bf(--ARG1)=tt(ARG2)\ ) DEFINEMACRO(loption)(1)(\ bf(--ARG1)\ ) DEFINEMACRO(soption)(1)(\ bf(-ARG1)\ ) DEFINEMACRO(sr)(0)(bf(simrisc)) DEFINEMACRO(Sr)(0)(bf(Simrisc)) DEFINEMACRO(Cpp)(0)(bf(C++)) DEFINEMACRO(prot)(0)(tt((prot))) DELETEMACRO(tt) DEFINEMACRO(tt)(1)(em(ARG1)) simrisc-16.02.00/documentation/man/include/changes.yo0000664000175000017500000000503014665030471021433 0ustar frankfrankCOMMENT( manpagesection(Changes introduced in version 15.01.00) itemization( it() ) manpagesection(Changes introduced in version 15.00.00) itemization( it() In addition to breast cancer simulations sr() can also perform lung cancer simulations for either men or women. By default breast cancer simulations are performed. it() The configuration file was reorganized and extended with parameters used when performing lung cancer simulations: specifications for tt(CT) scans; additional Tumor tt(Beir7, Growth, Incidence,) and tt(Survival) parameters, and a new section tt(S3) containing the age-range specific probabilities of encountering metastases. it() Sr() offers the new option tt(--cancer) specifying the type of simulation. ) When performing lung cancer simulations only the tt(CT) modality can be specified. When performing breast cancer simulations the tt(CT) modality cannot be specified, but as with previous versions: any combination of the tt(Mammo, Tomo) and tt(MRI) modalities can be specified. manpagesection(Changes introduced in version 14.04.00) itemization( it() Parameters affected by tt(spread: true)nl() Parameters that may vary are specified using triplets: value, spread and distribution. In all cases the spread values and distribution names are optional: they can both be omitted or both must be specified. If these parameters are not specified then their tt(value) parameter won't vary if tt(spread: true) is specified; it() The tt(Mammo, Tomo,) and tt(MRI) modalities are provided with std.dev and distribution parameters for their tt(Dose, M, Beta, Specificity,) and tt(Sensitivity) parameters; it() When tt(spread: true) is specified the actually used and original parameter values are listed in a file, by default tt(spread-$.txt), where tt($) is replaced by the loop iteration index. Use the option tt(-s) to specify a non-default filename (cf. bf(simrisc)(1)); it() Age ranges no longer have trailing colons; it() The Case-specific data matrix defines an extra (18th) column, showing the results of the screening rounds for each simulated case; it() The order of the tt(beir7 beta) and tt(eta) parameters is reversed: tt(eta) is specified first, followed by tt(beta). The tt(spread) and tt(distribution) parameters following tt(beta) apply to tt(beta), and not to tt(eta), which is a fixed value. ) END COMMENT) simrisc-16.02.00/documentation/man/simrisc.yo0000664000175000017500000005420314665030471020057 0ustar frankfrankNOUSERMACRO(simrisc line) includefile(../../release.yo) htmlbodyopt(text)(#27408B) htmlbodyopt(bgcolor)(#FFFAF0) whenhtml(mailto(Frank B. Brokken: f.b.brokken@rug.nl)) DEFINEMACRO(lsoption)(3)(\ bf(--ARG1)=tt(ARG3) (bf(-ARG2))\ ) DEFINEMACRO(laoption)(2)(\ bf(--ARG1)=tt(ARG2)\ ) DEFINEMACRO(loption)(1)(\ bf(--ARG1)\ ) DEFINEMACRO(soption)(1)(\ bf(-ARG1)\ ) DEFINEMACRO(sr)(0)(bf(simrisc)) DEFINEMACRO(Sr)(0)(bf(Simrisc)) DEFINEMACRO(Cpp)(0)(bf(C++)) DEFINEMACRO(prot)(0)(tt((prot))) IFDEF(man)( DELETEMACRO(tt) DEFINEMACRO(tt)(1)(em(ARG1)) )() def(itt)(1)(it()tt(ARG1)) COMMENT( man-request, section, date, distribution file, general name) manpage(simrisc)(1)(_CurYrs_)(simrisc._CurVers_) (simrisc cancer simulation program) manpagename(simrisc)(This program performs simulations in the context of breast and lung cancer) COMMENT( all other: add after () ) manpagesynopsis() sr() [options] tt(analyses) The tt(analyses) argument is the name of the file specifying the analyses to perform. See section bf(ANALYSES) for details. manpagedescription() Sr() was originally designed around 2010 by Marcel Greuter at the University Medical Center Groningen, and thereafter modified in 2015 by Chris de Jonge. includefile(include/changes.yo) manpageoptions() Short options are provided between parentheses, immediately following their long option equivalents. Several parameters specify the path-names of files produced by sr(). If a path-name starts with a tilde character (~) then the tilde is replaced by the user's home directory. An initial + is replaced by the program's base directory (see option tt(base)). When an analysis uses multiple iterations then `$' characters in filename specifications are replaced by the analysis' interation index. All single-letter options referring to filesystem entries (directories, filenames) are capitalized, all other single-letter options are lowercase. itemization( it() lsoption(base)(B)(basedir)nl() the base directory where the output files will be written. By default tt(./). If tt(basedir) doesn't exist it is created by the program. If the directory cannot be created and exception is thrown, terminating the program. The tt(basedir) specifications may specify relative or absolute directory locations; it() lsoption(cancer)(c)(type)nl() The simulation type (tt(type)) can be specified as tt(breast) to perform breast cancer simulations. Breast cancer simulations are performed by default when the tt(--cancer) option is not specified. Alternatively, to perform lung cancer simulations tt(type) must be specified as either tt(male) or tt(female) to perform simulations for, respectively, male or female cases. Be advised that the default configuration file specifies tt(Screening Mammo) rounds, which must either be changed to tt(CT) in locally used configuration files or in tt(Analysis:) sections (see section bf(ANALYSES) below); it() lsoption(config)(C)(path)nl() the location of the configuration file. By default tt(~/.config/simrisc') is used; it() lsoption(data)(D)(path)nl() path name of the file to contain the data of the cases generated by the simulation (default: '/data-$.txt'). If a data file should not be written specify tt(!) (mnemonic: the logical not operator, i.e., tt(--data !)). See section bf(OUTPUT) for a description of the generated data; it() lsoption(death-age)(a)(age)nl() run one simulation using a specific natural death-age. This option also requires the specification of tt(tumor-age), and is mutually exclusive with the tt(case) option; COMMENT( it() loption(err) (soption(e))nl() before version 14.05.00 the Beir7 risk vector was computed using an incorrect algorithm. The error was fixed in simrisc 14.05.00. When it is required to use the erroneous algorithm, e.g., to compare the results of simulations with previously obtained results, option tt(-e) must be specified. However, option tt(-e) should not be used for real simulations; END) it() loption(help) (soption(h))nl() shows help information and terminates; it() lsoption(last-case)(l)(nCases)nl() perform simulations until tt(nCases) cases have been analyzed and only write the data for the final case to the data file. The tt(rounds) and tt(sensitivity) files contain the summarized results of all tt(nCases) analyzed cases; it() loption(log) tt(begin end fname [set])nl() log process actions of cases tt(begin) thru tt(end) on the file tt(fname). This includes generated random values. Random values generated in several contexts can be suppressed. Specify+nl() * bf(C) to suppress generated case-specific uniformly distributed random values+nl() * bf(L) to suppress generated log-normal distributed random values+nl() * bf(U) to suppress generated uniformly distributed random values not associated with cases+nl() * bf(V) to suppress generated uniformly distributed random values associated with VSD computations. Note that tt(begin end) defines an inclusive range. To log the process for a single case (e.g. case 100) ignoring the L, U, and V generated values specify tt(--log "100 100 fname LUV"). Also note that only a em(single) argument ispassed to tt(--log). Therefore its argument must be surrounded by quotes; it() loption(one-analysis) (soption(o))nl() the program's arguments specify the parameters of a single analysis, rather than the name of an analyses-specification file. The program's arguments are optional and are used to alter the parameter values as defined in the config file or to define tt(label) specifications. See section bf(ANALYSES) for details; it() lsoption(parameters)(P)(path)nl() path name of the file showing the actually used parameter specifications. By default no parameter file is written. If the tt(--base (-B)) option was specified then tt(path) is written in the base directory if tt(path) does not contain a slash (/) (use tt(./path) to write the parameters file in the current directory if tt(--base) was specified); it() lsoption(rounds)(R)(path)nl() path name of the file to containing the summary info of the simulation rounds (default: '/rounds-$.txt'). If a rounds file should not be written specify tt(!) (i.e., tt(--rounds !)). See section bf(OUTPUT) for a description of the generated summary info; it() lsoption(spread)(s)(path)nl() path name of the file containing the configured and actually used parameter values when tt(spread: true) is specified (default: '/spread-$.txt'). If this file should not be written specify tt(!) (mnemonic: the logical not operator, i.e., tt(--spread !)). If a parameter doesn't use spreading then the 'using' part is omitted. See section bf(OUTPUT) for a sample of its content; it() lsoption(sensitivity)(S)(path)nl() path name of the file to containing the summary info of the simulation's sensitivity data (default: '/sensitivity.txt'). If a sensitivity file should not be written specify tt(!) (i.e., tt(--sensitivity !)). See section bf(OUTPUT) for a description of the produced sensitivity summary; it() loption(tnm) (soption(T))nl() The data file contains a column labeled tt(TNM) showing the (0-based) tt(TNM) categories for cases having developed tumors (see also the bf(simiscparams)(7) man-page). By default this column remains empty for cases not having developed tumors, which may be inconvenient when processing the data (e.g., to perform statistical analyses). When specifying the tt(--tnm) option cases not having developed tumors receive TNM column entries tt(-1,0) to avoid missing data; it() lsoption(tumor-age)(t)(age)nl() run one simulation using a specific tumor self-detect age. This option also requires the specification of tt(death-age), and is mutually exclusive with the tt(case) option; it() loption(verbose) (soption(V))nl() provides additional information while running; it() loption(version) (soption(v))nl() shows sr()'s version information and terminates; ) manpagesection(ANALYSES) Unless the tt(--one-analysis) option is used the program's first and only required argument is the name of a file providing the details of the analyses to perform. These files are called em(analysis files). These files must be a standard ascii text files. I.e., they can only contain 7-bit ascii printable and white-space characters. Identifiers used in analysis files and in configuration files are interpreted case sensitively. Configuration specifications starting with uppercase letters (like tt(Scenario:) and tt(Costs:)) specify (sub)sections and don't contain additional specifications. Specifications starting with lowercase letters (like tt(ageGroup:)) are followed by actual parameter values. For a complete overview refer to the bf(simriscparams)(7) man-page. Analysis files may define multiple analyses. Each analysis specification em(must) begin with a line containing verb( Analysis: ) At each tt(Analysis:) specification the program's initial configuration is reset. Options specified on the command-line cannot be specified in tt(Analysis:) sections and remain active while sr() is running. The default option values are reset at each separate tt(Analysis:) unless an option has been specified on the command-line, in which case those option values are used throughout the sr() run. Following tt(Analysis:) lines the characteristics of the analysis are specified which can be specified for each tt(Analysis:) specification, in the following order: itemization( it() a em(label:) line: tt(label:) lines, when used, must immediately follow tt(Analysis:) lines. The text following tt(label:) is written at the top of the output files; it() option lines: specifying sr() options (not specified on the command line) which are then used for that analysis. When program options are specified their long option names must be used. E.g.: verb( base: /tmp/ last-case: 20 ) it() parameter specifications: modify (some) parameter specifications defined in configuration files. When parameters of configuration file sections (cf. bf(simriscparams)(7)) are not specified then the parameters specified in the configuration file are used. ) All specifications in tt(Analysis:) sections are optional. An tt(Analysis:) section merely containing the line tt(Analysis:) defines an analysis using the explicitly specified command-line options or the default program options and using the parameter specifications provided in the configuration file. Empty lines, initial and trailing white-space, and all characters on lines starting at the hash-mark (tt(#)) are ignored and may be used anywhere in analysis files. Lines not conforming to the above description result in error messages, causing sr() to end. Filename specified in tt(Analysis:) sections may start with a tilde character (~) which is replaced by the user's home directory, or they may start with an initial + character, which is replaced by the program's base directory (see option tt(base)). When an analysis performs multiple iterations then `$' characters in filename specifications are replaced by the analysis' interation index. Multiple analysis sections should not specify identically named output files, as the output files are (re)written for each separate analysis. Analysis sections are commonly used to alter the default specifications of the configuration file. E.g., the default number of iterations equals 1. By specifying verb( Scenario: iterations: 3 ) the analysis performs 3 iterations. Parameters are either read from the configuration file or they are redefined in tt(Analysis:) sections. E.g., in de provided configuration file screening rounds use two-year intervals between the ages of 50 and 74. To use screening rounds using 5-year intervals, between ages 50 and 65, then an tt(Analysis:) specification could be, e.g., verb( Screening: round: 50 Mammo MRI round: 55 Mammo MRI round: 60 Mammo MRI round: 65 Mammo MRI ) When the tt(--one-analysis) option is used parameters are modified by providing comma-separated parameter specifications as program command-line arguments. E.g., to perform one analysis, writing the data file to tt(/tmp/data), simulating 1000 cases, and using 20 as seed for the random number generator the command verb( simrisc -D /tmp/data -o Scenario:, cases: 1000, seed: 20 ) can be used. Note that when using the tt(one-analysis) option parameter section names must precede parameter specifications. E.g., since the parameters tt(cases) and tt(seed) are defined in the `Scenario' section (cf. bf(simriscparams)(7)) they must be preceded by the tt(Scenario:) specification. When an tt(Analysis:) specification modifies parameters, then subsequent tt(Analysis:) sections start from the unmodified option and parameter specifications. Here is an example of an analysis file specifying two analyses: verb( Analysis: base: 1 cancer: male parameters: +params.txt Scenario: cases: 10 Screening: round: 50 CT round: 55 CT Analysis: base: 2 config: ~/src/simrisc/stdconfig/lung parameters: +params.txt cancer: breast Scenario: cases: 20 spread: true Screening: round: 50 Mammo MRI round: 55 Mammo MRI round: 60 Mammo MRI round: 65 Mammo MRI ) manpagesection(OUTPUT) The first lines of the generated files contain time stamps showing the date and time when the files were written and the used tt(SimRisc) version. Here is an example, following the RFC 2822 format for the timestamp: verb( Mon, 14 Nov 2022 15:30:26 +0100 (SimRisc V. 15.00.00) ) If tt(label:) lines are used then the time stamp is followed by the label specifications, which is then followed by an empty line. After this header the file's specific data are shown. The data in all files (except for the file listing the actually used parameters (option tt(--parameters) (tt(P)))) are written using the standard comma-separated format (cf. RFC 4180). The initial lines contain table headings and column labels documenting the meanings of the various columns. Likewise there is a final line ending the tables. bf(Data of simulated cases (data-X.txt files)) Below the date and label lines the legend of the death-status (see below at item tt(death status)) is shown. Each iteration generates a separate tt(data-X.txt) file, where tt(X) indicates the iteration index (starting at value 0). For each simulated case the values of the following variables are written to file (one line of comma-separated values per simulated case): itemization( itt(case:) the (1-based) case-index; itt(cause of death:) either tt(Natural) or tt(Tumor); itt(death age:) the case's age of death; itt(natural death age:) the case's natural age of death (if no tumor occurs); itt(death status:) a numeric index specifying how and at what stage the case died:nl() 1: natural death, no tumor, before the 1st screening round,nl() 2: natural death, undetected tumor, before the 1st screening round,nl() 3: self-detected tumor before the 1st screening round,nl() 4: natural death, no tumor, between screening rounds,nl() 5: natural death, undetected tumor, between screening rounds,nl() 6: self-detected tumor between screening rounds,nl() 7: screening-detected tumor,nl() 8: natural death, no tumor, after the last screening round,nl() 9: natural death, undetected tumor, after the last screening round,nl() 10: self-detected tumor after the last screening round; itt(tumor present:) tt(Yes) if the simulation resulted in a tumor, tt(No) if no tumor occurred; itt(tumor detected:) tt(Yes) if the tumor was detected, tt(No) if not; itt(interval tumor:) tt(Yes) if the tumor was an interval tumor, tt(No) if not; itt(tumor diameter:) the tumor's diameter in mm when it was detected. 0.00 is shown if no tumor occurred. In the exceptional case where the simulation produced a tumor whose diameter exceeded 1000 mm the value 1001 is shown. itt(tumor doubling days:) the time (in days) it takes for the tumor to double its size; itt(tumor preclinical period:) the age at which the tumor is potentially detectible by screening. -1.00 is shown if there's no pre-clinial period; itt(tumor onset age:) the age at which the tumor first occurred. -1.00 is shown if no tumor developed; itt(tumor self-detect age:) the age at which the tumor was self-detected. This age is the result of the simulation, and may exceed the case's actual death age (if so, the case's data report that no tumor is present). -1.00 is shown if there's no self-detect age; itt(tumor death age:) the age at which the tumor caused or would have caused he case's death. The simulation process uses ages ranging from 0 through 100. If the age at which the tumor causes the case's death exceeds 100, then 100.00 is reported. 0.00 is shown if no tumor developed; itt(costs screening:) the case's screening and (if appliccable) treatment costs; itt(costs biop:) the costs of a performed biopsy; itt(detected self): 1 if the tumor was self-detected, 0 if not (also if there's no tumor); itt(detected round): round number at which a tumor was detected, using the following values (assuming tt(N) screening rounds were specified):nl() verb( 0: no tumor was detected; -1: tumor was self-detected before the 1st screening round; 1: tumor was detected during/after the 1st screening round (and before the 2nd round); *1: tumor was self-detected after the 1st screening round (which was not attended); ... 3: tumor was detected during/after the 3rd screening round; *3: tumor was self-detected after the 3rd screening round (which was not attended); ... N: tumor was detected during/after the Nth screening round; *N: tumor was self-detected after the Nth screening round (which was not attended). ) itt(screening rounds:) this column show which screening rounds were attended by the simulated cases, and if so whether false negative or false positive diagnoses were made. The following digits are used: itemization( itt(0:) the case did not attend this screening round; itt(1:) the case did attend this screening round. it() 2: the case did attend this screening round, resulting in a false negative diagnosis; it() 3: the case did attend this screening round, resulting in a false positive diagnosis. ) There are as many digits as screening rounds. The leftmost digit refers to the first screening round, the rightmost digit to the last screening round. E.g., using 12 screening rounds the following indicators could be obtained: verb( 001101111000 ) Using screening round indices (which are also used to refer to rounds in the tt(rounds-$.txt) files), this case did not attent screening rounds 1, 2, 5, 10, 11, and 12. itt(TNM): The TNM status/stage of the tumor (see also the bf(simiscparams)(7) man-page). It specifies the row/column index of table of probabilities of positive lymph nodes and metastatis, given the size of the tumor (table S3, cf. Goldstraw et al., Journal of thoracic oncology, 2016, 11(1): 39-51; Yuan et al., Scientific Reports, 2016, 6(1): 1-9). ) bf(Actually used spread-values) When tt(spread: true) is specified then by default the actually used and orgiginal parameter values are written to the file tt(spread-$.txt), where tt($) is replaced by the loop's iteration index. Here is a sample from the content of such a file, showing the values of the tt(Tumor: DoublingTime:) agegroups parameters: verb( Tumor: DoublingTime ageGroup: 1 - 50 configured: 4.38, using: 3.41972 ageGroup: 50 - 70 configured: 5.06, using: 4.83591 ageGroup: 70 - * configured: 5.24, using: 5.30492 ) bf(The rounds-X.txt files) Each iteration generates a separate tt(rounds-X.txt) file, where tt(X) indicates the iteration index (starting at value 0). The rounds-files summarize the results of the simulations for each separate screening round. It contains at least eight columns plus a column for each used modality: quote( round: the round number (starting at 1);nl() false pos: the number of false positive screening results;nl() false neg: the number of false negative screening results;nl() number of tumors: the number of detected real tumors;nl() number of interval: the number of self-detected (interval) tumors;nl() number of trueInt: the number of self-detected (interval) real tumors;nl() screening costs: the total screening costs;nl() screening biop: the total costs of performed biopsies;nl() number of [modality]: the number of times each modality was used. ) includefile(include/configfiles.yo) manpageseealso() bf(simriscparams)(7) COMMENT( manpagediagnostics() EDN) manpagebugs() Versions before version 15.03.00 should not be used for lung cancer simulations. includefile(include/trailer.yo) COMMENT( it() lsoption(totalrisk)(T)(path)nl() path name of the file to containing the cumulative total risk values (default: '/totalrisk.txt'). By default the cumulative total risk values are not written to file; END) simrisc-16.02.00/documentation/man/simriscparams.yo0000664000175000017500000010211214665030471021254 0ustar frankfrankNOUSERMACRO(simriscparams N U L) includefile(../../release.yo) htmlbodyopt(text)(#27408B) htmlbodyopt(bgcolor)(#FFFAF0) whenhtml(mailto(Frank B. Brokken: f.b.brokken@rug.nl)) DEFINEMACRO(itq)(2)(\ it() verb(ARG1)ARG2 ) DEFINEMACRO(itt)(1)(it() tt(ARG1)nl()) DEFINEMACRO(sr)(0)(bf(simrisc)) DEFINEMACRO(Sr)(0)(bf(Simrisc)) IFDEF(man)( DELETEMACRO(tt) DEFINEMACRO(tt)(1)(em(ARG1)) )() COMMENT( man-request, section, date, distribution file, general name) manpage(simriscparams)(7)(_CurYrs_)(simrisc._CurVers_) (simrisc configuration file organization) COMMENT( man-request, larger title ) manpagename(simriscparams)(The description of the sc() configuration files) manpagedescription() This page describes the organization of the sr() configuration files. These files are formatted like standard unix configuration files. Lines are interpreted after removing initial white-space (blanks and tabs) and after removing all characters from lines starting at the first tt(#) character: this is considered comment and is ignored. If a line (not containing a tt(#) character) ends in a backslash (tt(\)), then the next line (initial white-space removed) is appended to the current line. Note that all parameter identifiers are interpreted case sensitively. E.g., tt(Costs:) is a different parameter than tt(costs:). The numeric values used in this man-page are for illustration purposes only. Some restrictions apply though: standard deviations cannot be negative; proportions and probabilities must lie in the range 0..1; multiple probabilities (like the ones used for breast densities) must add up to 1; etc. If restrictions apply then they are mentioned at the various parameter descriptions below. manpagesection(DEFAULT CONFIGURATION FILE) The configuration file provided in the sr() distribution is+nl() tt(/usr/share/doc/simrisc/simrisc.gz). Usually this file is unzipped by the user to the user's tt(~/.config) directory: verb( gunzip < /usr/share/doc/simrisc/simrisc.gz > ~/.config/ ) whereafter tt(~/.config/simrisc) can be edited to contain local modifications. Various parameters specify probability distributions. Usually the tt(Normal) distribution is specified. The program also recognizes the tt(LogNormal) and tt(Uniform) distributions, and uses the tt(Beta) distribution when handling parameter variations of the beta parameter used for lung cancer simulations (note that the similarity of the names tt(beta) (the parameter) and tt(Beta) (the distribution) is sheer accidentally). Parameter specifications start with keywords, followed by a colon. All keywords are covered below. The format of the specifications is fixed, but empty lines and white space may be used to improve the specifications' readabilities. Parameter specifications starting with uppercase letters (like tt(Scenario:)) COMMENT(tt(BreastDensities:)) specify (sub)sections and contain no additional specifications. Specifications starting with lowercase letters (like tt(ageGroup:)) are followed by actual parameter values. The configuration file must define all parameters of all configuration sections, but configuration parameters can be modified using a separate analysis file or they can be modified by command-line parameters. Several section namess are optional, e.g., `tt(Scenario:)'. In this manual page the label `tt((opt.))' is appended to the names of those sections. In actual confiuration specifications they can stil be used, but they can also completely be omitted. includefile(include/changes) manpagesection(Section `Scenario:' (opt.)) This section may start with a line containing tt(Scenario:) and specifies some general parameters of the simulation process. The default configuration file contains the following specifications: itemization( itt(spread: false) when specified as tt(true) parameter spreading is used; itt(iterations: 1) the (positive) number of iterations used in a simulation loop; itt(generator: fixed) in addition to tt(fixed) the modes tt(random) and tt(increasing) are available.nl() This parameter specificies the way tt(simrisc's) random number generators are initialized. When mode tt(fixed) is used the random number generators are initialized with tt(seed's) value; mode tt(random) results in the random number generators being initialized by randomly selected seeds and tt(seed) (below) is not used; mode tt(increasing) results in incrementing the seeds of the random number generators by a fixed increment at each iteration; itt(seed: 1) the (positive) value to seed the random number generator with. This parameter is ignored when tt(generator: random) was specified; itt(cases: 1000) the (positive) number of cases being simulated; itt(death: ...) the tt(death:) parameter may either be followed by the path to a file (if its initial character is a tilde (~) it is replaced by the user's home directory; if it's a plus (+) it is replaced by the base directory (specified with the tt(--base) option, see the bf(simrisc)(1) man-page)), or it must be followed by 101 cumulative death proportions, where each line starts with tt(:), where tt() is the next order number to read. The default configuration file specifies: verb( death: 1: .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 11: .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 21: .00000 .00014 .00028 .00042 .00056 .00070 .00106 .00142 .00178 .00214 31: .00250 .00382 .00514 .00646 .00778 .00910 .01118 .01326 .01534 .01742 41: .01950 .02312 .02674 .03036 .03398 .03760 .04414 .05068 .05722 .06376 51: .07030 .07776 .08522 .09268 .10014 .10760 .11564 .12368 .13172 .13976 61: .14780 .15718 .16656 .17594 .18532 .19470 .20658 .21846 .23034 .24222 71: .25410 .27560 .29710 .31860 .34010 .36160 .39368 .42576 .45784 .48992 81: .52200 .56240 .60280 .64320 .68360 .72400 .75826 .79252 .82678 .86104 91: .89530 .90962 .92394 .93826 .95258 .96690 .97104 .97518 .97932 .98346 101: .98760 ) which are the 101 cumulative death proportions used for breast cancer simulations. If the 101 cumulative death proportions are available in, e.g., the user's tt(.config/) directory as the file tt(cumdeath) then the specification could have been: verb( death: ~/.config/cumdeath ) which might be convenient when using different values in tt(Analysis:) specifications (see section tt(ANALYSES) in the bf(simrisc)(1) man-page). ) manpagesection(Section `Costs:' (opt.)) This section may start with a line containing tt(Costs:) and specifies several parameters used for cost-calculations. Modality-specific cost parameters are specified in Section tt(Modalities:) (see below). The default configuration file specifies: itemization( itt(biop: 176) the (positive) cost of performing a biopsy; itt(diameters: 0: 6438 20: 7128 50: 7701) pairs of tt(diameter: cost) values specifying the treatment cost starting at the specified tumor diameter, up to the next pair's diameter (if specified) or all diameters starting at the diameter specified at the last pair. The first diameter em(must) be 0. The second value of each pair specifies the (non-negative) treatment costs for that age-group. itt(Discount: (opt.)) the costs discount proportion starting at some age. This line is optional but the followed two additional lines are required: the line tt(discount:) contains two values specifying, respectively, the discount proportions for breast- and lung-cancer simulations. When only one proportion is specified it represents the proportion of the actually used simulation type (i.e., breast- or lung-cancer); the line tt(age:) specifies the discount's starting age (for both simulation types): verb( Discount: # breast lung proportion: 0 .04 age: 50 ) ) manpagesection(Section `BreastDensities:') This section starts with a line containing tt(BreastDensities:) which are used with breast-cancer simulations. It defines breast density values for various age groups, covering ages 0 through the maximum age for simulated cases. The default configuration file contains the following specifications: verb( # bi-rad: a b c d ageGroup: 0 - 40 0.05 0.30 0.48 0.17 40 - 50 0.06 0.34 0.47 0.13 50 - 60 0.08 0.50 0.37 0.05 60 - 70 0.15 0.53 0.29 0.03 70 - * 0.18 0.54 0.26 0.02 ) Optionally, each line may start with an tt(ageGroup:) specification, which is required for the first specification line.nl() Age groups are half-open ranges: starting at their first ages, and endinf at (but not including) their second ages. The first ages of subsequent age groups must be equal to the second ages of their previous age groups. For the last age group the specification tt(*) can be used, indicating that all ages at or above the last age group's begin age are handled by that group.nl() For each age group the probabilities of the four bi-rad classifications must sum to 1.0. manpagesection(Section Modalities: (opt.)) This section may start with a line containing tt(Modalities:) and specifies cancer-scanning modalities. Currently three modalities are supported for breast-cancer simulations: tt(Mammo, Tomo, MRI), and one modality is supported for lung-cancer simulations: tt(CT). Some modalities specify age groups, which are (like the age ranges used for tt(breastDensities)) half-open ranges: they start at their first ages, and end at (not including) their second-ages, while subsequent age ranges must connect. Also, the last age group may use the end-age specification tt(*). The default configuration file contains (below the line tt(Modalities:)) the following specifications (if modalities aren't used their specifications are optional): itemization( itt(CT:) The tt(CT) modality is used when performing lung cancer simulations. The screening costs are used instead of the value configured at the tt(Costs: biop:) specification. The tt(diagnosis:) costs specifies the costs of performing a CT-scan. The tt(M0) and tt(M1) values specify the costs when, respectively, no metastatis or a matastasis has been detected. The radiation dose of tt(CT) scans is configured at the tt(CT: dose:) specification. The sensitivity depends on the tumor diameter. For tumor sizes between 3 and 5 mm. the sensitivity is computed using the formula tt((.5 * diameter - 1..5) * 100) (e.g., 50% for tumors of 4 mm.) The default configuration file contains the following tt(CT) specifications: verb( CT: # screening diagnosis M0 M1 (M0, M1: Table S3) costs: 176 1908 37909 56556 dose: 1 # diam. value (must be integral 0..100 or -1) sensitivity: 0 - 3: 0 3 - 5: -1 # formula: (.5 * diam - 1.5) * 100 5 - *: 100 # mean stddev dist specificity: .992 .076 Normal ) Optionally, each tt(sensitivity) specification line may start with a tt(sensitivity:) specification, which is required for the first specification line.nl() itt(Mammo:) For the tt(Mammo) modality the costs, radiation doses and em(m:) parameter specifications per bi-rad category, specificity probabilities for age groups, the parameters of the beta-function, and the systematic error probability must be specified.nl() The tt(Mammo) sensitivity is computed using the beta-function published by Isheden and Humphreys (2017, Statistical Methods in Medical Research, 28(3), 681-702). From a randomly generated probability and the case's age the case's bi-rad category is determined and that category is then used to select the m-parameter that is used in the beta-function.nl() The default configuration file contains the following tt(Mammo) specifications: verb( Mammo: costs: 64 # bi-rad: a b c d dose: 3 3 3 3 m: .136 .136 .136 .136 # ageGroups: specificity: 0 - 40: .961 40 - *: .965 # 1 2 3 4 beta: -4.38 .49 -1.34 -7.18 systematicError: 0.1 ) itt(Tomo:) For the tt(Tomo) modality the costs, radiation doses per bi-rad category, sensitivity probabilities per bi-rad category, and specificity probabilities for age groups must be specified.nl() The default configuration file contains the following tt(Tomo) specifications: verb( Tomo: costs: 64 # bi-rad: a b c d dose: 3 3 3 3 sensitivity: .87 .84 .73 .65 # ageGroups: specificity: 0 - 40: .961 40 - *: .965 ) itt(MRI:) For the tt(MRI) modality the costs, and the sensitivity and specificity probabilities must be specified.nl() The default configuration file contains (below the line tt(MRI:)) the following specifications: verb( costs: 280 # proportion: sensitivity: .94 specificity: .95 ) ) manpagesection(Section `Screening:' (opt.)) This section may start with a line containing tt(Screening:) and it specifies the ages at which screenings are performed, the used screening modality/modalities for each of the used screening ages, and the probabilities that screening rounds are attended. If no screening rounds should be used then specify a single round-specification line: verb( round: none ) Otherwise, the first screening round must start with the keyword tt(round:) followed by an age, which in turn is followed by a list of at least one space delimited modality specification. Subsequent screening round specifications may optionally start with the keyword tt(round:). Currently tt(Mammo, Tomo, MRI) and tt(CT) are available. tt(Mammo, Tomo,) and tt(MRI) can be specified when performing breast-cancer simulations, tt(CT) can be specified when performing lung-cancer simulations. The default configuration file contains the following tt(round) specifications: verb( # round: 50 CT # 52 CT # 54 CT # 56 CT # 58 CT # 60 CT # 62 CT # 64 CT # 66 CT # 68 CT # 70 CT # 72 CT # 74 CT round: 50 Mammo 52 Mammo 54 Mammo 56 Mammo 58 Mammo 60 Mammo 62 Mammo 64 Mammo 66 Mammo 68 Mammo 70 Mammo 72 Mammo 74 Mammo ) The probability that a case will attend a screening round is specified by the tt(attendanceRate:) parameter: verb( # probability: attendanceRate: .8 ) manpagesection(Section `Tumor:' (opt.)) This section may start with a line containing tt(Tumor:) and it specifies the characteristics of tumors. Several of the parameters in this section can be varied by specifying tt(spread: true) in the section tt(Scenario:), in which case statistical variations are applied to these parameters. Supported distributions are tt(Normal, Uniform, LogNormal,) and (for the lung-cancer's tt(Beir7) parameters) the tt(Beta) distribution. If tt(value) is the specified tt(value) parameter value, and tt(spread) the specified tt(spread) parameter then the values that are actually used during the simulations are: itemization( it() when using the tt(Normal) distribution tt(N(mean, stddev)): verb( N(value, spread)) it() when using the tt(Uniform) distribution tt(U(begin, end)): verb( U(value - spread / 2, value + spread / 2)) it() when using the tt(LogNormal) distribution tt(L(mean, stddev)): verb( L(value, spread)) it() the tt(Beta) distribution is used when requestin lung cancer simulations. For male cases the 95% confidence intervals for the tt(beta) parameters ranges from .15 to .70, for female cases it ranges from .94 to 2.10, and values drawn from these distributions are used when tt(spread: true) has been specified (see also section bf(BETA DISTRIBUTIONS)). ) The tt(spread) parameters may not be negative. If tt(spread) values are configured then their distributions must also be specified. If tt(spread) is not specified, then the tt(value) parameter won't vary if tt(spread: true) is specified in the tt(Scenario) section. The same holds true for the tt(Beta) distribution: if no spreading should be applied, even though tt(spread: true) was specified, then the tt(Beta) distribution's specificatins should be omitted. The tt(Tumor:) section has four subsections: tt(Beir7:, Growth, Incidence:, Survival:,) and tt(S3:). They contain the following parameter specifications: bf(Beir7:) BEIR (tumor induction) parameters: only tumor induction type 7 (i.e., beir7) is used. The default configuration file contains specifications for breast cancer simulations and for male and female lung cancer simulations: verb( # eta beta spread dist. breast: -2.0 0.51 0.32 Normal # Beta-distribution parameters: # LC: eta beta dist constant factor aParam bParam male: -1.4 .32 Beta .234091 1.72727 2.664237 5.184883 female: -1.4 1.40 Beta .744828 .818966 3.366115 4.813548 ) If tt(spread: true) is specified then the actually used tt(beta) parameters are drawn from their respective distributions. See also National Research Council. 2006. Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2. Washington, DC: The National Academies Press (lurl(https://doi.org/10.17226/11340)). bf(Growth:) Tumor growth specifications consist of three elements: start diameters, self-detect parameterss and doubling time specifications. The tt(start) parameters define the start diameters (in millimeters) of emerging tumors used with respectively, breast and lung cancer simulations. The default configuration file specifies verb( # breast lung start: 5 3 ) The default configuration file contains the following specifications of the self-detect parameters for breast and lung cancer simulations: verb( #selfDetect: # stdev mean spread dist breast: 2.01375 18.5413 2.31637 Normal lung: 1.0141 20.8426 1.84043 Normal ) Four parameters are used when determining the diameter at which self-detection is possible. These parameters are: itemization( it() the standard deviation (tt(stdev)) used by the lognormal distribution to compute the diameter at which self-detection occurs. This parameter is required and cannot be negative; it() the tt(mean) (see below) used by the lognormal distribution. This parameter is required and cannot be negative. Its value will vary using the following two parameters if tt(spread: true) was specified; it() the spread (standard deviation) used by the distribution that is used to vary the mean if tt(spread: true) was specified. It can be omitted in which case the mean won't vary; it() the distribution used to vary the mean. If the previous parameter is omitted then this parameter must also be omitted. ) The actually used self-detect diameter is computed using: verb( diameter = L(mean, stdev) ) Finally, the tt(Growth:) subsection also defines tumor doubling times for various age groups when using breast cancer simulations and for all ages when using lung cancer simulations. Doubling times are computed like the self-detect diameters, i.e., using millimeters and lognormal distributions. Thus, for each age group and for the lung cancer simulation four parameters are specified (of which the final two are optional): the standard deviation of the lognormal distribution, the mean value of the lognormal distribution, and the spread and name of the distribution that is used when tt(spread: true) was specified. The age groups (used with breast cancer simulations) must cover ages 0 through the maximum age for simulated cases, and are specified as described at section tt(BreastDensities:). The default configuration file contains the following specifications: verb( DoublingTime: # stdev mean spread dist. ageGroup: 1 - 50: 1.84043 79.838 1.53726 Normal 50 - 70: 1.29693 157.591 1.1853 Normal 70 - * : 1.56831 188.67 1.2586 Normal # all ages stdev mean spread dist. lung: 1.23368 98.4944 2.09594 Normal ) Optionally, each tt(ageGroup) line may start with an tt(ageGroup:) specification, which is required for the first specification line.nl() bf(Incidence: (opt.)) For breast cancer simulations three carrier types are supported: tt(Normal, BRCA1) and tt(BRCA2). Each having a probability of occurrence. The probabilities of these carriers must add to 1. In the default configuration file tt(BRCA1) and tt(BRCA2) are specified, but their probabilties are set to 0, in which case their specifications can also be removed from configuration files. Each carrier is identified by name (i.e., when performing breast cancer simulations tt(Breast:, BRCA1:), and tt(BRCA2); when performing lung cancer simulations: tt(Male:) and tt(Female:)) followed by their parameter specifications: itemization( it() for breast cancer simulations: the probability that the carrier is observed; it() the lifetime risk: three parameters specifying a probability; it() the mean age: three parameters specifying the mean age,; it() the standard deviation used when computing the risk of getting a tumor. As this standard deviation is used in the denominator of expressions it must be larger than zero. COMMENT(incidence/settumorrisk2.cc) ) The lifetime risk, mean age and standard deviation parameters may optionally be followed by the standard deviation (spread) and distribution used to vary the probability when tt(spread: true) is specified; The default configuration file contains these specifications: verb( Male: # value spread distr. lifetimeRisk: .22 .005 Normal meanAge: 72.48 1.08 Normal stdDev: 9.28 1.62 Normal Female: # value spread distr. lifetimeRisk: .20 .004 Normal meanAge: 69.62 1.49 Normal stdDev: 9.73 1.83 Normal Breast: probability: 1 # value spread distr. lifetimeRisk: .226 .0053 Normal meanAge: 72.9 .552 Normal stdDev: 21.1 BRCA1: probability: 0 # value spread distr. lifetimeRisk: .96 meanAge: 53.9 stdDev: 16.51 BRCA2: probability: 0 # value spread distr. lifetimeRisk: .96 meanAge: 53.9 stdDev: 16.51 ) Instead of specifying the parameters of a distribution, a tt(riskTable) can also be used. If a tt(riskTable) is specified at a category (i.e., tt(Male: .. BRCA2:)) then the tt(lifetimeRisk, meanAge,) and tt(stdDev) parameters are ignored. A tt(riskTable) specification contains pairs of values. The first value of a pair specifies an age, the second value the probability of a tumor developing until that age. Both ages and probabilities must be cumulative and at least two pairs must be specified. Unless specified in the tt(riskTable) specification itself sr() adds a pair tt(0, .00) at the beginning, and an age specification tt(100) at the end. Its cumulative tumor probability is computed using linear extrapolation of the two age values before age 100, using a maximum value of 1.00. For ages in between pairs of age values linear interpolation is used, using the surrounding age specifications. Here is a (fictitious) example of a tt(riskTable) specification in the tt(Male:) category: verb( Male: riskTable: 40 .01 50 .1 55 .15 60 .22 65 .55 70 .62 75 .67 ) bf(Survival: (opt.)) For breast cancer simulations four types of survival parameters must be specified. Each type (a..d) specifies a mean, and (optionally) a spread and distribution (which are used when tt(spread: true) has been specified). The default configuration file specifies: verb( # value spread dist: type: a .00004475 .000004392 Normal b 1.85867 .0420 Normal c -.271 .0101 Normal d 2.0167 .0366 Normal e 1.00 .01 Normal ) Optionally, each line may start with a tt(type:) specification, which is required for the first specification line.nl() The tt(e) parameters can be used to estimate relative survival if not enough data are available (and can reflect the quality of care). The value 1 indicates that enough data are available to estimate survival using the tt(a) to tt(d) parameters. If not enough data are available the tt(e) parameter can be used to adjust the survival estimate to correct the use of the tt(a) to tt(f) parameters to the quality level of the medical care relative to a country for which the tt(a) to tt(d) parameters are available. E.g., in Dutch breast cancer research studying the survival in Indonesia the value 0.9 was used since using that factor in combination with the provided tt(a) to tt(d) parameter values the correct survival probabilities for Indonesia were obtained. When performing breast cancer simulations TNM indices (cf. the description of the S3 table below) are also determined. With breast cancer simulations the second TNM value is always 0, and the first TNM value is, as with table S3, determined by the tumor's diameter. The default configuration file contains the following tt(bc:) specification (see also option tt(--tnm)): verb( # BC TNM categories thru (<=) diameters (mm): bc: 20 50 * # TNM: T1 T2 T3 ) (cf. lurl(https://www.cancerresearchuk.org/about-cancer/breast-cancer/stages-types-grades/tnm-staging)). For lung cancer simulations table tt(S4) is used to determine the a..e parameters. Table tt(S4) contains four categories (lung0..lung3) defining these a..e parameters, where (for a known cancer's diameter) the category is randomly determined using table tt(S3) (see below). Table tt(S4) is appended to the breast cancer specifications. The default configuration file contains the following specifications of table tt(S4): verb( # table S4: 4 columns per a..d parameter # lungX: X is table S4's column index lung0: a .00143 .00095 Normal b 1.84559 .33748 Normal c -.22794 .07823 Normal d 1.06799 .16226 Normal e 1.00 .01 Normal lung1: a .01530 .00381 Normal b 1.69434 .10979 Normal c -.19358 .02105 Normal d .66690 .03869 Normal e 1.00 .01 Normal lung2: a .78600 .29815 Normal b .69791 .05425 Normal c .0 .0 Normal d .0 .0 Normal e 1.00 .01 Normal lung3: a 1.25148 .32305 Normal b .77852 .34149 Normal c .0 .0 Normal d .0 .0 Normal e 1.00 .01 Normal ) Optionally, each subsequent line following the first tt(lung0: .. lung3:) line may repeat its tt(lung1: .. lung3:) label. bf(S3: (opt.)) With lung cancer specifications tables tt(S3) and tt(S4) are used to determine the survival parameters. The tumor's diameter determines the row of table S3, and then its column is randomly determined using the probabilities listed in S3's rows. For each row the probabilities must sum to 1. Once the S3 column has been determined the column index which of the tt(lungX:) specifications is used. The row and column indices are 0-based. E.g., if a tumor diameter is 24, then row 2 (diameter <= 30) is selected. Then, if the random value is .630, column 1 is used (column N1-3,M0). Whenever a tumor is present these pairs of indices are reported in the comma-separated data file in the column marked as tt(TNM), using an entry like tt(2,1). The default configuration file contains the following table tt(S3): verb( S3: # diameter (mm) # T-row <= N0,M0 N1-3,M0 N1-3,M1a-b N0-3M1c prob: 10: .756 .157 .048 .039 # T1a,b 20: .703 .197 .055 .045 # T1b 30: .559 .267 .095 .078 # T1c 50: .345 .351 .167 .137 # T2a,b 70: .196 .408 .218 .178 # T3 *: .187 .347 .256 .210 # T4 ) Optionally, each line may start with a tt(prob:) specification, which is required for the first specification line.nl() (cf. lurl(https://www.sciencedirect.com/science/article/pii/S2667005421000491) and Table 1 of its appendix: lurl(https://ars.els-cdn.com/content/image/1-s2.0-S2667005421000491-mmc1.pdf)) manpagesection(BETA DISTRIBUTIONS) Values generated from Beta distributions range between 0 and 1 (cf. lurl(https://en.wikipedia.org/wiki/Beta_distribution)). The Beta distribution is computed using two Gamma distributions (cf. lurl(https://www.fmrib.ox.ac.uk/datasets/techrep/tr03tb1/tr03tb1/node24.html), lurl(https://stats.stackexchange.com/questions/502146/how-does-numpy-generate-samples-from-a-beta-distribution)): verb( gamma1 = Gamma(aParam, 1) Beta(aParam, bParam) = gamma1 / (gamma1 + Gamma(bParam, 1)) ) When using lung cancer simulations the 95% confidence interval (CI) for male cases ranges from .15 to .70, with a mean value of .32, and for women ranging from .94 to 2.10 with a mean value of 1.40. The male and female CI ranges are transformed to .025 to .975 ranges using linear transformations. To transform values tt(x) from the male range to the .025 to .975 range the transformation tt(y = 1.72727 * x - .234091) is used, and to transform back the transformation tt((y + .234091) / 1.72727) is used. For the female CI the transformations are tt(y = .818966 * x - .744828) and tt((y + .744828) / .818966). The tt(aParam) and tt(bParam) values are determined by first generating 1000 values so that their CI span the range 0.025 to .975, with a mean value of 0.318635 (for male cases) and 0.401724 (for female cases). Next the parameters of the corresponding beta distribution were estimated using maximum likelihood fitting, resulting in tt(aParam = 2.664237) and tt(bParam = 5.184883) for the distribution used with male lungcancer simulations, and tt(aParam = 3.366115) and tt(bParam = 4.813548) for the distribution used with female lungcancer simulations. The default configuration file shows these values at the Beir7 beta parameters. manpagesection(PARAMETER RESPECIFICATION) Parameters can be respecified by defining a separate parameter configuration file or by providing alternate parameter specifications in tt(Analysis:) sections of the program's input file, or by providing alternative parameter specifications as command-line arguments (cf. the bf(simrisc)(1) man-page) manpagefiles() includefile(include/configfiles.yo) manpageseealso() bf(simrisc)(1) manpagebugs() Versions before version 15.03.00 should not be used for lung cancer simulations. includefile(include/trailer.yo) simrisc-16.02.00/documentation/manual/0000775000175000017500000000000014665030471016533 5ustar frankfranksimrisc-16.02.00/documentation/manual/html/0000775000175000017500000000000014665030471017477 5ustar frankfranksimrisc-16.02.00/documentation/manual/html/modalities/0000775000175000017500000000000014665030471021631 5ustar 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The top-level sectioning command is chapter. ) mailto(f.b.brokken@rug.nl) DEFINEMACRO(C)(1)(COMMENT(ARG1)) DEFINEMACRO(s)(0)(tt(simrisc)) DEFINEMACRO(S)(0)(tt(Simrisc)) DEFINEMACRO(itt)(1)(it() tt(ARG1)) DEFINEMACRO(centt)(1)(center(tt(ARG1))) AfourEnlarged() IFDEF(html)(htmlstylesheet(simrisc.css))() latexoptions(11pt) latexpackage()(epsf) latexpackage()(simrisc) setlatexfigureext(.eps) C(sethtmlfigureext(.gif) ) htmlbodyopt(text)(black) htmlbodyopt(bgcolor)(white) includefile(abstract.yo) affiliation(University of Groningen) report(Simrisc Manual)(Frank B. Brokken)(September 01, 2024)()) chapter(Introduction) includefile(intro/intro.yo) lsect(GENERIC)(Generic Support Classes) lsubsect(ENUMS)(Enums: program-wide constants) includefile(generic/enums.yo) lsubsect(TYPEDEFS)(Program-wide type definitions) includefile(generic/typedefs.yo) subsect(Globally available functions) includefile(generic/globals.yo) subsect(Options) includefile(generic/options.yo) subsect(Err) includefile(generic/err.yo) lsubsect(DISTRIBUTION)(Distribution) includefile(generic/distribution.yo) lsubsect(VSD)(VSD) includefile(generic/vsd.yo) lsubsect(AGEGROUP)(AgeGroup) includefile(generic/agegroup.yo) chapter(Design) sect(the main() function) includefile(main/main.yo) sect(Simulator) includefile(simulator/simulator.yo) subsect(run) includefile(simulator/run.yo) lsect(ANALYSIS)(Analysis) includefile(analysis/analysis.yo) subsect(run) includefile(analysis/run.yo) lsect(SCENARIO)(Scenario) includefile(scenario/scenario.yo) lsect(LOOP)(Loop) includefile(loop/loop.yo) chapter(Support classes for Loop) lsect(COSTS)(Costs) includefile(costs/costs.yo) lsect(DENSITIES)(Densities) includefile(densities/densities.yo) lsubsect(DENSITY)(Density) includefile(densities/density.yo) lsect(MODALITIES)(Modalities) includefile(modalities/modalities.yo) subsect(the base class ModBase) includefile(modalities/modbase.yo) subsubsect(the derived class MRI) includefile(modalities/mri.yo) subsubsect(the derived class Mammo) includefile(modalities/mammo.yo) subsubsect(the derived class Tomo) includefile(modalities/tomo.yo) lsect(SCREENINGCLASS)(Screening and Rounds) includefile(screening/screening.yo) lsect(TUMOR)(Tumor) lsubsect(TUMORRESET)(Resetting the tumor data) lsubsect(TUMORCHARACT)(Computing the tumor's characteristics) lsubsect(TUMORDEATHAGE)(Computing the dying age because of the tumor) lsect(TUMORINFO)(TumorInfo) includefile(tumorinfo/tumorinfo.yo) lsubsect(BEIR)(Beir7) includefile(tumorinfo/beir7.yo) subsect(Growth) subsect(Incidence) subsect(Survival) 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white-space: nowrap; } simrisc-16.02.00/documentation/manual/densities/0000775000175000017500000000000014665030471020522 5ustar frankfranksimrisc-16.02.00/documentation/manual/densities/densities.yo0000664000175000017500000000425514665030471023070 0ustar frankfrankThe tt(Densities) object provides access to information about the breast densities (cf. url(bi-rads info) (https://radiologyassistant.nl/breast/bi-rads/bi-rads-for-mammography-and-ultrasound-2013)). The American College of Radiology (ACR) distinguishes four breast densitiy categories: itemization( it() a: the breasts are almost entirely fatty it() b: there are scattered areas of fibroglandular density it() c: the breasts are heterogeneously dense, which may obscure small masses it() d: the breasts are extremely dense, which lowers the sensitivity of mammograph ) (see also url(the ACR reference card) (https://www.acr.org/-/media/ACR/Files/RADS/BI-RADS/BIRADS-Reference-Card.pdf)) In the s() configuration file the distributions of probabilities of these four categories by age groups are provided by the tt(breastDensities:) specifications, e.g., verb( bi-rad classification ---------------------------- agegroup a b c d breastDensities: 0 - 40 0.05 0.30 0.48 0.17 ... breastDensities: 70 - * 0.18 0.54 0.26 0.02 ) Age groups consist of an initial age and an upper limit. The upper limit is not considered part of the age range, but becomes the initial age of the next range. The final age range may use age specification tt(*), indicating the maximum possible age of simulated cases. Specifications following a specification using ending age tt(*) are ignored. S() checks whether the bi-rad probabilities per age group add to 1.00, and whether the ending age of an age group is equal to the initial age of the next age group. At the initialization phase of tt(Loop::genCases) (cf. section ref(GENCASES) breast densitiy indices (0..3) corresponding to bi-rad classifications a..d are determined for the simulated case's screening ages. The member tt(Densities::indices) generates a random value from the uniform random distribution and uses that probability to determine the bi-rad classification for the various screening ages, returning a vector containing the bi-rad classifications (0..3) for each screening round. simrisc-16.02.00/documentation/manual/densities/density.yo0000664000175000017500000000042214665030471022550 0ustar frankfrankObjects of the class tt(Density) contain the information about a single density age-group. It contains the density's age-group, bi-rad values and a vector of cumulative bi-rad values allowing fast lookups of a bi-rad category given a (randomly determined) proportion value. simrisc-16.02.00/documentation/manual/densities/src0000777000175000017500000000000014665030471024002 2../../../densitiesustar frankfranksimrisc-16.02.00/documentation/manual/generic/0000775000175000017500000000000014665030471020147 5ustar frankfranksimrisc-16.02.00/documentation/manual/generic/options.yo0000664000175000017500000000236214665030471022216 0ustar frankfrankS(), like many other programs, expects arguments when it is activated. As described in the bf(simrisc)(1) man-page s()'s only argument is tt(analyses), describing the analyses s() performs. Other than that s() expects options. Options come as boolean options (like tt(--help, --one-analysis,) and tt(--verbose) and as options requiring arguments (like tt(--nCases), specifying the number of cases to simulate). The class tt(Options) inspects all options and stores their values. Since tt(Arg), the class receiving the program arguments and options is a singleton it is only natural for tt(Options) to be a singleton class as well, allowing all program components to access the options without having to pass an tt(Options) object as argument. Most members simply return their option values (like tt(string const &base()), returning the base directory where by default the results are written). But some members (like tt(fixedNaturalDeathAge)) (conditionally) assign values to their parameters instead of returning a value. Hier is an overview of tt(Options') public members. All members are tt(const) members except tt(alter), which is used to modify option values as found in the configuration file: verbinsert(-s4 //members ../../../options/options.h) simrisc-16.02.00/documentation/manual/generic/distribution.yo0000664000175000017500000000000514665030471023232 0ustar frankfrankTODO simrisc-16.02.00/documentation/manual/generic/err.yo0000664000175000017500000000264214665030471021314 0ustar frankfrankError messages are handled by the class tt(Err). This class defines the content of various error messages, some of which are plain messages, and some require a onfiguration line information (tt(LineInfo), cf. section ref(TYPEDEFS)). The messages are selected using symbolic names defined in the tt(enum Msg), nested under the class tt(Err). The following symbolic names are defined: verbinsert(//msg ../../../err/err.h) All members of tt(Err) are static. They are: itemization( itt(char const *src(ParamsSrc type))nl() returns the name of the parameter specification source tt(type) (cf. section ref(ENUMS)); itt(std::ostream &msg(Msg err))nl() merely inserts the error message into the error stream, returning a reference to that stream; itt(std::ostream &msg(Msg err, LineInfo const &lineInfo))nl() inserts confguration source, line nr, and the error message into the error stream, ending in `tt(: )'. A reference to the stream is returned; itt(void specification(LineInfo const &line))nl() shorthand for using tt(msg(SPEC_ERROR, line)). itt(void multiplySpecified(LineInfoVect const &lines, std::string const §ionList))nl() shorthand for using tt(MULTIPLY_SPECIFIED) in specification tt(sectionList), listing the info about the multiple specifications provided in tt(lines). ) simrisc-16.02.00/documentation/manual/generic/enums.yo0000664000175000017500000000161714665030471021654 0ustar frankfrankConstants used throughout the program are defined in enumerations in the tt(enums/enums.h) file. These enumerations are: itemization( itt(Constants), defining the number of bi-rad categories (tt(N_BIRADS = 4)) and the ending and maximum ages for simulated cases (tt(END_AGE = 101, MAX_AGE = END_AGE - 1)); itt(DistType), defining the types of the distributions used when generating random values. All classes using distributions (like tt(Distribution) and tt(Random)) use this enumeration when referring to statistical distributions. itt(GeneratorType), defining the diffent ways the random number generators can be initialized (cf. the tt(generator:) parameter in the configuration file); itt(ParamsSrc), specifying whether parameters are defined in a configuration file or in an tt(analysis:) specification section. ) simrisc-16.02.00/documentation/manual/generic/globals.yo0000664000175000017500000000240714665030471022146 0ustar frankfrankThe class tt(Globals) merely provides functions. These functions are all static member functions. They are: itemization( itt(double findAge(DoubleVect const &cumProb, double prob))nl() finds the last series of elements that are smaller than tt(prob) in tt(cumProb), using the index of the first of that series of elements as the begin index, and finds the first element in tt(cumProb) exceeding tt(prob) using that element's index as the end-index. It then interpolates tt(prob) in the half-open range tt([cumProb[begin], cumProb[end]CHAR(41)) C(]) returning the corresponding the (floating point) index; itt(bool isZero(double value))nl() returns true if tt(value's) absolute value is smaller than tt(1e-8); itt(bool isPositiveZero(double value))nl() returns true if tt(value) is not negative and smaller than tt(1e-8); itt(ostream &setPrecision(ostream &out, uint16_t nDigits))nl() sets tt(out's) precision when inserting tt(double) values to tt(nDigits) behind the decimal point; itt(int weakCompare(double lhs, double rhs))nl() using tolerance tt(1e-3) returns -1 if tt(lhs < rhs), 0 if tt(lhs == rhs), and 1 if tt(lhs > rhs). ) simrisc-16.02.00/documentation/manual/generic/agegroup.yo0000664000175000017500000000164114665030471022333 0ustar frankfrankThe class tt(AgeGroup) extracts age group specifications from the configuration file. Age group specifications look like this: verb( 0 - 40 40 - 50 50 - 60 60 - 70 70 - * ) which are half-open age ranges: tt([begin, end+CHAR41). The star specifies the maximum possible age (tt(MAX_AGE) as defined in tt(enums.h)). tt(AgeGroup) objects have two accessors: tt(beginAge), returning the begin age, and tt(endAge) returning the ending age of the half open range. When age groups are read then their ranges must connect. This is checked by the member verb( bool nextRange(std::vector const &vect, LineInfo const &lineInfo) const; ) returning tt(true) if the begin age read from tt(lineInfo) equals the end age in tt(vect.back()). This is used, e.g., when reading the age ranges of the various breast densities (cf. tt(densities/add.cc)). simrisc-16.02.00/documentation/manual/generic/typedefs.yo0000664000175000017500000000112614665030471022343 0ustar frankfrankThe file tt(typedefs/typedefs.h) contains type definitions of container types that are used throughout the program. Because of the types that are defined in tt(typedefs.h) source files may assume that the headers tt(cstdint, vector, string, unordered_set) and tt(enums.h) are also included. When parameter specifications are retrieved these specifications are stored in a dedicated tt(struct LineInfo): verbinsert(-s4 //struct ../../../typedefs/typedefs.h) In addition the following type definitions of various containers are defined: verbinsert(-s4 //types ../../../typedefs/typedefs.h) simrisc-16.02.00/documentation/manual/generic/vsd.yo0000664000175000017500000000213014665030471021310 0ustar frankfrankThe class tt(VSD) (Value, Standard deviation, Distribution) stores the value, standard deviation and distribution type of parameter values. Such parameters are usually specified in the configuration file like this: verb( # value spread distr. parameterName: 72.9 .552 Normal ) The parameter values are retrieved by accessor members. If the tt(Scenario's spread) parameter was configured as tt(true) then the member tt(refresh) applies a random variation to the value parameter, which is then returned by the tt(value) accessor. If tt(D) represents a random value from the used distribution and tt(orgValue) is the value that was originally read from the configuration file then tt(refresh) modifies tt(value) as verb( value = orgValue + spread * D() ) which value is thereupon returned by its tt(value) accessor. Note: if the tt(VSD spread) parameter is not specified then the default value 0 is used. In those cases the tt(VSD value) data member is not modified when tt(Scenario spread) is specified as tt(true). simrisc-16.02.00/documentation/manual/modalities/0000775000175000017500000000000014665030471020665 5ustar frankfranksimrisc-16.02.00/documentation/manual/modalities/modalities.yo0000664000175000017500000000605114665030471023372 0ustar frankfrankScreening modalities are accessed via the tt(Modalities) object. The modalities object provides the interface to modalities that are defined for screening rounds. All modalities that are thus accessible are derived from a base class tt(ModBase). tt(ModBase) defines the interface that must be offered by classes derived from tt(ModBase). This allows reuse of existing components of s() that use modalities, irrespective of what actual modalities are configured for the various screening rounds. The structure of this design is illustrated in Figure ref(MODFIG). figure(modalities/modalities)(The Modalities design)(MODFIG) Figure ref(MODFIG) shows the tt(Modality) object in blue. It communicates with tt(ModBase) objects. tt(ModBase) is a polymorphic base clase completely defining the interface modalities must provide. What modalities there are or will be at some poiny in the future is irrelevant, as long as these future modalities implement the interface required by tt(ModBase). Currently three modalities are available: an MRI modality, a Mammo modality and a Tomo modality. The arrows pointing down from tt(ModBase) suggest time: MammoTomo was originally implemented. At some later point in time MRI was added. At some point in the future another, as yet unknown, modality may be added. At that point only the new modality must be implemented, but the program using the new modality can be reused, not requiring additional modifications. The tt(Modality) constructor receives the tt(modality) parameter specifications from the configuration file. Modality parameters specify the name of the modality; the costs of using the modality; optionally specifications of radiation doses for the treatment of the four bi-rads categories; the modality's sensitivity (optionally differently specified for the four bi-rads categories, and the modality's specificity, optionally using age groups, like the age groups that were used when specifying breast density parameters. E.g., verb( # bi-rads bi-rads (agegroups: values) # modalities id cost dose sensitivity specificity # 1..4 1..4 modality: Mammo 64 3 3 3 3 0.87 0.84 0.73 0.65 0-40: 0.961 40-*: 0.965 modality: MRI 64 0.00 0.00 ) The constructor uses the specification ID to create the matching modality-handling object. Modality handlers are derived from the (polymorphic) modality base class tt(ModBase) (see the next section). When a screening is performed for a specific screening age (cf. section ref(SCREEN)) then all modalities that were specified for that screening age are visited in turn. Screening round specifications define the modalities that are used for those rounds (cf. section ref(SCREENINGCLASS)). The tt(Screening) class provides, per screening round, the names (IDs) of the modalities that are used for those rounds, The member tt(Modality::use) receives these IDs and returns pointers to the modalities that are associated with those IDs. Those modalities are then applied in turn to the current case. simrisc-16.02.00/documentation/manual/modalities/modbase.yo0000664000175000017500000000330514665030471022651 0ustar frankfrankThe class tt(ModBase) defines the interface for modalities that is available to other parts of s(), in particular to members of the class tt(Loop) (cf. section ref(LOOP)). The interface provides the following members: itemization( itt(double sensitivity(size_t idx)): the modality's sensitivity given a bi-rad category tt(idx). For modalities that are independent of bi-rad categories the tt(idx) argument is ignored; itt(double specificity(double age)): the modality's specificity given an age. For modalities that are independent of age the tt(age) argument is ignored; itt(uint16_t cost()): returns the costs associated with using the modality; itt(uint16_t nr() const): returns an identifying order-number of the modality; The order number is used, e.g., when updating the number of false negative decisions during screening loops; itt(void resetCounters(size_t nRounds)): clears the vector counting the number of times modalities are used by the screening rounds and resets the number of encountered false positives to 0; itt(void count(size_t round)): increments the usage count for the specified screening round; itt(void falsePositive()): increments the number of false positive decisions; itt(std::string const &id()): returns the name (e.g., MRI, Mammo) of the modality; itt(double const *dose()): returns the array of radiation doses associated with the modality or 0 if there are no associated radiation doses; itt(double dose(uint16_t idx)): returns the radiation dose of a specified bi-rad category or 0 if there are no associated radiation doses. ) simrisc-16.02.00/documentation/manual/modalities/mammo.yo0000664000175000017500000000163614665030471022352 0ustar frankfrankThe class tt(Mammo) is derived from tt(ModBase). tt(Mammo's) base class extracts the tt(costs) parameter from the configuration file. Its sensitivity is computed by its tt(vSensitivity) member. The sensitivity of the tt(Mammo) modality depends on the tumor's diameter and the configured tt(beta) parameters. As a reference, here is the member implementing tt(Mammo's) sensitivity computation: verbinsert(-s4 //code ../../../mammo/vsensitivity.cc) This function also uses the systematic error which is also configured in the configuration file (tt(Mammo: systematicError:)). The modality's specificity is obtained by finding the case's actual age in the vector tt(d_specVect) (as configured in the configuration file) and returning the associated specificity value. Likewise, the radiation doses are returned by the tt(vDose) members, where the bi-rad category can be used as index (0 for 'a' through 3 for 'd'). simrisc-16.02.00/documentation/manual/modalities/mri.yo0000664000175000017500000000050514665030471022025 0ustar frankfrankThe class tt(MRI) is derived from tt(ModBase). tt(MRI's) base class extracts the tt(costs) parameter from the configuration file. Its sensitivity (tt(vSensitivity)) and specificity tt(vSpecificity)) values are constants, and there are no radiation doses associated with this modality (the tt(vDose) members return zeroes). simrisc-16.02.00/documentation/manual/modalities/tomo.yo0000664000175000017500000000076514665030471022224 0ustar frankfrankThe class tt(Tomo) is derived from tt(ModBase). tt(Tomo's) base class extracts the tt(costs) parameter from the configuration file. The modality's specificity is obtained by finding the case's actual age in the vector tt(d_specVect) (as configured in the configuration file) and returning the associated specificity value. Likewise, the radiation doses and sensitivity values are returned by the tt(vDose) and tt(vSensitivity) members, using bi-rad category as index (0 for 'a' through 3 for 'd'). simrisc-16.02.00/documentation/manual/intro/0000775000175000017500000000000014665030471017666 5ustar frankfranksimrisc-16.02.00/documentation/manual/intro/intro.yo0000664000175000017500000000440414665030471021374 0ustar frankfrankThis manual is primarily a technical manual. Currently the user-information is covered by s()'s man-pages This manual covers the design and organization of s()'s software. Each section (except for section tt(main)) covers a class as encountered when reading the sources starting at the tt(main) function. In total almost 30 classes were defined. Starting from tt(main) only tt(Simulator) is required. At the other side of the spectrum there are several classes or comparable elements which are used by many classes. These elements are defined in separate header files: itemization( itt(enums/enums.h), containing enumeration values for errors and constant values; itt(typedefs/typedefs.h), defining short names for frequently used vectors (like tt(SizeVect) for tt(std::vector)) itt(globals/globals.h), a struct defining several static functions handling frquently encountered small computations (like tt(isZero) to determine whether a tt(double) value has a value that's closer to zero than a (compile time configurable) tolerance). ) These files are not further covered in this manual: they contain definitions and trivial support functions, and the reader should refer for these files themselves for further details. figure(outer) (The Outer Program Design) (OUTER) The outline of the organization of the outer levels of the program is shown in Figure ref(OUTER). tt(main) uses a tt(Simulator), and for each separate analysis the tt(Simulator) creates an tt(Analysis) object, which in turn creates a tt(Loop) object, doing all the hard work (hence the ellipsis in Figure ref(OUTER)). The configuration file defines elements that can be used in the analyses. Such elements are, e.g., tt(Screening), containing screening parameters, tt(Densities), containing parameters of breast densities, and tt(Incidence), containing tumor incidence parameters. Objects of those classes are used by tt(Loop). It is quite possible that future versions of s() also supports different types of simulations. It's likely that tt(Loop) itself then becomes a em(scenario) as defined by Gamma et al. (1995), and that analysis specification files also select the requested scenario(s) by specifying the requested simulation type(s). simrisc-16.02.00/documentation/manual/analysis/0000775000175000017500000000000014665030471020356 5ustar frankfranksimrisc-16.02.00/documentation/manual/analysis/run.yo0000664000175000017500000000112214665030471021527 0ustar frankfrankThe tt(run) member may immediately end if errors were encountered in the specifications of the tt(Scanario) and/or tt(ConfigFile) parameters. One of the options defines the base directory into which the output is written. The member tt(requireBase) checks whether the base directory exists, and if not creates it. If that fails the program ends, showing the message verb( Cannot create base directory ... ) where tt(...) is replaced by the name of the base directory provided by the tt(Options) object. If all's well, the actual simulation is then performed by a tt(Loop) object. simrisc-16.02.00/documentation/manual/analysis/analysis.yo0000664000175000017500000000314414665030471022554 0ustar frankfranktt(Analysis) class objects handle one simulation analysis. Since multiple analyses are performed independently from each other, each tt(Analysis) object initializes its own error count (class tt(Error)) and option handling (class tt(Options)). As options may specify the name of the file containing the analysis-parameters tt(Analysis) objects also define a configuration file object (ConfFile). In s()'s scientific context simulation parameters are also known as `scenarios'. Scenarios contain information like the number of iterations to perform and the number of cases to simulate. The analysis's tt(Scenario) object is initialized by tt(Analysis)'s constructor, and is used by its tt(run) member. Figure ref(ANADATA) provides an overview of tt(Analysis)'s data members. figure(analysis/data) (The Analysis data members) (ANADATA) verbinsert(-s4 //data src/analysis.h) The class tt(Analysis) uses the classes tt(Scenario, Loop, ConfFile, Options) and tt(Error), which are covered in separate sections of this technical manual. When the tt(Analysis) object is constructed it constructs its own tt(Scenario) object. That object receives the modifications that are specific for the current analysis (e.g., that were specified following an tt(analysis:) line in an analysis-specification file). When the tt(Scenario) object (cf. section tt(SCENARIO)) is returning specifications (e.g., using its tt(lines) members, then it returns the modified specifications if available. Modified specification must be complete, as they replace the corresponding specifications in the used (standard) configuration file. simrisc-16.02.00/documentation/manual/analysis/src0000777000175000017500000000000014665030471023472 2../../../analysisustar frankfranksimrisc-16.02.00/documentation/manual/random/0000775000175000017500000000000014665030471020013 5ustar frankfranksimrisc-16.02.00/documentation/manual/random/random.yo0000664000175000017500000000411214665030471021642 0ustar frankfrankObjects of the class tt(Random) generate random numbers. Mercenne twisters (defined in bf(C++)'s STL as the tt(std::mt19937) type) generate random values. Its public members returning random values are: verbinsert(//members src/random.h) Each of these member returns random values drawn from the corresponding statistical distribution. Each distribution uses its own mercenne twister to obtain its next random value. The members tt(uniform, uniformCase) return random values drawn from the uniform random distribution. and tt(logNormal) from the standard log-normal distribution. The other members are only used and are only available when tt(spread: true) is specified. In that case at least tt(N = 2) cases must be simulated as the chi+sups(2) distribution uses tt(N - 1) degrees of freedom. If tt(spread: true) is specified the following members are available and are used for random variations of various configured parameters: itemization( it() the member tt(binomial) draws from the binomial distribution, and its argument specifies the distribution's probability; it() the member tt(chi2) draws from the chi+sups(2) distribution having tt(N - 1) degrees of freedom; it() the member tt(normal) draws from the standard normal distribution, ) COMMENT( and tt(exponential) generate random numbers conforming their distribution type. ) At each new analysis tt(Scenario's seed) value is assigned to the tt(Random) object's tt(seed) value. Then, at each tt(Loop) iteration the tt(Random) object is re-initialized: itemization( it() the tt(Scenario) object is used to set its tt(d_spread) and tt(d_nCases) data members; it() if tt(generator: random) was specified, tt(d_seed) is initialized with a random seed. it() when tt(generator: increasing) was specified tt(d_seed) is incremented. ) Next the generators and distributions are reset by the member tt(reset). The member tt(reset) resets the mercenne twisters by assigning new tt(mt19937) objects, initialized with tt(d_seed). Next the various distributions are reset. simrisc-16.02.00/documentation/manual/random/src0000777000175000017500000000000014665030471022564 2../../../randomustar frankfranksimrisc-16.02.00/documentation/manual/screening/0000775000175000017500000000000014665030471020510 5ustar frankfranksimrisc-16.02.00/documentation/manual/screening/screening.yo0000664000175000017500000000002614665030471023034 0ustar frankfrankincludefile(intro.yo) simrisc-16.02.00/documentation/manual/screening/intro.yo0000664000175000017500000000246514665030471022223 0ustar frankfrankThe class tt(Screening) handles the screening parameters. Screening parameters are obtained from the tt(Scenario) object (cf. section ref(SCENARIO)). At construction time the following parameters are obtained: itemization( it() the probability that a case attends a screening: probability and distribution are specified like this: verb( # value distribution: attendanceRate: 0.8 Normal ) it() the screening rounds specify the screening ages and the modalities that are used for those rounds. Currently the modalities tt(MRI, Mammo) (mammography) and tt(Tomo) (tomosynthesis) are available. Screening rounds use specifications like this: verb( screeningRound: 58 Mammo MRI ) Information about these rounds is stored in its tt(d_roundVect) vector, containing tt(Round) objects. Each tt(Round) object contains the round's age, the indices of the specified modalities and the names (IDs) of the specified modalities. ) Its member tt(radiationRisk) returns a vector of tt(double) values for each (integral) age. It uses the bi-rad indices which are recomputed for each new case (cf. section ref(GENCASES)) and consequently it is called by tt(Loop::genCases) for each similated case. simrisc-16.02.00/documentation/manual/spread/0000775000175000017500000000000014665030471020011 5ustar frankfranksimrisc-16.02.00/documentation/manual/spread/stddevs.yo0000664000175000017500000000401014665030471022031 0ustar frankfrankExpected values and variances of chi+sups(2) distributions are directly related (cf. url(this link) (https://en.wikipedia.org/wiki/Variance#Distribution_of_the_sample_variance)): Their expected values are equal to the population variance (= tt(var)), and their variances are equal to verb( 2 * sqr(var) / (N - 1) ) where tt(N) represents the sample size. In tt(simrisc) the used chi+sups(2) distribution is computed from the population variance as specified in the configuration file (like 21.1 for the tt(Normal) carrier's standard deviation) and the number of simulated cases (like 100,000). In that case the variance of the variances of such samples equals verb( 2 * sqr(21.1) / (100,000 - 1) = 0.0089 ) (and std. dev. 0.0944) Using tt(sd) to represent the standard deviation drawn from a distribution of standard deviations using samples of size tt(N) and population standard deviation tt(sigma), then verb( (N - 1) * sqr(sd) / sqr(sigma) ) follows a chi+sups(2) distribution with tt(N - 1) degrees of freedom. Using tt(chi^2[df]) to represent such a distribution, we get verb( (N - 1) * sqr(sd) / sqr(sigma): distributed as chi^2[N - 1] ) From sigma, N and a random value drawn from tt(chi^2[N - 1]) a corresponding tt(sd) value can now be computed: verb( sd = sqrt( sqr(sigma) * chi^2[N - 1] / (N - 1) ) ) The following table illustrates what these tt(sd) values might look like when computed 10 times: (using N = 100,000) en sigma = 21.2): verb( ---------------------- chi^2 sd ---------------------- 1: 100805.0 -> 21.285 1: 99499.8 -> 21.147 2: 99867.1 -> 21.186 3: 99873.8 -> 21.187 4: 100076.0 -> 21.208 5: 99895.8 -> 21.189 6: 99952.9 -> 21.195 7: 100558.0 -> 21.259 8: 100126.0 -> 21.213 10: 99289.8 -> 21.125 ---------------------- ) The procedure described here is used to compute spread variations for standard deviations. simrisc-16.02.00/documentation/manual/spread/spread.yo0000664000175000017500000000540614665030471021645 0ustar frankfrankAs described in section ref(SCENARIO) the Scenario parameter tt(spread) may be set to tt(true) resulting in random variations of several parameters. Handling spreading is illlustrated in figure ref(SPREADFIG). figure(spread/spread) (Spread used by Simrisc components) (SPREADFIG) When an analysis starts tt(Loop::initialize) passes tt(Scenario::spread) on to the member tt(Loop::spread). Various components support random fluctuations of their parameters, and if tt(Scenario::spread) is true these random fluctiations are applied to these components. Figure ref(SPREADFIG) illustrates where random fluctuations may be applied: itemization( it() the tt(Mammo) modality's tt(systematicError); it() the tt(Screening's attendanceRate); it() various tt(Tumor) components: itemization( it() tt(Survival); it() tt(Growth); it() tt(TumorInfo): itemization( it() tt(Beir7); it() tt(Incidence's) carrier specifications. ) ) ) Random fluctuations can be applied to means, standard deviations and proportions. For means the normal distribution is used by default. For example, the specification of the tt(meanAge) distribution, specifified for carrier tt(Normal) in the tt(Incidence) component of the tt(Tumor) specification may look like this: verb( # value spread distr. meanAge: 72.9 .552 Normal ) 95% of the mean-values which are randomly drawn from this distribution are located in the interval 71.8 to 74.0. When spreading is used, thus computed mean values are used as mean values of the tt(Normal) carrier during the actual simulations. For standard deviations the chi+sups(2) distribution is used, ensuring that the standard deviation that is used for the simulations exceeds 0 (see the next section for a description of the theory and implementation in tt(simrisc)). For example, the standard deviations of the tt(Normal) carrier distribution may look like this: verb( # value spread distr. stdDev: 21.1 .048 Normal ) The number of degrees of freedom of the chi+sups(2) distribution to use tt(N - 1), where tt(N) is the number of cases that are used in a simulation. COMMENT( For proportions the binomial distrubution is used, ensuring that randomly selected proportions lie within the interval 0..1 (see section ref(BINOMIAL) for a description of the theory and implementation in tt(simrisc)). For example, the tt(Screening attendanceRate) specification may be specified as: verb( attendanceRate: .8 ) Likewise, the tt(systematicError) (Modality, Mammo) and risks (e.g., tt(Normal Incidence Tomor) carrier are proportions). ) simrisc-16.02.00/documentation/manual/loop/0000775000175000017500000000000014665030471017504 5ustar frankfranksimrisc-16.02.00/documentation/manual/loop/gencases.yo0000664000175000017500000000637714665030471021662 0ustar frankfrankThe member tt(genCases) performs one complete iteration over all screening rounds for all simulated cases. The option tt(nCases) may be used to simulate a specific number of cases. When tt(nCases) is specified only the data of the final case are written to file. By default as many cases as specified at the `nWomen' parameter (stored in the tt(Scenario) object) are simulated, and the data of all those simulated cases are written to file. Analyses up to a specific number of cases, or a single simulation using a preset death-age (see option tt(--death-age) in the bf(simrisc)(1) man-page) can also be performed. The number of cases to simulate is determined in the tt(nCases) member. For each simulated case: itemization( it() the simulation data are initialized: itemization( it() the costs of the case (tt((d)_caseCost)), the tumor-caused death age (tt(d_deathAge)), the screening round in which a tumor is detected (d_roundDetected), and the indicator indicating whether the tumor has been self-detected (d_selfDetected); it() breast density indices are determined (uses random numbers, and thus they are recomputed at each new simulated case) (cf. section ref(DENSITIES)). These indices are stored in tt(d_indices) for the different screening ages (the index computed for the first screening age is stored at the first element). For each age a randomly determined proportion is located in the cumulative proportions of the bi-rads categories of its age group. The thus determined bi-rad category is stored in tt(d_indices). E.g., for age 54 these bi-rads proportions could be used: verb( agegroup bi-rads1 bi-rads2 bi-rads3 bi-rads4 breastDensities: 50 - 60 0.08 0.50 0.37 0.05 ) resulting in category 3 if the randomly selected proportion is 70; it() cumulative total tumor risks are determined (uses breast density indices, and must therefore be recomputed at each simulated case) (cf. section ref(TUMORINFO)); it() the case's natural death age is determined as a random age <= MAX_AGE, which is a compiled constant (100). it() the status of the simulated case is intialized to tt(PRESENT). The case's state changes during the simulation and the case's simulation may end during the pre-screening phase, the screening phase, or the post-screening phase, because of the case's natural death, because of self-detection of a tumor or because of a tumor that's detected during a screening cycle; it() the parameters of the tumor-simulating object are reset (cf. section ref(TUMORRESET)). ) it() following the initialization three simulation phases are simulated: itemization( it() pre-screening (cf. section ref(PRESCREEN)) it() screening (cf. section ref(SCREENING)) it() postscreening (cf. section ref(POSTSCREEN)) ) it() Once a case's simulation ends the case's death age and computed costs are accumulated and the simulated data are written to the data file containing all case-specific values (or, when the option tt(--nCases) or tt(--death-age) was specified: only the data of the requested single simulated case). ) simrisc-16.02.00/documentation/manual/loop/iterate.yo0000664000175000017500000000304214665030471021511 0ustar frankfrankThe tt(iterate) member performs the number of iterations (scenario: iterations). At each iteration itemization( it() the random number generator is reset; it() the tt(TumorInfo) (cf. section ref(TUMORINFO)) parameters may be refreshed; it() The following tt(Loop)'s counters are reset: itemization( itt(d_totalCost), the sum of all simulated costs over all screening rounds; itt(d_sumDeathAge), the sum of all simulated dying ages over all screening rounds; itt(d_nIntervals), the vector storing the number of simulated interval cancers per screening round; itt(d_nRoundFP), the vector storing the number of false positive diagnoses per screening round; itt(d_nRoundFN), the vector storing the number of false negative diagnoses per screening round; itt(d_nDetections), the vector storing the number of self-detected cancers per screening round; itt(d_roundCost), the vector storing the total costs per screening round; itt(d_modalities), the counters maintained by the used tt(Modalities) are reset. ) it() The actual simulation is performed over `scenario nWomen' cases by tt(genCases); it() At each iteration summarizing and actual simulation data are (optionally) written to files (sensitivity, parameters, and rounds info, while actually produced simulation data are written to file by the tt(genCases) member itself). ) simrisc-16.02.00/documentation/manual/loop/loop.yo0000664000175000017500000000140014665030471021021 0ustar frankfrankincludefile(intro.yo) subsect(iterations) includefile(iterate.yo) lsubsect(GENCASES)(Simulate Cases) includefile(gencases.yo) lsubsect(PRESCREEN)(Pre-screening) includefile(prescreen.yo) subsubsect(Performing a pre-screening) includefile(prescreening.yo) lsubsect(CHARACTERISTICS) (Self-detected tumors during the pre- and post-screen phases) includefile(characteristics) lsubsect(SCREENING)(Screening) includefile(screening.yo) subsubsect(Leaving screening rounds) includefile(leaving.yo) lsubsubsect(SCREEN)(Performing a screening) includefile(screen.yo) lsubsect(POSTSCREEN)(Post-screening) C(<<<<<<<<<<<<<) includefile(postscreen.yo) simrisc-16.02.00/documentation/manual/loop/prescreening.yo0000664000175000017500000000142314665030471022541 0ustar frankfrankIf a pre-screening phase is used then the following happens: itemization( it() If there's no tumor but the case's natural death occurs before the tumor-induced death, then (tt(loop/pretumordeath.cc)) the case's simulation ends, setting its status to tt(LEFT_PRE). If at this point there also happens to be an existing tumor then the tumor's characteristics are determined as well (by tt(Tumor::characteristics), cf. section ref(TUMOR)). it() On the other hand, if the complement of the above condition holds true (i.e., there is a tumor and the tumor's self-dectected age is before the case's natural death) the characteristics of the tumor are determined (see the next section) resulting in the case leaving the simulation because the tumor was self detected. ) simrisc-16.02.00/documentation/manual/loop/characteristics.yo0000664000175000017500000000151514665030471023232 0ustar frankfrankThe function tt(Loop:characteristics) may be called during the pre-screening phase and during the post-screening phase. In both phases the tumor is self-detected, the tumor characteristics are determined (tt(Tumor::characteristics, Tumor::setDeathAge), cf. sections ref(TUMORCHARACT) and ref(TUMORDEATHAGE)), and the treatment costs are determined using the tumor's induced death age and the tumor's diameter (tt(Costs::treatment), cf. section ref(COSTS)). If the case's natural death occurs before the tumor would have caused the case's death then the case leaves the pre-screening or post-screening simulation with status (respectively) tt(LEFT_PRE) and tt(LEFT_POST). Otherwise death was caused by the tumor and the the case leaves the pre-screening or post-screening simulation with status (respectively) tt(TUMOR_PRE) and tt(TUMOR_POST). simrisc-16.02.00/documentation/manual/loop/postscreen.yo0000664000175000017500000000122314665030471022240 0ustar frankfrankPost screening is skipped if the case has left the simulation process during the pre-screening or screening phases. If there is a tumor and the tumor's self-detection age is before the case's natural death then the tumor characteristics and treatment costs are determined (cf. section ref(CHARACTERISTICS)). On the other hand, if there is no tumor or if the tumor's self-detection age would have been after the case's natural death then the case leaves the simulation at the case's natural death age. In this latter case (athough there is a tumor, it hasn't caused death) the tumor's characteristics are determined as well (cf. section ref(TUMORCHARACT)). simrisc-16.02.00/documentation/manual/loop/prescreen.yo0000664000175000017500000000350314665030471022044 0ustar frankfrankThe original program uses the following condition to determine whether prescreening must be performed: verb( if (Nscr > 0 && (naturalDeathAge < 1st screening age || (tumor present && tumor.selfDetectAge() < 1st screening age))) ) This results in a needlessly complex implementation of the pre-screening phase. It's much simpler to use the complement of this expression, skipping the pre-screening phase if the complementary condition is true. The pre-screening phase is therefore skipped if the following condition holds true: verb( not (Nscr > 0 && (naturalDeathAge < 1st screening age || (tumor present && tumor.selfDetectAge() < 1st screening age))) ) The expression can be simplified using De Morgan's rule tt(a && b == !a || !b): verb( not (Nscr > 0) or not ( naturalDeathAge < 1st screening age or (tumor present and tumor.selfDetectAge() < 1st screening age) ) ) Consequently, pre-screening is skipped if there are no screening rounds (not (Nscr > 0)) and also if the following condition holds true: verb( not ( naturalDeathAge < 1st screening age or (tumor present and tumor.selfDetectAge() < 1st screening age) ) ) Distributing the not-operator over the terms of the above condition, and applying De Morgan's rule tt(!(a || b) == !a && !b) we get: verb( naturalDeathAge >= 1st screening age and not ( tumor present and tumor.selfDetectAge() < 1st screening age ) ) Applying De Morgan's rule once more this finally results in: verb( naturalDeathAge >= 1st screening age and ( not tumor present or tumor.selfDetectAge() >= 1st screening age ) ) Thus, pre-screening is skipped if the above condition holds true. simrisc-16.02.00/documentation/manual/loop/screening.yo0000664000175000017500000000216114665030471022032 0ustar frankfrankFollowing the pre-screening phase the screening phase itself starts. However, when a case's simulation has already ended during the pre-screening phase the screening phase is skipped. Other than that, a case's simulation may also end during the screening phase itself, ending the screening phase. As long as the case simulation has not ended (i.e., the case's state is tt(PRESENT)) a screening is performed for each of the screening rounds defined by the tt(Screening) object (cf. section ref(SCREENINGCLASS)), initialized in tt(Loop's) constructor. At each screening round two actions are performend: itemization( it() given the round's screening age it is determined whether the case leaves the simulation at that particular screening round. If so then the case's state is no longer tt(PRESENT) and the screening phase ends for that case (see the next section for details); it() if the case is still present, then a screening is performed, which may also result in changing the case's state, which then also ends the screening phase for that case (cf. section ref(SCREEN)). ) simrisc-16.02.00/documentation/manual/loop/intro.yo0000664000175000017500000000306714665030471021216 0ustar frankfrankThe class tt(Loop) is the `workhorse' class. It performs the simulation as specified by the tt(Scenario) object which is passed to its objects when they are constructed. The class tt(Loop) uses many other classes, most of which encapsulate parameters specified in the configuration file. Those classes read configuration file parameters and prepare these parameters for their use by tt(Loop). The constructor of a tt(Loop) object defines the following objects: itemization( itt(d_costs): a tt(Costs) object providing various costs parameters (cf. section ref(COSTS)). This object does not provide the costs associated with various modalities. Those costs are directly stored at the modalities themselves; itt(d_densities): a tt(Densities) object providing the breast-densities parameters (cf. section ref(DENSITIES)); itt(d_modalities): a tt(Modalities) object providing the details about which screening modalities are used in a specific simulation (cf. section ref(MODALITIES)); itt(d_screening): a tt(Screening) object providing screening parameters (cf. section ref(SCREENING)); itt(d_tumor): a tt(Tumor) object handling the simulation related to the occurrence of tumors (cf. section ref(TUMOR)); itt(d_tumorInfo): a tt(TumorInfo) object providing tumor-related configuration parameters (like incidence, growth and survival parameters. Cf. section ref(TUMORINFO)); ) It also defines a tt(Random) object (tt(d_random)), generating random numbers (cf. section ref(RANDOM)). simrisc-16.02.00/documentation/manual/loop/leaving.yo0000664000175000017500000000252514665030471021506 0ustar frankfrankWhether the case leaves the simulation before an actual screening at the current screening age is determined by the member tt(Loop::leaving). In the original program this is determined as follows: itemization( it() the case's natural death occurs before the screening round's age, it() or there is a tumor and the tumor's self-detection age is before the screening round's age ) Converting this condition, then the case leaves the simulation if itemization( it() the screening round's age is at most equal to the case's natural death age, and it() there is no tumor or the screening round's age is at most equal to the tumor's self-detection age. ) If at this point the case hasn't left the simulation, then itemization( it() if there is a tumor and the tumor's self-detection age is at most equal to the case's natural death age then an interval cancer has occurred (handled by tt(Loop::intervalCancer)); it() otherwise, the case's state is set to tt(LEFT_DURING) as the case's natural death age has caused the case to leave the simulation. However, a tumor might still have developed at that point, and if so the tumor's characteristics are determined at the case's natural death age (cf. tt(Tumor::characteristics), section ref(TUMOR)). ) simrisc-16.02.00/documentation/manual/loop/screen.yo0000664000175000017500000000727414665030471021346 0ustar frankfrankIf the case has not yet left the simulation, then the member tt(Loop::screen) simulates a screening at a given screening age. At this point the modalities are considered. Each of the modalities configured for the current screening age is considered in turn. They are considered in their order of specification in the configuration file. E.g., when specifying verb( screeningRound: 50 Mammo MRI screeningRound: 52 MRI Mammo ) then Mammo is considered before MRI at screening age 50, and MRI is considered before Mammo at screening age 52. Modalities are made available by the tt(Modalities) member (tt(d_modalities), cf. section ref(MODALITIES)). The tt(use) member of this member returns the information of all modalities that have been configured for the current screening round. Whether a configured modality is actually going to be used at a particular screening round is determined by chance. In the configuration file the parameter tt(attendanceRate) defines the probability that a case attends a screening round. If the next random value drawn from the uniform random distribution exceeds the configured attendance rate then the screening round for that modality is skipped for the current case. If a case attends a screening round then the screening round's costs are determined (cf. section ref(COSTS)) and are added to the costs so far (cf. tt(Loop::addCost)): the costs are added to the case's accumulated cost and to the accumulated costs of the current screening round. In addition, if a tumor exists at a screening round then the tumor's characteristics are determined for the current screening age. Two factors determine whether a tumor may be detected or whether its detection may be a false positive. One factor (factor-1) is the (apparent) presence of a tumor, the other factor (factor-2) is whether the screening round's age is at least equal to the age that the tumor can be detected. If both factors are true, then the tumor may be detected. Otherwise there may be a false positive tumor detection. em(Maybe detecting the tumor (maybe a false negative conclusion):) The member tt(maybeDetect) (cf. tt(Loop::maybeDetect)) is used to decide whether a tumor may be found during the screening. A false negative screening result is obtained if a random value exceeds the current modality's sensitivity. The sensitivities of the various modalities are returned by the tt(ModBase::sensitivity) member (which in turn call their derived class's members tt(vSensitivity) returning the return values of the actually used modality's overridden tt(vSensitivity) members. If a false negative result isn't obtained then a tumor was detected: its treatment costs are added to the accumulated costs and the dying age because of the tumor is set to the age of the current screening round. If the natural dying age is earlier than the dying age caused by the cancer, then the case leaves the simulation (using status tt(LEFT_DURING)). Otherwise the case leaves the simulation using status tt(TUMOR_DURING). em(Maybe incorrectly detecting the tumor (maybe a false positive conclusion):) Once a tumor has apparently been observed it may in fact not exist, in which case a false positive observation was made. The memebr tt(maybeFalsePositive) handles this situation. The specificity of the used modality, given the current screening age is compared to a random value from the uniform random distribution. If the generated random value exceeds the modality's specificity then the simulation has encountered a false positive tumor detection. The numbers of false positive decisions for the modality and for the screening round are incremented and tt(addCoist) is called with argument the biopsy costs at the current screening age. simrisc-16.02.00/documentation/manual/loop/src0000777000175000017500000000000014665030471021746 2../../../loopustar frankfranksimrisc-16.02.00/documentation/manual/main/0000775000175000017500000000000014665030471017457 5ustar frankfranksimrisc-16.02.00/documentation/manual/main/main.yo0000664000175000017500000000071614665030471020760 0ustar frankfrankThe tt(main) function defines the long options in its global tt(g_longOpts) array. The tt(g_longOpts) and tt(g_longEnd) global variables are not declared for general use in a header file but are declared in class specific headers when needed. Currently that's only tt(scenario/scenario.ih). verbinsert(-s4 //main src/main.cc) The simulations themselves are controlled by a tt(Simulator), having only one public member: tt(run), performing the simulations. simrisc-16.02.00/documentation/manual/main/src0000777000175000017500000000000014665030471020750 2../../..ustar frankfranksimrisc-16.02.00/documentation/manual/abstract.yo0000664000175000017500000000157714665030471020721 0ustar frankfrankabstract( WIP describing spreading nl() WIP updating section Random (ref(RANDOM)) nl() Jan. 06: added subsection AgeGroup (ref(AGEGROUP)) nl() old: nl() Jan. 04: added subsection Distribution (ref(DISTRIBUTION)) nl() Jan. 04: added subsection VSD (ref(VSD)) nl() Jan. 04: added subsection Beir7 (ref(BEIR)) nl() Dec. 31: added the section about Generic Support Classes (ref(GENERIC)) nl() Dec. 31: added the section TumorInfo (ref(TUMORINFO)) nl() Dec. 30: completed subsection Density (ref(DENSITY)) nl() Dec. 29: completed section Modalities (ref(MODALITIES)) nl() Oct. 18: completed section Densities ref(DENSITIES) nl() Oct. 17: completed section Costs ref(COSTS) nl() Oct. 16: completed section Loop ref(LOOP) nl() ) simrisc-16.02.00/documentation/manual/tumorinfo/0000775000175000017500000000000014665030471020555 5ustar frankfranksimrisc-16.02.00/documentation/manual/tumorinfo/beir7.yo0000664000175000017500000000031014665030471022130 0ustar frankfrankThe class tt(Beir7) stores the tt(Tumor Beir7's beta, eta, spread) and the spread-distribution configuration parameters. It's a wrapper class for these parameters, offering accessors to each of them. simrisc-16.02.00/documentation/manual/tumorinfo/tumorinfo.yo0000664000175000017500000000114514665030471023151 0ustar frankfrankObjects of the class tt(TumorInfo) provide access to the following paramters: tt(Beir7, Growth, Incidence) and tt(Survival), which are covered in the following sections. In addition its member tt(cumTotalRisk) computes the cumulative total risk, given the radiationrisk as determined in tt(Loop::caseInit). For each case the (Incidence) carrier is randomly determined given the probabilites of the various carriers. The cumulative total risks over all ages are computed by subsequently adding the products of the risk of getting a tumor (given the selected carrier) times the radiation risk (for the used age). simrisc-16.02.00/documentation/translations.txt0000664000175000017500000000675714665030471020557 0ustar frankfrankTranslations of symbols used in the original sources to currently used symbols ============================================================================== mammoCosts, MRICosts, TomoCosts = mammotomo.h, mri.h biopsyCosts, treatmentCosts[3] = costs.h fpctrl - input/control.txt oid fpin - not used fpout - not used fpcosts - input/costs.txt fpdeath - test3/data-?.txt fpsensitivity - test3/sensitivity.txt fpdist - test3/dist-?.txt fp = test3/rounds-?.txt Nmam = loop.d_nMam Ntomo = loop.d_nTomo NfalseP = loop.d_nRoundFP NfalseN = loop.d_nRoundFN Ndect = loop.d_nDetections screeningRoundCosts = loop.d_roundCost naturalDeathAge = loop.d_naturalDeathAge deathStatus = loop.d_status deathAge = loop.d_deathAge AgeOfDetection = loop.d_detectionAge Nscr - scenario.rounds().size() scr[].age = scenario.age(idx) src[].T0 = scenario.round(idx).mammo() src[].T1 = scenario.round(idx).tomo() fpdist, distFileName: options::d_cumTotalRiskFile calcTotalRisk = tumorinfo/cumtotalrisk cumTotRisk = tumorinfo/d_cumRisk tumorinfo: DoubleVect const &cumTotalRisk() const beir = tumorInfo.induction() dose = modalities.mammoParams().dose() tomodose = modalities.tomoParams().dose() [a][b]: a = type (xray) b = id(Mammo, Tomo) specMam[?] = - d_modality.mammoParams()[?].value() - d_modality[XRAY][MAMMO][?].value() specTomo[?] = - d_modality.tomoParams[?].value() - d_modality[XRAY][TOMO][?].value() tumorSurvival[0..4] = Survival tumorRisk_f = incidence.risk().value() params(): vector of nCarriers values tumorRisk_m = incidence.mean().value() tumorRisk_s = incidence.stdDev().value() tumorRisk = incidence tumor.selfDetectAge() - d_tumor.selfDetectAge() tumor.deathAge(...) - d_tumor.deathAge() - wrt tumor.selfDetectAge() d_tumor.deathAge(x) - wrt age x (e.g. tumor.selfDetect() tumorConfig.startDiameter = growth.start() (VSD's) tumorConfig.selfDetectDiameterMu = growth.selfMu() tumorConfig.selfDetectDiameterSigma = growth.selfSigma() tumorConfig.doublingTimeMu[ageGroupIndex] - growth.group[idx].mean() tumorConfig.doublingTimeSigma[ageGroupIndex] - growth.group[idx].stdDev() RoundVect rounds() - vector of screening rounds: uint16_t age(), mammo() tomo() womenYears - Loop:d_sumDeathAge womenCosts - Loop:d_caseCost (was: Loop:d_totalCost) Ninterval - Loop:d_nIntervals (vector) womencost - Loop:d_roundCost (vector) screeningRoundCosts - Loop:d_screeningCost (vector) attendanceRate - Screening:d_attentanceRate densities - d_densities.indices() -> Loop:d_indices Breast density index at screening rounds int density[Nscr] - Loop:d_indices Ndect - Loop:d_nDetected; filenames: scenarioName is, e.g. 'noscreening', defined in control.txt iter is the string converted iteration index all filenames end in scenarioName + -i + iter + .txt (not used below) settingsFileName = "output/settings- writeSettings(settingsFileName); outputFileName = "output/summary- deathFileName = "./output/women- sensitivityFileName = ./output/sensitivity- resetRandomNumberGenerator - d_random.reset simrisc-16.02.00/dot.config/0000775000175000017500000000000014665030471014437 5ustar frankfranksimrisc-16.02.00/dot.config/simrisc0000664000175000017500000002752414665030471016045 0ustar frankfrank # supported distribution names are: Normal, LogNormal, Uniform, Beta # Modalities are: Mammo, Tomo, MRI, CT # (Sub)section names to which # is prefixed are optional #======================================================= #Scenario: # use true for variable spreading spread: false iterations: 1 # random generator behavior: # random, fixed, increasing generator: fixed # initial seed unless using generator: random seed: 1 # n cases to simulate cases: 1000 death: #death.txt 1: .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 11: .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 21: .00000 .00014 .00028 .00042 .00056 .00070 .00106 .00142 .00178 .00214 31: .00250 .00382 .00514 .00646 .00778 .00910 .01118 .01326 .01534 .01742 41: .01950 .02312 .02674 .03036 .03398 .03760 .04414 .05068 .05722 .06376 51: .07030 .07776 .08522 .09268 .10014 .10760 .11564 .12368 .13172 .13976 61: .14780 .15718 .16656 .17594 .18532 .19470 .20658 .21846 .23034 .24222 71: .25410 .27560 .29710 .31860 .34010 .36160 .39368 .42576 .45784 .48992 81: .52200 .56240 .60280 .64320 .68360 .72400 .75826 .79252 .82678 .86104 91: .89530 .90962 .92394 .93826 .95258 .96690 .97104 .97518 .97932 .98346 101: .98760 # ref.age proportion biop specs (first diameter must be 0) # Lungcancer costs: configured at Modalities: CT: costs: #Costs: # biop may be omitted with LC simulations: biop: 176 diameters: 0: 6438 20: 7128 50: 7701 # if one proportion value is specified it's the proportion value used # for the configured simulation. E.g., for just LC simulations: # proportion .04 # if two values are specified (as shown below) the 1st proportion # is used for BC simulations, the 2nd proportion for LC simulations #Discount: # breast lung proportion: 0 .04 age: 50 BreastDensities: # bi-rad: a b c d ageGroup: 0 - 40: .05 .30 .48 .17 #optionally the following lines may start with ageGroup: 40 - 50: .06 .34 .47 .13 50 - 60: .08 .50 .37 .05 60 - 70: .15 .53 .29 .03 70 - * : .18 .54 .26 .02 #Modalities: CT: # screening diagnosis M0 M1 (M0, M1: Table S3) costs: 176 1908 37909 56556 dose: 1 # diam. value (must be integral 0..100 or -1) sensitivity: 0 - 3: 0 #optionally the following lines may start with sensitivity: 3 - 5: -1 # formula: (.5 * diam - 1.5) * 100 5 - *: 100 # mean stddev dist specificity: .992 .076 Normal # defining outside could be OK. If also defined inside then that # definition takes precedence (also if defined in Mammo in the config file, # but stand-alone in an Analysis specification), see mammo/setbeta.cc, # # 1 2 3 4 # beta: -4.38 .49 -1.34 -7.18 Mammo: costs: 64 # bi-rad: a b c d dose: 3 3 3 3 m: .136 .136 .136 .136 # ageGroups: specificity: 0 - 40: .961 40 - *: .965 # 1 2 3 4 beta: -4.38 .49 -1.34 -7.18 systematicError: 0.1 Tomo: costs: 64 # bi-rad: a b c d dose: 3 3 3 3 sensitivity: .87 .84 .73 .65 # ageGroups: specificity: 0 - 40: .961 40 - *: .965 MRI: costs: 280 # proportion: sensitivity: .94 specificity: .95 #Screening: # round: age space separated modalities. # subsequent ages must exceed the last age by at least 1 # with lung cancer simulations only CT can be specified, # with breast cancer simulations CT cannot be specified, # round: 50 CT # #optionally the following lines may start with round: # 52 CT # 54 CT # 56 CT # 58 CT # 60 CT # 62 CT # 64 CT # 66 CT # 68 CT # 70 CT # 72 CT # 74 CT round: 50 Mammo #optionally the following lines may start with round: 52 Mammo 54 Mammo 56 Mammo 58 Mammo 60 Mammo 62 Mammo 64 Mammo 66 Mammo 68 Mammo 70 Mammo 72 Mammo 74 Mammo # proportion: attendanceRate: .8 #Tumor: Beir7: # only used with BC simulations: # eta beta spread dist. breast: -2.0 0.51 0.32 Normal #only used with LC simulations: # Beta-distribution parameters: # eta beta dist constant factor aParam bParam male: -1.4 .32 Beta .234091 1.72727 2.664237 5.184883 female: -1.4 1.40 Beta .744828 .818966 3.366115 4.813548 Growth: # if one start value is specified it's the start value used # for the configured simulation. E.g., for just LC simulations: # start: 3 # if two values are specified (as shown below) the 1st value # is used for BC simulations, the 2nd value for LC simulations # breast lung start: 5 3 # the following parameter values are now exp(old-values) # the original values are FOR NOW shown in comment lines #selfDetect: # stdev mean spread dist # .70 2.92 .084 Normal breast: 2.01375 18.5413 2.31637 Normal # .014 3.037 .61 Normal lung: 1.0141 20.8426 1.84043 Normal DoublingTime: # stdev mean spread dist. # 1 - 50: .61 4.38 .43 Normal ageGroup: 1 - 50: 1.84043 79.838 1.53726 Normal #optionally the following lines may start with ageGroup: # 50 - 70: .26 5.06 .17 Normal 50 - 70: 1.29693 157.591 1.1853 Normal # 70 - * : .45 5.24 .23 Normal 70 - * : 1.56831 188.67 1.2586 Normal # LC: all ages stdev mean spread dist. # .21 4.59 .74 Normal lung: 1.23368 98.4944 2.09594 Normal #Incidence: Male: # riskTable: consisting of >= 2 age cum.prob pairs may be # specified. If specified, lifetimeRisk:, meanAge: and # stdDev: specifications are ignored # value spread distr. # fictious example riskTable: # riskTable: # 40 .01 50 .1 55 .15 # 60 .22 65 .55 70 .62 # 75 .67 lifetimeRisk: .22 .005 Normal meanAge: 72.48 1.08 Normal stdDev: 9.28 1.62 Normal Female: # riskTable: may be specified as described at subsection Male: # value spread distr. lifetimeRisk: .20 .004 Normal meanAge: 69.62 1.49 Normal stdDev: 9.73 1.83 Normal Breast: # riskTable: may be specified as described at subsection Male: probability: 1 # value spread distr. lifetimeRisk: .226 .0053 Normal meanAge: 72.9 .552 Normal stdDev: 21.1 BRCA1: # riskTable: may be specified as described at subsection Male: probability: 0 # value spread distr. lifetimeRisk: .96 meanAge: 53.9 stdDev: 16.51 BRCA2: # riskTable: may be specified as described at subsection Male: probability: 0 # value spread distr. lifetimeRisk: .96 meanAge: 53.9 stdDev: 16.51 #Survival: # For LC simulations the type paramaters and the bc parameters can be # omitted # value spread dist: type: a .00004475 .000004392 Normal #optionally the following lines may start with type: b 1.85867 .0420 Normal c -.271 .0101 Normal d 2.0167 .0366 Normal e 1.00 .01 Normal # BC TNM categories thru (<=) diameters (mm): bc: 20 50 * # TNM: T1 T2 T3 # For BC simulations the lung[0-4] and S3 paramaters can be omitted # table S4: 4 columns per a..d parameter # lungX: X is table S4's column index lung0: a .00143 .00095 Normal #optionally the following lines may start with lung0: b 1.84559 .33748 Normal c -.22794 .07823 Normal d 1.06799 .16226 Normal e 1.00 .01 Normal lung1: a .01530 .00381 Normal #optionally the following lines may start with lung1: b 1.69434 .10979 Normal c -.19358 .02105 Normal d .66690 .03869 Normal e 1.00 .01 Normal lung2: a .78600 .29815 Normal #optionally the following lines may start with lung2: b .69791 .05425 Normal c .0 .0 Normal d .0 .0 Normal e 1.00 .01 Normal lung3: a 1.25148 .32305 Normal #optionally the following lines may start with lung3: b .77852 .34149 Normal c .0 .0 Normal d .0 .0 Normal e 1.00 .01 Normal #S3: # diameter (mm) # T-row <= N0,M0 N1-3,M0 N1-3,M1a-b N0-3M1c prob: 10: .756 .157 .048 .039 # T1a #optionally the following lines may start with prob: 20: .703 .197 .055 .045 # T1b 30: .559 .267 .095 .078 # T1c 50: .345 .351 .167 .137 # T2a,b 70: .196 .408 .218 .178 # T3 *: .187 .347 .256 .210 # T4 simrisc-16.02.00/enums/0000775000175000017500000000000014665030471013534 5ustar frankfranksimrisc-16.02.00/enums/enums.ih0000664000175000017500000000007614665030471015210 0ustar frankfrank#include "enums.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/enums/enums.h0000664000175000017500000000273614665030471015044 0ustar frankfrank#ifndef INCLUDED_ENUMS_ #define INCLUDED_ENUMS_ #include static unsigned const END_AGE = 101; static unsigned const MAX_AGE = END_AGE - 1; enum: uint16_t { UNDEFINED = static_cast(~0U) }; enum FirstChar // 1st char is capital or LC, used by Globals { // OPTION is the allowed value with --cancer (-c) CAPS, LC, OPTION }; enum VaryType { VARY_MEAN, // every value is OK VARY_NONNEG, // varied values must be >= 0 VARY_PROB, // varied values must be probabilities VARY_BETA_MALE, // used for the Beta distributions VARY_BETA_FEMALE, }; enum DistType // Distribution::s_name when modified { UNIFORM, // always used distributions UNIFORM_CASE, UNIFORM_VSD, LOGNORMAL, N_STD_DISTRIBUTIONS, NORMAL_VARY = N_STD_DISTRIBUTIONS, UNIFORM_VARY, UNIFORM_VSD_VARY, LOGNORMAL_VARY, BETA_VARY, // only used when parameter spead N_DISTRIBUTIONS }; enum GeneratorType { FIXED_SEED, INCREASING_SEED, RANDOM_SEED, }; enum ParamsSrc { CONFIGFILE, ANALYSIS, NONE, }; enum Series // see (Prob)Group { RANGE, // e.g., 0 - 40: SINGLE, // e.g., 20 }; enum SimulationType // update globals/data.cc when modified { BREAST, MALE, // = LC simulation FEMALE, // = LC simulation }; #endif simrisc-16.02.00/enums/frame0000664000175000017500000000006014665030471014545 0ustar frankfrank//#define XERR #include "enums.ih" Enums:: { } simrisc-16.02.00/err/0000775000175000017500000000000014665030471013175 5ustar frankfranksimrisc-16.02.00/err/negative.cc0000664000175000017500000000020214665030471015300 0ustar frankfrank//#define XERR #include "err.ih" // static void Err::negative() { msg(NEGATIVE) << '`' << s_lineInfo->txt << '\'' << endl; } simrisc-16.02.00/err/data.cc0000664000175000017500000000664014665030471014423 0ustar frankfrank//#define XERR #include "err.ih" ///Err Err::s_err; // the singleton object LineInfo const *Err::s_lineInfo; // last set LineInfo bool Err::s_handle = true; // handle a context message char const *Err::s_src[] { "config file", "analysis specification", "" }; char const *Err::s_plain[] // plain msg: no line context { "probabilities don't sum to 1" , // CUMPROB "Incidence carrier probabilites must sum to 1" , // INCIDENCE_SUM_PROB "specification(s) missing for" , // MISSING_SPEC "multiply specified: " , // MULTIPLY_SPECIFIED "CT: unknown sensitivity for diameter " , // CT_NO_SENS, "undefined specification" , // UNDEFINED_SPEC "Cumulative death proportions (" , // CUM_DEATH }; char const *Err::s_context[] // line context available { "parameter value too small" , // AT_LEAST "CT sensitivity must be 0..100 or -1" , // CT_SENS "CT sensitivity diameters must cover 0..*" , // CT_SENS_RANGE "Group specifications must end in :" , // GROUP_NO_COLON "invalid Survival type" , // INVALID_TYPE "invalid value" , // INVALID_VALUE "modality repeatedly specified" , // MODALITY_REPEATED "parameter cannot be negative" , // NEGATIVE "age ranges not consecutive" , // NOT_CONSECUTIVE "percentages must sum to 1" , // PROB_SUM, "parameter(s) must lie within 0..1" , // RANGE_0_1 "screening round ages don't increment" , // ROUND_AGES_DONT_INC "`round: none' conflicts with " "`round: age' specifications" , // ROUND_NONE "specification error" , // SPEC_ERROR "undefined distribution" , // UNDEFINED_DIST "undefined modality" , // UNDEFINED_MODALITY "VSD specification missing. Require " , // VSD_MISSING "Lung cancer simulations cannot specify " // LC_INVALID_MODALITY "modality " , "Breast cancer simulations cannot specify " // BC_CT_INVALID "modality CT" , "TableParams specification error" , // TABLEPARAMS }; // "integral number not found (parameter `" , // MISSING_NR, // "`tumorIncidence' probabilities must add up to 1" , // INVALID_PROBSUM, // string{"max. number of carrier specifications (" + // N_CARRIERS, // to_string(END_CARRIERS) + " exceeded"}.c_str() , // "`tumorGrowth:' startDiameter, Mu and Sigma not specified" , // TUMORGROWTH_STARTDIAM, // "`tumorGrowth:' no `agegroups' defined" , // TUMORGROWTH_AGEGROUPS, // "at least one `tumorIncidence:' parameter line is required" , // TUMORINCIDENCE_SIZE, // "missing `tumorSurvival' types (a, b, c and d are required)\n" , // TUMORSURVIVAL_TYPES, // string{"max. number of carrier specifications (" + // N_CARRIERS, // to_string(END_CARRIERS) + " exceeded"}.c_str() , // "age ranges not consecutive " , // NOT_CONSECUTIVE, simrisc-16.02.00/err/reset.cc0000664000175000017500000000025514665030471014630 0ustar frankfrank#define XERR #include "err.ih" // static LineInfo const * Err::reset(LineInfo const &lineInfo) { s_lineInfo = &lineInfo; s_handle = true; return s_lineInfo; } simrisc-16.02.00/err/specification.cc0000664000175000017500000000021114665030471016316 0ustar frankfrank//#define XERR #include "err.ih" // static void Err::specification() { msg(SPEC_ERROR) << '`' << s_lineInfo->txt << '\'' << endl; } simrisc-16.02.00/err/range.cc0000664000175000017500000000020014665030471014570 0ustar frankfrank//#define XERR #include "err.ih" // static void Err::range() { msg(RANGE_0_1) << '`' << s_lineInfo->txt << '\'' << endl; } simrisc-16.02.00/err/err.h0000664000175000017500000000552214665030471014142 0ustar frankfrank#ifndef INCLUDED_ERR_ #define INCLUDED_ERR_ #include #include #include "../typedefs/typedefs.h" // err messages to cerr, messages may end in '\n' class Err { static char const *s_plain[]; static char const *s_context[]; static char const *s_src[]; static LineInfo const *s_lineInfo; // last set LineInfo static bool s_handle; // handle a context message public: enum Plain // plain errors, { // no line context CUMPROB, INCIDENCE_SUM_PROB, MISSING_SPEC, MULTIPLY_SPECIFIED, CT_NO_SENS, UNDEFINED_SPEC, CUM_DEATH, }; enum Context { AT_LEAST, CT_SENS, CT_SENS_RANGE, GROUP_NO_COLON, INVALID_TYPE, INVALID_VALUE, MODALITY_REPEATED, NEGATIVE, NOT_CONSECUTIVE, PROB_SUM, RANGE_0_1, ROUND_AGES_DONT_INC, ROUND_NONE, SPEC_ERROR, UNDEFINED_DIST, UNDEFINED_MODALITY, VSD_MISSING, LC_INVALID_MODALITY, BC_CT_INVALID, TABLEPARAMS }; static char const *src(ParamsSrc type); // merely the error message: static std::ostream &msg(Plain err); // 1. // error msg + src and line nr, ending in ": " static std::ostream &msg(Context err); // 2. static void msgTxt(Context err); // also inserts line txt // msg(RANGE_0_1 using line) static void range(); // msg(NEGATIVE using line) static void negative(); // msg(AT_LEAST using line) static void atLeast(double minimum); // msg(SPEC_ERROR using line static void specification(); // msg(MULTIPLY_SPECIFIED) static void multiplySpecified(LineInfoVect::const_iterator begin, LineInfoVect::const_iterator end, std::string const §ionList); static LineInfo const *reset(LineInfo const &lineInfo); static std::string const &txt(); // status of all operations since the static bool valid(); // last reset }; inline bool Err::valid() { return s_handle; } inline char const *Err::src(ParamsSrc type) { return s_src[type]; } inline void Err::msgTxt(Context err) { msg(err) << '`' << s_lineInfo->txt << '\'' << std::endl; } inline std::string const &Err::txt() { return s_lineInfo->txt; } #endif simrisc-16.02.00/err/msg2.cc0000664000175000017500000000057214665030471014360 0ustar frankfrank#define XERR #include "err.ih" // line context available ostream &Err::msg(Context err) { if (not s_handle) return imsg; // switched 'off' s_handle = false; return emsg << s_src[s_lineInfo->src] << " [" << s_lineInfo->lineNr << "]: " << s_context[err] << ": "; } simrisc-16.02.00/err/msg1.cc0000664000175000017500000000020614665030471014351 0ustar frankfrank#define XERR #include "err.ih" ostream &Err::msg(Plain plain) // no line context { return emsg << s_plain[plain]; } simrisc-16.02.00/err/icmconf0000664000175000017500000000007214665030471014535 0ustar frankfrank#define LIBRARY "err" #include "../icmconf.lib" simrisc-16.02.00/err/atleast.cc0000664000175000017500000000027514665030471015145 0ustar frankfrank//#define XERR #include "err.ih" // static void Err::atLeast(double minimum) { msg(AT_LEAST) << '`' << s_lineInfo->txt << "': parameter must be >= " << minimum << endl; } simrisc-16.02.00/err/err.ih0000664000175000017500000000015414665030471014307 0ustar frankfrank#include "err.h" #include "../xerr/xerr.ih" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/err/frame0000664000175000017500000000005414665030471014211 0ustar frankfrank//#define XERR #include "err.ih" Err:: { } simrisc-16.02.00/err/multiplyspecified.cc0000664000175000017500000000064114665030471017240 0ustar frankfrank//#define XERR #include "err.ih" // static void Err::multiplySpecified(LineInfoVect::const_iterator begin, LineInfoVect::const_iterator end, string const §ionList) { msg(MULTIPLY_SPECIFIED) << sectionList << ". Lines:"; for (; begin != end; ++begin) // list the line nrs emsg << ' ' << begin->lineNr << ','; emsg << endl; } simrisc-16.02.00/extractable/0000775000175000017500000000000014665030471014703 5ustar frankfranksimrisc-16.02.00/extractable/extractable.h0000664000175000017500000000047414665030471017357 0ustar frankfrank#ifndef INCLUDED_EXTRACTABLE_ #define INCLUDED_EXTRACTABLE_ // concept used by Parser's extract templates to ensure that // the arguments to extract can actually be extracted template concept Extractable = requires(std::istream in, Type value) { in >> value; }; #endif simrisc-16.02.00/flexc++scanner/0000775000175000017500000000000014665030471015206 5ustar frankfranksimrisc-16.02.00/flexc++scanner/scanner.ih0000664000175000017500000000021414665030471017156 0ustar frankfrank// Generated by Flexc++ V2.07.09 on Mon, 23 Mar 2020 12:52:39 +0100 // $insert class_h #include "scanner.h" #include "../parser/tokens.h" simrisc-16.02.00/flexc++scanner/scanner.h0000664000175000017500000000240114665030471017005 0ustar frankfrank// Generated by Flexc++ V2.07.11 on Sat, 07 Nov 2020 16:28:03 +0100 #ifndef Scanner_H_INCLUDED_ #define Scanner_H_INCLUDED_ // $insert baseclass_h #include "scannerbase.h" // $insert classHead class Scanner: public ScannerBase { public: Scanner(std::string const &infile, std::string const &outfile); // $insert lexFunctionDecl int lex(); private: int lex_(); int executeAction_(size_t ruleNr); void print(); void preCode(); // re-implement this function for code that must // be exec'ed before the patternmatching starts void postCode(PostEnum_ type); // re-implement this function for code that must // be exec'ed after the rules's actions. }; inline Scanner::Scanner(std::string const &infile, std::string const &outfile) : ScannerBase(infile, outfile) {} // $insert inlineLexFunction inline int Scanner::lex() { return lex_(); } inline void Scanner::preCode() { // optionally replace by your own code } inline void Scanner::postCode([[maybe_unused]] PostEnum_ type) { // optionally replace by your own code } inline void Scanner::print() { print_(); } #endif // Scanner_H_INCLUDED_ simrisc-16.02.00/flexc++scanner/lexer0000664000175000017500000000536314665030471016257 0ustar frankfrank%filenames scanner // %interactive //%debug %% [ \t\n]+ // skip ws #.* // skip comment true | false return Tokens::BOOL; random | fixed | increasing return Tokens::GENTYPE; ageGroup:? return Tokens::AGEGROUP; BreastDensities:? return Tokens::BREASTDENSITIES; Costs:? return Tokens::COSTS; Discount:? return Tokens::DISCOUNT; Scenario:? return Tokens::SCENARIO; age:? return Tokens::AGE; biop:? return Tokens::BIOP; cases:? return Tokens::CASES; diameters:? return Tokens::DIAMETERS; generator:? return Tokens::GENERATOR; iterations:? return Tokens::ITERATIONS; prop:? return Tokens::PROP; seed:? return Tokens::SEED; spread:? return Tokens::SPREAD; Modalities:? return Tokens::MODALITIES; Mammo:? return Tokens::MAMMO; Tomo:? return Tokens::TOMO; MRI:? return Tokens::MRI; costs:? return Tokens::COST; dose:? return Tokens::DOSE; sensitivity:? return Tokens::SENSITIVITY; specificity:? return Tokens::SPECIFICITY; beta:? return Tokens::BETA; systematicError:? return Tokens::SYSERR; Normal:? return Tokens::NORMAL; Screening:? return Tokens::SCREENING; round:? return Tokens::ROUND; attendanceRate:? return Tokens::ATTENDANCERATE; Tumor:? return Tokens::TUMOR; Beir7:? return Tokens::BEIR7; eta:? return Tokens::ETA; Incidence:? return Tokens::INCIDENCE; prob:? return Tokens::PROB; lifetimeRisk:? return Tokens::LIFETIMERISK; meanAge:? return Tokens::MEANAGE; stdDev:? return Tokens::STDDEV; BRCA1:? return Tokens::BRCA1; BRCA2:? return Tokens::BRCA2; Growth:? return Tokens::GROWTH; start:? return Tokens::START; selfDetectMu:? return Tokens::SELFDETECTMU; selfDetectSigma:? return Tokens::SELFDETECTSIGMA; DoublingTime:? return Tokens::DOUBLINGTIME; Survival:? return Tokens::SURVIVAL; type:?[ \t]+. return Tokens::TYPE; [0-9]+ return Tokens::NR; -?[0-9]*\.[0-9]+ | -?[0-9]+\.[0-9]* return Tokens::REAL; . return matched()[0]; simrisc-16.02.00/frame0000664000175000017500000000007114665030471013420 0ustar frankfrank//#define XERR #include "incidence.ih" void Incidence:: simrisc-16.02.00/globals/0000775000175000017500000000000014665030471014030 5ustar frankfranksimrisc-16.02.00/globals/findsimtype.cc0000664000175000017500000000031714665030471016673 0ustar frankfrank//#define XERR #include "globals.ih" bool Globals::findSimType(string const &value) { return find(s_label[OPTION], s_label[OPTION + 1], value) != s_label[OPTION + 1]; } simrisc-16.02.00/globals/setprecision.cc0000664000175000017500000000031214665030471017042 0ustar frankfrank//#define XERR #include "globals.ih" // static ostream &Globals::setPrecision(ostream &out, uint16_t nDigits) { out.setf(ios::fixed, ios::floatfield); out.precision(nDigits); return out; } simrisc-16.02.00/globals/weakcompare.cc0000664000175000017500000000035414665030471016637 0ustar frankfrank//#define XERR #include "globals.ih" // static int Globals::weakCompare(double lhs, double rhs) { lhs -= rhs; return lhs < -WEAK_TOLERANCE ? -1 : lhs > WEAK_TOLERANCE ? 1 : 0; } simrisc-16.02.00/globals/data.cc0000664000175000017500000000157114665030471015254 0ustar frankfrank//#define XERR #include "globals.ih" uint16_t const Globals::uint16_max = numeric_limits::max(); bool Globals::s_vary = false; SimulationType Globals::s_simType = BREAST; double const Globals::s_sqrt2PI = sqrt(2 * M_PI); unsigned Globals::s_width = 0; //char const *Globals::s_label[][3] = // update when enums //{ // SimulationType is modified // { "Breast:", "breast:", "breast" },// the top line represents the default // { "Male:", "male:", "male" }, // { "Female:", "female:", "female" } //}; char const *Globals::s_label[][3] = // update when enums { // SimulationType is modified { "Breast:", "Male:", "Female:" }, // the first elements represent { "breast:", "male:", "female:" }, // the default { "breast", "male", "female" } }; simrisc-16.02.00/globals/globals.f0000664000175000017500000000157214665030471015627 0ustar frankfrank// static inline char const *Globals::defaultSimType() { return s_label[OPTION][0]; } // static inline bool Globals::isBreast() { return s_simType == BREAST; } // static inline bool Globals::isMale() { return s_simType == MALE; } // static inline bool Globals::isPositiveZero(double value) { return 0 <= value and value <= TOLERANCE; } // static inline char const *Globals::label(SimulationType type) { return s_label[CAPS][type]; } // static inline bool Globals::proportion(double const &value) { return 0 <= value and value <= 1; } // static inline void Globals::setVary(bool vary) { s_vary = vary; } // static inline char const *Globals::simTypeLabel(FirstChar fc) { return s_label[fc][s_simType]; } // static inline SimulationType Globals::simulationType() { return s_simType; } // static inline bool Globals::vary() { return s_vary; } simrisc-16.02.00/globals/globals.ih0000664000175000017500000000034314665030471015775 0ustar frankfrank#include "globals.h" #include "../xerr/xerr.ih" #include #include #include #include #include "../enums/enums.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/globals/setsimtype.cc0000664000175000017500000000055714665030471016554 0ustar frankfrank#define XERR #include "globals.ih" // static void Globals::setSimType(std::string const &value) { s_simType = static_cast( find(s_label[OPTION], s_label[OPTION + 1], value) - s_label[OPTION] ); // xerr("set simtype to " << value << ": " << s_simType); } simrisc-16.02.00/globals/iszero.cc0000664000175000017500000000017414665030471015654 0ustar frankfrank//#define XERR #include "globals.ih" // static bool Globals::isZero(double value) { return fabs(value) <= TOLERANCE; } simrisc-16.02.00/globals/icmconf0000664000175000017500000000007614665030471015374 0ustar frankfrank#define LIBRARY "globals" #include "../icmconf.lib" simrisc-16.02.00/globals/setwidthprec.cc0000664000175000017500000000044314665030471017045 0ustar frankfrank//#define XERR #include "globals.ih" // static ostream &Globals::setWidthPrec(ostream &out, unsigned width, unsigned precision) { if (width != 0) { out.width(width); setPrecision(out, precision); } return out; } simrisc-16.02.00/globals/frame0000664000175000017500000000006414665030471015045 0ustar frankfrank//#define XERR #include "globals.ih" Globals:: { } simrisc-16.02.00/globals/globals.h0000664000175000017500000000426214665030471015630 0ustar frankfrank#ifndef INCLUDED_GLOBALS_ #define INCLUDED_GLOBALS_ #include #include #include #include "../typedefs/typedefs.h" class Globals { static bool s_vary; static SimulationType s_simType; static unsigned s_width; static char const *s_label[][3]; public: static uint16_t const uint16_max; static constexpr double TOLERANCE = 1e-8; static constexpr double WEAK_TOLERANCE = 1e-3; static constexpr double NO_TUMOR = -1; // tumor/ static double const s_sqrt2PI; static char const *defaultSimType(); // .f static double findAge(DoubleVect const &cumProb, double prob); static bool findSimType(std::string const &value); static bool isBreast(); // simType == BREAST .f static bool isMale(); // simType == MALE .f static bool isPositiveZero(double value); // .f static bool isZero(double value); // .f static char const *label(SimulationType type); // .f static bool proportion(double const &value); // .f static void setSimType(std::string const &analysis); // .f static void setVary(bool vary); // .f static std::ostream &setWidthPrec(std::ostream &out, unsigned width, unsigned precision); static char const *simTypeLabel(FirstChar fc); // .f static SimulationType simulationType(); // .f // -1: lhs < rhs // 0: lhs == rhs // 1: lhs > rhs static int weakCompare(double lhs, double rhs); // uses WEAK_TOLERANCE static std::ostream &setPrecision(std::ostream &out, uint16_t nDigits); static bool vary(); // .f }; #include "globals.f" #endif simrisc-16.02.00/globals/findage.cc0000664000175000017500000000143714665030471015741 0ustar frankfrank//#define XERR #include "globals.ih" // linear interpolation: for a -> f(a) = p, b -> f(b) = q // compute f(x), where a <= x <= b as // p + (q - p) / b - a) * (x - a) // = p + (q - p) * (x - a) / b - a) // static double Globals::findAge(DoubleVect const &cumProb, double prob) { auto begin = cumProb.begin(); auto last = upper_bound(begin, cumProb.end(), prob); auto first = lower_bound(begin, last, *(last - 1)); return (first - begin) + ( // interpolate 'prob' in the range of (last - first) * // categories containing 'prob' (prob - *first) / ((last == cumProb.end() ? 1.0 : *last) - *first) ); } simrisc-16.02.00/globals/driver/0000775000175000017500000000000014665030471015323 5ustar frankfranksimrisc-16.02.00/globals/driver/main.cc0000664000175000017500000000106014665030471016553 0ustar frankfrank#include #include #include "../globals.h" using namespace std; int main() { DoubleVect dv{.1, .1, .5, .5, .5, .7, .8, .9, 1}; while (true) { cout << "prob? "; double prob; cin >> prob; cin.ignore(100, '\n'); auto begin = dv.begin(); auto last = upper_bound(begin, dv.end(), prob); auto first = lower_bound(begin, last, *(last - 1)); cout << (first - begin) << ", " << (last - begin) << '\n' << Globals::findAge(dv, prob) << '\n'; } } simrisc-16.02.00/globals/driver/compile0000775000175000017500000000004714665030471016702 0ustar frankfrankg++ -Wall main.cc -L ../tmp/ -lglobals simrisc-16.02.00/group/0000775000175000017500000000000014665030471013541 5ustar frankfranksimrisc-16.02.00/group/group.ih0000664000175000017500000000027114665030471015217 0ustar frankfrank#include "group.h" #include "../xerr/xerr.ih" #include #include #include "../err/err.h" #include "../globals/globals.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/group/maxend.cc0000664000175000017500000000024014665030471015320 0ustar frankfrank//#define XERR #include "group.ih" bool Group::maxEnd() { if (d_end != END_AGE) return false; d_end = Globals::uint16_max; return true; } simrisc-16.02.00/group/group.h0000664000175000017500000000251514665030471015051 0ustar frankfrank#ifndef INCLUDED_GROUP_ #define INCLUDED_GROUP_ #include #include #include #include "../enums/enums.h" #include "../typedefs/typedefs.h" #include "../hasgroup/hasgroup.h" // group specifications MUST end in ':' class Group { friend std::istream &operator>>(std::istream &in, Group &group); // .f friend std::ostream &operator<<(std::ostream &out, Group const &group); Series d_series; uint16_t d_begin = 0; uint16_t d_end = END_AGE; public: Group(Series series); // .f uint16_t begin() const; // .f uint16_t end() const; // .f // Err::NOT_CONSECUTIVE if false template // .f bool nextRange(std::vector const &vect) const; bool operator==(Group const &other) const; // != in .f bool contains(double value) const; bool maxEnd(); // true: changed END_AGE to max uint16_t value private: std::istream &extract(std::istream &in); // error message if not connecting bool connects(Group const &previous) const; }; #include "group.f" #endif simrisc-16.02.00/group/opinsert.cc0000664000175000017500000000105214665030471015711 0ustar frankfrank//#define XERR #include "group.ih" std::ostream &operator<<(std::ostream &out, Group const &group) { out << setw(3); if (group.d_series == RANGE) { out << group.d_begin << " - " << setw(2); if ( Globals::isZero(group.d_end - END_AGE) or group.d_end == Globals::uint16_max ) out << '*'; else out << group.d_end; } else if (group.d_end == Globals::uint16_max) // SINGLE out << '*'; else out << group.d_end; return out; } simrisc-16.02.00/group/group.f0000664000175000017500000000111414665030471015041 0ustar frankfrankinline Group::Group(Series series) : d_series(series) {} inline uint16_t Group::begin() const { return d_begin; } inline uint16_t Group::end() const { return d_end; } template bool Group::nextRange(std::vector const &vect) const { return vect.empty() // no Type elements yet or connects(vect.back().group()); } inline std::istream &operator>>(std::istream &in, Group &group) { return group.extract(in); } inline bool operator!=(Group const &lhs, Group const &rhs) { return not (lhs == rhs); } simrisc-16.02.00/group/connects.cc0000664000175000017500000000072214665030471015665 0ustar frankfrank//#define XERR #include "group.ih" bool Group::connects(Group const &previous) const { if // subsequent SINGLE diameters must increase ( // subsequent RANGE d_begin must be equal to previous.d_end (d_series == SINGLE and d_end > previous.d_end) or (d_series == RANGE and d_begin == previous.d_end) ) return true; Err::msg(Err::NOT_CONSECUTIVE) << d_begin << " - ..." << endl; return false; } simrisc-16.02.00/group/opequal.cc0000664000175000017500000000022714665030471015517 0ustar frankfrank//#define XERR #include "group.ih" bool Group::operator==(Group const &other) const { return d_begin == other.d_begin and d_end == other.d_end; } simrisc-16.02.00/group/icmconf0000664000175000017500000000007414665030471015103 0ustar frankfrank#define LIBRARY "group" #include "../icmconf.lib" simrisc-16.02.00/group/extract.cc0000664000175000017500000000224014665030471015520 0ustar frankfrank//#define XERR #include "group.ih" // e.g., 40 - 50: // 70 - * : // separating blanks are optional std::istream &Group::extract(std::istream &in) { char sep = 0; if (d_series == SINGLE) // with SINGLE d_begin is not { // used. d_end is inclusive in >> sep; // maybe '*', then the max if (sep == '*') // possible value d_end = Globals::uint16_max; else { in.unget(); // or extract the inclusive in >> d_end; // end value } } else { in >> d_begin >> sep >> sep; // get '40 - 5', or '70 - *' if (sep == '*') d_end = END_AGE; // set end else { in.unget(); // or extract the age in >> d_end; } } if (not (in >> sep) or sep != ':') // group must end in ':' Err::msgTxt(Err::GROUP_NO_COLON); return in; // return } simrisc-16.02.00/group/contains.cc0000664000175000017500000000032114665030471015662 0ustar frankfrank//#define XERR #include "group.ih" bool Group::contains(double value) const { return d_series == RANGE ? d_begin <= value and value < d_end : value <= d_end; } simrisc-16.02.00/group/frame0000664000175000017500000000006014665030471014552 0ustar frankfrank//#define XERR #include "group.ih" Group:: { } simrisc-16.02.00/growth/0000775000175000017500000000000014665030471013717 5ustar frankfranksimrisc-16.02.00/growth/growth1.cc0000664000175000017500000000032114665030471015615 0ustar frankfrank#define XERR #include "growth.ih" Growth::Growth() : d_base{ "Growth:", "" }, d_bc{ Globals::isBreast() }, d_selfMean(VARY_NONNEG) { setSelfDetect(); setDoublingTime(); setStart(); } simrisc-16.02.00/growth/vary.cc0000664000175000017500000000050414665030471015206 0ustar frankfrank//#define XERR #include "growth.ih" void Growth::vary(ostream &out) { d_selfMean.vary(); out << " Growth:\n" " selfDetect: "; d_selfMean.showVary(out); out.put('\n'); AgeGroupVSD::vary(out, 2, // d_doublingTime.size(), "DoublingTime:", d_doublingTime); } simrisc-16.02.00/growth/agegroupvsdlung.cc0000664000175000017500000000021314665030471017436 0ustar frankfrank//#define XERR #include "growth.ih" AgeGroupVSD const &Growth::ageGroupVSDlung(uint16_t idx) const { return d_doublingTime.front(); } simrisc-16.02.00/growth/growth.ih0000664000175000017500000000027614665030471015560 0ustar frankfrank#include "growth.h" #include "../xerr/xerr.ih" #include #include #include "../globals/globals.h" #include "../parser/parser.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/growth/nextrange.cc0000664000175000017500000000031514665030471016220 0ustar frankfrank//#define XERR #include "growth.ih" bool Growth::nextRange(AgeGroupVSD const &next) const { return d_doublingTime.empty() or next.beginAge() == d_doublingTime.back().endAge(); } simrisc-16.02.00/growth/setdoublingtime.cc0000664000175000017500000000255514665030471017433 0ustar frankfrank#define XERR #include "growth.ih" void Growth::setDoublingTime() { d_base.back() = "DoublingTime:"; size_t size = d_base.size(); if (not Globals::isBreast()) // used for LC sim.s { d_base.push_back("lung:"); AgeGroupVSD spec{ VARY_NONNEG, true, false }; // useStdDev and don't // extract Group Parser::extract(d_base, spec); spec.ln(); d_doublingTime.push_back(spec); d_ageGroupVSD = &Growth::ageGroupVSDlung; d_base.resize(size); return; } d_base.push_back("ageGroup:"); auto lines = Parser::any(d_base); bool push = true; while (true) { LineInfo const *line = lines.get(); if (line == 0) break; AgeGroupVSD spec{ VARY_NONNEG, true }; // do extract Group if (not Parser::extract(*line, spec)) push = false; if (not push) continue; // continue for syntax-check // purposes if (not spec.group().nextRange(d_doublingTime)) { push = false; continue; } spec.ln(); d_doublingTime.push_back(spec); } d_ageGroupVSD = &Growth::ageGroupVSDbreast; d_base.resize(size); } simrisc-16.02.00/growth/icmconf0000664000175000017500000000007514665030471015262 0ustar frankfrank#define LIBRARY "growth" #include "../icmconf.lib" simrisc-16.02.00/growth/growth.h0000664000175000017500000000420514665030471015403 0ustar frankfrank#ifndef INCLUDED_GROWTH_ #define INCLUDED_GROWTH_ // Tumor: // Growth: // # breast lung // start: 5 3 // // #selfDetect: # stdev mean spread dist // breast: .70 2.92 .084 Normal // lung: .014 3.037 .061 Normal // // DoublingTime: // # stdev mean spread dist. // ageGroup: 1 - 50: .61 4.38 .43 Normal // ageGroup: 50 - 70: .26 5.06 .17 Normal // ageGroup: 70 - * : .45 5.24 .23 Normal // // # all ages stdev mean spread dist. // lung: .21 4.59 .74 Normal #include "../agegroupvsd/agegroupvsd.h" class VSD; class Growth { StringVect d_base; bool d_bc; // not --cancer: breast was specified double d_start; double d_selfSD; // SD of d_selfMean's mean value VSD d_selfMean; // mean and SD/Distr. used when 'vary'is set AgeGroupVSDvect d_doublingTime; AgeGroupVSD const &(Growth::*d_ageGroupVSD)(uint16_t idx) const; public: Growth(); AgeGroupVSD const &ageGroupVSD(uint16_t idx) const; // .f void vary(std::ostream &out); double start() const; // .f VSD const &selfMu() const; // .f double selfSigma() const; // .f void writeParameters(std::ostream &out) const; private: AgeGroupVSD const &ageGroupVSDbreast(uint16_t idx) const; AgeGroupVSD const &ageGroupVSDlung(uint16_t idx) const; void setStart(); void setSelfDetect(); void setDoublingTime(); bool nextRange(AgeGroupVSD const &next) const; static void writeDiameter(std::ostream &out, char const *name, VSD const &vsd); // static void writeDT(std::ostream &out, char const *name, // size_t idx, double value); }; #include "growth.f" #endif simrisc-16.02.00/growth/writeparameters.cc0000664000175000017500000000204214665030471017442 0ustar frankfrank//#define XERR #include "growth.ih" void Growth::writeParameters(ostream &out) const { VSD::fmt(1, 2, 0, 3); // used at selfDetect out << " Growth:\n" " diameters:\n" << setw(8) << ' ' << "start: " << setw(4) << d_start << '\n' << setw(8) << ' ' << "self-detect std.dev.: " << setw(4) << exp(d_selfSD) << '\n' << setw(8) << ' ' << "self-detect mean: " << d_selfMean << '\n' << setw(6) << ' ' << "DoublingTime:\n"; if (d_bc) { AgeGroupVSD::fmt(8, 1, 2, 0, 2); out << d_doublingTime << '\n'; } else { auto const &first = d_doublingTime.front(); double sd = first.stdDev(); out << setw(8) << ' ' << "value: " << exp(first.value()) << '\n'; if (sd >= 0) out << setw(8) << ' ' << "std.dev: " << exp(sd) << '\n'; out.put('\n'); } } simrisc-16.02.00/growth/setselfdetect.cc0000664000175000017500000000102714665030471017064 0ustar frankfrank#define XERR #include "growth.ih" void Growth::setSelfDetect() { // extract the selfdetect // specifications d_base.back() = Globals::isBreast() ? "breast:" : "lung:"; Parser::extract(d_base, d_selfSD, d_selfMean); if (0 <= d_selfSD) // OK if selfSD is positive { d_selfSD = log(d_selfSD); d_selfMean.ln(); return; } Err::negative(); d_selfSD = 0; } simrisc-16.02.00/growth/setstart.cc0000664000175000017500000000123714665030471016102 0ustar frankfrank//#define XERR #include "growth.ih" void Growth::setStart() { d_base.back() = "start:"; LineInfo const *lineInfo = Parser::one(d_base).get(); istringstream in{ lineInfo->tail }; // get the line's tail if (not (in >> d_start)) { Err::msg(Err::SPEC_ERROR) << "[Growth:] start: must specify at least one value" << endl; return; } if (not Globals::isBreast()) // use a 2nd value for LC { double lcStart; if (in >> lcStart) d_start = lcStart; } if (d_start < 1) // start value must be >= 1 Err::atLeast(1); } simrisc-16.02.00/growth/growth.f0000664000175000017500000000046214665030471015402 0ustar frankfrankinline AgeGroupVSD const &Growth::ageGroupVSD(uint16_t idx) const { return (this->*d_ageGroupVSD)(idx); } inline double Growth::start() const { return d_start; } inline VSD const &Growth::selfMu() const { return d_selfMean; } inline double Growth::selfSigma() const { return d_selfSD; } simrisc-16.02.00/growth/agegroupvsdbreast.cc0000664000175000017500000000021214665030471017750 0ustar frankfrank//#define XERR #include "growth.ih" AgeGroupVSD const &Growth::ageGroupVSDbreast(uint16_t idx) const { return d_doublingTime[idx]; } simrisc-16.02.00/growth/frame0000664000175000017500000000006214665030471014732 0ustar frankfrank//#define XERR #include "growth.ih" Growth:: { } simrisc-16.02.00/handleexception.cc0000664000175000017500000000046314665030471016071 0ustar frankfrank#include "main.ih" int handleException() try { rethrow_exception(current_exception()); } catch(int x) { return Arg::instance().option("hv") ? 0 : x; } catch (exception const &exc) { cerr << exc.what() << '\n'; return 1; } catch (...) { cerr << "unexpected exception\n"; return 1; } simrisc-16.02.00/hasgroup/0000775000175000017500000000000014665030471014235 5ustar frankfranksimrisc-16.02.00/hasgroup/hasgroup.h0000664000175000017500000000055414665030471016242 0ustar frankfrank#ifndef INCLUDED_HASAGEGROUP_ #define INCLUDED_HASAGEGROUP_ // concept used by Group to ensure that // Type has a member group() returning a const & to a Group class Group; template concept HasGroup = requires(std::vector const &object) { { object.back().group() } -> std::same_as; }; #endif simrisc-16.02.00/hierarchy.odp0000664000175000017500000007660414665030471015104 0ustar frankfrankPK%k[X3&¬¨//mimetypeapplication/vnd.oasis.opendocument.presentationPK%k[XConfigurations2/toolbar/PK%k[XConfigurations2/toolpanel/PK%k[XConfigurations2/floater/PK%k[XConfigurations2/menubar/PK%k[XConfigurations2/popupmenu/PK%k[XConfigurations2/progressbar/PK%k[XConfigurations2/statusbar/PK%k[XConfigurations2/images/Bitmaps/PK%k[XConfigurations2/accelerator/PK%k[X styles.xmlí]Kã6¾ï¯0$7ÉzX~tÒ$$»ÀLÌLØS K´­Œ, ’ÜîžÓþƒ=ìaÿßþ’å[”õ0å–ŸÑÈŒÉ"Yõ±X$‹Eê›oŸ7áà $i£Ç¡©Ãˆ<èÑêqøÛǵÙðÛ7ù.—|èm7 Ê´4{ A:@…£ôÁ‚Íãp›DÐMƒô!r7 }ȼƒˆyÈiÝ 5ö@Ú¢‰é&U+À´š71ªe¹š8)"$Õ«V'—‘ëòÒÔ·ë,‹F£Ýn§ïl&«ÑÇ÷#œ§eà9qêUâûaµeöh5òÝÌÕž°û‚—x^g›Êæ|>‘\NêÃMMÕæQhà ,½$ˆ3e4 µ,ø&ʉi岨g×52ÍFïP&ùß»·œžj•jkL¥ö „¢9\€RptÆ#ú;—Lµ¥ç4Ô–°FËP£»ÆVwIDttDŸê;犎NÜ]£H¦1Â4'^#'žz¢òœ4Þ&!!ò½<™º)Ô—CêÍàJVbÜ/á6òéX¡øç$ÎrCRì¡PCac“¡¬—˜X.åü,œíµ —ê*†ÊY¢Mu}³ŽÍG„HîAÕ¶0-²²2£~bûêÅm_.›ÄYŸÎ(1L2ÑO+å®xZÕŒoí&ÊBˆ‹½‚<oq°•ÕÀÝãw2Wµ0¦•Ë†ðˆÁ,–Tƒ\e´Ý,@¢Üßh )ŠeB®1¼JN Ô6©DÈ2ÁøA*M«c%¥…€=|Ãgý%D3þÒõ€æ/Lß|CùÉú7û8üüáþc;øàFhJBºÃÉдýò8üÊaúµDC†ƒB•˜V[ñ¬Vú’f`S ‰ƒÌC3Í“›døšyú1 †!)딼 PW=iFfNnܨ+ÖP•K%Þ0á9˜ûf°1AqVvÌNøQÓ«QÝ0dét-þæ<¡ •¨ëhÌÈ/¦þAH“Ø4ŒÖÀMD²ÍÈȇ™£/–äËBvHdxäO¡ 6(QdH|Ó0¾” Uç¸Ñ ·n>X±¤L|lÍè ¿[Æï߇[ÀÊúA‡î‹&“ ¤üÃÂN­ùÒ«Övk2¿¸°?!û5I+(ˆ;]x§B\ÓšN,ëââ¾zZ)ìûVj<ñ'~•Ï-ÓõŸ á®IÚ…ŠÀ>pæ/ÆÓ™1¾ÀÖn Ò¢ ð2Tã6’xÏCG´æ½È¿ŠRŒ,eÁl½JÊf!7nò $²ˆß% î&³¥¦@ ‚ö 9§x¯ç]cæK"mS ¡­¢wiœÁ•%xž£Û ˆ›ÇÚŒu™&*-Ün´ ô¹šïg¡%-#ÉV·,D½BòÓà3Ê·ÆqFÒB<’ÝJÂóJðО(K/¿}(Õ«¡}Žíïr\7§¡-°î`ð¼ÏkžÃZãý¹Ü&Þ½†àù@«‚ª²]‘»ö[Yÿy˜wsaÜðþ•…:ßMüaû¡%T (·]àã!nx›áÁQHmšF­&/¨[¸h9ßxÉ5½@€Mk}qb­+ c $¨· $ Km “à3Ä›[4°ƒêú?¶i,_ˆÆ®]Øz˜Ór03RÆfö«Vå…`™ö3’`µ–rh¬]Ÿ8ßÏb$®dÚsbæKe&—}fàÿŸVˆl´Ö C2Yž@H‰µÅ­'²ÍÄéd> ?i–†½3Ãÿý÷ßBá¤J$#e6A¤…î刾ž FuVŒ®ÛP~xÙ,`8T±pE»3vÈä4j’´Ö+p 3Œ¶K˜Âý!dw†IõüîwˆÐì.r:CÈÒÇw‰Ð¤3„ì»ÄgÚ>wj§g!4¾S;=ï¡û´Ó¦ÑDÎmj)›íØFu¯F'jívVX`º‹`[–ÈwÅTºK)¦‰ K&^†5 åéf¥ä⇠¤1%' ˜:‚ÉÆ óZ²m‹iôG# „t§ÎÂÜfXR±A”²Ù:ÛÕZcŽ.™Ó2QöïÑÔ88ˆC`_ëNw"·§¡æŒ¹Rh—¬Ø=|ŸY’x‹z?¡>(^ÝŽ© ¯ c¡m¸†våñZÑîlé¬a‚3ªöG»¼dÝ1ÏÏq«ñQåL2¶YnQr ”‚¢ß¨éX‰ˆ ,ˆkEõB ’±E~½à5$DŸÀ&^»T1K#'a–JŸªt°Š€ÙÜ–H>³¾2¸øxÙ.ÈÖÈJ`QÓŒûxÝDÄ*j%WI³_ú¤ˆÊüýBøÃ>{Ì#þ;‚øÿ¸.ü7j:OÄ`pF‹^}ZÍ×1ˆà— ¢øßr¡͉´÷ŽÆá#êðîý™•@\‡€ü©ŸK“‚oP=tn éwãöÝNº¡ž7/¤ÙJ]‚,$ÇX¹Em'ƒcäCeZ)´¢|ãqùþ\ìn’‘\“ŒV+±"5v!Ê?—tŠÃŸšá2>r¸ÃåùN¤JóɱåFB1\®GÆ©uÔp©ëB2\Î#Ç?›n;g˜„Y`†ú$|e;3ey¨KÛ~ý©åÚ¨´<ãq72ú¼ë£5/Ò§ï逿…ÁÁƒ<p,’œJÖøU£ù uŸn²9e¥3³&ÒÊ ^áOáâ5ÏIœêÈYI`Ø2˜“†É«¨¨¿˜z˜‹€GÎFG"È"ïUäAúE°Öê üŽ²ûG¢Ç‚ùUÐãqÿE¯ÉÜ 5ø**zYÙ\ùõ‚³ãúÉz†íV=H¯¶ìäæV‹·µ§„dðö(Ç?èœrp¯¸ÌÐ&,D~e¹šhàt wÚ6 2vìØ-~塯"E׈qÍÀW6ÔÙÿE„/\ïÓ*Á‡÷ù“£xýaMõÀ¥©•ç¿¯„Í•c+TB»Ïr}#˜•-Ø)´@-V…FÆÕF«‚M4Åž>Þäò{ûýÓãJâMP™Ü„ä=Ħ¦ùv#R(Är&™dî="¥Fì»HávœY󄦜ÝPÝfPCãe'B‹©Y…l” ZºN‚èÎ\ŠuWó¥¢’hgº\´©¦1œ}~eQ¤¯¼vô¯ÿseĹ„¦×zíÈj֞ݪU_;:F‡®&à¿cêîÚÑE³_àÚÑäN¯Õtwñhz§—Fº»x4¿K|º»vd×b¨¯÷Þ‘iÞ–©¾‚‹GúÄ7_>ê¯ÝÛgÜ»}Níö±­?¥Û§Fì?‹ÛÇjtûÔ6U¸XNdàÇóyמvŒíì÷¼ì-ÝO+: [×îewƒ¹u:Ìí©}"ÌKNÖšG³ª0ouñc¬Ò ã0·O‡¹5žs«QÏ+;¤è?s§ÌǧÃÜ´N¤çÃ|Ò æN¹:æÓn0Ÿô˜«c>ëói¹:æón0Ÿõ˜+`žn¾/yòcYºô„KzyàÒ&ðýPõ¨U°Û¿ãØ¿ãØ¿ãx%ªý;Ž§8Píßqìßqìßqìßqìßq¼òóÔ‹|¹Ìq*œ-ùé ÷ý±é½›ÒíþØ´?6íM»96½%ŸLïé2½C¦wÈ\)B½C¦wÈô™Þ!Ó;d®¡Þ!ÓC¦ÂËÒ;TnÏ¡â8½CåÄ•q) ôOáP©ûN*²‡D‹ñGiC÷‚ßâ»·ÆG GÁÉÔqˆf5 ÑÐ2è»=õ‹LÞƒ÷´zÀñ6ºáÌø{†ø1/}:¶ùo6ט†î8žÈß#РݲM: ½ŽÍtæøÂL칦ui .ÁÄ>ˆ§üÅËKq£æñÔr¼™ÖÃ{@Õ›eëó¼Ï¹T¶îÓc•"ãêºwfÏ”x0mD ª;Bk Àcv ­÷ØOüªÉ‘{Ïà ÁjÐ}g +hªÏïT>®Ö⨴Ç1ug.§sL¬©>§zÊ q‡IÀQyÆ0A+@j¬RÁZ̶èÆìÀ #ApŒ*&Fâ—Ýòïü¸ôÈööã¯sã *rbéø@ZõÑy}ŸÙý#â«t ¬_…QÊ_4\×b÷QI²„0;@BšŠ¶›…ôÝõJBßÍÐf"Àò´{ÎîÝ*)õÊÙ>KUÿʼnO&aíFª-ì˜nϧòæ¹rJ³vIá^D»=ÄW˜hÙ¢Z%]¹´jOͨµ¸ZL㲶Œ¬/?fy-ziÌ&gÂðµ7Y¯Ãóéáko¦žÃ[ñ¿–³1³‘R`T’ U|4÷Ã}iB©q9þï˜÷`Þò(Çð5xŽ;ÇÓ´tËRÁTÄ ¶Õn «hæÈZ—ÒTk¢;4º» ZÎyZu¥mœÔÓ«k3°RlçZK‹ç ¼ù*̾¦ÿüj•}ͱ•Ž…žÔ‘­Q%‘„-uôÙ´¹?ÕñTBÔÒ§¦)#šÇr] uÓÐÇcçrÍÏôñÜ>[ó¦­Æäbà—š?3úåö%øGUk¾bË>Ì^ÁËÂ)›Ö9fõ:Ç,®s ÖD&Ý{ÎHÛÑçó’}³uk6“RžŠõéĪ3m¬ýº @âk¿ë2ª·ìοvüZ™ñÇÚ,»Fè±îÌœ:¡ç›Æ–wµZ0«&6gZƒ9Õç´Dg ±ö †ÎbGB@ô…ñ·;xÊ}ÈÙ¥A‹Çë>N¾G~Ö*ËHþfñ˜ç»»åòùùÙz&V’>,?ý¼mf|Ηuï‡t½ŽÚzcÛ&ˇåÚÏ}ó) žÿTßñù1߶Þ8çË¢µéš…FËÿúðþãê1Øúfg¹¯‚Ã]ëþ»šÎ›$Ýfýñ²l®;¯“mç“¡‡< Mïl•†»\›ºEo™bhÝ»E_ù^à´ÇŒ½åh,þúð¾î_²¹îh•PHã%IÒ 'n({ÔèÐeùûðfº#}Î"s“tp= ú|vÔç4̃´!uÆ¿u3žhmúÏg_ ÙKÑGšÉêìLV~´j~èºÛ§QÑi½ZQ ^<[" 5â%îq«àJE´Iöñº”Ý¿àó.HCÑäGÅmwÊ¥“¿DÚ´.:Ëwç‡ùôÞœœlôY îÃ͘>þ<ñeÑI¦ îX¢/¨}y¢ë”¬õo'kùÞt—Ÿ™'[¦Á.IsYÊ?WC5Ûhš$BÅ$ë (<àêd×!úÙÓƒ6mŸ:Dkõè§ÚT.:«d/ÑG/U'ÔÓæ+ÿh¾Û ÷uo}å{£d„„Ut’ž ?2ÞoïƒT›ÀFžˆÙ& ¢µ_$æ6;f qwù¸êNÉÕ!‹·µ_SZlÙ\Ø€cnüU`®ƒU”½ý®œXsÙ(‹y¼Y¼ ~õÙýŒ0SÝ •—7‹õwIöoRŸòÂÂP)úšA /z1{Éò`«tÙ…ù lÙ“Ÿ†…€/ÏÏé¯itLHjºæ Þ‡@û‚qÎ#sÔO4Ùúñ¥¦ÜhÍMtœcrOòä‹¿•é¯w¨¬šteçÌÿ,ê;å‹æ4HæaJxpï¯~{H…B_> M§{PÞ]Ý’û_ƒUží¾³]ä¿€ƒ—äB[žéR̮֪?ʺ:‚. 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Ç."|A|A*4Thumbnails/thumbnail.pngPK%k[Xôë_—È-Üumeta.xmlPK%k[Xµºâ&ÉÚwMETA-INF/manifest.xmlPK+Cysimrisc-16.02.00/icmake/0000775000175000017500000000000014665030471013636 5ustar frankfranksimrisc-16.02.00/icmake/pspdf0000664000175000017500000000063314665030471014677 0ustar frankfrankvoid pspdf(string basename) { string pdfname; string psname; string papersizeoption = "a4"; psname = basename + ".ps"; if (basename + ".dvi" younger psname) system("dvips -t " + papersizeoption + " -o" + psname + " " + basename); pdfname = basename + ".pdf"; system("ps2pdf -sPAPERSIZE=" + papersizeoption + " " + psname + " " + pdfname); chdir(g_cwd); } simrisc-16.02.00/icmake/setopt0000664000175000017500000000033314665030471015076 0ustar frankfrankstring setOpt(string install_im, string envvar) { list optvar; string ret; optvar = getenv(envvar); if (optvar[0] == "1") ret = optvar[1]; else ret = install_im; return ret; } simrisc-16.02.00/icmake/installer0000775000175000017500000000050614665030471015562 0ustar frankfrank#!/bin/bash if [ $# -eq 0 ] ; then echo destination path, ending in /, must be provided exit 0 fi for src in `find -mindepth 1 -type d` # create missing target dirs do [ ! -e $1$src ] && mkdir -p $1$src done for file in `find -type f -or -type l` do cp -d --preserve=timestamps $file $1$file done simrisc-16.02.00/icmake/manpage0000664000175000017500000000070414665030471015172 0ustar frankfrankvoid _manpage(string dest, string manpage, string source) { run("yodl2man -o " + dest + manpage + " " + source); run("yodl2html " "-o ../../tmp/manhtml/" + manpage + ".html " + source); } void manpage() { md("tmp/man tmp/manhtml"); chdir("documentation/man"); _manpage("../../tmp/man/", PROGRAM ".1", PROGRAM ".yo"); _manpage("../../tmp/man/", PROGRAM "params.7", PROGRAM "params.yo"); exit(0); } simrisc-16.02.00/icmake/findall0000664000175000017500000000107414665030471015174 0ustar frankfrank// assuming we're in g_cwd, all entries of type 'type' matching source/pattern // are returned w/o final \n list findAll(string type, string source, string pattern) { string cmd; list entries; list ret; int idx; chdir(source); cmd = "find ./ -mindepth 1 -maxdepth 1 -type " + type; if (pattern != "") pattern = "-name '" + pattern + "'"; entries = backtick(cmd + " " + pattern + " -printf \"%f\\n\""); for (idx = listlen(entries); idx--; ) ret += (list)cutEoln(entries[idx]); chdir(g_cwd); return ret; } simrisc-16.02.00/icmake/cxxdefine0000664000175000017500000000007214665030517015536 0ustar frankfrank // Compiler to use: #define CXX "g++" simrisc-16.02.00/icmake/log0000775000175000017500000000063014665030471014344 0ustar frankfrank#!/bin/bash find tmp/install -type f -exec md5sum "{}" \; | sed 's|tmp/install|'$1'|' > $2 find tmp/install -type l -exec printf "link %s\n" "{}" \; | sed 's|tmp/install|'$1'|' >> $2 find tmp/install -type d -exec printf "dir %s\n" "{}" \; | sed 's|tmp/install|'$1'|' >> $2 simrisc-16.02.00/icmake/pathfile0000664000175000017500000000054314665030471015357 0ustar frankfranklist path_file(string path) { list ret; int len; int idx; for (len = strlen(path), idx = len; idx--; ) { if (path[idx] == "/") { ret = (list)substr(path, 0, idx) + (list)substr(path, idx + 1, len); return ret; } } ret = (list)"" + (list)path; return ret; } simrisc-16.02.00/icmake/clean0000664000175000017500000000042514665030471014644 0ustar frankfrankvoid clean(int dist) { run("rm -rf " "build-stamp configure-stamp " "options/SKEL " "tmp/*.o tmp/*-stamp " + "o */o release.yo tmp/lib*.a " ); if (dist) run("rm -rf tmp *.ih.gch */*.ih.gch"); exit(0); } simrisc-16.02.00/icmake/uninstall0000664000175000017500000000044714665030471015577 0ustar frankfrankvoid uninstall(string logfile) { int idx; list entry; string dir; list line; if (!exists(logfile)) { printf("installation log file " + logfile + " not found\n"); exit(0); } run("icmake/remove " + logfile + " " + (string)g_echo); exit(0); } simrisc-16.02.00/icmake/cuteoln0000664000175000017500000000023314665030471015230 0ustar frankfrankstring cutEoln(string text) { int len; len = strlen(text) - 1; if (text[len] == "\n") text = substr(text, 0, len); return text; } simrisc-16.02.00/icmake/run0000664000175000017500000000032714665030471014367 0ustar frankfrankint g_dryrun = setOpt("", "DRYRUN") != ""; void runP(int testValue, string cmd) { if (g_dryrun) printf(cmd, "\n"); else system(testValue, cmd); } void run(string cmd) { runP(0, cmd); } simrisc-16.02.00/icmake/md0000664000175000017500000000073314665030471014164 0ustar frankfrank// md: target should be a series of blank-delimited directories to be created // If an element is a whildcard, the directory will always be created, // using mkdir -p. // // uses: run() void md(string target) { int idx; list paths; string dir; if (!exists(target)) run("mkdir -p " + target); else if (((int)stat(target)[0] & S_IFDIR) == 0) { printf(target + " exists, but is not a directory\n"); exit(1); } } simrisc-16.02.00/icmake/gitlab0000664000175000017500000000020414665030471015017 0ustar frankfrankvoid gitlab() { run("cp -r tmp/manhtml release.yo ../../wip"); run("cp changelog ../../wip/changelog.txt"); exit(0); } simrisc-16.02.00/icmake/remove0000775000175000017500000000116614665030471015065 0ustar frankfrank#!/bin/bash g_echo=$2 rm_f() { [ $g_echo -ne 0 ] && echo rm $1 rm -f $1 } rm_dir() { [ $g_echo -ne 0 ] && echo rmdir $1 rmdir --ignore-fail-on-non-empty -p $1 } IFS=" " for line in `cat $1` do field1=`echo $line | awk '{printf $1}'` field2=`echo $line | awk '{printf $2}'` if [ $field1 == "link" ] ; then rm_f $field2 elif [ $field1 == "dir" ] ; then rm_dir $field2 elif [ -e "$field2" ] ; then if [ "$field1" != "`md5sum $field2 | awk '{printf $1}'`" ] ; then echo $field2 changed, not removed else rm_f $field2 fi fi done rm_f $1 simrisc-16.02.00/icmake/backtick0000664000175000017500000000015714665030471015337 0ustar frankfranklist backtick(string arg) { list ret; echo(OFF); ret = `arg`; echo(g_echo); return ret; } simrisc-16.02.00/icmake/manual0000664000175000017500000000065614665030471015045 0ustar frankfrankvoid manual() { list files; string file; string cwd; int idx; cwd = chdir("."); md("tmp/manual"); chdir("documentation"); run("cp -r manual/html ../tmp/manual"); chdir("manual"); run("yodl2html -l3 " PROGRAM ".yo"); run("mv *.html ../../tmp/manual/html"); run("cp simrisc.css ../../tmp/manual/html"); // run("cp -r images/*.jpg ../../tmp/manual/images"); exit(0); } simrisc-16.02.00/icmake/latexdoc0000664000175000017500000000125314665030471015365 0ustar frankfrankvoid latexdoc() { string basename; string latexname; string yodldefine; md("tmp/latex"); // cp necessary files for LaTeX if (!exists("tmp/latex/cplusplus.sty")) system("cp -r documentation/manual/latex tmp"); // assign file name variables basename = "simrisc"; latexname = basename + ".latex"; chdir("documentation/manual"); system("yodl2latex --no-warnings -l3 " "-o ../../tmp/latex/simrisc.latex simrisc.yo"); chdir("../../tmp/latex"); system("latex " + latexname); system("latex " + latexname); system("latex " + latexname); } simrisc-16.02.00/icmake/install0000664000175000017500000000441414665030471015232 0ustar frankfrank void install(string request, string dest) { string target; int components = 0; list pathsplit; string localInstall = "tmp/install/"; // this is the LOCAL tmp/install dir md(localInstall); if (request == "x") components = 63; else { if (strfind(request, "b") != -1) components |= 2; if (strfind(request, "d") != -1) components |= 4; if (strfind(request, "m") != -1) components |= 8; } if (components & 2) { target = localInstall + BINARY; pathsplit = path_file(target); printf(" installing the executable `", target, "'\n"); logFile("tmp/bin", "binary", pathsplit[0], pathsplit[1]); } if (components & (4 | 8)) { target = localInstall + DOC "/"; if (components & 4) { printf(" installing the changelog at `", target, "\n"); logZip("", "changelog", target); printf(" installing stdconfig/simrisc at `", target, "\n"); logZip("stdconfig", "simrisc", target); // printf(" installing the pdf-manual at `", target, "\n"); // logInstall("tmp/pdf", "simrisc.pdf", target); // // printf(" installing the html-manual at `", target, "\n"); // logInstall("tmp/manual/html", "", target + "manual"); // logInstall("tmp/manual/html/analysis", "", // target + "manual/analysis"); } if (components & 8) { printf(" installing the html man pages at `", target, "\n"); logInstall("tmp/manhtml", "", target); } } if (components & 8) { target = localInstall + MAN; printf(" installing the man pages below `", target, "'\n"); logZip("tmp/man", "simrisc.1", target + "/man1/"); logZip("tmp/man", "simriscparams.7", target + "/man7/"); } chdir(g_cwd); if (dest == "") dest = "/"; else md(dest); dest = cutEoln(backtick("readlink -f " + dest)[0]); if (g_logPath != "") backtick("icmake/log " + dest + " " + g_logPath); chdir(localInstall); run("../../icmake/installer " + dest + "/"); printf("\n Installation completed\n"); exit(0); } simrisc-16.02.00/icmake/beep0000664000175000017500000000024214665030471014472 0ustar frankfrankvoid beep() { printf << "icmake/beep: tmp off\n"; exit(0); if (exists("/usr/local/bin/beep")) system("/usr/local/bin/beep"); exit(0); } simrisc-16.02.00/icmake/logfile0000664000175000017500000000025714665030471015206 0ustar frankfrankvoid logFile(string srcdir, string src, string destdir, string dest) { chdir(g_cwd); md(destdir); run("cp " + srcdir + "/" + src + " " + destdir + "/" + dest); } simrisc-16.02.00/icmake/loginstall0000664000175000017500000000130014665030471015723 0ustar frankfrank// source and dest, absolute or reachable from g_cwd, should exist. // files and links in source matching dest (if empty: all) are copied to dest // and are logged in g_log // Before they are logged, dest is created void logInstall(string src, string pattern, string dest) { list entries; int idx; chdir(g_cwd); md(dest); src += "/"; dest += "/"; if (listlen(makelist(O_DIR, src)) == 0) { printf("Warning: ", src, " not found: can't install ", src, pattern, " at ", dest, "\n"); return; } entries = findAll("f", src, pattern); for (idx = listlen(entries); idx--; ) run("cp " + src + entries[idx] + " " + dest); } simrisc-16.02.00/icmake/pdf0000664000175000017500000000034214665030471014331 0ustar frankfrankvoid pdf() { md("tmp/pdf"); latexdoc(); // now in tmp/latex system("dvips simrisc"); system("ps2pdf simrisc.ps ../pdf/simrisc.pdf"); printf("the log files are in tmp/latex\n"); exit(0); } simrisc-16.02.00/icmake/special0000664000175000017500000000072014665030471015200 0ustar frankfrankvoid special() { if (! exists("release.yo") || "VERSION" newer "release.yo") { system("touch version.cc"); // using FORTIFY is weird, but Nilesh // Patra noticed some complaints when // omitted. run("gcc -D_FORTIFY_SOURCE=2 -E VERSION.h | grep -v '#' | " "sed 's/\\\"//g' > release.yo"); } } simrisc-16.02.00/icmake/logzip0000664000175000017500000000165314665030471015072 0ustar frankfrank// names may be a series of files in src, not a wildcard. // if it's empty then all files in src are used. // the files are gzipped and logged in dest. // src and dest do not have to end in / void logZip(string src, string names, string dest) { list files; int idx; string file; chdir(g_cwd); md(dest); dest += "/"; if (src != "") { if (listlen(makelist(O_DIR, src)) == 0) { printf("Warning: ", src, " not found: can't install ", src, names, " at ", dest, "\n"); return; } chdir(src); } if (names == "") files = makelist("*"); else files = strtok(names, " "); for (idx = listlen(files); idx--; ) { file = files[idx]; run("gzip -n -9 < " + file + " > " + file + ".gz"); } run("tar cf - *.gz | (cd " + g_cwd + "; cd " + dest + "; tar xf -)"); run("rm *.gz"); } simrisc-16.02.00/icmconf0000664000175000017500000000113614665030471013747 0ustar frankfrank#define MULTICOMP "jobs -q" #define SPCH "-k xerr/xerr.ih" // #define PRECOMP "-x c++-header" #define USE_ALL "a" #include "INSTALL.im" #define MAIN "main.cc" #define ADD_LIBRARIES "bobcat" #define ADD_LIBRARY_PATHS "" #define REFRESH #define LIBRARY "ofiles" #define IH ".ih" #define SHAREDREQ "" #define SOURCES "*.cc" #define USE_ECHO ON #define TMP_DIR "tmp" #define OBJ_EXT ".o" #define USE_VERSION #define DEFCOM "program" simrisc-16.02.00/icmconf.lib0000664000175000017500000000074014665030471014514 0ustar frankfrank#define MULTICOMP "jobs -q" //#define PRECOMP "-x c++-header" #define CLS #define SOURCES "*.cc" #define OBJ_EXT ".o" #define TMP_DIR "tmp" #define USE_ECHO ON #define IH ".ih" #define CXX "ccache g++" #define CXXFLAGS "-Wall -Werror -O2 -fdiagnostics-color=never" #define ADD_LIBRARIES "bobcat" #define ADD_LIBRARY_PATHS "" #define DEFCOM "library" simrisc-16.02.00/incidence/0000775000175000017500000000000014665030471014326 5ustar frankfranksimrisc-16.02.00/incidence/sumprobs.cc0000664000175000017500000000037614665030471016515 0ustar frankfrank//#define XERR #include "incidence.ih" double Incidence::sumProbs() { double sumProb = 0; for (ParamsPtr const ¶msPtr: d_params) { sumProb += paramsPtr->prob(); d_cumProb.push_back(sumProb); } return sumProb; } simrisc-16.02.00/incidence/lifetimerisk.cc0000664000175000017500000000031114665030471017317 0ustar frankfrank//#define XERR //#include "incidence.ih" // ////static //bool Incidence::lifetimeRisk(StringVect &base, VSD &vsd) //{ // base.back() = "lifetimeRisk:"; // return Parser::one(base, vsd ); //} // simrisc-16.02.00/incidence/vary.cc0000664000175000017500000000077614665030471015630 0ustar frankfrank//#define XERR #include "incidence.ih" void Incidence::vary(ostream &out) { out << " Incidence:\n"; for (ParamsPtr ¶msPtr: d_params) { // if this incidence spec. if (paramsPtr->prob() >= Globals::TOLERANCE) { // is used, then vary the paramsPtr->vary(out); // distribution's value out.put('\n'); } } cptTumorRisk(); } simrisc-16.02.00/incidence/incidence.h0000664000175000017500000000615414665030471016426 0ustar frankfrank#ifndef INCLUDED_INCIDENCE_ #define INCLUDED_INCIDENCE_ // Either Male, Female, or Breast plus the BRCA specs. // // Tumor: // Incidence: // Male: // specifying 'riskTable' takes precedence: must be pairs of // age proportion values. The ages must be increasing and must // be >= 0 and <= MAX_AGE (-> enums) // // riskTable: 25 0.001 // 30 0.003 35 0.005 // 40 0.009 45 0.014 // # value spread distr. // lifetimeRisk: .22 .005 Normal // meanAge: 72.48 1.08 Normal // stdDev: 9.28 1.62 Normal // // Female: // # value spread distr. // lifetimeRisk: .20 .004 Normal // meanAge: 69.62 1.49 Normal // stdDev: 9.73 1.83 Normal // // Breast: // probability: 1 // # value spread distr. // lifetimeRisk: .226 .0053 Normal // meanAge: 72.9 .552 Normal // stdDev: 21.1 // // BRCA1: // probability: 0 // # value spread distr. // lifetimeRisk: .96 // meanAge: 53.9 // stdDev: 16.51 // // BRCA2: // probability: 0 // # value spread distr. // lifetimeRisk: .96 // meanAge: 53.9 // stdDev: 16.51 // as in the original sources: with 0 probabilities the specified values // are set to 0 #include #include #include #include "../typedefs/typedefs.h" #include "../params/params.h" class Incidence { using ParamsPtr = std::unique_ptr; std::vector d_params; DoubleVect d_cumProb; DoubleVect2 d_tumorRisk; // tumor risks per incidence category public: Incidence(); void vary(std::ostream &out); // vary (d_vsd's) values // was: carrier() MODIFY for LC uint16_t index() const; // randomly selected carrier index DoubleVect const &tumorRisk(size_t idx) const; // .f void writeParameters(std::ostream &out) const; private: void cptTumorRisk(); // assign values to d_tumorRisk // 'incidence' originally named 'carrier' void setIncidence(); // sets d_params // 1 void setIncidence(StringVect &base, size_t idx, bool setProb); // 2 static bool valid(double sumProb); // .ih double sumProbs(); // not used: static bool onlyRiskTable(StringVect &base); static void writeCarrier(std::ostream &out, size_t idx, char type, double value); }; #include "incidence.f" #endif simrisc-16.02.00/incidence/incidence.ih0000664000175000017500000000073614665030471016577 0ustar frankfrank#include "incidence.h" #include "../xerr/xerr.ih" #include #include "../globals/globals.h" #include "../parser/parser.h" #include "../random/random.h" #include "../log/log.h" #include "../vsdparams/vsdparams.h" #include "../tableparams/tableparams.h" // static inline bool Incidence::valid(double sumProb) { return 1 - Globals::TOLERANCE <= sumProb and sumProb <= 1 + Globals::TOLERANCE; } #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/incidence/incidence.f0000664000175000017500000000014114665030471016412 0ustar frankfrankinline DoubleVect const &Incidence::tumorRisk(size_t idx) const { return d_tumorRisk[idx]; } simrisc-16.02.00/incidence/cpttumorrisk.cc0000664000175000017500000000052414665030471017404 0ustar frankfrank//#define XERR #include "incidence.ih" void Incidence::cptTumorRisk() { // visit all incidence modes for (size_t idx = 0, end = d_params.size(); idx != end; ++idx) // compute the tumorrisks per age d_params[idx]->cptTumorRisk(d_tumorRisk[idx]); } simrisc-16.02.00/incidence/incidence1.cc0000664000175000017500000000072214665030471016640 0ustar frankfrank#define XERR #include "incidence.ih" Incidence::Incidence() { setIncidence(); // compute the tumor risks per category for END_AGE elements // room for the age-risks per d_tumorRisk.resize(d_params.size()); // carrier category for (auto &vect: d_tumorRisk) // resize for all ages vect.resize(END_AGE); cptTumorRisk(); // then set the tumor risks } simrisc-16.02.00/incidence/meanage.cc0000664000175000017500000000030514665030471016230 0ustar frankfrank////#define XERR //#include "incidence.ih" // //// static //bool Incidence::meanAge(StringVect &base, VSD &vsd) //{ // base.back() = "meanAge:"; // // return Parser::one(base, vsd ); //} // simrisc-16.02.00/incidence/stddev.cc0000664000175000017500000000031314665030471016123 0ustar frankfrank////#define XERR //#include "incidence.ih" // //// static //bool Incidence::stdDev(StringVect &base, double &sd) //{ // base.back() = "stdDev:"; // // return Parser::nonNegative(base, sd); //} // simrisc-16.02.00/incidence/onlyrisktable.cc0000664000175000017500000000111314665030471017513 0ustar frankfrank////#define XERR //#include "incidence.ih" // //// static //bool Incidence::onlyRiskTable(StringVect &base) //{ // for (string const &type: // StringVect{ "lifetimeRisk:", "meanAge:", "stdDev:" }) // { // base.back() = type; // if (Parser::hasSection(base)) // incompatible with riskTable: // { // Err::msg(Err::TABLEPARAMS) << // " cannot be specified together with 'riskTable:'\n"; // return false; // } // } // // base.back() = "riskTable:"; // // return true; //} // simrisc-16.02.00/incidence/icmconf0000664000175000017500000000016114665030471015665 0ustar frankfrank#define LIBRARY "incidence" //#define SPCH "-k xerr/xerr.ih" #include "../icmconf.lib" simrisc-16.02.00/incidence/writecarrier.cc0000664000175000017500000000041214665030471017334 0ustar frankfrank//#define XERR #include "incidence.ih" // static void Incidence::writeCarrier(ostream &out, size_t idx, char type, double value) { out << " " << type << "_carrier_" << idx << ":\t" << setw(8) << value << '\n'; } simrisc-16.02.00/incidence/writeparameters.cc0000664000175000017500000000121614665030471020053 0ustar frankfrank#define XERR #include "incidence.ih" void Incidence::writeParameters(ostream &out) const { out << " Incidence:\n"; auto simulationType = Globals::simulationType(); for ( size_t idx = 0, end = simulationType == BREAST ? 3 : 1; idx != end; ++idx ) { string label; switch (simulationType) { case BREAST: label = Params::label(idx); break; case FEMALE: case MALE: label = Globals::label(simulationType); break; } d_params[idx]->writeParameters(out); } } simrisc-16.02.00/incidence/setincidence1.cc0000664000175000017500000000250614665030471017356 0ustar frankfrank#define XERR #include "incidence.ih" // Incidence parameters: Male, Female, Breast. // BRCA1 and BRCA2 are configured, but not used because their // probabilities are 0. void Incidence::setIncidence() { SimulationType simulationType = Globals::simulationType(); StringVect base; switch (simulationType) { case BREAST: base.resize(2); // set [0] and [1] in break; // setincidence2.cc case MALE: base.push_back(Globals::label(MALE)); break; case FEMALE: base.push_back(Globals::label(FEMALE)); break; } if (simulationType != BREAST) // LC simulation { base.push_back(""); setIncidence(base, 0, false); // no probability d_cumProb.push_back(1); } else { // Breast:, currently: BRCA1:, BRCA2: for (size_t idx = 0, end = Params::nLabels(); idx != end; ++idx) { base[0] = Params::label(idx); setIncidence(base, idx, true); // set probability } if (not valid(sumProbs())) // probs must sum to 1 { Err::msg(Err::INCIDENCE_SUM_PROB) << endl; return; } } } simrisc-16.02.00/incidence/index.cc0000664000175000017500000000060114665030471015741 0ustar frankfrank//#define XERR #include "incidence.ih" uint16_t Incidence::index() const { if (d_cumProb.size() == 1) return 0; double value = Random::instance().uniform(); return find_if(d_cumProb.begin(), d_cumProb.end(), [&](double cumProb) { return value <= cumProb; } ) - d_cumProb.begin(); } simrisc-16.02.00/incidence/frame0000664000175000017500000000007014665030471015340 0ustar frankfrank//#define XERR #include "incidence.ih" Incidence:: { } simrisc-16.02.00/incidence/setincidence2.cc0000664000175000017500000000140514665030471017354 0ustar frankfrank#define XERR #include "incidence.ih" void Incidence::setIncidence(StringVect &base, size_t idx, bool setProb) { base.back() = "riskTable:"; ParamsPtr ptr{ Parser::hasSection(base) ? static_cast(new TableParams{ base, idx, setProb }) : static_cast(new VSDParams{ base, idx, setProb }) }; if (ptr->prob() >= 0) d_params.push_back(move(ptr)); } //=========================================================== // ParamsPtr ptr; // // if (not Parser::hasSection(base)) // ptr.reset(new VSDParams{ base, idx, setProb }); // else if (onlyRiskTable(base)) // ptr.reset(new TableParams{ base, idx, setProb }); // else // return; // // } simrisc-16.02.00/INSTALL0000664000175000017500000001021214665030471013432 0ustar frankfrankSee also the KICKSTART chapter in the manual: doc/manual/index.html, click the kickstart chapter. =========================================================================== To install simrisc by hand instead of using a binary distribution perform the following steps: 0. simrisc and its construction depends, in addition to the normally standard available system software on specific software and versions which is documented in the file `required'. (If you compile the bobcat library yourself, note that simrisc does not use the SSL, Milter and Xpointer classes; they may --as far as simrisc is concerned-- be left out of the library by running './build light') 1. It is expected you use icmake for the package construction. For this a top-level script (build) and support scripts in the ./icmake/ directory are available. By default, the 'build' script echoes the commands it executes to the standard output stream. By specifying the option -q (e.g., ./build -q ...) this is prevented, significantly reducing the output generated by 'build'. 2. Inspect the values of the variables in the file INSTALL.im Modify these when necessary. 3. Run ./build program [strip] to compile simrisc. The argument `strip' is optional and strips symbolic information from the final executable. 4. If you installed Yodl then you can create the documentation: ./build man builds the man-page, and ./build manual builds the manual. 5. Before installing the components of simrisc, consider defining the environment variable SIMRISC, defining its value as the (preferably absolute) filename of a file on which installed files and directories are logged. Defining the SIMRISC environment variable as ~/.simrisc usually works well. 6. Run (probably as root) ./build install 'what' 'base' to install. Here, 'what' specifies what you want to install. Specify: x, to install all components, or specify a combination of: a (additional documentation), b (binary program), d (standard documentation), m (man-pages) u (user guide) E.g., use ./build install bm 'base' if you only want to be able to run simrisc, and want its man-page to be installed below 'base'. ./build install's last argument 'base' is optional: the base directory below which the requested files are installed. This base directory is prepended to the paths #defined in the INSTALL.im file. If 'base' is not specified, then INSTALL.im's #defined paths are used as-is. When requesting non-existing elements (e.g., './build install x' was requested, but the man-pages weren't constructed) then these non-existing elements are silently ignored by the installation process. If the environment variable SIMRISC was defined when issuing the `./build install ...' command then a log of all installed files is written to the file indicated by the SIMRISC environment variable (see also the next item). Defining the SIMRISC environment variable as ~./simrisc usually works well. 7. Uninstalling previously installed components of simrisc is easy if the environment variable SIMRISC was defined before issuing the `./build install ...' command. In that case, run the command ./build uninstall logfile where 'logfile' is the file that was written by ./build install. Modified files and non-empty directories are not removed, but the logfile itself is removed following the uninstallation. 8. Following the installation nothing in the directory tree which contains this file (i.e., INSTALL) is required for the proper functioning of simrisc, so consider removing it. If you only want to remove left-over files from the build-process, just run ./build distclean simrisc-16.02.00/INSTALL.im0000664000175000017500000000260414665030471014044 0ustar frankfrank // Specify the name of the project: #define PROGRAM "simrisc" // Compiler to use: #include "icmake/cxxdefine" // The compiler options to use: #define CXXFLAGS "-Wall -Werror -O2 -fdiagnostics-color=never" // #define CXXFLAGS "-Wall -Werror -O2 -pthread -fdiagnostics-color=never" // Flags passed to the linker: //#define LDFLAGS "-lpthread" #define LDFLAGS "" #define CPOPTS // COMPONENTS TO INSTALL // ===================== // For an operational non-Debian installation, you probably must be // `root'. // If necessary, adapt DOC, HDR, LIB and MAN (below) to your situation. // The provided locations are used by Debian Linux. // With 'build install' you can dynamically specify a location to prepend // to the locations configured here, and select which components you want // to install // ONLY USE ABSOLUTE DIRECTORY NAMES: // the directory where the additional documentation is stored #define ADD "/usr/share/doc/"${PROGRAM}"-doc" // the final program #define BINARY "/usr/bin/"${PROGRAM} // the directory where the standard documentation is stored #define DOC "/usr/share/doc/"${PROGRAM} // the directory whre the manual page is stored #define MAN "/usr/share/man" // the directory whre the user guide is stored #define UGUIDE "/usr/share/doc/"${PROGRAM}"-doc/manual" simrisc-16.02.00/LICENSE0000644000175000017500000010451514665030517013417 0ustar frankfrank GNU GENERAL PUBLIC LICENSE Version 3, 29 June 2007 Copyright (C) 2007 Free Software Foundation, Inc. Everyone is permitted to copy and distribute verbatim copies of this license document, but changing it is not allowed. Preamble The GNU General Public License is a free, copyleft license for software and other kinds of works. The licenses for most software and other practical works are designed to take away your freedom to share and change the works. By contrast, the GNU General Public License is intended to guarantee your freedom to share and change all versions of a program--to make sure it remains free software for all its users. We, the Free Software Foundation, use the GNU General Public License for most of our software; it applies also to any other work released this way by its authors. You can apply it to your programs, too. When we speak of free software, we are referring to freedom, not price. Our General Public Licenses are designed to make sure that you have the freedom to distribute copies of free software (and charge for them if you wish), that you receive source code or can get it if you want it, that you can change the software or use pieces of it in new free programs, and that you know you can do these things. To protect your rights, we need to prevent others from denying you these rights or asking you to surrender the rights. Therefore, you have certain responsibilities if you distribute copies of the software, or if you modify it: responsibilities to respect the freedom of others. For example, if you distribute copies of such a program, whether gratis or for a fee, you must pass on to the recipients the same freedoms that you received. You must make sure that they, too, receive or can get the source code. And you must show them these terms so they know their rights. 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IN NO EVENT UNLESS REQUIRED BY APPLICABLE LAW OR AGREED TO IN WRITING WILL ANY COPYRIGHT HOLDER, OR ANY OTHER PARTY WHO MODIFIES AND/OR CONVEYS THE PROGRAM AS PERMITTED ABOVE, BE LIABLE TO YOU FOR DAMAGES, INCLUDING ANY GENERAL, SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES ARISING OUT OF THE USE OR INABILITY TO USE THE PROGRAM (INCLUDING BUT NOT LIMITED TO LOSS OF DATA OR DATA BEING RENDERED INACCURATE OR LOSSES SUSTAINED BY YOU OR THIRD PARTIES OR A FAILURE OF THE PROGRAM TO OPERATE WITH ANY OTHER PROGRAMS), EVEN IF SUCH HOLDER OR OTHER PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. 17. Interpretation of Sections 15 and 16. If the disclaimer of warranty and limitation of liability provided above cannot be given local legal effect according to their terms, reviewing courts shall apply local law that most closely approximates an absolute waiver of all civil liability in connection with the Program, unless a warranty or assumption of liability accompanies a copy of the Program in return for a fee. END OF TERMS AND CONDITIONS How to Apply These Terms to Your New Programs If you develop a new program, and you want it to be of the greatest possible use to the public, the best way to achieve this is to make it free software which everyone can redistribute and change under these terms. To do so, attach the following notices to the program. It is safest to attach them to the start of each source file to most effectively state the exclusion of warranty; and each file should have at least the "copyright" line and a pointer to where the full notice is found. Copyright (C) This program is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version. This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details. You should have received a copy of the GNU General Public License along with this program. If not, see . Also add information on how to contact you by electronic and paper mail. If the program does terminal interaction, make it output a short notice like this when it starts in an interactive mode: Copyright (C) This program comes with ABSOLUTELY NO WARRANTY; for details type `show w'. This is free software, and you are welcome to redistribute it under certain conditions; type `show c' for details. The hypothetical commands `show w' and `show c' should show the appropriate parts of the General Public License. Of course, your program's commands might be different; for a GUI interface, you would use an "about box". You should also get your employer (if you work as a programmer) or school, if any, to sign a "copyright disclaimer" for the program, if necessary. For more information on this, and how to apply and follow the GNU GPL, see . The GNU General Public License does not permit incorporating your program into proprietary programs. If your program is a subroutine library, you may consider it more useful to permit linking proprietary applications with the library. If this is what you want to do, use the GNU Lesser General Public License instead of this License. But first, please read . simrisc-16.02.00/log/0000775000175000017500000000000014665030471013166 5ustar frankfranksimrisc-16.02.00/log/nl.cc0000664000175000017500000000034214665030471014105 0ustar frankfrank//#define XERR #include "log.ih" Log &nl(Log &log) { if (log.d_active) log.d_logFile.put('\n'); else if (log.d_ignore) { log.d_active = true; log.d_ignore = false; } return log; } simrisc-16.02.00/log/data.cc0000664000175000017500000000005514665030471014406 0ustar frankfrank//#define XERR #include "log.ih" Log g_log; simrisc-16.02.00/log/log.h0000664000175000017500000000266514665030471014131 0ustar frankfrank#ifndef INCLUDED_LOG_ #define INCLUDED_LOG_ #include #include #include class Log { friend Log &nl(Log &log); bool d_active; unsigned d_begin; unsigned d_end; bool d_ignore; // log is ignored if in d_ignored // g_log('X') calls are not logged std::string d_ignored; // if X in d_ignored std::ofstream d_logFile; bool d_set; public: Log(); // only interpreted at the // first call (in d_options) void set(unsigned begin, unsigned end, std::string const &fname, std::string const &ignored); bool active() const; // true: logs are produced void caseIdx(size_t idx); // sets d_active if nr in range std::ofstream &out(); // d_logFile Log &operator()(int ignore); // if ignored -> no log }; inline bool Log::active() const { return d_active; } inline std::ofstream &Log::out() // d_logFile { return d_logFile; } Log &nl(Log &log); inline Log &operator<<(Log &log, Log &(*nl)(Log &)) { return nl(log); } template Log &operator<<(Log &log, Type &&type) { if (log.active()) log.out() << std::forward(type); return log; } extern Log g_log; #endif simrisc-16.02.00/log/log.ih0000664000175000017500000000023314665030471014267 0ustar frankfrank#include "log.h" #include "../xerr/xerr.ih" #include #include #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/log/set.cc0000664000175000017500000000115114665030471014266 0ustar frankfrank#define XERR #include "log.ih" void Log::set(unsigned begin, unsigned end, std::string const &fname, string const &ignored) { if (d_set) // activating log can only be done return; // once if (begin > end) throw Exception{} << "--log: " << begin << " thru " << end << " 1st value must be <= 2nd value"; d_logFile = Exception::factory(fname); *this << "Logging cases " << begin << " thru " << end << '\n'; d_set = true; d_begin = begin; d_end = end; d_ignored = ignored; } simrisc-16.02.00/log/caseidx.cc0000664000175000017500000000031214665030471015111 0ustar frankfrank//#define XERR #include "log.ih" void Log::caseIdx(size_t idx) { if (d_set and (d_active = d_begin <= idx and idx <= d_end)) d_logFile << "\n" "CASE " << idx << '\n'; } simrisc-16.02.00/log/icmconf0000664000175000017500000000007214665030471014526 0ustar frankfrank#define LIBRARY "log" #include "../icmconf.lib" simrisc-16.02.00/log/log1.cc0000664000175000017500000000013014665030471014331 0ustar frankfrank//#define XERR #include "log.ih" Log::Log() : d_active(false), d_set(false) {} simrisc-16.02.00/log/frame0000664000175000017500000000005414665030471014202 0ustar frankfrank//#define XERR #include "log.ih" Log:: { } simrisc-16.02.00/log/operatorfun.cc0000664000175000017500000000034714665030471016045 0ustar frankfrank#define XERR #include "log.ih" size_t count = 0; Log &Log::operator()(int ignore) { if (d_active and d_ignored.find(ignore) != string::npos) { d_ignore = true; d_active = false; } return *this; } simrisc-16.02.00/log/driver/0000775000175000017500000000000014665030471014461 5ustar frankfranksimrisc-16.02.00/log/driver/main.cc0000664000175000017500000000043014665030471015711 0ustar frankfrank#include "../log.h" using namespace std; int main() { g_log << "nothing\n"; g_log.set(4, 5, "out"); g_log.caseIdx(1); g_log << "nothing\n"; g_log.caseIdx(4); g_log << "special line for case 4\n"; g_log.caseIdx(6); g_log << "nothing\n"; } simrisc-16.02.00/log/driver/compile0000775000175000017500000000005414665030471016036 0ustar frankfrankg++ -Wall main.cc -L ../tmp/ -llog -lbobcat simrisc-16.02.00/loop/0000755000175000017500000000000014665030471013354 5ustar frankfranksimrisc-16.02.00/loop/fillzeroes.cc0000664000175000017500000000023314665030471016041 0ustar frankfrank//#define XERR #include "loop.ih" // static void Loop::fillZeroes(ostream &out, size_t idx) { for ( ; idx < N_RESULTS; ++idx) out << "0\t"; } simrisc-16.02.00/loop/notnm.cc0000664000175000017500000000017314665030471015021 0ustar frankfrank//#define XERR #include "loop.ih" // static void Loop::noTNM(ostream &out) { // no further action, see also fillTNM } simrisc-16.02.00/loop/tumordetected.cc0000664000175000017500000000074314665030471016541 0ustar frankfrank//#define XERR #include "loop.ih" void Loop::tumorDetected(ModBase *modBase, double screeningAge) { // Found a tumor during the screening d_tumor.found(); ++d_nDetections[d_round]; d_caseCost += treatmentCosts(screeningAge); addBiopCosts(d_costs.usingAt(screeningAge)); d_tumor.setDeathAge(screeningAge); d_deathAge = min(d_tumor.deathAge(), d_naturalDeathAge); d_roundDetected = d_round + 1; left(SCREEN_DETECTED, d_deathAge); } simrisc-16.02.00/loop/intervalcancer.cc0000664000175000017500000000142514665030471016667 0ustar frankfrank#define XERR #include "loop.ih" // a self-detected tumor before screeningAge or natural death: // an interval cancer. // the tumor characteristics (at self-detection age) have already been // determined in loop/leaving.cc. bool Loop::intervalCancer() // (double screeningAge) { d_tumor.intervalCancer(); // sets d_interval true ++d_nIntervals[d_round]; if (d_screening.attend(d_round)) ++d_nTrueIntervals[d_round]; // treat the tumor and determine the death-age of the women // since the tumor is present, no need to call diameterCheck() // addCost(treatmentCosts(d_tumor.selfDetectAge())); // d_tumor.setDeathAge(); return left(SELF_DURING, min(d_naturalDeathAge, d_tumor.deathAge())); } simrisc-16.02.00/loop/headerdata.cc0000664000175000017500000001127414665030471015754 0ustar frankfrank//#define XERR #include "loop.ih" // woman, death cause, death age, tumor present, tumor detected, tumor is // interval, tumor diameter, tumor self-detect age, tumor death age, tumor // doubling time, tumor onset age, tumor preclinical period, natural death age, // death status, costs, self detected, round detected, screening rounds, TNM CSVTable Loop::headerData(size_t iter) const { CSVTable tab{ outStream(d_options.dataFile(), iter), " " }; if (not tab.stream()) // tab.stream(): the stream to write the return tab; // data to. labels(tab.stream()); ostream &out = tab.stream(); // write the status legenda out << "exit status legend:\n"; for (size_t status = NATURAL_PRE; status != Status_END; ++status) out << setw(5) << status << ": " << s_status[status] << '\n'; // the fmt() insertions define the widths of the columns, // not their header labels. Blanks are ignored, hence 'costs67890' // case cause age natural status present detected interval // 1 2 3 4 4 6 7 8 // diameter days period onset self-detect death // 9 10 11 12 13 14 // costs self round rounds TNM // 15 16 17 18 19 // ** tab.fmt() << right(7) << // 1 "Natural" << right("100.12", 2) << // 2 - 3 "natural" << "status" << // 4 - 5 "present" << "detected" << "interval" << // 6 - 8 "diameter" << "doubling" << "preclinical" << // 9 - 11 // death: "onset" << "self-detect" << "100.00" << // 12 - 14 "costs67890" << // 15 "biop567" << "self" << "round" << // 15-pre - 17 right(d_nRounds > 10 ? d_nRounds : 10) << // 18 right(5); // 19 tab << hline(); // 6 - 14 + hline tab.row(5) << join(9, FMT::CENTER) << "tumor"; tab.row(5) << hline(9); tab.row(1) << // 1 join(4, FMT::CENTER) << "death" << // 2 - 5 join(6, FMT::RIGHT) << ' ' << // 6 - 11 ' ' << // 12 join(2, FMT::CENTER) << "age" << // 13 - 14 join(2, FMT::CENTER) << "costs" << // 15-pre 15 join(2, FMT::CENTER) << "detected"; // 16 - 17 tab.row(1) << // 1 hline(4) << // 2 - 5 join(4, FMT::RIGHT) << ' ' << // 6 - 9 "doubling" << "preclinical" << ' ' << // 10 - 12 hline(2) << // 13 - 14 hline(2) << // 15-pre 15 hline(2) << "screening"; // 16 - 18 tab << "case" << // 1 "cause" << "age" << // 2 - 3 "natural" << "status" << // 4 - 5 "present" << "detected" << "interval" << // 6 - 8 "diameter" << "days" << "period" << // 9 - 11 "onset" << "self-detect" << "death" << // 12 - 14 "screening" << // 15 "biop" << // 15-pre "self" << "round" << "rounds" << "TNM"; // 16 - 19 tab << hline(); tab.sep(", "); return tab; } // out << // 1 " woman, " // 2 "death cause, " // 3 "death age, " // 4 "tumor present, " // 5 "tumor detected, " // 6 "tumor is interval, " // 7 "tumor diameter, " // 8 11 "tumor self-detect age, " // 9 12 "tumor death age, " // 10 8 "tumor doubling time, " // 11 10 "tumor onset age, " // 12 9 "tumor preclinical period, " // 13 "natural death age, " // 14 "death status, " // 15 "costs, " // 16 "self detected, " // 17 "round detected, " // 18 "screening rounds, " // 19 "TNM, " // "\n"; // } simrisc-16.02.00/loop/data.cc0000664000175000017500000000505414665030471014602 0ustar frankfrank//#define XERR #include "loop.ih" unordered_set Loop::s_availableFiles; char const *Loop::s_status[] = { "", // PRESENT, "natural death, no tumor, before the 1st screening round", // NATURAL_PRE, "natural death, undetected tumor, before the 1st screening round", // UNDETECTED_PRE, "self-detected tumor before the 1st screening round", // SELF_PRE, "natural death, no tumor, between screening rounds", // NATURAL_DURING, "natural death, undetected tumor, between screening rounds", // UNDETECTED_DURING, "self-detected tumor between screening rounds", // SELF_DURING, "screening-detected tumor", // SCREEN_DETECTED, "natural death, no tumor, after the last screening round", // NATURAL_POST, "natural death, undetected tumor, after the last screening round", // UNDETECTED_POST, "self-detected tumor after the last screening round", // SELF_POST, }; //// from original input/CumDeathProb.txt // //DoubleVect Loop::s_cumDeathProb = //{ // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0, // 0.00014, // 0.00028, // 0.00042, // 0.00056, // 0.0007, // 0.00106, // 0.00142, // 0.00178, // 0.00214, // 0.0025, // 0.00382, // 0.00514, // 0.00646, // 0.00778, // 0.0091, // 0.01118, // 0.01326, // 0.01534, // 0.01742, // 0.0195, // 0.02312, // 0.02674, // 0.03036, // 0.03398, // 0.0376, // 0.04414, // 0.05068, // 0.05722, // 0.06376, // 0.0703, // 0.07776, // 0.08522, // 0.09268, // 0.10014, // 0.1076, // 0.11564, // 0.12368, // 0.13172, // 0.13976, // 0.1478, // 0.15718, // 0.16656, // 0.17594, // 0.18532, // 0.1947, // 0.20658, // 0.21846, // 0.23034, // 0.24222, // 0.2541, // 0.2756, // 0.2971, // 0.3186, // 0.3401, // 0.3616, // 0.39368, // 0.42576, // 0.45784, // 0.48992, // 0.522, // 0.5624, // 0.6028, // 0.6432, // 0.6836, // 0.724, // 0.75826, // 0.79252, // 0.82678, // 0.86104, // 0.8953, // 0.90962, // 0.92394, // 0.93826, // 0.95258, // 0.9669, // 0.97104, // 0.97518, // 0.97932, // 0.98346, // 0.9876, //}; // simrisc-16.02.00/loop/postscreen.cc0000664000175000017500000000474714665030471016066 0ustar frankfrank#define XERR #include "loop.ih" void Loop::postScreen() { if (d_status != PRESENT) // the woman has died: no further return; // actions g_log << "\nLoop::postScreen\n"; // C1 if (not d_tumor.at(END_AGE)) // no tumor beyond the last screening { // round left(NATURAL_POST, d_naturalDeathAge); return; } // tumor beyond the last screening age: determine its // characteristics // C2 d_tumor.characteristicsAt(d_tumor.selfDetectAge()); d_tumor.setDeathAge(); if (d_tumor.selfDetectBefore(d_naturalDeathAge)) d_caseCost += treatmentCosts(d_tumor.selfDetectAge()); d_deathAge = min(d_naturalDeathAge, d_tumor.deathAge()); left( d_tumor.selfDetectBefore(d_naturalDeathAge) ? SELF_POST : d_naturalDeathAge < d_tumor.onset() ? NATURAL_POST : UNDETECTED_POST, d_deathAge); // d_tumor.selfDetectAge()); } //////////////////////////////////////////////////////////////////// // // // // // main consequence block when self-detecting a tumor after the screenings // // vvvvvvvvvvvvvvvvv // there may be a tumor, detected before // if ( // the woman's natural death // d_tumor.selfDetectable() // and d_tumor.selfDetectAge() < d_naturalDeathAge // ) // { // // this results in a tumor caused death. // // (the condition check in the original // // sources is superfluous) // g_log << " *** case died because of a tumor detected at age " << // d_tumor.selfDetectAge() << '\n'; // // d_roundDetected = d_screening.nRounds(); // characteristics(NATURAL_POST, SELF_POST); // } // else // or a naturally caused death // { // //if (g_caseIdx >= g_err)xerr(g_caseIdx << " setStatus"); // setStatus(NATURAL_POST, d_naturalDeathAge); // g_log << " *** case died at natural death age " << // d_naturalDeathAge << '\n'; // // // although the woman has died, still // // determine the tumor's characteristics // if (d_tumor.selfDetectable()) // d_tumor.characteristicsAt(d_deathAge); // } simrisc-16.02.00/loop/showround.cc0000664000175000017500000000073214665030471015717 0ustar frankfrank#define XERR #include "loop.ih" string Loop::showRound() const { switch (d_roundDetected) { case -1: // no tumor detected return "0"s; case 0: // tumor detected before the return "-1"s; // 1st screening round default: return (not d_screening.attend(d_roundDetected - 1) ? '*' : ' ') + to_string(d_roundDetected); } } simrisc-16.02.00/loop/prescreen.cc0000664000175000017500000000435114665030471015656 0ustar frankfrank//#define XERR //#include "loop.ih" // //void Loop::preScreen() //{ // // see prescreen.txt // // if (d_nRounds == 0) // no scenario rounds, no pre-screening // return; // // g_log << "\nLoop::preScreen\n"; // // // age 0: the 1st screening age, e.g. 50 // double age0 = d_screening.roundAge(0); // using the complement of the // if ( // prescreen in the original code // d_naturalDeathAge >= age0 // and // ( // not d_tumor.selfDetectable() // these are accessor calls // or // d_tumor.selfDetectAge() >= age0 // ) // ) // { // g_log << " case alive and no (detectable) tumor before age " << // age0 << ": no preScreen\n"; // return; // } // //// --------------------------------------------------------------------- //// action: //// self- nat.death < ----------------------- //// detectable tumor:selfDetect nat.death tumordetect alternative //// --------------------------------------------------------------------- //// 0 0 1 0 if //// 0 1 0 1 if //// 1 0 1 0 else //// 1 1 1 0 if //// --------------------------------------------------------------------- // // // main block resulting in the case leaving when prescreening // // ========================================================== // // if ( // pre-screening is performed: // not d_tumor.selfDetectable() or // ( // d_tumor.selfDetectable() // and // d_naturalDeathAge < d_tumor.selfDetectAge() // ) // ) // { // g_log << " *** preTumorDeath: case died naturally\n"; // preTumorDeath(); // natural death: no tumor or not self-detected // } // else // { // g_log << // " *** self detected: case self-detected a tumor and leaves\n"; // preSelfDetected(); // self detected the tumor before the screening // } //} // simrisc-16.02.00/loop/headerrounds.cc0000664000175000017500000000314514665030471016353 0ustar frankfrank#define XERR #include "loop.ih" CSVTable Loop::headerRounds(size_t iteration) const { CSVTable tab{ outStream( d_nRounds == 0 ? "" : d_options.roundsFile(), iteration), " " }; // false number of number of // --------- ------------------------ screening -------------- // round pos. neg. tumors interval trueInt costs Mammo Tomo MRI // --------------------------------------------------------------------- if (not tab.stream() or d_nRounds == 0) return tab; labels(tab.stream()); tab.fmt() << "round" << // 1: round "pos." << "neg." << // 2-3 "tumors" << "interval" << // 4-5 "trueInt" << "screening" << "biop567yyy"; // 6-8 // E.g., "Mammo" << "Tomo" << "MRI"; // 9-11 (generally: 9..) size_t nFields = d_modalities.roundFmt(tab); tab << hline(); tab.row(1) << join(2, FMT::CENTER) << "false" << // 2-3 join(3, FMT::CENTER) << "number of" << // 4-6 join(2, FMT::CENTER) << "costs" << // 8 join(nFields, FMT::CENTER) << "number of"; tab.row(1) << hline(2) << hline(3) << hline(2) << hline(nFields); tab.more() << "round" << "pos." << "neg." << // 1-3 "tumors" << "interval" << "trueInt" << // 4-6 "screening" << "biop"; // 7-8 d_modalities.roundHeaders(tab); tab.row(); tab << hline(); tab.sep(", "); return tab; } simrisc-16.02.00/loop/filltnm.cc0000664000175000017500000000017614665030471015336 0ustar frankfrank//#define XERR #include "loop.ih" // static void Loop::fillTNM(ostream &out) // see also noTNM { out << "-1,0"; } simrisc-16.02.00/loop/naturaldeathage.cc0000664000175000017500000000104014665030471017011 0ustar frankfrank//#define XERR #include "loop.ih" double Loop::naturalDeathAge() { double rnd; double ret = findAge( // Globals:: d_scenario.cumDeathProp(), rnd = Random::instance().uniformCase() ); double age = ret < MAX_AGE ? ret : MAX_AGE; g_log << " Loop::naturalDeathAge: locate " << rnd << " in cum.death probs\n" << " natural death age: " << age << '\n'; return age; } simrisc-16.02.00/loop/loop.h0000664000175000017500000001577614665030471014520 0ustar frankfrank#ifndef INCLUDED_LOOP_ #define INCLUDED_LOOP_ #include #include "../typedefs/typedefs.h" #include "../globals/globals.h" #include "../scenario/scenario.h" #include "../screening/screening.h" #include "../densities/densities.h" #include "../modalities/modalities.h" #include "../tumorinfo/tumorinfo.h" #include "../tumor/tumor.h" #include "../costs/costs.h" class Options; class Scenario; namespace FBB { class CSVTable; } class Loop: public Globals { // // 2 -> 1, 5 -> 4, 9 -> 8 if the natural death is before the tumor's onset. // enum Status // labels in data.cc { PRESENT, // 0 NATURAL_PRE, // 1 natural death before the 1st screening round UNDETECTED_PRE, // 2 nat. death, undetected tumor, before 1st scr. SELF_PRE, // 3 self-detected tumor before 1st scr. NATURAL_DURING, // 4 nat. death between screening rounds UNDETECTED_DURING, // 5 nat. death, undetected tumor, between scr. SELF_DURING, // 6 self-detected tumor between scr. rounds SCREEN_DETECTED, // 7 screening-detected tumor NATURAL_POST, // 8 nat. death after the last screening round UNDETECTED_POST, // 9 nat. death, undetected tumor, afer last scr. SELF_POST, // 10 self-detected tumor after last scr. round Status_END }; enum // round info (per case) '0': not attended { ATTENDED = '1', FALSE_NEGATIVE = '2', FALSE_POSITIVE = '3' }; enum { N_RESULTS = 13 // weird... used in results() }; Options const &d_options; Status d_status = PRESENT; StringVect const &d_labels; Scenario d_scenario; Costs d_costs; Densities d_densities; TumorInfo d_tumorInfo; Tumor d_tumor; Modalities d_modalities; Screening d_screening; int16_t d_roundDetected; // -1: no detection // Analysis &d_analysis; // Beir7 const &d_beir7; // Incidence const &d_incidence; double d_sumDeathAge = 0; double d_naturalDeathAge = 0; // dying age w/o tumor double d_deathAge = 0; // actual dying age uint16_t d_nRounds; // from Screening::nRounds() // when screening is used: uint16_t d_firstRoundAge; // age of the first screening round uint16_t d_round = 0; // currently used screening round std::string d_roundInfo; SizeVect d_nIntervals; // # interval cancer per round SizeVect d_nTrueIntervals; // # interval cancer per round // following a previously attended // screening round SizeVect d_nRoundFP; // # of false-positives per round SizeVect d_nRoundFN; // # of false-negatives per round SizeVect d_nDetections; double d_caseCost; double d_biopCosts; // sum of biop costs per case DoubleVect d_roundBiopCosts; // and per round double d_totalCost; DoubleVect d_roundCost; // sum of costs over all scr. rounds // (org: screeningRoundCosts) // randomly determined (breast cancer) // bi-rad indices for the ages of the // screening rounds, or table S3 indices // for lung cancer. Uint16Vect d_indices; // ('densities' in the original sources) std::string d_timestamp; void (*d_tnm)(std::ostream &out); // noTNM or fillTNM ProbGroup::Vector const *d_groupVector; // breast- or lung cancer // probGroup::Vector to use when // constructing d_indices static StringSet s_availableFiles; static char const *s_status[]; public: Loop(StringVect const &labels); void iterate(); private: double addBiopCosts(double costs); bool betaFunction(uint16_t modalityNr); void caseInit(); size_t cases() const; // #cases in womenLoop Uint16Vect cptIndices() const; // cpt d_indices static void fillTNM(std::ostream &out); static void fillZeroes(std::ostream &out, size_t idx); void genCases(size_t iter, size_t nCases); FBB::CSVTable headerData(size_t iter) const; FBB::CSVTable headerRounds(size_t iter) const; FBB::CSVTable headerSensitivity() const; bool intervalCancer(); void labels(std::ostream &out) const; bool leaving(double screeningAge); void maybeFalseNegative(ModBase *modBase, double screeningAge); bool falseNegative(ModBase *modBase); void tumorDetected(ModBase *modBase, double screeningAge); void maybeFalsePositive(ModBase *modBase, double screeningAge); double naturalDeathAge(); static void noTNM(std::ostream &out); static std::ofstream open(std::string const &fname); static std::ofstream outStream(std::string const &fname, size_t idx); void postScreen(); static std::string replaceDollar(std::string const &settingsFile, size_t idx); void resetCounters(); // returns the sensitivity for the double sensitivity(ModBase *modBase) const; // current round 1.cc bool left(Status status, double deathAge); // also logs the reason void screen(double screeningAge); void screening(); std::string showRound() const; double treatmentCosts(double screeningAge) const; // .ih // NOTE: in the orig. source density NRs are used: 1..4 // here density INDICES are usd: 0..3 // but when writing the data file (e.g., data-0.txt, original // name e.g., women-test-i0.txt) a + 1 correction is // currently applied bool use(ModBase *modBase); // use this modality void writeData(FBB::CSVTable &dataTable, size_t idx) const; void writeParameters(size_t iter) const; // also opens the file void writeRounds(FBB::CSVTable &roundTable) const; void writeSensitivity(FBB::CSVTable &sensTable, size_t iter) const; }; // OBSOLETE // void characteristics(Status natural, Status tumor); // OBSOLETE // void preTumorDeath(); // early natural death // OBSOLETE // void preScreen(); // OBSOLETE void preSelfDetected(); // self detected tumor pre-screening // OBSOLETE: covered by 'left(...)' // void setStatus(Status status, double age); // only sets the d_ vars. // void removeCase(double screeningAge, double selfDetectAge); #endif simrisc-16.02.00/loop/sensitivity1.cc0000664000175000017500000000124214665030471016337 0ustar frankfrank#define XERR #include "loop.ih" double Loop::sensitivity(ModBase *modBase) const { // NOTE: d_indices uses indices (0..4) instead of numbers // (as used in the original code) return modBase->sensitivity(d_indices[d_round]); } ////Calculate sensitivity for the modality and breastdensity (possibility to make function of age and tumorsize in the future but not used for now) //float calcSens(float age, float tumorsize, int modality, int density ) { // switch (modality) { // case 0: //Mammography // return sensMam[density-1]; // case 1: //Tomo // return sensTomo[density-1]; // } //} // simrisc-16.02.00/loop/leaving.cc0000664000175000017500000000322114665030471015310 0ustar frankfrank#define XERR #include "loop.ih" // true: the case has died or detected a tumor bool Loop::leaving(double screeningAge) { bool before1stRound = screeningAge == d_firstRoundAge; // A1: if (not d_tumor.at(screeningAge)) // no tumor yet at this age return d_naturalDeathAge <= screeningAge ? // case dies naturally left(before1stRound ? NATURAL_PRE : NATURAL_DURING, d_deathAge) : false; // nothing happened: perform // the screening // A2: there is a tumor at 'screeningAge' if ( // A3 d_naturalDeathAge < screeningAge and not d_tumor.selfDetectBefore(d_naturalDeathAge) ) { d_tumor.characteristicsAt(d_naturalDeathAge); d_deathAge = d_naturalDeathAge; bool died = d_naturalDeathAge < d_tumor.onset(); return left( before1stRound ? died ? NATURAL_PRE : UNDETECTED_PRE : died ? NATURAL_DURING : UNDETECTED_DURING, d_naturalDeathAge); } // A4 if (d_tumor.selfDetectBefore(screeningAge)) // self-detectable? { d_tumor.characteristicsAt(d_tumor.selfDetectAge()); d_tumor.setDeathAge(); d_caseCost += treatmentCosts(d_tumor.selfDetectAge()); return before1stRound ? left(SELF_PRE, min(d_naturalDeathAge, d_tumor.deathAge())) : intervalCancer(); } return false; // perform the screening } simrisc-16.02.00/loop/open.cc0000664000175000017500000000103614665030471014626 0ustar frankfrank//#define XERR #include "loop.ih" // static ofstream Loop::open(string const &fname) { // already saw fname if (s_availableFiles.find(fname) != s_availableFiles.end()) { ofstream out{ Exception::factory(fname, ios::in | ios::out | ios::ate) }; out << setfill('-') << setw(40) << '-' << setfill(' ') << "\n\n"; return out; } s_availableFiles.insert(fname); return Exception::factory(fname); } simrisc-16.02.00/loop/writesensitivity.cc0000664000175000017500000000040114665030471017325 0ustar frankfrank//#define XERR #include "loop.ih" void Loop::writeSensitivity(CSVTable &tab, size_t iter) const { if (tab.stream()) tab << iter << static_cast(round(d_sumDeathAge)) << static_cast(round(d_totalCost)); } simrisc-16.02.00/loop/loop.ih0000664000175000017500000000143214665030471014651 0ustar frankfrank#include "loop.h" #include "../xerr/xerr.ih" #include #include #include #include #include #include #include "../random/random.h" #include "../options/options.h" #include "../modbase/modbase.h" #include "../log/log.h" extern size_t g_caseIdx; extern size_t g_err; namespace Icmake { extern char version[]; } inline double Loop::treatmentCosts(double screeningAge) const { // diameter unused with lung cancer // otherwise metastasis unused return d_costs.treatment(screeningAge, d_tumor.diameter(), d_tumor.metastasis()); } #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/loop/addbiopcosts.cc0000664000175000017500000000024314665030471016342 0ustar frankfrank//#define XERR #include "loop.ih" double Loop::addBiopCosts(double costs) { d_biopCosts += costs; d_roundBiopCosts[d_round] += costs; return costs; } simrisc-16.02.00/loop/screening.cc0000664000175000017500000000156314665030471015647 0ustar frankfrank#define XERR #include "loop.ih" extern size_t g_caseIdx; void Loop::screening() { if (d_status == PRESENT and d_nRounds > 0) g_log << "\nLoop::screening starts\n"; // d_round is a data member: available in all of Loop's members for (d_round = 0; d_status == PRESENT and d_round != d_nRounds; ++d_round) { double screeningAge = d_screening.roundAge(d_round); g_log << __FILE__ << " screening round " << d_round << " at age " << screeningAge << '\n'; if (leaving(screeningAge)) // the case died or detected a tumor return; screen(screeningAge); // perform the screening } } //if (g_caseIdx == 102) //xerr("screening " << g_caseIdx << " at age " << screeningAge); //if (g_caseIdx == 102) //xerr("screening " << g_caseIdx << " LEAVES at age " << screeningAge); simrisc-16.02.00/loop/falsenegative.cc0000664000175000017500000000112714665030471016503 0ustar frankfrank#define XERR #include "loop.ih" bool Loop::falseNegative(ModBase *modBase) { // modified using Jing Wang's email (Tue, 20 Oct 2020 16:04:42 +0000) if ( double uval = Random::instance().uniform(), sval = sensitivity(modBase); //uval > sval sval < uval ) { g_log << " detected FALSE_NEGATIVE (" << uval << " > sensitivity (" << sval << ")\n"; ++d_nRoundFN[d_round]; d_roundInfo[d_round] = FALSE_NEGATIVE; return true; } return false; // not a false negative conclusion } simrisc-16.02.00/loop/labels.cc0000664000175000017500000000042214665030471015125 0ustar frankfrank//#define XERR #include "loop.ih" void Loop::labels(ostream &out) const { out << "Analysis " << d_timestamp << " (SimRisc V. " << Icmake::version << ")\n"; for (auto const &line: d_labels) out << line << '\n'; out.put('\n'); } simrisc-16.02.00/loop/replacedollar.cc0000664000175000017500000000070014665030471016473 0ustar frankfrank//#define XERR #include "loop.ih" // static string Loop::replaceDollar(string const &settingsFile, size_t idx) { string ret{ settingsFile }; string nr{ to_string(idx) }; idx = 0; while (true) { idx = ret.find('$', idx); // find the next $ if (idx == string::npos) // no more return ret; ret.replace(idx, 1, nr); // replace the $ by nr } } simrisc-16.02.00/loop/outstream.cc0000664000175000017500000000040214665030471015704 0ustar frankfrank//#define XERR #include "loop.ih" // static ofstream Loop::outStream(string const &fname, size_t idx) { ofstream ret; if (fname.empty()) ret.setstate(ios::failbit); else ret = open(replaceDollar(fname, idx)); return ret; } simrisc-16.02.00/loop/maybefalsenegative.cc0000664000175000017500000000107014665030471017516 0ustar frankfrank#define XERR #include "loop.ih" extern size_t g_caseIdx; void Loop::maybeFalseNegative(ModBase *modBase, double screeningAge) { d_tumor.characteristicsAt(screeningAge); if (not falseNegative(modBase)) tumorDetected(modBase, screeningAge); } // see also: Marcel: Tue, 9 Jun 2020 13:01:00 +0000 // Marcel: Thu, 11 Jun 2020 10:35:44 +0000 (MRI, Mammo, Tomo are // all used // the check for tumor.diameter() >= 1 is omitted, since // all tumors have at least 1 mm diameter // (see Marcel: Tue, 30 Jun 2020 10:46:05 +0000) simrisc-16.02.00/loop/headersensitivity.cc0000664000175000017500000000110314665030471017423 0ustar frankfrank//#define XERR #include "loop.ih" // ----------------------------------- // iteration women years total costs // ----------------------------------- // 0, 795, 13478 // ----------------------------------- CSVTable Loop::headerSensitivity() const { CSVTable tab{ outStream(d_options.sensitivityFile(), 0), " " }; if (not tab.stream()) return tab; labels(tab.stream()); tab.fmt("iteration, women years, total costs"); tab << hline(); tab("iteration, women years, total costs"); tab << hline(); return tab; } simrisc-16.02.00/loop/icmconf0000664000175000017500000000007314665030471014717 0ustar frankfrank#define LIBRARY "loop" #include "../icmconf.lib" simrisc-16.02.00/loop/maybefalsepositive.cc0000664000175000017500000000141714665030471017563 0ustar frankfrank#define XERR #include "loop.ih" // no tumor is present void Loop::maybeFalsePositive(ModBase *modBase, double screeningAge) { double rnd = Random::instance().uniform(); double spec = modBase->specificity(screeningAge); if (rnd <= spec) g_log << " " << rnd << " <= specificity(" << screeningAge << ") = " << spec << ": no false positive\n"; else { g_log << " " << rnd << " > specificity(" << screeningAge << ") = " << spec << ": false positive\n"; modBase->falsePositive(); ++d_nRoundFP[d_round]; d_roundInfo[d_round] = FALSE_POSITIVE; // add the using costs to the case and biop costs d_caseCost += addBiopCosts(d_costs.usingAt(screeningAge)); } } simrisc-16.02.00/loop/prescreen.txt0000664000175000017500000000310214665030471016101 0ustar frankfrankIn the original code's prescreen handling the following condition is used: if (Nscr > 0 && (naturalDeathAge < scr[0].age || (tumor.isTumor() && tumor.selfDetectAge() < scr[0].age))) Following this a lot of code is provided to be executed when the condition is true. It's more elegant to put this code in a function, returning when the condition isn't true. So: if ( not (Nscr > 0 && (naturalDeathAge < scr[0].age || (tumor.isTumor() && tumor.selfDetectAge() < scr[0].age))) ) return; But this isn't too readabile. However, the condition can be rewritten using De Morgan's rules. First the condition is simplified by using symbols: not (Nscr > 0 && (naturalDeathAge < scr[0].age || (tumor.isTumor() --> not ( A and ( B or ( C && tumor.selfDetectAge() < scr[0].age))) --> and D ))) And thus: not ( A and ( B or ( C and D ) ) ) Now distribute the 'not' using De Morgan: not A or not ( B or ( C and D ) ) The 2nd 'not' is next: not A or not B and not( C and D ) And maybe also the 3rd 'not': not A or not B and (not C or not D ) Now substitute the original expressions: // if (not A) -> if (Nscr == 0) // (Nscr is never negative) return; // if (not B and (not C or not D )) -> if ( naturalDeathAge >= scr[0].age // not B and (not tumor.isTumor() or tumor.selfDetectAge() >= scr[0].age) // not C or not D ) return; simrisc-16.02.00/loop/writeparameters.cc0000664000175000017500000000106614665030471017106 0ustar frankfrank#define XERR #include "loop.ih" void Loop::writeParameters(size_t iteration) const { ofstream out{ outStream(d_options.parametersFile(), iteration) }; if (not out) return; labels(out); // timestamp and scenatio explanatory labels setPrecision(out, 3); d_scenario.writeParameters(out, iteration + 1); d_costs.writeParameters(out); if (Globals::isBreast()) d_densities.writeParameters(out); d_modalities.writeParameters(out); d_screening.writeParameters(out); d_tumorInfo.writeParameters(out); } simrisc-16.02.00/loop/gencases.cc0000664000175000017500000000230714665030471015457 0ustar frankfrank#define XERR #include "loop.ih" size_t g_caseIdx; // -> loop.ih if (caseIdx > 24842) size_t g_err = 14; void Loop::genCases(size_t iter, size_t nCases) { CSVTable dataTable = headerData(iter); bool showAll = not d_options.specificAges() and d_options.lastCase() == 0; // perform 'nCases' simulations for (size_t caseIdx = 0; caseIdx != nCases; ++caseIdx) { g_caseIdx = caseIdx; g_log.caseIdx(caseIdx); caseInit(); // initialize the data for this case screening(); // no action unless screening rounds are specified postScreen(); d_sumDeathAge += d_deathAge; d_totalCost += d_caseCost; if (dataTable.stream() and (showAll or caseIdx + 1 == nCases)) { d_tumor.checkDeath(d_naturalDeathAge); writeData(dataTable, caseIdx); } } dataTable << hline(); } // In the original womanloop function a test is performed whether the // woman has died or not. This test is superfluous because if the woman enters // postScreen with status PRESENT then in postScreen the status either changes // to NATURAL_POST or SELF_POST. simrisc-16.02.00/loop/writerounds.cc0000664000175000017500000000125314665030471016253 0ustar frankfrank#define XERR #include "loop.ih" void Loop::writeRounds(CSVTable &tab) const { if (not tab.stream() or d_nRounds == 0) return; for (size_t rnd = 0; rnd != d_nRounds; ++rnd) { tab.more() << (rnd + 1) << // rounds.txt: natural round nrs d_nRoundFP[rnd] << d_nRoundFN[rnd] << d_nDetections[rnd] << d_nIntervals[rnd] << d_nTrueIntervals[rnd] << static_cast(round(d_roundCost[rnd])) << static_cast(round(d_roundBiopCosts[rnd])); d_modalities.writeRounds(tab, rnd); tab.row(); } tab << hline(); } simrisc-16.02.00/loop/left.cc0000664000175000017500000000030514665030471014615 0ustar frankfrank#define XERR #include "loop.ih" bool Loop::left(Status status, double deathAge) { d_status = status; d_deathAge = deathAge; g_log << s_status[status] << '\n'; return true; } simrisc-16.02.00/loop/cases.cc0000664000175000017500000000072614665030471014770 0ustar frankfrank#define XERR #include "loop.ih" // if last case (--nCases) was specified, use that number of cases // if death-age (--death-age) was specified simulate one case having // the specified death age. Otherwise use nWomen cases size_t Loop::cases() const { return d_options.lastCase() != 0 ? d_options.lastCase() : d_options.specificAges() ? 1 : d_scenario.nCases(); } simrisc-16.02.00/loop/screen.cc0000664000175000017500000000552514665030471015153 0ustar frankfrank#define XERR #include "loop.ih" // perform a screening void Loop::screen(double screeningAge) { // visit all modalities: for (ModBase *...) or comparable g_log << __FILE__ " performing screening at age " << screeningAge << '\n'; // org/screen: 4, screen.txt: 1 for (ModBase *modBase: d_modalities.use( d_screening.round(d_round).modalityIndices()) ) { if (not use(modBase)) continue; // adds the basic costs: screening // for lungcancer, 'costs:' for // other modalities double cost = d_costs.screening(screeningAge, modBase->cost()); d_caseCost += cost; g_log << "Screening costs, round " << (d_round + 1) << ", case " << (g_caseIdx + 1) << ": cost: " << cost << ", old sum: " << d_roundCost[d_round] << ", new sum: "; d_roundCost[d_round] += cost; g_log << d_roundCost[d_round] << '\n'; if (not d_tumor.at(screeningAge)) // no tumor, but screening may maybeFalsePositive(modBase, screeningAge); // detect a tumor else // there is a tumor which may not maybeFalseNegative(modBase, screeningAge); // be detected } g_log << __FILE__ " completed screening at age " << screeningAge << '\n'; } // // // determine the tumor // // characteristics. // if (d_tumor.selfDetectable()) // d_tumor.characteristicsAt(d_tumor.selfDetectAge()); //screeningAge); // // // Org. 2nd term: screeningAge >= d_tumor.onset()) // // test2 (see below) // if (d_tumor.selfDetectable() and d_tumor.onset() <= screeningAge) // maybeDetect(modBase, screeningAge); // else // maybeFalsePositive(modBase, screeningAge); // tumor test2 selfDetectabledetect selfDetectablefalsepos // 1 1 1 0 // 1 0 0 1 // 0 1 0 1 // 0 0 0 1 // // -> calling selfDetectableFalsePositive may not be called when just 'not d_tumor' // is true. // Sensitivity (true positive rate) refers to the probability of a positive // test, conditioned on truly being positive (so: the power) // // Specificity (true negative rate) refers to the probability of a negative // test, conditioned on truly being negative. (so: 1 - alpha) //xerr(""); //for (auto const &id: d_screening.round(d_round).modalityIDs()) //cerr<<" id: " << id <<'\n'; //xerr("use " << modBase->id()); //xerr("cpt costs"); simrisc-16.02.00/loop/caseinit.cc0000664000175000017500000000276414665030471015475 0ustar frankfrank#define XERR #include "loop.ih" extern size_t g_caseIdx; void Loop::caseInit() { g_log << "\nLoop::caseInit\n"; d_caseCost = 0; // org: womenCosts d_roundDetected = -1; // org: roundDetected d_roundInfo.assign(d_nRounds, '0'); // attendance info per round per // case at [idx] the info of round // idx is stored d_biopCosts = 0; //xerr("cptIndices"); // BC simulation: bi-rad column indices or d_indices = cptIndices(); // LC simulation: 0-vector //xerr("cumTotalRisk"); d_tumorInfo.cumTotalRisk( // 24/1 also sets the attended d_screening.radiationRisk( // 24/1 flag d_modalities, d_indices, d_tumorInfo.beir7().beta(), d_tumorInfo.beir7().eta() ) ); // naturalDeathAged is called to standardize the Random::uniformCase // calls d_options.fixedNaturalDeathAge(d_naturalDeathAge = naturalDeathAge()); d_deathAge = d_naturalDeathAge; // iniial deathAge estimate. d_status = PRESENT; d_tumor.reset(); // determine this case's tumor parameters g_log << "\n" "case init:\n" " Natural death age: " << d_naturalDeathAge << '\n' << d_tumor << '\n'; } simrisc-16.02.00/loop/cptindices.cc0000664000175000017500000000233414665030471016014 0ustar frankfrank//#define XERR #include "loop.ih" // with BreastDensities: compute the bi-rad category to use (a: 0 .. d: 3) // with LC: a 0-initialized vector of d_nRounds elements Uint16Vect Loop::cptIndices() const { Uint16Vect ret; if (not Globals::isBreast()) // LC: a 0-initialized vector is used ret.resize(d_nRounds); else // for BC: compute the indices used to obtain { // dose values double prob = Random::instance().uniform(); for (double age: d_screening.ages()) { // d_groupVector initialized at the constructor to // the LC s3 table or the Densities biRad vector. RowCol rowCol = ProbGroup::probIndexOf(*d_groupVector, age, prob); // invalid age if (rowCol.first == static_cast(string::npos)) throw Exception{} << "runtime-error: no age category for age " << age; // store the birad/s3 column index to use for prob/age: ret.push_back(rowCol.second); } } return ret; } simrisc-16.02.00/loop/loop1.cc0000664000175000017500000000077014665030471014723 0ustar frankfrank#define XERR #include "loop.ih" Loop::Loop(StringVect const &labels) : d_options(Options::instance()), d_labels(labels), d_tumor(d_tumorInfo), d_modalities(d_tumor), d_screening(d_modalities), d_nRounds(d_screening.nRounds()), d_firstRoundAge(d_nRounds == 0 ? 0 : d_screening.roundAge(0)), d_timestamp(DateTime{ DateTime::LOCALTIME }.rfc2822()), d_tnm(d_options.tnm() ? &fillTNM : &noTNM) { if (Globals::isBreast()) d_groupVector = d_densities.biRad(); } simrisc-16.02.00/loop/resetcounters.cc0000664000175000017500000000105114665030471016567 0ustar frankfrank//#define XERR #include "loop.ih" void Loop::resetCounters() { d_totalCost = 0; // org: womenCosts d_sumDeathAge = 0; // org: womenYears d_nIntervals = SizeVect(d_nRounds); d_nTrueIntervals = SizeVect(d_nRounds); d_nRoundFP = SizeVect(d_nRounds); // # of false-positives per round d_nRoundFN = SizeVect(d_nRounds); // # of false-positives per round d_nDetections = SizeVect(d_nRounds); d_roundCost = DoubleVect(d_nRounds); d_modalities.resetCounters(d_nRounds); } simrisc-16.02.00/loop/frame0000664000175000017500000000005614665030471014374 0ustar frankfrank//#define XERR #include "loop.ih" Loop:: { } simrisc-16.02.00/loop/writedata.cc0000664000175000017500000000306214665030471015652 0ustar frankfrank#define XERR #include "loop.ih" void Loop::writeData(CSVTable &tab, size_t idx) const { static Status detection[] = { SELF_PRE, SELF_DURING, SELF_POST }; // case numbers in data*.txt are now natural nrs. tab.more() << (idx + 1) << // 1 (d_deathAge == d_naturalDeathAge ? "Natural" : "Tumor") << // 2 d_deathAge << d_naturalDeathAge << d_status; // 3 - 5 d_tumor.writeData(tab); // 6 - 14 ostringstream out; if (Globals::isZero(d_tumor.diameter())) (*d_tnm)(out); else { // set the tumor S3 RowCol rowCol = d_tumor.rowCol(); // row/col. For BC out << rowCol.first << ',' << rowCol.second; // row is bc: TNM, col } // = 0 (via Survival:: // setVSD // self round // 16 17 // ** tab << static_cast(round(d_caseCost)) << // 15 static_cast(round(d_biopCosts)) << // 15-pre (find(detection, detection + size(detection), d_status) != detection + size(detection)) << // 16 showRound() << d_roundInfo << // 17 - 18 out.str(); // 19 } simrisc-16.02.00/loop/setstatus.cc0000664000175000017500000000023114665030471015720 0ustar frankfrank// #define XERR //#include "loop.ih" // //void Loop::setStatus(Status status, double age) //{ // d_status = status; // d_deathAge = age; //} // simrisc-16.02.00/loop/characteristics.cc0000664000175000017500000000226114665030471017041 0ustar frankfrank// #define XERR // #include "loop.ih" // // // treatmentDeath(): characteristics(LEFT_POST, TUMOR_POST); // // extern size_t g_caseIdx; // // void Loop::characteristics(Status natural, Status tumor) // { // // the tumor was self-detected: determine // // its characteristics // d_tumor.characteristicsAt(d_tumor.selfDetectAge()); // // d_selfDetected = true; // // // treat the tumor: add the treatment cost and compute the age of // // tumor-caused death. There is a tumor: no need to call // // diameterCheck() // d_caseCost += treatmentCosts(d_tumor.selfDetectAge()); // // d_tumor.setDeathAge(); // // if (d_naturalDeathAge < d_tumor.deathAge()) // naturally caused death // setStatus(natural, d_naturalDeathAge); // else // or tumor caused death // setStatus(tumor, d_tumor.deathAge()); // } // // // // // double cost = treatmentCosts(d_tumor.selfDetectAge()); // // xerr("costs: " << cost << ", age: " << d_tumor.selfDetectAge() << ", dia: " <<[bsl] // // d_tumor.diameter()); // // d_caseCost += cost; // simrisc-16.02.00/loop/use.cc0000664000175000017500000000416614665030471014470 0ustar frankfrank//#define XERR #include "loop.ih" // true: this modality is used // d_round contains the screening round index bool Loop::use(ModBase *modBase) { bool attends = d_screening.attend(d_round); // 24/1 // if (d_screening.rate() < Random::instance().uniform()) // 24/1 if (not attends) // 24/1 return false; // xerr("round " << d_round << ", count " << d_round); d_roundInfo[d_round] = ATTENDED; modBase->count(d_round); // screen around line 22 -> return true; } // ---------------------------------------------------------------------- // //// screen: line 26: densities not used anymore // // // uint16_t density = d_indices[d_round]; // // // NOTE: in the orig. source density NRs are used: 1..4 // // here density INDICES are usd: 0..3 // // if ( use Modalities member: // modality == MAMMOGRAPHY and d_screening.round(d_round).mammo() //// and (density == 0 or density == 1) // // ) // { // ++d_nMam[d_round]; // return true; // } // // if ( // modality == TOMOSYNTHESIS and d_screening.round(d_round).tomo() //// and (density == 2 or density == 3) // ) // { // ++d_nTomo[d_round]; // return true; // } // // return false; // return RandomPool::instance().attendance(d_round * (modality + 1) // <= d_screening.rate().value() // and // ... // ( // rndPoolAttendance[ screeningRound * (modality + 1) ] // <= // attendanceRate // ) // && // ( // ( // ( modality == 0) && // (scr[screeningRound].T0) && // ( // (density[screeningRound] == 1) // || // (density[screeningRound] == 2) // ) // ) // || // ( // ( modality == 1) && // (scr[screeningRound].T1) && // ( // (density[screeningRound] == 3) || // (density[screeningRound] == 4) // ) // ) // ) simrisc-16.02.00/loop/pretumordeath.cc0000664000175000017500000000076314665030471016556 0ustar frankfrank// //#define XERR // #include "loop.ih" // // // Woman dies because of natural cause before screening and // // does not have tumor or dies before self-detecting the tumor // // void Loop::preTumorDeath() // { // setStatus(NATURAL_PRE, d_naturalDeathAge); // // would have developed a // if (d_tumor.selfDetectable()) // tumor. Compute the tumor's // d_tumor.characteristicsAt(d_deathAge); // characteristics // } // simrisc-16.02.00/loop/iterate.cc0000664000175000017500000000256514665030471015332 0ustar frankfrank#define XERR #include "loop.ih" void Loop::iterate() { CSVTable sensTable = headerSensitivity(); // table to collect // sensitivity values Random::instance().setSeed(d_scenario.seed()); d_modalities.active(); // prepare the active Mods. for (size_t idx = 0, end = d_scenario.nIterations(); idx != end; ++idx) { ofstream spreadStream; size_t nCases = cases(); d_roundBiopCosts.assign(d_nRounds, 0); // reset the rounds biop costs Random::instance().reinit(nCases, d_scenario.generatorType()); if (Globals::vary()) // maybe vary the parameters { spreadStream = outStream(d_options.spreadFile(), idx); labels(spreadStream); d_modalities.vary(spreadStream); // vary the used modalities d_tumorInfo.vary(spreadStream); // vary Beir7, Growth, // Incidence, and Survival } writeParameters(idx); // write the actual parameter values, CSVTable rounds = headerRounds(idx); resetCounters(); genCases(idx, nCases); writeRounds(rounds); // -> ORG/loopendout.cpp writeSensitivity(sensTable, idx); } if (sensTable.stream()) sensTable << hline(); } simrisc-16.02.00/loop/preselfdetected.cc0000664000175000017500000000032514665030471017027 0ustar frankfrank// //#define XERR // #include "loop.ih" // // void Loop::preSelfDetected() // { // d_roundDetected = 0; // pre-screen tumor detected // characteristics(NATURAL_PRE, SELF_PRE); // } // // simrisc-16.02.00/main.cc0000664000175000017500000000321714665030471013643 0ustar frankfrank#define XERR #include "main.ih" // update Options::alter, Options::inspect and // Options::Options if g_longOpts is modified Arg::LongOption g_longOpts[] = { Arg::LongOption{"base", 'B'}, Arg::LongOption{"cancer", 'c' }, // breast (def.), // male, or female (implies LC) Arg::LongOption{"config", 'C'}, Arg::LongOption{"cum-death", 'd'}, Arg::LongOption{"data", 'D'}, Arg::LongOption{"death-age", 'a'}, Arg::LongOption{"err", 'e'}, Arg::LongOption{"help", 'h'}, Arg::LongOption{"last-case", 'l'}, Arg::LongOption{"log", Arg::Required}, Arg::LongOption{"one-analysis", 'o'}, Arg::LongOption{"parameters", 'P'}, Arg::LongOption{"rounds", 'R'}, Arg::LongOption{"sensitivity", 'S'}, Arg::LongOption{"spread", 's'}, Arg::LongOption{"tnm", 'T'}, Arg::LongOption{"tumor-age", 't'}, Arg::LongOption{"verbose", 'V'}, Arg::LongOption{"version", 'v'}, }; auto const *g_longEnd = g_longOpts + size(g_longOpts); //main int main(int argc, char **argv) try { Arg const &arg = Arg::initialize("a:B:c:C:d:D:el:hoP:R:S:s:t:TvV", g_longOpts, g_longEnd, argc, argv); arg.versionHelp(usage, Icmake::version, arg.option('o') ? 0 : 1); Options::instance(); // construct the Options object Simulator simulator; // construct the simulator simulator.run(); // and run it. } //= catch (...) { return handleException(); } simrisc-16.02.00/main.ih0000664000175000017500000000062014665030471013651 0ustar frankfrank#include #include #include #include #include "xerr/xerr.ih" #include "simulator/simulator.h" #include "options/options.h" namespace Icmake { extern char version[]; extern char years[]; extern char author[]; }; int handleException(); void usage(std::string const &progname); #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/mammo/0000775000175000017500000000000014665030471013513 5ustar frankfranksimrisc-16.02.00/mammo/vspecificity.cc0000664000175000017500000000112014665030471016515 0ustar frankfrank//#define XERR #include "mammo.ih" // E.g., age groups: // 0-40 // 40-100 // then by searching from the last to the first: find the agegroup // where the begin-age is < specified age. // Examples: age 50: the last group, // age 40: the first group // 'age' may not be negative double Mammo::vSpecificity(double age) const { return find_if(d_specVect.rbegin(), d_specVect.rend(), [&](AgeGroupVSD const &spec) { return spec.beginAge() < age; } )->value(); } simrisc-16.02.00/mammo/vdose1.cc0000664000175000017500000000014014665030471015216 0ustar frankfrank//#define XERR #include "mammo.ih" VSDvect const *Mammo::vDose() const { return &d_dose; } simrisc-16.02.00/mammo/mammo.ih0000664000175000017500000000030214665030471015136 0ustar frankfrank#include "mammo.h" #include "../xerr/xerr.ih" #include #include "../tumor/tumor.h" #include "../parser/parser.h" #include "../log/log.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/mammo/setsystematicerror.cc0000664000175000017500000000023314665030471017773 0ustar frankfrank//#define XERR #include "mammo.ih" void Mammo::setSystematicError() { base().back() = "systematicError:"; Parser::proportion(base(), d_sysErr); } simrisc-16.02.00/mammo/mammo.h0000664000175000017500000000323714665030471014777 0ustar frankfrank#ifndef INCLUDED_MAMMO_ #define INCLUDED_MAMMO_ #include "../enums/enums.h" #include "../modbase/modbase.h" #include "../agegroupvsd/agegroupvsd.h" // Mammo: // costs: 64 // // # bi-rad: a b c d // dose: 3 3 3 3 // m: .136 .136 .136 .136 // // # ageGroup // specificity: 0 - 40: .961 40 - *: .965 // // # 1 2 3 4 // beta: -4.38 .49 -1.34 -7.18 // // systematicError: 0.1 class Tumor; class Mammo: public ModBase { Tumor const &d_tumor; double d_sysErr; VSDvect d_dose; VSDvect d_m; VSDvect d_beta; AgeGroupVSDvect d_specVect; public: Mammo(Tumor const &tumor); ~Mammo() override; private: void setSystematicError(); void setBeta(); void setM(); VSDvect const *vDose() const override; // 1 double vDose(uint16_t) const override; // 2 void vInsert(std::ostream &out) const override; double vSensitivity(size_t idx) const override; double vSpecificity(double age) const override; void vVary(std::ostream &out) override; }; //Modalities: // // Mammo: // costs: 64 // // # bi-rad: a b c d // dose: 3 3 3 3 // m: .136 .136 .136 .136 // // # ageGroup // specificity: 0 - 40: .961 40 - *: .965 // // # 1 2 3 4 // beta: -4.38 .49 -1.34 -7.18 // // systematicError: 0.1 #endif simrisc-16.02.00/mammo/vdose2.cc0000664000175000017500000000016014665030471015221 0ustar frankfrank//#define XERR #include "mammo.ih" double Mammo::vDose(uint16_t idx) const { return d_dose[idx].value(); } simrisc-16.02.00/mammo/icmconf0000664000175000017500000000007414665030471015055 0ustar frankfrank#define LIBRARY "mammo" #include "../icmconf.lib" simrisc-16.02.00/mammo/mammo1.cc0000664000175000017500000000143214665030471015211 0ustar frankfrank#define XERR #include "mammo.ih" // Mammo: // costs: 64 // // # bi-rad: a b c d // dose: 3 3 3 3 // #Mammo: // m: .136 .136 .136 .136 // // # ageGroup // specificity: 0 - 40: .961 40 - *: .965 // // # 1 2 3 4 // #Mammo: // beta: -4.38 .49 -1.34 -7.18 // // #Mammo: // systematicError: 0.1 Mammo::Mammo(Tumor const &tumor) : ModBase("Mammo"), d_tumor(tumor) { if (not defined()) return; setSystematicError(); // must be before doseBase setM(); setBeta(); doseBase(d_dose); // ModBase members specificityBase(d_specVect); } simrisc-16.02.00/mammo/destructor.cc0000664000175000017500000000006714665030471016223 0ustar frankfrank//#define XERR #include "mammo.ih" Mammo::~Mammo() {} simrisc-16.02.00/mammo/setm.cc0000664000175000017500000000021214665030471014765 0ustar frankfrank#define XERR #include "mammo.ih" void Mammo::setM() { base().back() = "m:"; d_m = Parser::VSDparameters(VARY_PROB, base(), 4); } simrisc-16.02.00/mammo/setbeta.cc0000664000175000017500000000041714665030471015453 0ustar frankfrank#define XERR #include "mammo.ih" void Mammo::setBeta() { base().back() = "beta:"; // if (Parser::hasSection(base())) d_beta = Parser::VSDparameters(VARY_MEAN, base(), 4); // else // d_beta = Parser::VSDparameters(VARY_MEAN, { "beta:" }, 4); } simrisc-16.02.00/mammo/vinsert.cc0000664000175000017500000000121414665030471015512 0ustar frankfrank#define XERR #include "mammo.ih" void Mammo::vInsert(ostream &out) const { //Globals::setPrecision(out, 3) << Globals::setWidthPrec(out, 4, 3) << setw(4) << ' ' << "systematicError: " << d_sysErr << '\n'; VSD::fmt(6, "bi-rad:", 'a', 1, 0, 1, 0); out << setw(4) << ' ' << "Dose:\n" << d_dose; VSD::fmt(6, "bi-rad:", 'a', 0, 3, 0, 3); out << setw(4) << ' ' << "M:\n" << d_m; VSD::fmt(6, "nr:", 0, 3, 2, 0, 4); out << setw(4) << ' ' << "Beta:\n" << d_beta; AgeGroupVSD::fmt(6, 0, 3, 0, 3); out << setw(4) << ' ' << "Specificity:\n" << d_specVect; } simrisc-16.02.00/mammo/frame0000664000175000017500000000006014665030471014524 0ustar frankfrank//#define XERR #include "mammo.ih" Mammo:: { } simrisc-16.02.00/mammo/vsensitivity.cc0000664000175000017500000000144514665030471016606 0ustar frankfrank//#define XERR #include "mammo.ih" //code // cf. Isheden, G., & Humphreys, K. (2017). Modelling breast cancer tumour // growth for a stable disease population. Statistical Methods in Medical // Research, 28(3), 681-702. double Mammo::vSensitivity(size_t idx) const { double diameter = d_tumor.diameter(); double mValue = d_m[idx].value(); double expBeta = exp( d_beta[0].value() + d_beta[1].value() * diameter + d_beta[2].value() * mValue + d_beta[3].value() * mValue / (diameter * diameter) ); double ret = (1 - d_sysErr) * expBeta / (1 + expBeta); g_log << __FILE__ " idx = " << idx << ", diameter: " << diameter << ", m: " << mValue << ", sens.: " << ret << "\n"; return ret; } //= simrisc-16.02.00/mammo/vvary.cc0000664000175000017500000000047414665030471015176 0ustar frankfrank//#define XERR #include "mammo.ih" void Mammo::vVary(ostream &out) { out << " Mammo:\n"; VSD::vary(out, 4, "Dose:", "bi-rad", 'a', d_dose); VSD::vary(out, 4, "M:" , "bi-rad", 'a', d_m); VSD::vary(out, 4, "Beta:", "nr", '1', d_beta); AgeGroupVSD::vary(out, 4, "Specificity:", d_specVect); } simrisc-16.02.00/manual2oo60000775000175000017500000000011314665030471014311 0ustar frankfrank#!/bin/bash scp -r tmp/manual/html/* oosix:/var/www/ssl_icce.rug/simrisc/ simrisc-16.02.00/modalities/0000775000175000017500000000000014665030471014537 5ustar frankfranksimrisc-16.02.00/modalities/find.cc0000664000175000017500000000100114665030471015756 0ustar frankfrank//#define XERR #include "modalities.ih" uint16_t Modalities::find(std::string const &modality) const { auto iter = std::find_if(d_modalityIDs.begin(), d_modalityIDs.end(), [&](string const &available) { return modality == available; } ); return iter != d_modalityIDs.end() ? iter - d_modalityIDs.begin() : UNDEFINED; } simrisc-16.02.00/modalities/vary.cc0000664000175000017500000000030714665030471016027 0ustar frankfrank//#define XERR #include "modalities.ih" void Modalities::vary(ostream &out) { out << "Modalities\n"; for (ModBase *modBase: d_modBaseVect) modBase->vary(out); out.put('\n'); } simrisc-16.02.00/modalities/addmod.cc0000664000175000017500000000066014665030471016300 0ustar frankfrank//#define XERR #include "modalities.ih" void Modalities::addMod(ModBase *modBase) // d_base in ModBase, initialized { // to { modName, "costs:" }, // read by costs/costs1.cc if (not modBase->defined()) { delete modBase; return; } d_modBaseVect.push_back(modBase); d_modalityIDs.push_back(modBase->id()); } simrisc-16.02.00/modalities/modalities.f0000664000175000017500000000027214665030471017041 0ustar frankfrankinline StringVect const &Modalities::modalityIDs() const { return d_modalityIDs; } inline void Modalities::activate(std::string const &modality) { d_active.emplace(modality); } simrisc-16.02.00/modalities/modalities.ih0000664000175000017500000000047114665030471017215 0ustar frankfrank#include "modalities.h" #include "../xerr/xerr.ih" #include #include #include #include "../globals/globals.h" #include "../tomo/tomo.h" #include "../mammo/mammo.h" #include "../mri/mri.h" #include "../ct/ct.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/modalities/icmconf0000664000175000017500000000010114665030471016070 0ustar frankfrank#define LIBRARY "modalities" #include "../icmconf.lib" simrisc-16.02.00/modalities/writeparameters.cc0000664000175000017500000000032414665030471020263 0ustar frankfrank//#define XERR #include "modalities.ih" void Modalities::writeParameters(ostream &out) const { out << "Modalities:\n" "\n"; for (auto modBasePtr: d_modBaseVect) out << *modBasePtr; } simrisc-16.02.00/modalities/destructor.cc0000664000175000017500000000021314665030471017240 0ustar frankfrank//#define XERR #include "modalities.ih" Modalities::~Modalities() { for (auto modBasePtr: d_modBaseVect) delete modBasePtr; } simrisc-16.02.00/modalities/modalities1.cc0000664000175000017500000000047414665030471017266 0ustar frankfrank#define XERR #include "modalities.ih" #include "../parser/parser.h" Modalities::Modalities(Tumor const &tumor) : d_tumor(tumor) { if (not Globals::isBreast()) addMod(new CT{ d_tumor }); else { addMod(new Mammo{ d_tumor }); addMod(new Tomo); addMod(new MRI); } } simrisc-16.02.00/modalities/roundheaders.cc0000664000175000017500000000032014665030471017524 0ustar frankfrank//#define XERR #include "modalities.ih" void Modalities::roundHeaders(CSVTable &tab) const { for (ModBase const *modBase: d_activeVect) // insert the IDs tab.more() << modBase->id(); } simrisc-16.02.00/modalities/writerounds.cc0000664000175000017500000000034214665030471017432 0ustar frankfrank#define XERR #include "modalities.ih" void Modalities::writeRounds(CSVTable &tab, size_t round) const { for (ModBase const *modBase: d_activeVect) // insert the values tab.more() << (*modBase)[round]; } simrisc-16.02.00/modalities/modalities.comment0000664000175000017500000000525314665030471020262 0ustar frankfrank //////////////////////////////////////////////////////////////////// // // 1st dimension is the type index, // // 2nd dimension is the id dimension // ParamsVect2 d_modality; // // static Map s_type; // static Map s_id; // // class Params // { // friend class Modalities; // // double d_dose[N_DOSES]; // double d_sens[N_SENS]; // sensitivities // SpecVect d_spec; // specificities // // public: // double const *dose() const; // double const *sens() const; // // double dose(size_t idx) const; // double sens(size_t idx) const; // Specificity const &operator[](size_t idx) const; // }; // // typedef std::vector ParamsVect; // typedef std::vector ParamsVect2; // // // // ParamsVect const &operator[](size_t idx) const; // // Params const &mammoParams() const; // Params const &tomoParams() const; // // void writeParameters(std::ostream &out) const; // 1 // // private: // void params(std::ostream &out, char const *label, Constants type) // const; // void birads(std::ostream &out, char const *label, // double const *value, Constants count) const; // // // void makeRoom(uint16_t typeIdx, uint16_t idIdx); // // static bool readSpecificities(std::istream &in, Params ¶ms); // inline Modalities::ParamsVect const &Modalities::operator[](size_t idx) const // { // return d_modality[idx]; // } // // inline Modalities::Params const &Modalities::mammoParams() const // { // return d_modality[XRAY][MAMMO]; // } // // inline Modalities::Params const &Modalities::tomoParams() const // { // return d_modality[XRAY][TOMO]; // } // // inline uint16_t Modalities::Specificity::beginAge() const // { // return d_beginAge; // } // // inline uint16_t Modalities::Specificity::endAge() const // { // return d_endAge; // } // // inline double Modalities::Specificity::value() const // { // return d_value; // } // // inline double Modalities::Params::dose(size_t idx) const // { // return d_dose[idx]; // } // // inline double const *Modalities::Params::dose() const // { // return d_dose; // } // // inline double Modalities::Params::sens(size_t idx) const // { // return d_sens[idx]; // } // // inline double const *Modalities::Params::sens() const // { // return d_sens; // } // // inline Modalities::Specificity // const &Modalities::Params::operator[](size_t idx) const // { // return d_spec[idx]; // } simrisc-16.02.00/modalities/active.cc0000664000175000017500000000043414665030471016322 0ustar frankfrank#define XERR #include "modalities.ih" void Modalities::active() { for (string const &modality: // use sorted modality names set{ d_active.begin(), d_active.end() }) d_activeVect.push_back(d_modBaseVect[ find(modality) ]); } simrisc-16.02.00/modalities/roundfmt.cc0000664000175000017500000000054114665030471016704 0ustar frankfrank#define XERR #include "modalities.ih" size_t Modalities::roundFmt(CSVTable &tab) const { if (d_activeVect.size() == 1) { tab.fmt(tab.size()) << "number of"; return 1; } size_t nActive = d_activeVect.size(); for (size_t idx = 0; idx != nActive; ++idx) tab.fmt(tab.size()) << "12345"; return nActive; } simrisc-16.02.00/modalities/resetcounters.cc0000664000175000017500000000025714665030471017757 0ustar frankfrank#define XERR #include "modalities.ih" void Modalities::resetCounters(size_t nRounds) { for (auto modBasePtr: d_modBaseVect) modBasePtr->resetCounters(nRounds); } simrisc-16.02.00/modalities/frame0000664000175000017500000000007214665030471015553 0ustar frankfrank//#define XERR #include "modalities.ih" Modalities:: { } simrisc-16.02.00/modalities/modalities.h0000664000175000017500000000417614665030471017052 0ustar frankfrank#ifndef INCLUDED_MODALITIES_ #define INCLUDED_MODALITIES_ // See README #include #include #include "../typedefs/typedefs.h" #include "../enums/enums.h" class ModBase; class Tumor; namespace FBB { class CSVTable; } class Modalities { Tumor const &d_tumor; // used by Mammo and CT std::vector d_modBaseVect; // defined modalities StringVect d_modalityIDs; // and their IDs StringSet d_active; // the active modalities std::vector d_activeVect; // ptrs to active modalities public: Modalities(Tumor const &tumor); ~Modalities(); // visit all modalities and initialize // their data, see loop/initialize // see also Loop::d_nModalityFP: modality specific, to become // a size_t variables in each used modality void resetCounters(size_t nRounds); // returns UNDEFINED if 'modality' is unknown uint16_t find(std::string const &modality) const; // return a vector of ModBase ptrs matching the names specified // in 'active' std::vector use(Uint16Vect const &active) const; StringVect const &modalityIDs() const; void vary(std::ostream &out); void writeParameters(std::ostream &out) const; // determine the Mod. size_t roundFmt(FBB::CSVTable &tab) const; // #fields & width void roundHeaders(FBB::CSVTable &tab) const; // write the Mod names // write the Mod data void writeRounds(FBB::CSVTable &tmp, size_t round) const; void active(); // sets d_activeVect void activate(std::string const &modality); private: void addMod(ModBase *modBase); }; // double specificity(age) const: age may not be negative // currently not used // double const *hasDose(StringVect const &ids) const; #include "modalities.f" #endif simrisc-16.02.00/modalities/use.cc0000664000175000017500000000061014665030471015637 0ustar frankfrank//#define XERR #include "modalities.ih" vector Modalities::use(Uint16Vect const &active) const { vectorret; for (uint16_t idx: active) ret.push_back(d_modBaseVect[idx]); // store the Modality ptr // return ptrs to the return ret; // requested Modality handlers } simrisc-16.02.00/modbase/0000775000175000017500000000000014665030471014017 5ustar frankfranksimrisc-16.02.00/modbase/vdose1.cc0000664000175000017500000000013614665030471015527 0ustar frankfrank//#define XERR #include "modbase.ih" VSDvect const *ModBase::vDose() const { return 0; } simrisc-16.02.00/modbase/modbase1.cc0000664000175000017500000000035114665030471016020 0ustar frankfrank//#define XERR #include "modbase.ih" ModBase::ModBase(string const &id) : d_base{ id + ':', "costs:" }, d_id(id), d_defined(Parser::hasSection(d_base)) { if (d_defined) Parser::nonNegative(d_base, d_cost); } simrisc-16.02.00/modbase/opinsert.cc0000664000175000017500000000041314665030471016167 0ustar frankfrank//#define XERR #include "modbase.ih" std::ostream &operator<<(std::ostream &out, ModBase const &modBase) { out << " " << modBase.id() << ":\n" << " costs: " << modBase.d_cost << '\n'; modBase.vInsert(out); return out.put('\n'); } simrisc-16.02.00/modbase/extractbase.cc0000664000175000017500000000041114665030471016627 0ustar frankfrank//#define XERR #include "modbase.ih" // used by MRI and CT void ModBase::extractBase(VSD &dest) { auto lines = Parser::one(d_base); // get one line LineInfo const *line = lines.get(); if (line != 0) Parser::extract(*line, dest); } simrisc-16.02.00/modbase/vdose2.cc0000664000175000017500000000016314665030471015530 0ustar frankfrank//#define XERR #include "modbase.ih" double ModBase::vDose([[maybe_unused]] uint16_t idx) const { return 0; } simrisc-16.02.00/modbase/icmconf0000664000175000017500000000007614665030471015363 0ustar frankfrank#define LIBRARY "modbase" #include "../icmconf.lib" simrisc-16.02.00/modbase/destructor.cc0000664000175000017500000000007514665030471016526 0ustar frankfrank//#define XERR #include "modbase.ih" ModBase::~ModBase() {} simrisc-16.02.00/modbase/specificitybase.cc0000664000175000017500000000170514665030471017477 0ustar frankfrank#define XERR #include "modbase.ih" // # ageGroup // specificity: 0 - 40: .961 40 - *: .965 void ModBase::specificityBase(AgeGroupVSDvect &dest) { d_base.back() = "specificity:"; auto lines = Parser::one(d_base); if (lines.size() != 1) // keywords not found return; istringstream in{ lines.get()->tail }; // prepare for extraction bool nextRange = false; while (true) { AgeGroupVSD spec{ VARY_PROB, false }; // agegroupvsd w/o sd. if (not (in >> spec)) // try to extract break; // no (more) nextRange = spec.group().nextRange(dest); //FBB spec.ageGroup().nextRange(dest)) if (not nextRange) break; dest.push_back(move(spec)); if (spec.group().end() == END_AGE) return; } if (not nextRange) Err::specification(); } simrisc-16.02.00/modbase/outspec.cc0000664000175000017500000000071414665030471016012 0ustar frankfrank//#define XERR #include "modbase.ih" // static void ModBase::outSpec(ostream &out, char const *prefix, unsigned fill, AgeGroupVSD const &spec) { out << prefix << setw(fill) << ' ' << setw(2) << spec.beginAge() << " - " << setw(2); if (Globals::isZero(spec.endAge() - END_AGE)) out << '*'; else out << spec.endAge(); out << ':' << setw(6) << spec.value() << ";\n"; } simrisc-16.02.00/modbase/dosebase.cc0000664000175000017500000000024514665030471016114 0ustar frankfrank#define XERR #include "modbase.ih" void ModBase::doseBase(VSDvect &dose) { d_base.back() = "dose:"; dose = Parser::VSDparameters(VARY_NONNEG, d_base, 4); } simrisc-16.02.00/modbase/modbase.ih0000664000175000017500000000023214665030471015750 0ustar frankfrank#include "modbase.h" #include "../xerr/xerr.ih" #include "../globals/globals.h" #include "../parser/parser.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/modbase/resetcounters.cc0000664000175000017500000000022114665030471017226 0ustar frankfrank//#define XERR #include "modbase.ih" void ModBase::resetCounters(size_t nRounds) { d_count = SizeVect(nRounds); d_falsePositives = 0; } simrisc-16.02.00/modbase/modbase.h0000664000175000017500000000477514665030471015617 0ustar frankfrank#ifndef INCLUDED_MODBASE_ #define INCLUDED_MODBASE_ // see ../modalities/README #include #include #include "../err/err.h" #include "../typedefs/typedefs.h" #include "../agegroupvsd/agegroupvsd.h" class ModBase { friend std::ostream &operator<<(std::ostream &, ModBase const &); StringVect d_base; std::string const d_id; bool d_defined; size_t d_cost = 0; // cost of using th modality SizeVect d_count; uint16_t d_falsePositives; public: ModBase(std::string const &id); virtual ~ModBase(); size_t cost() const; // .f void count(size_t round); // .f bool defined() const; // .f double dose(uint16_t idx) const; // .f void falsePositive(); // .f std::string const &id() const; // .f size_t operator[](size_t round) const; // .f void resetCounters(size_t nRounds); double sensitivity(size_t idx) const; // .f double specificity(double age) const; // .f void vary(std::ostream &out); // see Growth::vary() // .f protected: StringVect &base(); // .f void doseBase(VSDvect &dose); void extractBase(VSD &dest); // used by MRI and CT // ageGroup and specificity // sets keywords: [2]: Specificity // [3]: ageGroup void specificityBase(AgeGroupVSDvect &dest); private: // vDose members return 0 virtual VSDvect const *vDose() const; // 1 virtual double vDose(uint16_t idx) const; // 2 virtual void vInsert(std::ostream &out) const = 0; virtual double vSensitivity(size_t idx) const = 0; virtual double vSpecificity(double age) const = 0; virtual void vVary(std::ostream &out) = 0; static void outSpec(std::ostream &out, char const *prefix, unsigned fill, AgeGroupVSD const &spec); }; // protected void costBase(StringVect &keywords); sets d_cost from "costs:" #include "modbase.f" #endif simrisc-16.02.00/modbase/frame0000664000175000017500000000006414665030471015034 0ustar frankfrank//#define XERR #include "modbase.ih" ModBase:: { } simrisc-16.02.00/modbase/modbase.f0000664000175000017500000000143014665030471015576 0ustar frankfrankinline StringVect &ModBase::base() { return d_base; } inline size_t ModBase::cost() const { return d_cost; } inline void ModBase::count(size_t round) { ++d_count[round]; } inline bool ModBase::defined() const { return d_defined; } inline void ModBase::falsePositive() { ++d_falsePositives; } inline std::string const &ModBase::id() const { return d_id; } inline double ModBase::dose(uint16_t idx) const { return vDose(idx); } inline size_t ModBase::operator[](size_t idx) const { return d_count[idx]; } inline double ModBase::sensitivity(size_t idx) const { return vSensitivity(idx); } inline double ModBase::specificity(double age) const { return vSpecificity(age); } inline void ModBase::vary(std::ostream &out) { return vVary(out); } simrisc-16.02.00/modifications0000664000175000017500000000316214665030471015162 0ustar frankfrank3: cumDeathProbs are not read from file, but are hard-coded in Loop::s_cumDeathProb. 4. The costs are not read from file anymore, but are specified in the configuration file at 'costs:', reading values for, resp.: cost_XM cost_Tomo cost_<2 cost_2-5 cost_>5 cost_biop discount (all ints, except for the last, a double. 5. Cf calculateSize: when computing _volume = _startVolume * //Exponential growth of tumorvolume pow(2.0, ((womenAge - _preclinAge) / _doublingTimeYear)); using floats, then for values, resp. 65.4499, 40, 26.1368 and 0.109376 _volume is 'inf' when using floats, but in fact (using doubles) it is 9.34711e+39. -> the new version uses doubles, and avoids floats. 6. loop/loop.h: // NOTE: in the orig. source density NRs are used: 1..4 // here density INDICES are usd: 0..3 // but when writing the data file (e.g., data-0.txt, original // name e.g., women-test-i0.txt) a + 1 correction is // currently applied bool use(size_t modality); //+ use this modality See also loop/sensitivity1.cc loop/results.cc and densities/biradsidx.cc 7: the 'no tumor' age is computed as -1, not as 0 as reported in the original program. See tumor/results.cc. Also see tumor/reset: when there is no tumor all ages are reported as -1, and start volume and self-detect (diameter) are set to 0 8. To synchronize the output of the current and original program, tumor diameters exceeding 1000 mm. are reported as 1001 mm (used to be 'inf') (tumor/results.cc) simrisc-16.02.00/mri/0000775000175000017500000000000014665030471013174 5ustar frankfranksimrisc-16.02.00/mri/vspecificity.cc0000664000175000017500000000016314665030471016204 0ustar frankfrank//#define XERR #include "mri.ih" double MRI::vSpecificity(double age) const { return d_specificity.value(); } simrisc-16.02.00/mri/setspecificity.cc0000664000175000017500000000015514665030471016533 0ustar frankfrank//#define XERR #include "mri.ih" void MRI::setSpecificity() { extract("specificity:", d_specificity); } simrisc-16.02.00/mri/setsensitivity.cc0000664000175000017500000000015514665030471016612 0ustar frankfrank//#define XERR #include "mri.ih" void MRI::setSensitivity() { extract("sensitivity:", d_sensitivity); } simrisc-16.02.00/mri/icmconf0000664000175000017500000000007214665030471014534 0ustar frankfrank#define LIBRARY "mri" #include "../icmconf.lib" simrisc-16.02.00/mri/extract.cc0000664000175000017500000000021414665030471015152 0ustar frankfrank//#define XERR #include "mri.ih" void MRI::extract(char const *keyword, VSD &dest) { base().back() = keyword; extractBase(dest); } simrisc-16.02.00/mri/mri.h0000664000175000017500000000144714665030471014142 0ustar frankfrank#ifndef INCLUDED_MRI_ #define INCLUDED_MRI_ #include #include "../vsd/vsd.h" #include "../modbase/modbase.h" // MRI: // costs: 280 // # value spread distr. // sensitivity: .94 0.005 Normal // specificity: .95 0.005 Normal class MRI: public ModBase { VSD d_sensitivity; VSD d_specificity; public: MRI(); ~MRI() override; private: void setSensitivity(); void setSpecificity(); void vInsert(std::ostream &out) const override; double vSensitivity(size_t idx) const override; double vSpecificity(double age) const override; void vVary(std::ostream &out) override; void extract(char const *keyword, VSD &dest); }; #endif simrisc-16.02.00/mri/destructor.cc0000664000175000017500000000006114665030471015676 0ustar frankfrank//#define XERR #include "mri.ih" MRI::~MRI() {} simrisc-16.02.00/mri/vinsert.cc0000664000175000017500000000036714665030471015203 0ustar frankfrank//#define XERR #include "mri.ih" void MRI::vInsert(ostream &out) const { VSD::fmt(0, 2, 0, 3); out << setw(4) << ' ' << "sensitivity: " << d_sensitivity << '\n'; out << setw(4) << ' ' << "specificity: " << d_specificity << '\n'; } simrisc-16.02.00/mri/mri.ih0000664000175000017500000000025314665030471014305 0ustar frankfrank#include "mri.h" #include "../xerr/xerr.ih" #include #include "../globals/globals.h" #include "../parser/parser.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/mri/mri1.cc0000664000175000017500000000057114665030471014356 0ustar frankfrank//#define XERR #include "mri.ih" // configfile lines: // MRI cost: 280 // sensitivity: .94 0.005 Normal // specificity: .95 0.005 Normal MRI::MRI() : ModBase("MRI"), d_sensitivity(VARY_PROB), d_specificity(VARY_PROB) { if (not defined()) return; setSpecificity(); setSensitivity(); } simrisc-16.02.00/mri/frame0000664000175000017500000000005414665030471014210 0ustar frankfrank//#define XERR #include "mri.ih" MRI:: { } simrisc-16.02.00/mri/vsensitivity.cc0000664000175000017500000000016314665030471016263 0ustar frankfrank//#define XERR #include "mri.ih" double MRI::vSensitivity(size_t idx) const { return d_sensitivity.value(); } simrisc-16.02.00/mri/vvary.cc0000664000175000017500000000044014665030471014650 0ustar frankfrank//#define XERR #include "mri.ih" // override void MRI::vVary(ostream &out) { d_sensitivity.vary(); d_specificity.vary(); out << " MRI:\n" " sensitivity: "; d_sensitivity.showVary(out); out << " specificity: "; d_specificity.showVary(out); } simrisc-16.02.00/options/0000775000175000017500000000000014665030471014100 5ustar frankfranksimrisc-16.02.00/options/unused0000664000175000017500000000052514665030471015330 0ustar frankfrank// std::string d_cumTotalriskFile; // std::string const &totalriskFile() const; // .h // only used in Simulator, but there it's commented out // std::string const &deathProb() const; // .h //inline std::string const &Options::totalriskFile() const //{ // return d_cumTotalriskFile; //} simrisc-16.02.00/options/instance.cc0000664000175000017500000000031414665030471016211 0ustar frankfrank//#define XERR #include "options.ih" // static Options &Options::instance() { if (s_options == 0) s_options = new Options; // Note: not deleted at end of program return *s_options; } simrisc-16.02.00/options/data.cc0000664000175000017500000000061114665030471015316 0ustar frankfrank//#define XERR #include "options.ih" Options *Options::s_options; char const Options::s_base[] = "./"; char const Options::s_config[] = "~/.config/simrisc"; unordered_map Options::s_fileName { { 'D', "+data-$.txt" }, { 'P', "" }, { 'R', "+rounds-$.txt" }, { 'S', "+sensitivity.txt" }, { 's', "+spread-$.txt" }, }; simrisc-16.02.00/options/logoption.cc0000664000175000017500000000064614665030471016427 0ustar frankfrank#define XERR #include "options.ih" void Options::logOption(string const &value) { istringstream in{ value }; unsigned begin; unsigned end; string fname; string ignored; if (not (in >> begin >> end >> fname)) throw Exception{} << "--log '" << value << "': specification error"; in >> ignored; // may remain empty g_log.set(begin, end, fname, ignored); } simrisc-16.02.00/options/replaceplus.cc0000664000175000017500000000031214665030471016722 0ustar frankfrank//#define XERR #include "options.ih" void Options::replacePlus(string &fname) { if (not fname.empty() and fname.front() == '+') fname.replace(0, 1 + (fname[1] == '/'), d_base[ANALYSIS]); } simrisc-16.02.00/options/options1.cc0000664000175000017500000000175614665030471016174 0ustar frankfrank#define XERR #include "options.ih" Options::Options() : d_arg(Arg::instance()), d_naturalDeathAge(END_AGE), d_tumorAge(END_AGE), d_lastCase(0) { imsg.off(); if (char *cp = getenv("HOME"); cp) d_home = cp; if (d_arg.option('V')) { d_specified[STARTUP] += 'V'; imsg.on(); } configOption(); // set d_config[STARTUP] baseOption(); fileOption(d_dataFile, 'D'); fileOption(d_roundsFile, 'R'); fileOption(d_sensitivityFile, 'S'); fileOption(d_spreadFile, 's'); fileOption(d_parametersFile, 'P'); string value; if (d_arg.option(&value, 'a')) deathAgeOption(value); if (d_arg.option(&value, 'd')) cumDeathOption(value); if (d_arg.option(&value, 't')) tumorAgeOption(value); if (d_arg.option(&value, 'l')) lastCaseOption(value); if (d_arg.option(&value, "log")) logOption(value); setSimulationType(); // 'c' } simrisc-16.02.00/options/lastcaseoption.cc0000664000175000017500000000022214665030471017433 0ustar frankfrank//#define XERR #include "options.ih" void Options::lastCaseOption(string const &value) { d_specified[STARTUP] += 'l'; lastCase(value); } simrisc-16.02.00/options/tumorageoption.cc0000664000175000017500000000022214665030471017457 0ustar frankfrank//#define XERR #include "options.ih" void Options::tumorAgeOption(string const &value) { d_specified[STARTUP] += 't'; tumorAge(value); } simrisc-16.02.00/options/activate.cc0000664000175000017500000000136314665030471016212 0ustar frankfrank#define XERR #include "options.ih" void Options::activate() { // activate the options, to be used in the analyses. // d_specified contains the single-letter option characters // of the options that were specified on the command-line d_specified[ANALYSIS] = d_specified[STARTUP]; d_base[ANALYSIS] = d_base[STARTUP]; d_cancer[ANALYSIS] = d_cancer[STARTUP]; d_config[ANALYSIS] = d_config[STARTUP]; d_dataFile[ANALYSIS] = d_dataFile[STARTUP]; d_parametersFile[ANALYSIS] = d_parametersFile[STARTUP]; d_roundsFile[ANALYSIS] = d_roundsFile[STARTUP]; d_sensitivityFile[ANALYSIS] = d_sensitivityFile[STARTUP]; d_spreadFile[ANALYSIS] = d_spreadFile[STARTUP]; } simrisc-16.02.00/options/setsimulationtype.cc0000664000175000017500000000126114665030471020211 0ustar frankfrank#define XERR #include "options.ih" void Options::setSimulationType() // handle -c option { string value; // not specified -> if (not d_arg.option(&value, 'c')) // reconfigurable d_cancer[STARTUP] = Globals::defaultSimType(); // default: BREAST else if (Globals::findSimType(value)) { d_specified[STARTUP] += 'c'; // option -c was d_cancer[STARTUP] = value; // specified } else throw Exception{} << "specify '--cancer breast', " "'--cancer male', or '--cancer female'"; } simrisc-16.02.00/options/tumorage.cc0000664000175000017500000000021714665030471016232 0ustar frankfrank//#define XERR #include "options.ih" void Options::tumorAge(string const &value) { d_specificAges = true; d_tumorAge = stod(value); } simrisc-16.02.00/options/alter.cc0000664000175000017500000000306614665030471015523 0ustar frankfrank//#define XERR #include "options.ih" bool Options::alter(int optChar, std::string const &value) { // if a command-line option was specified, then do not alter // options in 'Analysis: specifications // if (d_specified[ANALYSIS].find(optChar) != string::npos) return false; d_specified[ANALYSIS] += optChar; switch (optChar) // these options can be altered { // they set the [1] parameters case 'a': deathAge(value); break; case 'B': d_base[ANALYSIS] = value; break; case 'c': d_cancer[ANALYSIS] = value; break; case 'C': d_config[ANALYSIS] = value; break; case 'D': d_dataFile[ANALYSIS] = value; break; case 'l': lastCase(value); break; case 'o': throw Exception{} << "`one-scenario' cannot be used in scenario specifications"; break; case 'P': d_parametersFile[ANALYSIS] = value; break; case 'R': d_roundsFile[ANALYSIS] = value; break; case 'S': d_sensitivityFile[ANALYSIS] = value; break; case 's': d_spreadFile[ANALYSIS] = value; break; case 't': tumorAge(value); break; case 'V': d_specified[ANALYSIS] += 'V'; imsg.on(); break; } return true; } simrisc-16.02.00/options/actualize.cc0000664000175000017500000000121614665030471016370 0ustar frankfrank#define XERR #include "options.ih" void Options::actualize() // transform ~ and + { d_specificAges = d_specified[STARTUP].find("at") != string::npos; replaceHome(d_config[ANALYSIS]); replaceHome(d_cumDeath); setBase(); replacePlus(d_cumDeath); replacePlus(d_dataFile[ANALYSIS]); replacePlus(d_parametersFile[ANALYSIS]); replacePlus(d_roundsFile[ANALYSIS]); replacePlus(d_sensitivityFile[ANALYSIS]); replacePlus(d_spreadFile[ANALYSIS]); Globals::setSimType(d_cancer[ANALYSIS]); // set the cancer type conflictCheck(); // prevent conflicting options } simrisc-16.02.00/options/configoption.cc0000664000175000017500000000044214665030471017105 0ustar frankfrank//#define XERR #include "options.ih" void Options::configOption() { string value; if (d_arg.option(&value, 'C')) d_specified[STARTUP] += 'C'; else value = s_config; d_config[STARTUP] = value; imsg << "using configuration file `" << value << "'\n"; } simrisc-16.02.00/options/fixednaturaldeathage.cc0000664000175000017500000000030414665030471020555 0ustar frankfrank//#define XERR #include "options.ih" void Options::fixedNaturalDeathAge(double &deathAge) const { if (d_specified[ANALYSIS].find('a') != string::npos) deathAge = d_naturalDeathAge; } simrisc-16.02.00/options/deathageoption.cc0000664000175000017500000000022214665030471017376 0ustar frankfrank//#define XERR #include "options.ih" void Options::deathAgeOption(string const &value) { d_specified[STARTUP] += 'a'; deathAge(value); } simrisc-16.02.00/options/lastcase.cc0000664000175000017500000000022314665030471016203 0ustar frankfrank#define XERR #include "options.ih" void Options::lastCase(string const &value) { // xerr("value: " << value); d_lastCase = stoul(value); } simrisc-16.02.00/options/icmconf0000664000175000017500000000007614665030471015444 0ustar frankfrank#define LIBRARY "options" #include "../icmconf.lib" simrisc-16.02.00/options/options.h0000664000175000017500000001042314665030471015744 0ustar frankfrank#ifndef INCLUDED_OPTIONS_ #define INCLUDED_OPTIONS_ #include #include #include #include "../enums/enums.h" namespace FBB { class Arg; } class Options { enum Specified { STARTUP, ANALYSIS }; FBB::Arg const &d_arg; std::string d_cumDeath; // file containing the cum. death props. std::string d_home; // current 'HOME' directory std::string d_specified[2]; // specified options: // [0]: command-line, [1]: analysis bool d_specificAges = false; double d_naturalDeathAge; // single run, subject age double d_tumorAge; // single run, tumor self-detect age size_t d_lastCase; // compute until d_lastCase, report // d_lastCase's results std::string d_base[2]; // guaranteed to end in '/' // [0]: as specified, [1]: as used // in Analysis: sections std::string d_cancer[2]; // [0]: as specified, [1]: as used // in Analysis: sections std::string d_config[2]; // [0]: as specified, [1]: as used // in Analysis: sections std::string d_dataFile[2]; // [0]: as specified, [1]: as used // after replacing + by base std::string d_parametersFile[2]; std::string d_roundsFile[2]; std::string d_sensitivityFile[2]; std::string d_spreadFile[2]; static char const s_base[]; static char const s_config[]; static std::unordered_map s_fileName; static Options *s_options; public: static Options &instance(); Options(Options const &other) = delete; void reset(); // reset options to the // default/command-line values std::string const &base() const; // .f std::string const &configFile() const; // .f std::string const &cumDeathFile() const; // .f std::string const ¶metersFile() const; // .f std::string const &dataFile() const; // .f std::string const &roundsFile() const; // .f std::string const &sensitivityFile() const; // .f std::string const &spreadFile() const; // .f bool specificAges() const; // .f void fixedNaturalDeathAge(double &deathAge) const; void fixedTumorAge(double &tumorAge) const; size_t lastCase() const; // .f void activate(); // [ANALYSIS] = [STARTUP] // try to change this option's // value in this analysis bool alter(int optChar, std::string const &value); void actualize(); // transform ~ and + bool tnm() const; // --tnm was specified private: Options(); void baseOption(); void configOption(); void cumDeathOption(std::string const &value); void conflictCheck() const; // prevent conflicting options void deathAge(std::string const &value); void deathAgeOption(std::string const &value); void fileOption(std::string *dest, int option); void lastCase(std::string const &value); void lastCaseOption(std::string const &value); void logOption(std::string const &value); // xxx[STARTUP]: as specified, xxx[ANALYSIS]: as used void replaceHome(std::string &path); void replacePlus(std::string &fname); void setBase(); void setSimulationType(); // handle the -c option void tumorAge(std::string const &value); void tumorAgeOption(std::string const &value); // dest[0]: as specified, dest[1]: as used // void setFile(std::string *dest, std::string const &newValue, // 2 // int option); }; #include "options.f" #endif simrisc-16.02.00/options/replacehome.cc0000664000175000017500000000051414665030471016673 0ustar frankfrank//#define XERR #include "options.ih" void Options::replaceHome(string &path) { static bool warned = false; if (not path.empty() and path.front() == '~') path.replace(0, 1, d_home); if (d_home.empty() and not warned) { warned = true; wmsg << "No HOME environment variable found\n"; } } simrisc-16.02.00/options/options.ih0000664000175000017500000000041214665030471016112 0ustar frankfrank#include "options.h" #include "../xerr/xerr.ih" #include #include #include #include #include "../globals/globals.h" #include "../log/log.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/options/options.f0000664000175000017500000000156114665030471015745 0ustar frankfrankinline std::string const &Options::base() const { return d_base[ANALYSIS]; } inline std::string const &Options::configFile() const { return d_config[ANALYSIS]; } inline std::string const &Options::cumDeathFile() const { return d_cumDeath; } inline size_t Options::lastCase() const { return d_lastCase; } inline std::string const &Options::parametersFile() const { return d_parametersFile[ANALYSIS]; } inline std::string const &Options::dataFile() const { return d_dataFile[ANALYSIS]; } inline std::string const &Options::roundsFile() const { return d_roundsFile[ANALYSIS]; } inline std::string const &Options::sensitivityFile() const { return d_sensitivityFile[ANALYSIS]; } inline std::string const &Options::spreadFile() const { return d_spreadFile[ANALYSIS]; } inline bool Options::specificAges() const { return d_specificAges; } simrisc-16.02.00/options/tnm.cc0000664000175000017500000000014214665030471015202 0ustar frankfrank//#define XERR #include "options.ih" bool Options::tnm() const { return d_arg.option('T'); } simrisc-16.02.00/options/setbase.cc0000664000175000017500000000025514665030471016037 0ustar frankfrank#define XERR #include "options.ih" void Options::setBase() { replaceHome(d_base[ANALYSIS]); if (d_base[ANALYSIS].back() != '/') d_base[ANALYSIS] += '/'; } simrisc-16.02.00/options/baseoption.cc0000664000175000017500000000054514665030471016556 0ustar frankfrank//#define XERR #include "options.ih" void Options::baseOption() { string value; if (d_arg.option(&value, 'B')) // get the option's value d_specified[STARTUP] += 'B'; else value = s_base; // or use the default d_base[STARTUP] = value; imsg << "using base directory `" << value << "'\n"; } simrisc-16.02.00/options/deathage.cc0000664000175000017500000000022614665030471016151 0ustar frankfrank//#define XERR #include "options.ih" void Options::deathAge(string const &value) { d_specificAges = true; d_naturalDeathAge = stod(value); } simrisc-16.02.00/options/cumdeathoption.cc0000664000175000017500000000022514665030471017431 0ustar frankfrank//#define XERR #include "options.ih" void Options::cumDeathOption(string const &value) { d_specified[STARTUP] += 'd'; d_cumDeath = value; } simrisc-16.02.00/options/conflictcheck.cc0000664000175000017500000000076514665030471017216 0ustar frankfrank//#define XERR #include "options.ih" void Options::conflictCheck() const { size_t count = (d_specified[ANALYSIS].find('a') != string::npos) + (d_specified[ANALYSIS].find('t') != string::npos); if (count == 1) throw Exception{} << "Options --death-age and --tumor-age " "must both be specified"; if (count != 0 and d_specified[ANALYSIS].find('c') != string::npos) throw Exception{} << "--case and --death_age are mutually exclusive"; } simrisc-16.02.00/options/frame0000664000175000017500000000006414665030471015115 0ustar frankfrank//#define XERR #include "options.ih" Options:: { } simrisc-16.02.00/options/fixedtumorage.cc0000664000175000017500000000026614665030471017256 0ustar frankfrank//#define XERR #include "options.ih" void Options::fixedTumorAge(double &tumorAge) const { if (d_specified[ANALYSIS].find('t') != string::npos) tumorAge = d_tumorAge; } simrisc-16.02.00/options/fileoption.cc0000664000175000017500000000115514665030471016561 0ustar frankfrank#define XERR #include "options.ih" // dest[0] (STARTUP): as specified, dest[1] (ANALYSIS): as used void Options::fileOption(string *dest, int option) { if (not d_arg.option(&dest[STARTUP], option)) dest[STARTUP] = s_fileName[option]; // use the default if not spec'd else { d_specified[STARTUP] += option; if (dest[STARTUP] == "!") // specified as `!': do not use dest[STARTUP].clear(); else if (option == 'P') { if (dest[STARTUP].find('/') == string::npos) dest[STARTUP].insert(0, 1, '+'); } } } simrisc-16.02.00/params/0000775000175000017500000000000014665030471013670 5ustar frankfranksimrisc-16.02.00/params/data.cc0000664000175000017500000000020214665030471015102 0ustar frankfrank//#define XERR #include "params.ih" StringVect const Params::s_label { Globals::label(BREAST), "BRCA1:", "BRCA2:" }; simrisc-16.02.00/params/params.h0000664000175000017500000000361114665030471015325 0ustar frankfrank#ifndef INCLUDED_PARAMS_ #define INCLUDED_PARAMS_ // Params is the base class for VSDParams and for TableParams. // // VSDParams handles the computation of the tumor risk values based on // lifetimeRisk, meanAge, and stdDev // // TableParams handles the computation of the tumor risk values based on the // riskTable values // // The base class defines member // virtual void cptTumorRisk(DoubleVect &ageValues) // which calls the overriding member from the derived class. // // The vector d_params contains unique_ptr, so for each defined // Incidence type the appropriate ageValues is computed #include "../typedefs/typedefs.h" class Params { unsigned d_idx; // see setIncidence (.2): this is the // index used in the d_params vector // set to -1 if prob. setting fails in double d_prob = 1; // the constructor static StringVect const s_label; // labels of the BC incidence modes public: Params(StringVect &base, size_t idx, bool setProb); virtual ~Params(); void cptTumorRisk(DoubleVect &ageValues); double prob() const; // .f void vary(std::ostream &out); // .f void writeParameters(std::ostream &out); static std::string const &label(size_t idx); // .f static size_t nLabels(); // .f protected: void invalid(); // sets d_prob = -1 // .f std::string const &label() const; // .f private: void virtual v_cptTumorRisk(DoubleVect &ageValues) = 0; void virtual v_vary(std::ostream &out) = 0; void virtual v_writeParameters(std::ostream &out) const = 0; }; #include "params.f" #endif simrisc-16.02.00/params/params.ih0000664000175000017500000000017114665030471015474 0ustar frankfrank#include "params.h" #include "../xerr/xerr.ih" #include "../parser/parser.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/params/params1.cc0000664000175000017500000000046314665030471015546 0ustar frankfrank#define XERR #include "params.ih" Params::Params(StringVect &base, size_t idx, bool setProb) : d_idx(idx) { if (setProb) { base.back() = "probability:"; if (not Parser::proportion(base, d_prob)) d_prob = -1; // prob-setting failed } } simrisc-16.02.00/params/icmconf0000664000175000017500000000015614665030471015233 0ustar frankfrank#define LIBRARY "params" //#define SPCH "-k xerr/xerr.ih" #include "../icmconf.lib" simrisc-16.02.00/params/writeparameters.cc0000664000175000017500000000071414665030471017417 0ustar frankfrank#define XERR #include "params.ih" void Params::writeParameters(std::ostream &out) { Globals::setPrecision(out, 1) << setw(6) << ' ' << label() << '\n' << setw(8) << ' ' << "probability: " << prob() << ( Globals::isZero(prob()) ? " (carrier ignored)\n" : "\n" ); v_writeParameters(out); } simrisc-16.02.00/params/destructor.cc0000664000175000017500000000007014665030471016372 0ustar frankfrank#define XERR #include "params.ih" Params::~Params() {} simrisc-16.02.00/params/params.f0000664000175000017500000000100714665030471015320 0ustar frankfrankinline void Params::cptTumorRisk(DoubleVect &ageValues) { v_cptTumorRisk(ageValues); } inline double Params::prob() const { return d_prob; } inline void Params::invalid() { d_prob = -1; } inline void Params:: vary(std::ostream &out) { v_vary(out); } inline std::string const &Params::label() const { return s_label[d_idx]; } // static inline std::string const &Params::label(size_t idx) { return s_label[idx]; } // static inline size_t Params::nLabels() { return s_label.size(); } simrisc-16.02.00/params/frame0000664000175000017500000000006014665030471014701 0ustar frankfrank#define XERR #include "params.ih" Params:: { } simrisc-16.02.00/parser/0000775000175000017500000000000014665030471013701 5ustar frankfranksimrisc-16.02.00/parser/parser.h0000664000175000017500000001637414665030471015361 0ustar frankfrank#ifndef INCLUDED_PARSER_ #define INCLUDED_PARSER_ #include #include #include #include #include #include "../extractable/extractable.h" //#include "../unsignedcastable/unsignedcastable.h" #include "../typedefs/typedefs.h" #include "../err/err.h" #include "../globals/globals.h" #include "../vsd/vsd.h" class ConfigLines; struct Parser { struct OptionInfo { std::string name; std::string value; uint16_t lineNr; }; using OptionsVect = std::vector; private: using Map = std::unordered_map; // each element holds the specs LineInfoVect d_lines; // of one series of keywords Map d_map; static Map s_map; public: class Lines { friend class Parser; unsigned d_size; // initial size LineInfoVect::const_iterator d_iter; // first and last elements LineInfoVect::const_iterator d_end; // of a selected vector public: // by repeated calls get all lines, // from the first to the last until // 0 is returned LineInfo const *get(); // linesget.cc unsigned size() const; operator bool() const; // size() != 0 private: // no lines found Lines(LineInfoVect const &lines); // lineslines1.cc // >= 1 line found // lineslines2.cc Lines(LineInfoVect::const_iterator const &begin, LineInfoVect::const_iterator const &end); Lines(Lines const &other) = default; LineInfoVect::const_iterator begin() const; // .ih LineInfoVect::const_iterator end() const; // .ih }; using MapValue = Map::value_type; Parser(); // 1. Parser(Map &&tmp); // 2. ~Parser(); // any number (>= 1) lines is OK static Lines any(StringVect const &keywords); // extract 'dest' variables from lines.get()->tail // returns 'good' if ok, else if no lines then // eof() else fail() + error msg template // .f static std::istringstream extract(Lines &&ines, Types &...dest); // same as 1.f, but LineInfo is already available // extracts from line.tail template // .f static std::istringstream extract(LineInfo const &line, Types &...dest); // extract 'size' 'dest' elements from lines.get()->tail // return values as with extract1.f template // .f static std::istringstream extract(Lines &&lines, Type *dest, size_t size); // extract 'dest' values from one configuration line at 'keywords' template // .f static std::istringstream extract(StringVect const &keywords, Types &...dest); static bool hasSection(StringVect const &keywords); // analysis file void load(std::istream &in, uint16_t startLineNr, // 1. StringVect &labels, OptionsVect &options); void load(std::string const &fname); // configuration file 2. // requires specs like Survival: // type: a .00004475 .000004392 Normal // type: b 1.85867 .0420 Normal static VSDvect VSDparameters( // 1.cc VaryType varyType, StringVect const &keywords, std::initializer_list const &required); // exactly 1 configuration line is required static Lines one(StringVect const &keywords); // requires one line specs like Mammo: // m: .136 .136 .136 .136 static VSDvect VSDparameters( // 2.cc VaryType varyType, StringVect const &keywords, size_t nRequired); // exactly 1 line is required. // .f static bool nonNegative(StringVect const &keywords, double &dest); template // .f static bool nonNegative(StringVect const &keywords, Type &dest); // extract exactly one value associated with keywords template // .f static bool one(StringVect const &keywords, Type &dest); static bool positive(StringVect const &keywords, double &dest); // .f // exactly 1 line is required static bool proportion(StringVect const &keywords, double &dest); private: // add the next parser line to the // appropriate map-section static void addConfigLine(std::vector &mapPtrVect, ConfigLines &lines, ParamsSrc src); static bool atLeast(double minimum, StringVect const &keywords, double &dest); static std::string checkRedo(ConfigLines &configLine); // deepest nesting level in the map static bool endPoint(Map::value_type const &mapValue); template // .f static bool extract(std::istream &in, Type &first, Types &...more); static bool extract(std::istream &in); // .f // define d_lines[0] // at s_map's deepest static void initLineInfoVects(Map &map); // nesting levels static LineInfoVect const &keywordsLines(StringVect const &keywords); static Lines lines(StringVect const &keywords); // 1. static void locateError(std::vector &mapPtrVect, ConfigLines &lines, ParamsSrc src); static std::string sectionList(StringVect const &keywords); static void setLabels(ConfigLines &parser, StringVect &labels); static void setOptions(ConfigLines &parser, OptionsVect &options); static void rmLineInfoVectors(Map &map); }; #include "parser.f" #endif simrisc-16.02.00/parser/parser1.cc0000664000175000017500000000037314665030471015570 0ustar frankfrank//#define XERR #include "parser.ih" Parser::Parser() { initLineInfoVects(s_map); // define d_lines[0] // at s_map's deepest // nesting levels } simrisc-16.02.00/parser/addlineinfovectors.cc0000664000175000017500000000000014665030471020060 0ustar frankfranksimrisc-16.02.00/parser/one.cc0000664000175000017500000000045214665030471014772 0ustar frankfrank//#define XERR #include "parser.ih" // static Parser::Lines Parser::one(StringVect const &keywords) { Lines lines = any(keywords); if (lines.size() > 1) Err::multiplySpecified(lines.begin(), lines.end(), sectionList(keywords)); return lines; } simrisc-16.02.00/parser/parser.f0000664000175000017500000000473514665030471015355 0ustar frankfrank// static template std::istringstream Parser::extract(StringVect const &keywords, Types &...dest) { return extract(one(keywords), std::forward(dest) ...); } // static template std::istringstream Parser::extract(Lines &&lines, Types &...dest) { if (lines) return extract(*lines.get(), std::forward(dest) ...); std::istringstream in; in.setstate(std::ios::eofbit); return in; } // static template std::istringstream Parser::extract(LineInfo const &line, Types &...dest) { std::istringstream in{ line.tail }; if (not extract(in, std::forward(dest) ...)) { in.setstate(std::ios::failbit); Err::specification(); } return in; } // static template std::istringstream Parser::extract(Lines &&lines, Type *dest, size_t size) { std::istringstream in; if (not lines) { in.setstate(std::ios::eofbit); return in; } in.str(lines.get()->tail); for (; size--; ++dest) // fill 'size' elements starting at dest { if (not (in >> *dest)) { in.setstate(std::ios::failbit); Err::specification(); break; } } return in; } // static template bool Parser::extract(std::istream &in, Type &first, Types &...more) { in >> first; return extract(in, std::forward(more)...); } inline bool Parser::extract(std::istream &in) { return static_cast(in); } // static template bool Parser::one(StringVect const &base, Type &dest) { return static_cast(extract(one(base), dest)); } //template //static bool nonNegative(StringVect const &keywords, Types &...dest) //{ // return extract(one(keywords)->get(), std::forward(dest) ...); //} inline bool Parser::nonNegative(StringVect const &base, double &dest) { return atLeast(0, base, dest); } template bool Parser::nonNegative(StringVect const &base, Type &dest) { double tmp; bool ret = nonNegative(base, tmp); dest = tmp; return ret; } // static inline bool Parser::positive(StringVect const &base, double &dest) { return atLeast(Globals::WEAK_TOLERANCE, base, dest); } inline unsigned Parser::Lines::size() const { return d_size; } inline Parser::Lines::operator bool() const { return d_size != 0; } simrisc-16.02.00/parser/data.cc0000664000175000017500000002511714665030471015127 0ustar frankfrank//#define XERR #include "parser.ih" // In the configuration file specifications are just lines. Each keyword // must therefore be searched via a unique path. So searching for // e.g., { 'costs:' } returns multiple hits, but searching for // { 'Scenario:', 'costs:' } returns only one hit // Named MapValues must be used only once. E.g., for Mammo 'Dose' is // specified by mdose, for Tomo it is specified by tdose. // final "named" keys are always unique and can be specified at MapValue // specifications. // see also the description at the end of this file namespace { //#Scenario: Parser::MapValue spread { "spread:", new Parser }; Parser::MapValue iterations { "iterations:", new Parser }; Parser::MapValue generator { "generator:", new Parser }; Parser::MapValue seed { "seed:", new Parser }; Parser::MapValue cases { "cases:", new Parser }; Parser::MapValue death { "death:", new Parser }; //#Costs: Parser::MapValue diameters { "diameters:", new Parser }; //#Discount: Parser::MapValue age { "age:", new Parser }; Parser::MapValue proport { "proportion:", new Parser }; Parser::MapValue biop // only used for BC { "biop:", new Parser }; //BreastDensities: - required [ cf. densities/ ] // Parser::MapValue breastDensities { "BreastDensities:", new Parser { { // map {"ageGroup:", new Parser}, } } }; //#Modalities: // only within Mammo: (for which Mammo: therefore is optional): Parser::MapValue betaMap { "beta:", new Parser }; //x Parser::MapValue systematicError //x { //x "systematicError:", //x new Parser //x }; //x //x Parser::MapValue m //x { //x "m:", //x new Parser //x }; Parser::MapValue mammo { "Mammo:", new Parser { { {"costs:", new Parser }, {"dose:", new Parser }, {"specificity:", new Parser }, {"m:", new Parser }, {"beta:", new Parser }, {"systematicError:", new Parser }, } } }; Parser::MapValue tomo { "Tomo:", new Parser { { {"costs:", new Parser }, {"dose:", new Parser }, {"sensitivity:", new Parser }, {"specificity:", new Parser }, } } }; Parser::MapValue mri { "MRI:", new Parser { { {"costs:", new Parser }, {"sensitivity:", new Parser }, {"specificity:", new Parser }, } } }; Parser::MapValue ct { "CT:", new Parser { { {"costs:", new Parser }, // set by costs/costs1.cc {"dose:", new Parser }, {"sensitivity:", new Parser }, {"specificity:", new Parser }, } } }; //#Screening: Parser::MapValue roundMap { "round:", new Parser }; Parser::MapValue attendanceRate { "attendanceRate:", new Parser }; //#Tumor: //# only within Beir7: (for which Beir7: therefore is optional): //x Parser::MapValue male //x { //x "male:", //x new Parser //x }; //x //x Parser::MapValue female //x { //x "female:", //x new Parser //x }; Parser::MapValue beir7 { "Beir7:", new Parser { { // map { "breast:", new Parser }, { "male:", new Parser }, { "female:", new Parser }, } } }; //# only within Growth: (for which Growth: therefore is optional): //x Parser::MapValue start //x { //x "start:", //x new Parser //x }; //#DoublingTime: only used in Growth, therefore optional Parser::MapValue groDoublingTime { "DoublingTime:", new Parser { { {"ageGroup:", new Parser}, {"lung:", new Parser}, } } }; Parser::MapValue growth { "Growth:", new Parser { { {"breast:", new Parser }, {"lung:", new Parser }, {"start:", new Parser }, groDoublingTime, } } }; //#Incidence: with Tumor: - optional Parser::MapValue Male { Globals::label(MALE), new Parser { { {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; Parser::MapValue Female { Globals::label(FEMALE), new Parser { { {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; Parser::MapValue Breast { Globals::label(BREAST), new Parser { { {"probability:", new Parser }, {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; Parser::MapValue Brca1 { "BRCA1:", new Parser { { {"probability:", new Parser }, {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; Parser::MapValue Brca2 { "BRCA2:", new Parser { { {"probability:", new Parser }, {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; //#Survival: Parser::MapValue type { "type:", new Parser }; Parser::MapValue lung0 { "lung0:", new Parser }; Parser::MapValue lung1 { "lung1:", new Parser }; Parser::MapValue lung2 { "lung2:", new Parser }; Parser::MapValue lung3 { "lung3:", new Parser }; //#S3: Parser::MapValue prob { "prob:", new Parser }; Parser::MapValue bc { "bc:", new Parser }; } // anonymous namespace ends Parser::Map Parser::s_map // see the configuration file: these are the { // configurations for the top-level keywords // e.g., scenario here (above) and Scenario: // in the configuration file spread, iterations, generator, seed, cases, death, biop, diameters, proport, age, breastDensities, betaMap, // systematicError, // m, mammo, tomo, mri, ct, roundMap, attendanceRate, // male, // female, beir7, // start, growth, Male, Female, Breast, Brca1, Brca2, type, bc, lung0, lung1, lung2, lung3, prob, { "Scenario:", new Parser }, { "Costs:", new Parser }, { "Discount:", new Parser }, { "Modalities:", new Parser }, { "Screening:", new Parser }, { "Tumor:", new Parser }, { "Incidence:", new Parser }, { "Survival:", new Parser }, { "S3:", new Parser }, }; // By convention, keywords of lines mererly containing the keyword // start with capitals, and those followed by actual parameter values // start with lower-case letters // // MapValue definitions ending in 'new Parser' match one or more // configuration lines which are handled by the objects for which // the configuration line is intended. // // Parser specifications merely consisting of identifiers refer to // separately defined specifications // // E.g., // // Parser::MapValue modalities // { // "Modalities:", // new Parser // { // { // mammo, // tomo, // mri // } // } // }; // // specifies Modalities: as a keyword, followed by the definitions of mammo, // tomo, and mri. The 'tomo' MapValue is // // Parser::MapValue tomo // { // "Tomo:", // new Parser // { // { // {"costs:", new Parser }, // dose, // ... // } // } // }; // // and so 'costs:' is followed by >= 1 parameter values, but 'dose' is // specified separately: // // Parser::MapValue dose // { // "Dose:", // new Parser // { // { // {"bi-rad:", new Parser }, // } // } // }; // // The keyword 'Dose:' is on a line by itself, followed by lines starting // with 'bi-rad:' containing parameter specifications. // // What the parameter specifications are is determined by the objects parsing // the configuration lines. E.g., ageGroup: is specified as // ageGroup: 0 - 40: .961 .005 Normal // but also as: // ageGroup: 0 - 40: .05 .30 .48 .17 simrisc-16.02.00/parser/load2.cc0000664000175000017500000000053314665030471015212 0ustar frankfrank#define XERR #include "parser.ih" // load the configuration file 'fname' void Parser::load(string const &fname) { ConfigLines lines{ fname }; vector mapPtrVect{ &s_map }; // start loading at the top while (lines.get()) // add the parser lines addConfigLine(mapPtrVect, lines, CONFIGFILE); } simrisc-16.02.00/parser/sectionlist.cc0000664000175000017500000000057214665030471016554 0ustar frankfrank//#define XERR #include "parser.ih" // for keywords A, B, C // where is set to: C, in section B, in section A // static string Parser::sectionList(StringVect const &keywords) { string where = " `" + keywords.back() + '\''; for (auto iter = keywords.rbegin() + 1; iter != keywords.rend(); ++iter) where += ", in section " + *iter; return where; } simrisc-16.02.00/parser/proportion.cc0000664000175000017500000000041514665030471016423 0ustar frankfrank//#define XERR #include "parser.ih" bool Parser::proportion(StringVect const &base, double &dest) { if (extract(one(base), dest)) { if (Globals::proportion(dest)) return true; Err::range(); } dest = 0; return false; } simrisc-16.02.00/parser/data.cc.org0000664000175000017500000002020214665030471015703 0ustar frankfrank//#define XERR #include "parser.ih" // In the configuration file specifications are just lines. Each keyword // must therefore be searched via a unique path. So searching for // e.g., { 'costs:' } returns multiple hits, but searching for // { 'Scenario:', 'costs:' } returns only one hit // Named MapValues must be used only once. E.g., for Mammo 'Dose' is // specified by mdose, for Tomo it is specified by tdose. // final "named" keys are always unique and can be specified at MapValue // specifications. // see also the description at the end of this file namespace { Parser::MapValue scenario { "Scenario:", new Parser { { // map {"spread:", new Parser }, {"iterations:", new Parser }, {"generator:", new Parser }, {"seed:", new Parser }, {"cases:", new Parser }, {"death:", new Parser }, } } }; Parser::MapValue screening { "Screening:", new Parser { { // map {"round:", new Parser }, {"attendanceRate:", new Parser }, } } }; Parser::MapValue breastDensities { "BreastDensities:", new Parser { { // map {"ageGroup:", new Parser}, } } }; Parser::MapValue mammo { "Mammo:", new Parser { { {"beta:", new Parser }, {"costs:", new Parser }, {"dose:", new Parser }, {"m:", new Parser }, {"specificity:", new Parser }, {"systematicError:", new Parser }, } } }; Parser::MapValue tomo { "Tomo:", new Parser { { {"costs:", new Parser }, {"dose:", new Parser }, {"sensitivity:", new Parser }, {"specificity:", new Parser }, } } }; Parser::MapValue mri { "MRI:", new Parser { { {"costs:", new Parser }, {"sensitivity:", new Parser }, {"specificity:", new Parser }, } } }; Parser::MapValue ct { "CT:", new Parser { { {"costs:", new Parser }, {"dose:", new Parser }, {"sensitivity:", new Parser }, {"specificity:", new Parser }, } } }; Parser::MapValue modalities { "Modalities:", new Parser { { // map mammo, tomo, mri, ct } } }; Parser::MapValue incMale { Globals::label(MALE), new Parser { { {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; Parser::MapValue incFemale { Globals::label(FEMALE), new Parser { { {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; Parser::MapValue incBreast { Globals::label(BREAST), new Parser { { {"probability:", new Parser }, {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; Parser::MapValue incBrca1 { "BRCA1:", new Parser { { {"probability:", new Parser }, {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; Parser::MapValue incBrca2 { "BRCA2:", new Parser { { {"probability:", new Parser }, {"riskTable:", new Parser }, {"lifetimeRisk:", new Parser }, {"meanAge:", new Parser }, {"stdDev:", new Parser }, } } }; Parser::MapValue tumIncidence { "Incidence:", new Parser { { incMale, incFemale, incBreast, incBrca1, incBrca2, } } }; Parser::MapValue groDoublingTime { "DoublingTime:", new Parser { { {"ageGroup:", new Parser}, {"lung:", new Parser}, } } }; Parser::MapValue tumGrowth { "Growth:", new Parser { { {"start:", new Parser }, {"breast:", new Parser }, {"lung:", new Parser }, groDoublingTime, } } }; Parser::MapValue tumSurvival { "Survival:", new Parser { { {"type:", new Parser }, {"lung0:", new Parser }, {"lung1:", new Parser }, {"lung2:", new Parser }, {"lung3:", new Parser }, } } }; Parser::MapValue s3 { "S3:", new Parser { { {"prob:", new Parser }, } } }; Parser::MapValue tumBeir7 { "Beir7:", new Parser { { // map { "breast:", new Parser }, { "male:", new Parser }, { "female:", new Parser }, } } }; Parser::MapValue tumor { "Tumor:", new Parser { { // map tumIncidence, tumGrowth, tumBeir7, { "beir7:", new Parser }, tumSurvival, s3, { "bc:", new Parser }, } } }; Parser::MapValue cosDiscount { "Discount:", new Parser { { // map {"age:", new Parser }, {"proportion:", new Parser }, } } }; Parser::MapValue costs { "Costs:", new Parser { { {"biop:", new Parser }, {"diameters:", new Parser }, cosDiscount, } } }; } // namespace Parser::Map Parser::s_map // see the configuration file: these are the { // configurations for the top-level keywords scenario, // e.g., scenario here (above) and Scenario: costs, // in the configuration file breastDensities, modalities, screening, tumor, }; // By convention, keywords of lines mererly containing the keyword // start with capitals, and those followed by actual parameter values // start with lower-case letters // // MapValue definitions ending in 'new Parser' match one or more // configuration lines which are handled by the objects for which // the configuration line is intended. // // Parser specifications merely consisting of identifiers refer to // separately defined specifications // // E.g., // // Parser::MapValue modalities // { // "Modalities:", // new Parser // { // { // mammo, // tomo, // mri // } // } // }; // // specifies Modalities: as a keyword, followed by the definitions of mammo, // tomo, and mri. The 'tomo' MapValue is // // Parser::MapValue tomo // { // "Tomo:", // new Parser // { // { // {"costs:", new Parser }, // dose, // ... // } // } // }; // // and so 'costs:' is followed by >= 1 parameter values, but 'dose' is // specified separately: // // Parser::MapValue dose // { // "Dose:", // new Parser // { // { // {"bi-rad:", new Parser }, // } // } // }; // // The keyword 'Dose:' is on a line by itself, followed by lines starting // with 'bi-rad:' containing parameter specifications. // // What the parameter specifications are is determined by the objects parsing // the configuration lines. E.g., ageGroup: is specified as // ageGroup: 0 - 40: .961 .005 Normal // but also as: // ageGroup: 0 - 40: .05 .30 .48 .17 simrisc-16.02.00/parser/setlabels.cc0000664000175000017500000000043214665030471016165 0ustar frankfrank//#define XERR #include "parser.ih" // static void Parser::setLabels(ConfigLines &parser, StringVect &labels) { while (parser.get() and parser.key() == "label:") labels.push_back(parser.tail()); parser.redo(); // redo the line not containing a label } simrisc-16.02.00/parser/parser.ih0000664000175000017500000000064714665030471015526 0ustar frankfrank#include "parser.h" #include "../xerr/xerr.ih" #include #include #include #include #include "../configlines/configlines.h" inline LineInfoVect::const_iterator Parser::Lines::begin() const { return d_iter; } inline LineInfoVect::const_iterator Parser::Lines::end() const { return d_end; } #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/parser/keywordslines.cc0000664000175000017500000000207714665030471017120 0ustar frankfrank#define XERR #include "parser.ih" // static LineInfoVect const &Parser::keywordsLines(StringVect const &keywords) { Map const *mapPtr = &s_map; Map::const_iterator mapIter; // E.g., Scenario: iterator: returns the pointer to the Parser // at Scenario's iterator: specification for (auto const &keyword: keywords) // visit the range of keywords { mapIter = mapPtr->find(keyword); // ptr to Map::value_type if (mapIter == mapPtr->end()) // internal error: throw exception throw Exception{} << "Internal error: keyword `" << keyword << "' not configured"; mapPtr = &mapIter->second->d_map; // use the next keyword } // with Scenario: death: this is just one line, which may be empty, // in which case it's followed by 101 cumulative death probabilities // or it may contain one word, which is the name of the file containing // the specifications return mapIter->second->d_lines; // return the LineInfoVect } simrisc-16.02.00/parser/initlineinfovects.cc0000664000175000017500000000104414665030471017743 0ustar frankfrank#define XERR #include "parser.ih" // static void Parser::initLineInfoVects(Map &map) { // element.first: the key // element.second: Parser * // visit all elements of 'map' (there may be none) for (auto &element: map) { if (not endPoint(element)) // there's a deeper link: initLineInfoVects(element.second->d_map); // continue else // no map is used here element.second->d_lines.push_back(LineInfo{ NONE }); } } simrisc-16.02.00/parser/locateerror.cc0000664000175000017500000000166114665030471016535 0ustar frankfrank#define XERR #include "parser.ih" // static void Parser::locateError(vector &mapPtrVect, ConfigLines &lines, ParamsSrc src) { string key = lines.key(); // look for this key for (size_t idx = mapPtrVect.size(); idx--; ) // upwards from the most { // nested level Map &map = *mapPtrVect[idx]; // found the key at an earlier if (map.find(key) != map.end()) // level { mapPtrVect.resize(idx + 1); // remove nested pointers lines.redo(); // reprocess this line return; } } // the key at the current line was not found in this section emsg << Err::src(src) << " [" << lines.lineNr() << "]: "; Err::msg(Err::UNDEFINED_SPEC) << " `" << lines.line() << '\'' << endl; } simrisc-16.02.00/parser/vsdparameters1.cc0000664000175000017500000000240514665030471017152 0ustar frankfrank#define XERR #include "parser.ih" // static VSDvect Parser::VSDparameters(VaryType varyType, StringVect const &keywords, initializer_list const &required) { VSDvect vsdVect(required.size(), VSD{ varyType }); auto lines = any(keywords); // all config lines of 'keywords' unsigned count = 0; while (true) { auto const *line = lines.get(); // get the next line if (not line) break; VSD vsd{ varyType }; char type; if (not Parser::extract(*line, type, vsd)) // get the next VSD continue; // check whether the // type (a..x) is OK auto idIter = find(required.begin(), required.end(), type); if (idIter == required.end()) { Err::msg(Err::INVALID_TYPE) << '`' << type << '\'' << endl; continue; } ++count; // found a VSD specification vsdVect[idIter - required.begin()] = vsd; // store the extracted VSD } if (count != required.size()) Err::msg(Err::VSD_MISSING) << count << " specifications\n"; return vsdVect; } simrisc-16.02.00/parser/lines.cc0000664000175000017500000000122314665030471015320 0ustar frankfrank//#define XERR #include "parser.ih" // static Parser::Lines Parser::lines(StringVect const &keywords) { // get the lines // matching the LineInfoVect const &lines = keywordsLines(keywords); // keywords return lines.front().src == NONE ? // no spec? Lines{ LineInfoVect{} } // then nothing : Lines{ lines.begin(), lines.end() }; // else return the // specifications } simrisc-16.02.00/parser/endpoint.cc0000664000175000017500000000026514665030471016033 0ustar frankfrank//#define XERR #include "parser.ih" // static bool Parser::endPoint(Map::value_type const &value) { return value.second->d_map.empty(); // the next Parser has an empty map } simrisc-16.02.00/parser/lib/0000775000175000017500000000000014665030471014447 5ustar frankfranksimrisc-16.02.00/parser/lib/libparser.a0000777000175000017500000000000014665030471021727 2../tmp/libparser.austar frankfranksimrisc-16.02.00/parser/lib/libconfiglines.a0000777000175000017500000000000014665030471026452 2../../configlines/tmp/libconfiglines.austar frankfranksimrisc-16.02.00/parser/lib/liberr.a0000777000175000017500000000000014665030471021522 2../../err/tmp/liberr.austar frankfranksimrisc-16.02.00/parser/vsdparameters2.cc0000664000175000017500000000170714665030471017157 0ustar frankfrank#define XERR #include "parser.ih" // static VSDvect Parser::VSDparameters(VaryType varyType, StringVect const &keywords, size_t nRequired) { VSDvect vsdVect(nRequired, VSD{ varyType }); string values[nRequired]; // one config line for 'keywords' if (not Parser::extract(one(keywords), values, nRequired)) Err::msg(Err::VSD_MISSING) << nRequired << " value specifications\n"; else { for (size_t idx = 0; idx != nRequired; ++idx) { istringstream in{ values[idx] }; // extract single values if (not (in >> vsdVect[idx])) // store with SD 0 in the { // vsdVect Err::msg(Err::VSD_MISSING) << nRequired << " value specifications\n"; break; } } } return vsdVect; } simrisc-16.02.00/parser/icmconf0000664000175000017500000000007514665030471015244 0ustar frankfrank#define LIBRARY "parser" #include "../icmconf.lib" simrisc-16.02.00/parser/lineslines1.cc0000664000175000017500000000023114665030471016432 0ustar frankfrank//#define XERR #include "parser.ih" Parser::Lines::Lines(LineInfoVect const &lines) : d_size(0), d_iter(lines.end()), d_end(lines.end()) {} simrisc-16.02.00/parser/rmlineinfovectors.cc0000664000175000017500000000100114665030471017750 0ustar frankfrank#define XERR #include "parser.ih" //static void Parser::rmLineInfoVectors(Map &map) { // element.first: the key // element.second: Parser * for (auto &element: map) // all elements of 'map' { if (not endPoint(element)) // there's a deeper link: rmLineInfoVectors(element.second->d_map); // continue there else // no map is used here element.second->d_lines.clear(); } } simrisc-16.02.00/parser/atleast.cc0000664000175000017500000000045114665030471015645 0ustar frankfrank//#define XERR #include "parser.ih" // static bool Parser::atLeast(double minimum, StringVect const &base, double &dest) { if (extract(one(base), dest)) { if (minimum <= dest) return true; Err::atLeast(minimum); } dest = minimum; return false; } simrisc-16.02.00/parser/checkredo.cc0000664000175000017500000000362514665030471016145 0ustar frankfrank#define XERR #include "parser.ih" // If the previous key allows additional number-lines and a number-line is // read next then set that line's key to the last-read key, so multiple // lines of that key are returned. namespace { enum { INIT, REDO, }; size_t s_state = INIT; string s_key; unordered_set redo{ "death:", "riskTable:", "ageGroup:", "sensitivity:", "round:", "prob:", "type:", "lung0:", "lung1:", "lung2:", "lung3:" }; unordered_set survival{ "type:", "lung0:", "lung1:", "lung2:", "lung3:" }; unordered_set abcd{ "a", "b", "c", "d", "e" }; } //static string Parser::checkRedo(ConfigLines &configLine) { string key = configLine.key(); if (redo.find(key) != redo.end() ) // at a key: refill with that key { s_key = key; s_state = REDO; } else if // digits always OK. '*' OK for prob: ( // a..d OK voor 'survival:' isdigit(key.front()) or (s_key == "prob:" and key.front() == '*') or ( survival.find(s_key) != survival.end() and abcd.find(key) != abcd.end() ) ) configLine.key(key = s_key); else s_state = INIT; return key; } // if (s_state == INIT) // { // if (redo.find(key) != redo.end() ) // { // s_key = key; // s_state = REDO; // } // } // else if ( // digits always OK. '*' OK for prob: // isdigit(key.front()) // a..d OK voor survival: // or // (s_key == "prob:" and key.front() == '*') // ) // configLine.key(key = s_key); // else // s_state = INIT; simrisc-16.02.00/parser/destructor.cc0000664000175000017500000000024414665030471016406 0ustar frankfrank#define XERR #include "parser.ih" //extern size_t rmCount; Parser::~Parser() { //rmCount = 0; rmLineInfoVectors(s_map); //xerr("# REMOVED: " << rmCount); } simrisc-16.02.00/parser/linesget.cc0000664000175000017500000000061314665030471016022 0ustar frankfrank#define XERR #include "parser.ih" LineInfo const *Parser::Lines::get() { return d_iter == d_end ? // no more lines 0 : Err::reset(*d_iter++); // allow new error messages, provide // Err with the current line and // return the current line's address } simrisc-16.02.00/parser/parser2.cc0000664000175000017500000000013114665030471015561 0ustar frankfrank//#define XERR #include "parser.ih" Parser::Parser(Map &&tmp) : d_map(move(tmp)) {} simrisc-16.02.00/parser/setoptions.cc0000664000175000017500000000203414665030471016416 0ustar frankfrank#define XERR #include "parser.ih" // OptionsVect: vector of OptionInfo elements, processed by actualize() // OptionInfo: defined by Parser // static void Parser::setOptions(ConfigLines &parser, OptionsVect &optionsVect) { while ( parser.get() // got a line and it's not and // a top-level parser s_map.find(parser.key()) == s_map.end() // parameter ) // store the option spec. optionsVect.push_back( // long option name and value { parser.key().back() == ':' ? // rm a final : parser.key().substr(0, parser.key().length() - 1) : parser.key(), parser.value(), parser.lineNr(), } ); parser.redo(); // redo the line not containing a label } simrisc-16.02.00/parser/lineslines2.cc0000664000175000017500000000040414665030471016435 0ustar frankfrank//#define XERR #include "parser.ih" Parser::Lines::Lines(LineInfoVect::const_iterator const &begin, LineInfoVect::const_iterator const &end) : d_size(end - begin), d_iter(begin), d_end(end) { Err::reset(*d_iter); } simrisc-16.02.00/parser/frame0000664000175000017500000000006214665030471014714 0ustar frankfrank//#define XERR #include "parser.ih" Parser:: { } simrisc-16.02.00/parser/hassection.cc0000664000175000017500000000023514665030471016350 0ustar frankfrank#define XERR #include "parser.ih" // static bool Parser::hasSection(StringVect const &keywords) { return keywordsLines(keywords).front().src != NONE; } simrisc-16.02.00/parser/load1.cc0000664000175000017500000000125714665030471015215 0ustar frankfrank#define XERR #include "parser.ih" //extern size_t addCount; // load an analysis file specification void Parser::load(std::istream &in, uint16_t startLineNr, StringVect &labels, OptionsVect &options) { ConfigLines lines{ in, startLineNr }; // read the current stream setLabels(lines, labels); // set label: specifications setOptions(lines, options); vector mapPtrVect{ &s_map }; // start loading at the top // add the config lines while (lines.get()) // to the matching Parser addConfigLine(mapPtrVect, lines, ANALYSIS); } simrisc-16.02.00/parser/any.cc0000664000175000017500000000037614665030471015005 0ustar frankfrank#define XERR #include "parser.ih" //static Parser::Lines Parser::any(StringVect const &keywords) { Lines lines = Parser::lines(keywords); if (not lines) Err::msg(Err::MISSING_SPEC) << sectionList(keywords) << endl; return lines; } simrisc-16.02.00/parser/addconfigline.cc0000664000175000017500000000504114665030471016776 0ustar frankfrank#define XERR #include "parser.ih" // static void Parser::addConfigLine(vector &mapPtrVect, ConfigLines &configLine, ParamsSrc src) { // accept nr-specs following string key = checkRedo(configLine); // death: or riskTable: Map &map = *mapPtrVect.back(); // look for the key in the current auto iter = map.find(key); // map section if (iter == map.end()) // key was not found { locateError(mapPtrVect, configLine, src); return; } if (not endPoint(*iter)) // key found, but not an endpoint { // (endpoint: next Parser is empty) mapPtrVect.push_back(&iter->second->d_map); // go nesting return; } // no deeper level: handle the line // -------------------------------------------------- // existing // ---------------------------------- // new: NONE CONFIGFILE ANALYSIS // -------------------------------------------------- // CONFIGFILE replace add ignore // // ANALYSIS replace Exception add // (ANALYSIS is // handled first) // -------------------------------------------------- LineInfoVect &liVect = iter->second->d_lines; ParamsSrc currentSrc = liVect.front().src; // replace the initialization vector if (currentSrc == NONE) // by the current spec. { liVect.front() = LineInfo{ src, configLine.lineNr(), configLine.line(), configLine.tail() }; return; } // if the next line has the same ParamSrc: if (src == currentSrc) // store it. { liVect.push_back // there: store it ( { src, configLine.lineNr(), configLine.line(), configLine.tail() } ); return; } // ignore CONFIGFILE if there's // already an ANALYSIS spec. if (src == CONFIGFILE and liVect.front().src == ANALYSIS) return; // cell[1][1] in the above table throw Exception{} << __FILE__": internal error: ANALYSIS spec. " " read after reading CONFIGFILE specs."; } simrisc-16.02.00/probgroup/0000775000175000017500000000000014665030471014424 5ustar frankfranksimrisc-16.02.00/probgroup/insert.cc0000664000175000017500000000071614665030471016243 0ustar frankfrank//#define XERR #include "probgroup.ih" std::ostream &ProbGroup::insert(ostream &out) const { out << s_labels[d_breastCancer][0] << d_group << s_labels[d_breastCancer][1]; if (not d_breastCancer) Globals::setWidthPrec(out, 2, 4); for (size_t idx = 0; idx != N_PROBCATS; ++idx) out << static_cast('a' + idx) << ": " << setw(4) << d_prob[idx] << ", "; return out; } simrisc-16.02.00/probgroup/data.cc0000664000175000017500000000035414665030471015646 0ustar frankfrank//#define XERR #include "probgroup.ih" char const *ProbGroup::s_labels[][2] = { { "diameter: ", ", prob.: " }, // labels for lung cancer sim. { "ageGroup: ", ", bi-rad: " } // labels for breast cancer sim. }; simrisc-16.02.00/probgroup/probgroup.h0000664000175000017500000000540114665030471016614 0ustar frankfrank#ifndef INCLUDED_PROBGROUP_ #define INCLUDED_PROBGROUP_ #include #include #include #include "../typedefs/typedefs.h" #include "../group/group.h" #include "../enums/enums.h" #include "../globals/globals.h" // This class used to be 'Density', but with the introduction of lung cancer // simulations cumulative probabilites are also used by 'Survival'. // // config. params using probabilities: // BreastDensities: (RANGE) // # bi-rad: a b c d // ageGroup: 0 - 40: .05 .30 .48 .17 // Table S3 probabilities (SINGLE) // prob: 20: .703 .197 .055 .045 # T1b // prob: *: .187 .347 .256 .210 # T4 class ProbGroup { friend std::istream &operator>>(std::istream &in, ProbGroup &probgroup); friend std::ostream &operator<<(std::ostream &out, ProbGroup const &probgroup); enum { N_PROBCATS = 4, // # of probability categories }; // d_group contains the age group (begin() and end() // d_prob the probabilities, d_cumProbs the cumulative probabilities // cf Group::extract(). begin() Group d_group; // not used, end() is inclusive std::vector d_prob; std::vector d_cumProbs; // false: lung cancer sim., bool d_breastCancer; // true: breast cancer sim. static char const *s_labels[][2]; public: using Vector = std::vector; // ensure sorted by group-end // and that the full range is // covered ProbGroup(Series series); uint16_t begin() const; // .f uint16_t end() const; // .f Group const &group() const; // .f std::vector const &prob() const; // was: birad // .f double prob(size_t idx) const; // was: birad // .f bool sumOne() const; static RowCol probIndexOf(Vector const &vect, double value, double prob); private: bool contains(double value) const; // .f std::istream &extract(std::istream &in); std::ostream &insert(std::ostream &out) const; // string::npos: 'value' not // in the ProbGroup's. uint16_t indexOf(double value) const; }; #include "probgroup.f" #endif simrisc-16.02.00/probgroup/probgroup1.cc0000664000175000017500000000030214665030471017026 0ustar frankfrank//#define XERR #include "probgroup.ih" ProbGroup::ProbGroup(Series series) : d_group(series), d_prob(N_PROBCATS), d_cumProbs(N_PROBCATS), d_breastCancer(Globals::isBreast()) {} simrisc-16.02.00/probgroup/indexof.cc0000664000175000017500000000135414665030471016372 0ustar frankfrank//#define XERR #include "probgroup.ih" // 0 <= prob <= 1 and so indexOf always returns a column extern size_t g_caseIdx; extern size_t g_err; uint16_t ProbGroup::indexOf(double prob) const { //if (g_caseIdx >= g_err)// and prob > .9999) //{ //xerr("PROBGROUP: " << g_caseIdx << " prob: " << prob << '\n'); //for (double prob: d_cumProbs) //cerr << prob << ' '; //cerr << '\n'; //} uint16_t ret = prob > d_cumProbs.back() ? d_cumProbs.size() - 1 : find_if(d_cumProbs.begin(), d_cumProbs.end(), [&](double cumProb) { return prob <= cumProb; } ) - d_cumProbs.begin(); return ret; } simrisc-16.02.00/probgroup/icmconf0000664000175000017500000000010014665030471015754 0ustar frankfrank#define LIBRARY "probgroup" #include "../icmconf.lib" simrisc-16.02.00/probgroup/extract.cc0000664000175000017500000000117014665030471016404 0ustar frankfrank//#define XERR #include "probgroup.ih" // E.g., // ageGroup: 0 - 40: -> // .05 .30 .48 .17 // or (e.g., S3): // prob: 20: -> // .703 .197 .055 .045 istream &ProbGroup::extract(istream &in) { in >> d_group; // extract the group double cumProb = 0; for (size_t idx = 0; idx != N_PROBCATS; ++idx) { double probability; in >> probability; d_prob[idx] = probability; cumProb += probability; d_cumProbs[idx] = cumProb; } return in; } simrisc-16.02.00/probgroup/probindexof.cc0000664000175000017500000000126414665030471017255 0ustar frankfrank//#define XERR #include "probgroup.ih" // see README.probgroup // with Survival::cptVSDrow 'value' is the tumor diameter // then, the group is determined from the diameter, and in the selected // group the column index of that row of S3 is omputed as 'idx' // static RowCol ProbGroup::probIndexOf(Vector const &vect, double value, double prob) { size_t rowIdx = 0; for (ProbGroup const &group: vect) { if (group.contains(value)) { uint16_t idx = group.indexOf(prob); return RowCol{ rowIdx, idx }; } ++rowIdx; } return RowCol{ static_cast(string::npos), 0 }; } simrisc-16.02.00/probgroup/probgroup.f0000664000175000017500000000143514665030471016615 0ustar frankfrankinline uint16_t ProbGroup::begin() const { return d_group.begin(); } inline bool ProbGroup::contains(double value) const { return d_group.contains(value); } inline uint16_t ProbGroup::end() const { return d_group.end(); } inline Group const &ProbGroup::group() const { return d_group; } inline std::vector const &ProbGroup::prob() const { return d_prob; } inline double ProbGroup::prob(size_t idx) const { return d_prob[idx]; } inline bool ProbGroup::sumOne() const { return Globals::isZero(d_cumProbs[N_PROBCATS - 1] - 1); } inline std::istream &operator>>(std::istream &in, ProbGroup &probgroup) { return probgroup.extract(in); } inline std::ostream &operator<<(std::ostream &out, ProbGroup const &probgroup) { return probgroup.insert(out); } simrisc-16.02.00/probgroup/probgroup.ih0000664000175000017500000000037414665030471016771 0ustar frankfrank#include "probgroup.h" #include "../xerr/xerr.ih" #include #include #include #include #include "../globals/globals.h" extern size_t g_caseIdx; extern size_t g_err; #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/probgroup/frame0000664000175000017500000000007014665030471015436 0ustar frankfrank//#define XERR #include "probgroup.ih" ProbGroup:: { } simrisc-16.02.00/random/0000775000175000017500000000000014665030471013665 5ustar frankfranksimrisc-16.02.00/random/reinit.cc0000664000175000017500000000102114665030471015460 0ustar frankfrank#define XERR #include "random.ih" // Called from Loop::iterate, defines the betadistributions if vary is set void Random::reinit(size_t nCases, GeneratorType type) { if (Globals::vary() and nCases == 1) throw Exception{} << "'spread: true' cannot be used with 'cases: 1'"; d_nCases = nCases; switch (type) { case INCREASING_SEED: ++d_seed; break; case FIXED_SEED: break; default: d_seed = time(0); break; } reset(); } simrisc-16.02.00/random/instance.cc0000664000175000017500000000030714665030471016000 0ustar frankfrank//#define XERR #include "random.ih" // static Random &Random::instance() { if (not s_random) throw Exception{} << "Random::instance: Random not yet initiaized"; return *s_random; } simrisc-16.02.00/random/data.cc0000664000175000017500000000011214665030471015077 0ustar frankfrank//#define XERR #include "random.ih" unique_ptr Random::s_random; simrisc-16.02.00/random/lognormalvary.cc0000664000175000017500000000033114665030471017065 0ustar frankfrank//#define XERR #include "random.ih" double Random::logNormalVary(double mean, double stdDev) { d_logNormalVary->param(LogNormalParams{ mean, stdDev }); return (*d_logNormalVary)(d_engine[LOGNORMAL_VARY]); } simrisc-16.02.00/random/random.ih0000664000175000017500000000037414665030471015473 0ustar frankfrank#include "random.h" #include "../xerr/xerr.ih" #include #include #include #include #include "../globals/globals.h" #include "../log/log.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/random/reset.cc0000664000175000017500000000205614665030471015321 0ustar frankfrank#define XERR #include "random.ih" void Random::reset() { size_t seed = d_seed; for (size_t idx = 0; idx != N_STD_DISTRIBUTIONS; ++idx) { d_engine[idx] = mt19937{seed <<= 1}; // xerr(seed); } d_uniform.reset(); // clear the generators' caches d_uniformCase.reset(); d_uniformVSD.reset(); d_logNormal.reset(); if (Globals::vary()) // clear the varying distributions' caches { seed <<= 1; d_engine[NORMAL_VARY] = mt19937{ seed }; d_normalVary->reset(); seed <<= 1; d_engine[UNIFORM_VARY] = mt19937{ seed }; d_uniformVary->reset(); seed <<= 1; d_engine[LOGNORMAL_VARY] = mt19937{ seed }; d_logNormalVary->reset(); seed <<= 1; d_engine[UNIFORM_VARY] = mt19937{ seed }; d_uniformVSDvary->reset(); if (d_betaVary) { d_engine[BETA_VARY] = mt19937{ d_seed }; // std seed is used d_betaVary->reset(); // reset the beta distr.'s cache } } } simrisc-16.02.00/random/lognormal.cc0000664000175000017500000000043714665030471016172 0ustar frankfrank//#define XERR #include "random.ih" double Random::logNormal(double mean, double stdDev) { d_logNormal.param(LogNormalParams{ mean, stdDev }); double ret = d_logNormal(d_engine[LOGNORMAL]); g_log('L') << " logNormal random value: " << ret << nl; return ret; } simrisc-16.02.00/random/uniformvsdvary.cc0000664000175000017500000000030114665030471017264 0ustar frankfrank//#define XERR #include "random.ih" double Random::uniformVSDvary() { // return d_uniform(d_engine[UNIFORM_VARY]); throw Exception{} << "Random::uniformVSDvary() not yet available"; } simrisc-16.02.00/random/uniformvary.cc0000664000175000017500000000016414665030471016556 0ustar frankfrank//#define XERR #include "random.ih" double Random::uniformVary() { return d_uniform(d_engine[UNIFORM_VARY]); } simrisc-16.02.00/random/random.h0000664000175000017500000000604614665030471015324 0ustar frankfrank#ifndef INCLUDED_RANDOM_ #define INCLUDED_RANDOM_ #include #include // using the stl's mercenne twister #include #include #include #include "../enums/enums.h" #include "../betadist/betadist.h" class Random { using LogNormalParams = std::lognormal_distribution::param_type; using EngineVect = std::vector; size_t d_nEngines; size_t d_seed; size_t d_nCases; EngineVect d_engine; // all distribution types are default: double // and are allways available std::uniform_real_distribution<> d_uniform; // default: 0, max std::uniform_real_distribution<> d_uniformCase; // used by std::uniform_real_distribution<> d_uniformVSD; // Survival::cptVSDrow std::lognormal_distribution<> d_logNormal; // default: 0, 1 // these distributions are used with // Scenario: spread // default: 0, 1 std::unique_ptr> d_normalVary; std::unique_ptr> d_uniformVary; std::unique_ptr> d_uniformVSDvary; std::unique_ptr> d_logNormalVary; // BetaDist is not used with SimulationType BREAST std::unique_ptr d_betaVary; static std::unique_ptr s_random; public: Random(Random const &other) = delete; std::pair betaParameters() const; // called by void prepareBeta(std::istream &in); // Distribution::extract // called at each iteration void reinit(size_t nCases, GeneratorType type); static Random &initialize(); static Random &instance(); double uniform(); // used for generating reproducible double uniformCase(); // case characteristics // used for generating reproducible double uniformVSD(); // case characteristics double logNormal(double mean, double stdDev); // only used when 'spread: true': double betaVary(); double normalVary(); double uniformVary(); double uniformVSDvary(); // TO DO double logNormalVary(double mean, double stdDev); void setSeed(size_t seed); private: Random(); void reset(); }; inline void Random::setSeed(size_t seed) { d_seed = seed; } inline std::pair Random::betaParameters() const { return d_betaVary->parameters(); } // when parsing the config file // specify which vary-specific // distributions are used // OBS void use(DistType distribution); #endif simrisc-16.02.00/random/uniformcase.cc0000664000175000017500000000032414665030471016506 0ustar frankfrank#define XERR #include "random.ih" double Random::uniformCase() { double ret = d_uniformCase(d_engine[UNIFORM_CASE]); g_log('C') << " uniform case random value: " << ret << nl; return ret; } simrisc-16.02.00/random/betavary.cc0000664000175000017500000000016214665030471016010 0ustar frankfrank//#define XERR #include "random.ih" double Random::betaVary() { return (*d_betaVary)(d_engine[BETA_VARY]); } simrisc-16.02.00/random/normalvary.cc0000664000175000017500000000066414665030471016374 0ustar frankfrank#define XERR #include "random.ih" double Random::normalVary() { return (*d_normalVary)(d_engine[NORMAL_VARY]); } //////////////////////////////////////////// // ?? // d_normal is the std. normal distribution. To obtain a value from the // std. normal distribution return d_normal(d_engine) // double x1 = uniform(); // double x2 = uniform(); // double y = sqrt( -2 * log(x1) ); // // return y * sin( 2 * M_PI * x2 ); simrisc-16.02.00/random/preparebeta.cc0000664000175000017500000000017114665030471016465 0ustar frankfrank//#define XERR #include "random.ih" void Random::prepareBeta(istream &in) { d_betaVary.reset(new BetaDist{ in }); } simrisc-16.02.00/random/icmconf0000664000175000017500000000007514665030471015230 0ustar frankfrank#define LIBRARY "random" #include "../icmconf.lib" simrisc-16.02.00/random/random1.cc0000664000175000017500000000064314665030471015540 0ustar frankfrank#define XERR #include "random.ih" Random::Random() : d_nEngines(Globals::vary() ? N_DISTRIBUTIONS : N_STD_DISTRIBUTIONS), d_engine(d_nEngines) { // xerr("vary = " << Globals::vary()); if (not Globals::vary()) return; d_normalVary.reset(new normal_distribution<>{}); d_uniformVary.reset(new uniform_real_distribution<>{}); d_logNormalVary.reset(new lognormal_distribution<>{}); } simrisc-16.02.00/random/initialize.cc0000664000175000017500000000033514665030471016336 0ustar frankfrank//#define XERR #include "random.ih" // static Random &Random::initialize() { // if (s_random) // throw Exception{} << "Random::initiaize already called"; s_random.reset(new Random); return *s_random; } simrisc-16.02.00/random/uniformvsd.cc0000664000175000017500000000032114665030471016364 0ustar frankfrank#define XERR #include "random.ih" double Random::uniformVSD() { double ret = d_uniformCase(d_engine[UNIFORM_VSD]); g_log('V') << " uniform vsd random value: " << ret << nl; return ret; } simrisc-16.02.00/random/UNUSED/0000775000175000017500000000000014665030471014670 5ustar frankfranksimrisc-16.02.00/random/UNUSED/binomial.cc0000664000175000017500000000034214665030471016770 0ustar frankfrank//#define XERR #include "random.ih" double Random::binomial(double percentage) { d_binomial->param(BinomialParams{ N_TRIALS, percentage }); return (*d_binomial)(d_engine[BINOMIAL]) / static_cast(N_TRIALS); } simrisc-16.02.00/random/UNUSED/chi2.cc0000664000175000017500000000025114665030471016022 0ustar frankfrank//#define XERR #include "random.ih" double Random::chi2() { // d_chi2->param( Chi2Params(d_nCases - 1) ); // // return (*d_chi2)(d_engine[CHI2]); return 0; } simrisc-16.02.00/random/UNUSED/exponential.cc0000664000175000017500000000031214665030471017521 0ustar frankfrank// //#define XERR // #include "random.ih" // // double Random::exponential(double mean) // { // d_exponential.param(ExponentialParams{ 1 / mean }); // return d_exponential(d_engine); // } // // simrisc-16.02.00/random/uniform.cc0000664000175000017500000000030414665030471015650 0ustar frankfrank//#define XERR #include "random.ih" double Random::uniform() { double ret = d_uniform(d_engine[UNIFORM]); g_log('U') << " uniform random value: " << ret << nl; return ret; } simrisc-16.02.00/random/frame0000664000175000017500000000006214665030471014700 0ustar frankfrank//#define XERR #include "random.ih" Random:: { } simrisc-16.02.00/random/users.txt0000664000175000017500000000447614665030471015602 0ustar frankfrankdensities/indices.cc -- randomly determines the bi-rad category for every screening round age tumor/reset.cc -- resets the tumor's parameters like tumor age, p(survival), doublingtime, selfdetect age etc. Called from Loop:initialize, called from Loop::womenLoop for every simulated case tumor/tumorage.cc -- given the cumulative risk distribution for having a tumor, an age from that distribution is randomly drawn (used by Tumor::reset) incidence/carrier.cc -- determines which incidence carrier is used vary/refresh.cc -- if 'variableVary:' was specified, the values used for the Growth, Survival, and Incidence parameters like risk, mean and std. dev. are updated loop/maybedetect.cc -- determines whether, given a modality's sensitivity, a false negative occurred loop/naturaldeathage.cc -- from Loop::initialize in Loop::womenLoop: for each simulated case (woman): determines the case's natural death age loop/checkseed.cc -- at each new iteration: determines whether the random number generator is reset using the original seed or using the next seed value loop/maybefalsepositive.cc -- determines whether, given a modality's specificity, a false positive occurred loop/use.cc -- determines whether a modality is used by a screening round loop/loop1.cc -- resets the generators if variableVary was specified loop/iterate.cc -- initializes the generators ---------------------------------- Candidates for a separate random number generator: loop/naturaldeathage.cc simrisc-16.02.00/replacements0000664000175000017500000000253514665030471015017 0ustar frankfrank// replace objdump's idea of what a string is by ours: #std::__cxx11::basic_string, std::allocator >#std::string# #__gnu_cxx::__normal_iterator > >#Scenario::const_iterator# #, std::allocator > > const&, Scenario::Range&, char const*, std::vector > const*## #, std::hash, std::equal_to, std::allocator > ## #__gnu_cxx::__normal_iterator >#Next::ConstIter # #std::set const*> >#std::set# #[abi:cxx11]## #, std::hash## #, std::equal_to## #, std::allocator## #, std::allocator## #, std::allocator## #, std::allocator## #, std::allocator >## #, std::allocator ## #, std::allocator > ## #, std::allocator*> ## #, std::allocator ## #, std::allocator ## #, std::allocator ## #, std::allocator ## simrisc-16.02.00/requests.txt0000664000175000017500000001567414665030471015036 0ustar frankfrankWensenlijstje Simrisc Update: 17 feb 2024 > 1. Robuust maken van de input > > Het lijkt er sterk op dat Simrisc erg gevoelig is voor het precieze format van > de input: zijn er wel of geen meerdere spaties, volgorde van invoer, etc. Het > zou mooi zijn als Simrisc meer robuust met de input kan omgaan. Zie mijn mail van gisteren: hebben jullie een invoer die niet wordt geaccepteerd? =========================================================================== Gedaan: > 2. Ontkoppelen borstkanker en longkanker screening > > Gebruikers van borstkanker screening en longkanker screening werken wel veel > samen, maar zijn toch ook veel met hun eigen onderzoeksgebied bezig. Als > gebruiker van Simrisc word je bij het simuleren van borstkanker screening nu > voortdurend ‘lastig gevallen’ met informatie over longkanker screening en > omgekeerd. Het zou mooi zijn als dit volledig ontkoppeld wordt. Kan dat iets preciezer worden beschreven? In de configuratiefile zijn parameters voor beide kankers opgenomen omdat dat nou eenmaal door simrisc wordt aangeboden, maar ws. (moet ik even testen) kunnen de parameters voor borstkanker achterwege blijven wanneer longkankersimulaties worden uitgevoerd, en omgekeerd. Wanneer er in de uitvoer info over het ene type wordt geproduceerd terwijl 't andere type werd gesimuleerd kunnen jullie dan aangeven wat niet moet worden vermeld bij de resp. simulatiemethoden? Bij de borstkanker rounds.txt file (Marcel,Tue, 20 Feb 2024 07:44:23 +0000): in de rounds file die ook als uitvoer wordt gegenereerd worden Mammo, Tomo en MRI ook genoemd, ook al worden ze in rondes niet gebruikt. Voor die file ligt 't voor de hand om niet gebruikte modaliteiten niet te vermelden als ze bij de round-specificaties niet worden genoemd. > 3. Risico op kanker > > Het risico op kanker op een bepaalde leeftijd is gedefinieerd via 3 parameters > (f, m en s). Het zou mooi zijn als er ook de mogelijkheid zou zijn om een > tabel met incidentie per leeftijd in te lezen. Dat geldt voor alle parameters bij 'Incidence:' (Marcel, Wed, 21 Feb 2024 07:55:47 +00000) Moeten we ook een minimum aantal waarden vereisen in zo'n tabel? cf. Marcel Wed, 21 Feb 2024 09:43:32 +0000: > Leeftijd-1 indicentie-1 > Leeftijd-2 indicentie-2 > Etc > Waarbij per default > 0 0 > 100 1 > Bv: > 25 0.001 > 30 0.003 > 35 0.005 > 40 0.009 > 45 0.014 > > Hoe dat dan met de spread moet, weet ik nog zoeven niet, even over nadenken Geldt voor lifetiemRisk. meanAge en stdDev: vervallen bij gebruik van een tabel: > de specificatie wordt dan: > ... > Male: > riskTable: 25 0.001 (etc) > 4. Participatie = attendanceRate > > De participatie wordt nu slechts met 1 decimaal geaccepteerd, dat zouden we > graag in 2 decimalen willen Wat is de participatieparameter in de config file? Noch in de config file, noch in de simriscparams man-page wordt participatie (of participation) genoemd Aanpassen in Screening::writeParameters(ostream &out) op 't aantal gewenste parameters Marcel (Wed, 21 Feb 2024 07:48:49 +0000): 3 decimalen > 5. Definitie van interval: ‘echte’ interval tumoren toevoegen > > Bij het bepalen of een tumor een interval tumor is, wordt nu geen rekening > gehouden met of de vrouw wel of niet naar de voorgaande screening is > gegaan. Het huidige aantal willen we graag behouden, maar daarnaast zouden we > graag het aantal intervallen hebben waarin alleen de tumoren worden meegenomen > na een bijgewoonde screeningronde. OK, (d_nTrueIntervals in loop/) (Wed, 21 Feb 2024 07:44:09 +0000) > 6. Output detection round: verander nummering > > Detection round geeft aan als er een gedetecteerde tumor is en in welke ronde > deze is gedetecteerd. Deze begint voor screening ronde 1 bij 0 en telt zo door > tot 12 (in normale NL setting). Een 0 wordt ook gegeven als de tumor niet > wordt gedetecteerd. We zouden de nummering daarom graag aanpassen, zodat deze > 0en makkelijker te onderscheiden zijn. -> wachten op Keris (Marcel Wed, 21 Feb 2024 07:43:03 +0000) Keris Mon, 26 Feb 2024 14:59:40 +0000: > -1 tumor gedetecteerd voor de eerste screeningsronde > 0 tumor gedetecteerd na de eerste screeningsronde (en dus > voor de 2e screeningsronde) > *0 tumor gedetecteerd na de eerste screeningsronde, die niet > is bijgewoond > 2 tumor gedetecteerd na de derde screeningsronde > *2 tumor gedetecteerd na de derde screeningsronde, die niet > is bijgewoond > 9 tumor gedetecteerd na de laatste screeningsronde > *9 tumor gedetecteerd na de laatste screeningsronde, die niet > is bijgewoond wordt (screeningsrondes genummerd van 1..N): 0 geen tumor -1 tumor gedetecteerd voor de eerste screeningsronde 1 tumor gedetecteerd na de eerste screeningsronde (en dus voor de 2e screeningsronde) *1 tumor gedetecteerd na de eerste screeningsronde, die niet is bijgewoond 3 tumor gedetecteerd na de derde screeningsronde *3 tumor gedetecteerd na de derde screeningsronde, die niet is bijgewoond N tumor gedetecteerd na de laatste screeningsronde *N tumor gedetecteerd na de laatste screeningsronde, die niet is bijgewoond screeningsrondes in rounds.txt worden ook genummerd van 1..N > 7. Input in zelfde eenheid, niet logaritmisch > > Verschillende input van simrisc wordt nu logaritmisch gegeven, bijvoorbeeld > gemiddelde grootte zelf-detectie, waar andere input in mm wordt gegeven, bijv > startgrootte tumoren. We zouden graag alle input in mm geven en de logaritme > door het model laten berekenen. Over welke parameters gaat 't? Zijn dat (alle) 'mean' parameters bij Growth (waarbij in de config file 'selfDetect' wordt genoemd) of zijn 't (ook) andere parameters? Bij die gemiddelden worden ook stddev en spread genoemd. Moeten die zo blijven of moeten die ook worden aangepast (bv selfDetect breast: spread is nu .084, e^.084 = 1.08763)? Op dit moment in Growth: # values must be changed to exp(value) #selfDetect: # stdev mean spread dist breast: .70 2.92 .084 Normal lung: .014 3.037 .61 Normal DoublingTime: # stdev mean spread dist. # values must be changed to exp(value) ageGroup: 1 - 50: .61 4.38 .43 Normal ageGroup: 50 - 70: .26 5.06 .17 Normal ageGroup: 70 - * : .45 5.24 .23 Normal # all ages stdev mean spread dist. # values must be changed to exp(value) lung: .21 4.59 .74 Normal simrisc-16.02.00/round/0000775000175000017500000000000014665030471013534 5ustar frankfranksimrisc-16.02.00/round/round.h0000664000175000017500000000327414665030471015042 0ustar frankfrank#ifndef INCLUDED_ROUND_ #define INCLUDED_ROUND_ #include #include #include // contains a round specification from the config file #include "../typedefs/typedefs.h" #include "../globals/globals.h" class Round { friend std::istream &operator>>(std::istream &in, Round &round); friend std::ostream &operator<<(std::ostream &out, Round const &round); double d_age; Uint16Vect d_modalities; // modalities used in this screening round StringVect const &d_modalityIDs; public: Round(StringVect const &modalityIDs); bool add(uint16_t idx); bool none() const; // true: none was specified; double age() const; uint16_t rndAge() const; // rounded double age value // modality indices used by Uint16Vect const &modalityIndices() const; // this screening round // StringVect const &modalityIDs() const; // screening round private: std::ostream &insert(std::ostream &out) const; }; inline bool Round::none() const { return Globals::isZero(d_age - END_AGE); } inline Round::Round(StringVect const &modalityIDs) : d_modalityIDs(modalityIDs) {} inline Uint16Vect const &Round::modalityIndices() const { return d_modalities; } // inline StringVect const &Round::modalityIDs() const // { // return d_modalities; // } inline double Round::age() const { return d_age; } inline uint16_t Round::rndAge() const { return round(d_age); } inline std::ostream &operator<<(std::ostream &out, Round const &round) { return round.insert(out); } typedef std::vector RoundVect; #endif simrisc-16.02.00/round/insert.cc0000664000175000017500000000041014665030471015342 0ustar frankfrank//#define XERR #include "round.ih" std::ostream &Round::insert(std::ostream &out) const { out << "age: " << static_cast(round(d_age)); for (uint16_t modalityIdx: d_modalities) out << ", " << d_modalityIDs[modalityIdx]; return out; } simrisc-16.02.00/round/round.ih0000664000175000017500000000022514665030471015204 0ustar frankfrank#include "round.h" #include "../xerr/xerr.ih" #include #include #include #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/round/icmconf0000664000175000017500000000007414665030471015076 0ustar frankfrank#define LIBRARY "round" #include "../icmconf.lib" simrisc-16.02.00/round/extract.cc0000664000175000017500000000106014665030471015512 0ustar frankfrank////#define XERR //#include "round.ih" // //std::istream &Round::extract(istream &in) //{ // string modality; // // if (in >> d_age >> modality) // at least one modality must be // { // specified // do // { // d_idx = d_modalities.size(); // d_modalities.push_back(move(modality)); // 'modality' must be // // configured // } // while (in >> modality); // // in.clear(); // } // // return in; //} // simrisc-16.02.00/round/opextract.cc0000664000175000017500000000056714665030471016064 0ustar frankfrank//#define XERR #include "round.ih" std::istream &operator>>(std::istream &in, Round &round) { string specification; in >> specification; if (specification == "none") round.d_age = END_AGE; else { istringstream inStr{ specification }; if (not (inStr >> round.d_age)) in.setstate(ios::failbit); } return in; } simrisc-16.02.00/round/frame0000664000175000017500000000006014665030471014545 0ustar frankfrank//#define XERR #include "round.ih" Round:: { } simrisc-16.02.00/round/add.cc0000664000175000017500000000040414665030471014571 0ustar frankfrank//#define XERR #include "round.ih" bool Round::add(uint16_t idx) { if ( find(d_modalities.begin(), d_modalities.end(), idx) != d_modalities.end() ) return false; d_modalities.push_back(idx); return true; } simrisc-16.02.00/run0000755000175000017500000000016414545530666013146 0ustar frankfrank#!/bin/bash ~/src/icmake/compile/tmp/bin/binary -t 4 tmp/jobs '/usr/bin/g++ -c -o $2 --std=c++23 -Wall -Werror $1' simrisc-16.02.00/scenario/0000775000175000017500000000000014665030471014210 5ustar frankfranksimrisc-16.02.00/scenario/scenario.ih0000664000175000017500000000052414665030471016336 0ustar frankfrank#include "scenario.h" #include "../xerr/xerr.ih" #include #include #include #include #include "../globals/globals.h" #include "../options/options.h" #include "../random/random.h" #include "../distribution/distribution.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/scenario/find.cc0000664000175000017500000000046214665030471015441 0ustar frankfrank//#define XERR #include "scenario.ih" // static int Scenario::find(StringVect const &haystack, string const &needle) { auto iter = std::find(haystack.begin(), haystack.end(), needle); if (iter != haystack.end()) return iter - haystack.begin(); Err::specification(); return -1; } simrisc-16.02.00/scenario/setvary.cc0000664000175000017500000000057714665030471016225 0ustar frankfrank#define XERR #include "scenario.ih" void Scenario::setVary() { d_base.back() = "spread:"; bool vary = false; if (string spread; Parser::one(d_base, spread)) { if (int idx = find(s_bool, spread); idx != -1) vary = static_cast(idx); } Globals::setVary(vary); // xerr("vary = " << Globals::vary()); Random::initialize(); } simrisc-16.02.00/scenario/data.cc0000664000175000017500000000055014665030471015430 0ustar frankfrank//#define XERR #include "scenario.ih" StringVect Scenario::s_generatorType = { "fixed", // the SeedType ordering must "increasing", // correspond to the order of the "random", // GeneratorType enum's values }; StringVect Scenario::s_bool = { "false", "true" }; simrisc-16.02.00/scenario/checkcumdeath.cc0000664000175000017500000000173514665030471017315 0ustar frankfrank//#define XERR #include "scenario.ih" void Scenario::checkCumDeath(string const &source, LineInfo const *previous) const { if (size_t size = d_cumDeathProportions.size(); size != END_AGE) { previous = showLineInfo(previous); Err::msg(Err::CUM_DEATH) << source << "): " << END_AGE << " proportions required, " << size << " specified" << endl; } for (auto begin = d_cumDeathProportions.begin(), iter = begin, next = iter + 1, end = d_cumDeathProportions.end(); next < end; ++iter, ++next) { if (*next < *iter) { previous = showLineInfo(previous); Err::msg(Err::CUM_DEATH) << source << ") proportions decrease: " << (next - begin) << " (" << *next << ") less than " << (iter - begin) << " (" << *iter << ')' << endl; } } } simrisc-16.02.00/scenario/setdeath.cc0000664000175000017500000000142514665030471016322 0ustar frankfrank#define XERR #include "scenario.ih" void Scenario::setDeath() { LineInfo const *previous = 0; string cumDeath; if (cumDeath = Options::instance().cumDeathFile(); not cumDeath.empty()) readCumDeath(cumDeath); else { d_base.back() = "death:"; Parser::Lines lines = Parser::any(d_base); if (lines.size() == 1) readCumDeath(cumDeath = lines.get()->tail); else { cumDeath = "analysis specification"; LineInfo const *ptr = lines.get(); // skip the first (empty) line do previous = ptr; // keep the previous line while ((ptr = lines.get()) and appendCumDeath(ptr->tail)); } } checkCumDeath(cumDeath, previous); } simrisc-16.02.00/scenario/showlineinfo.cc0000664000175000017500000000037514665030471017230 0ustar frankfrank//#define XERR #include "scenario.ih" // static LineInfo const *Scenario::showLineInfo(LineInfo const *ptr) { if (ptr != 0) cout << "[Error] At line " << ptr->lineNr << " `" << ptr->tail << '\'' << endl; return 0; } simrisc-16.02.00/scenario/appendcumdeath.cc0000664000175000017500000000062514665030471017504 0ustar frankfrank//#define XERR #include "scenario.ih" bool Scenario::appendCumDeath(string const &line) { istringstream in{ line }; char ch; size_t nr; if ( not (in >> nr >> ch) or nr != (d_cumDeathProportions.size() + 1) or ch != ':' ) return false; double value; while (in >> value) d_cumDeathProportions.push_back(value); return true; } simrisc-16.02.00/scenario/setseed.cc0000664000175000017500000000034214665030471016152 0ustar frankfrank#define XERR #include "scenario.ih" void Scenario::setSeed() { if (d_generatorType == RANDOM_SEED) { d_seed = 0; return; } d_base.back() = "seed:"; Parser::nonNegative(d_base, d_seed); } simrisc-16.02.00/scenario/scenario1.cc0000664000175000017500000000035514665030471016406 0ustar frankfrank#define XERR #include "scenario.ih" Scenario::Scenario() : d_base{ "" } // 1st field set by set-members { setNiterations(); setNcases(); setGeneratorType(); setSeed(); setVary(); setDeath(); } simrisc-16.02.00/scenario/scenario.h0000664000175000017500000000467114665030471016174 0ustar frankfrank#ifndef INCLUDED_SCENARIO_ #define INCLUDED_SCENARIO_ #include // Scenario: // # default values are shown // // # use true for variable varying // spread: false // // iterations: 1 // // # random generator behavior: // # random, fixed, increasing // generator: random // // # initial seed unless using generator: random // seed: 1 // // # n cases to simulate // cases: 1000 // // death: #death.txt // 1: .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 // 11: .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 // ... (101 values) #include "../parser/parser.h" class Scenario { struct DLine // offending Death Line specification in case of errors { std::string const *line; size_t lineNr; }; StringVect d_base; GeneratorType d_generatorType; std::vector d_cumDeathProportions; size_t d_nIterations; size_t d_nCases; size_t d_seed; static StringVect s_generatorType; static StringVect s_bool; public: Scenario(); std::vector const &cumDeathProp() const; size_t nIterations() const; size_t seed() const; GeneratorType generatorType() const; size_t nCases() const; void writeParameters(std::ostream &out, size_t iter) const; private: bool appendCumDeath(std::string const &line); void checkCumDeath(std::string const &source, LineInfo const *previous) const; void readCumDeath(std::string const &fname); void setDeath(); // set the cum. death proportions void setNiterations(); // set n iteratations void setNcases(); // set nCases void setSeed(); // set seed value void setGeneratorType(); // set the random generator type void setVary(); // set variableSpread static int find(StringVect const &haystack, // must succeed or std::string const &needle); // Err::specification static LineInfo const *showLineInfo(LineInfo const *ptr); }; #include "scenario.f" #endif simrisc-16.02.00/scenario/icmconf0000664000175000017500000000007714665030471015555 0ustar frankfrank#define LIBRARY "scenario" #include "../icmconf.lib" simrisc-16.02.00/scenario/writeparameters.cc0000664000175000017500000000154014665030471017735 0ustar frankfrank//#define XERR #include "scenario.ih" void Scenario::writeParameters(ostream &out, size_t iter) const { out << "Scenario:\n" " iteration: " << iter << "\n" " generator: " << s_generatorType[d_generatorType] << "\n" " n iterations: " << d_nIterations << "\n" " n cases: " << d_nCases << "\n" " seed " << d_seed << "\n" " spread: " << s_bool[Globals::vary()] << '\n'; if (d_cumDeathProportions.size() != 0) { out << " death:"; size_t idx = 0; for (double prop: d_cumDeathProportions) { if (idx++ % 10 == 0) out << '\n' << setw(7) << idx << ':'; out << ' ' << prop; } if (idx % 10 != 0) out.put('\n'); } out.put('\n'); } simrisc-16.02.00/scenario/setgeneratortype.cc0000664000175000017500000000045314665030471020125 0ustar frankfrank#define XERR #include "scenario.ih" void Scenario::setGeneratorType() { d_base.back() = "generator:"; string type; if (Parser::one(d_base, type)) { if (int idx = find(s_generatorType, type); idx != -1) d_generatorType = static_cast(idx); } } simrisc-16.02.00/scenario/setncases.cc0000664000175000017500000000021614665030471016506 0ustar frankfrank#define XERR #include "scenario.ih" void Scenario::setNcases() { d_base.back() = "cases:"; Parser::nonNegative(d_base, d_nCases); } simrisc-16.02.00/scenario/setniterations.cc0000664000175000017500000000023714665030471017574 0ustar frankfrank//#define XERR #include "scenario.ih" void Scenario::setNiterations() { d_base.back() = "iterations:"; Parser::nonNegative(d_base, d_nIterations); } simrisc-16.02.00/scenario/scenario.f0000664000175000017500000000060614665030471016164 0ustar frankfrankinline std::vector const &Scenario::cumDeathProp() const { return d_cumDeathProportions; } inline size_t Scenario::nIterations() const { return d_nIterations; } inline size_t Scenario::seed() const { return d_seed; } inline GeneratorType Scenario::generatorType() const { return d_generatorType; } inline size_t Scenario::nCases() const { return d_nCases; } simrisc-16.02.00/scenario/frame0000664000175000017500000000006614665030471015227 0ustar frankfrank//#define XERR #include "scenario.ih" Scenario:: { } simrisc-16.02.00/scenario/readcumdeath.cc0000664000175000017500000000124214665030471017144 0ustar frankfrank//#define XERR #include "scenario.ih" void Scenario::readCumDeath(string const &fname) { ifstream in = Exception::factory(fname); string line; size_t lineNr = 0; while (getline(in, line)) { ++lineNr; if ( size_t pos = line.find_first_not_of(" \t"); // ignore empty and pos == string::npos or line[pos] == '#' // comment lines ) continue; if (not appendCumDeath(line)) { Err::msg(Err::CUM_DEATH) << fname << " line " << lineNr << "): format error in `" << line << '\'' << endl; return; } } } simrisc-16.02.00/screening/0000775000175000017500000000000014665030471014362 5ustar frankfranksimrisc-16.02.00/screening/screening.f0000664000175000017500000000050414665030471016505 0ustar frankfrankinline bool Screening::attend(size_t idx) const // 24/1 { return d_attend[idx]; } inline double Screening::rate() const { return d_rate; } inline uint16_t Screening::nRounds() const { return d_roundVect.size(); } inline Round const &Screening::round(size_t idx) const { return d_roundVect[idx]; } simrisc-16.02.00/screening/ages.cc0000664000175000017500000000030214665030471015603 0ustar frankfrank//#define XERR #include "screening.ih" DoubleVect Screening::ages() const { DoubleVect ret; for (auto const &round: d_roundVect) ret.push_back(round.age()); return ret; } simrisc-16.02.00/screening/addmodality.cc0000664000175000017500000000347614665030471017176 0ustar frankfrank#define XERR #include "screening.ih" bool Screening::addModality(istream &in, Round &round) { string modality; // determine the modalities to use while (in >> modality) { Err::Context context; if (uint16_t idx = d_modalities.find(modality); idx == UNDEFINED) context = Err::UNDEFINED_MODALITY; // ------------------------------------------- // lungCancer CT action // ------------------------------------------- // 0 0 add // 0 1 BC_CT_INVALID // 1 0 LC_INVALID_MODALITY // 1 1 add // ------------------------------------------- // if LC simulation is requested // but no CT modality requested else if (d_lungCancer and modality != "CT") { Err::msg(Err::LC_INVALID_MODALITY) << modality << endl; return false; } // BC simulation and CT is spec'd else if (not d_lungCancer and modality == "CT") context = Err::BC_CT_INVALID; else { // TODO: the last entry in d_roundVect (may still be empty) // may not contain modality 'idx' if (round.add(idx)) { d_modalities.activate(modality); continue; } context = Err::MODALITY_REPEATED; } Err::msg(context) << modality << endl; return false; } return true; } // if ((this->*d_checkCT)(modality)) // issue one warning if CT is // continue; // not specified simrisc-16.02.00/screening/screening.h0000664000175000017500000001244614665030471016517 0ustar frankfrank#ifndef INCLUDED_SCREENING_ #define INCLUDED_SCREENING_ // Screening: // // # round: age space separated modalities. // round: 50 Mammo // round: 52 Mammo // round: 54 Mammo // round: 56 Mammo // round: 58 Mammo // round: 60 Mammo // round: 62 Mammo // round: 64 Mammo // round: 66 Mammo // round: 68 Mammo // round: 70 Mammo // round: 72 Mammo // round: 74 Mammo // alternatively: // round: none // // # screening value // attendanceRate: .8 // #include #include "../round/round.h" class Modalities; class Screening { Modalities &d_modalities; StringVect d_base; // this vector's size holds the RoundVect d_roundVect; // #rounds BoolVect d_attend; // true: case attends the round // attendance rate, configured at double d_rate; // Screening: attendanceRate: // points to static members: // errRisk1404 or void (*d_errRiskVector)(DoubleVect &, // errRiskA1405 Modalities const &, Round const &, uint16_t, double, double); bool d_lungCancer; public: Screening(Modalities &modalities); double rate() const; // .f DoubleVect radiationRisk( // 24/1 also sets d_attend's values Modalities const &modalities, Uint16Vect const &indices, double beta, double eta); // beir7 values DoubleVect ages() const; // vector of ages of the screening rounds uint16_t nRounds() const; // .f double roundAge(size_t idx) const; // age at round idx .f // roundIdx is, e.g. Round const &round(size_t roundIdx) const; // Loop::d_round .f void writeParameters(std::ostream &out) const; bool attend(size_t idx) const; // 24/1 true: case attended this round private: bool addModality(std::istream &in, Round &round); // false: round: none, noneLine // has the last noneLine bool addRound(LineInfo *noneLine, LineInfo const &line); bool increasingAge(Round const &round) const; static void errRisk1404(DoubleVect &riskVect, Modalities const &modalities, Round const &round, uint16_t biRadIdx, double beta, double eta); static void errRisk1405(DoubleVect &riskVect, Modalities const &modalities, Round const &round, uint16_t biRadIdx, double beta, double eta); // called by errRiskRelative static double beir7Err(Round const &round, uint16_t idx, double beta, double eta, Modalities const &modalities); // called by earRisk static double beir7Err(uint16_t age, Round const &round, uint16_t idx, double beta, double eta, Modalities const &modalities); void setAttendanceRate(); void setRounds(); // bool warnCT(std::string const &modality); // bool warnedCT(std::string const &modality); // bool warnNotCT(std::string const &modality); // bool warnedNotCT(std::string const &modality); }; #include "screening.f" // // CT for lung cancer, // // not CT for breast cancer // bool (Screening::*d_checkCT)(std::string const &modality); // // void beir7dose(double const *dose); // .h // // // // // RoundVect const &rounds() const; // // // StringSet const &modalities() const; // double const *d_beir7dose; // set from Screening using // // beir7dose() // // RoundVect d_rounds; // StringSet d_modalities; // specified modalities // void set(Distribution *dest, // 1 // Scenario const &scenario, char const *id); // // 2 // static bool set(Distribution *dest, // Scenario::const_iterator const &iter); // // // inline StringSet const &Screening::modalities() const // { // return d_modalities; // } // // inline RoundVect const &Screening::rounds() const // { // return d_rounds; // } // // inline void Screening::beir7dose(double const *dose) // { // d_beir7dose = dose; // } //////////////////////////////////////////////////////////// // inline double Screening::Distribution::value() const // { // return d_value; // } // static char const s_errorID[]; // static char const s_attendanceID[]; // static char const s_roundID[]; #endif simrisc-16.02.00/screening/roundage.cc0000664000175000017500000000022214665030471016471 0ustar frankfrank//#define XERR #include "screening.ih" double Screening::roundAge(size_t idx) const { double ret = d_roundVect[idx].age(); return ret; } simrisc-16.02.00/screening/errrisk1404.cc0000664000175000017500000000144314665030471016665 0ustar frankfrank//#define XERR #include "screening.ih" // (deprecated, used for backward compatibility) // called from radiationrisk.cc // index is the biRad column index to use with BC // and 0 when used with LC, as LC has no dose variation. // static void Screening::errRisk1404(DoubleVect &vect, Modalities const &modalities, Round const &round, uint16_t index, double beta, double eta) { // compute beir7Err once, double error = beir7Err(round, index, beta, eta, modalities); // then visit all subsequent ages for (uint16_t age = round.rndAge() + 1; age != END_AGE; ++age) vect[age] *= error; } simrisc-16.02.00/screening/setattendancerate.cc0000664000175000017500000000027214665030471020370 0ustar frankfrank//#define XERR #include "screening.ih" // attendanceRate: 0.8 void Screening::setAttendanceRate() { d_base.back() = "attendanceRate:"; Parser::proportion(d_base, d_rate); } simrisc-16.02.00/screening/addround.cc0000664000175000017500000000137514665030471016477 0ustar frankfrank#define XERR #include "screening.ih" // false: round: none was specified // true: round: age modality/ties was specified bool Screening::addRound(LineInfo *noneLine, LineInfo const &lineInfo) { Round round(d_modalities.modalityIDs()); //xerr(lineInfo.txt); auto in = Parser::extract(lineInfo, round); // extracts the age if (round.none()) { *noneLine = lineInfo; // save the last round: none line return false; } if (not in) return true; if (not increasingAge(round)) // ages must increase { Err::msg(Err::ROUND_AGES_DONT_INC) << endl; return true; } if (addModality(in, round)) d_roundVect.push_back(move(round)); return true; } simrisc-16.02.00/screening/icmconf0000664000175000017500000000010014665030471015712 0ustar frankfrank#define LIBRARY "screening" #include "../icmconf.lib" simrisc-16.02.00/screening/radiationrisk.cc0000664000175000017500000000403514665030471017536 0ustar frankfrank#define XERR #include "screening.ih" // called from loop/initialize.cc // indices are Breast bi-rad indices used for the screening round // ages, determined by Densities // or lung-cancer table S3 indices // to use for the ages of the screening rounds extern size_t g_caseIdx; DoubleVect Screening::radiationRisk( Modalities const &modalities, Uint16Vect const &indices, double beta, double eta) // beir7 values { DoubleVect vect = DoubleVect(END_AGE, 1); //xerr("d_errRiskVector: " << d_errRiskVector); g_log << " Screening::radiationRisk:\n" " rate: " << d_rate << ", beta: " << beta << ", eta: " << eta << " using " << ( d_errRiskVector == errRisk1405 ? "errRisk1405\n" : "errRisk1404\n" ); d_attend = BoolVect( d_roundVect.size() ); // 24/1 for ( size_t roundIdx = 0, end = d_roundVect.size(); roundIdx != end; ++roundIdx ) { // probabilities *lower* than the attendance rate mean the case // is attending. if (double rnd = Random::instance().uniform(); rnd > d_rate) g_log << " round " << roundIdx << ": rnd = " << rnd << " > rate: round not attended (" << d_attend[roundIdx] << ")\n"; else { d_attend[roundIdx] = true; // 24/1 g_log << " round " << roundIdx << ", rnd = " << rnd << " <= rate: compute radiation risk\n"; (*d_errRiskVector) // errRisk1405, or (deprecated) with option ( // -e: errRisk1404 vect, modalities, d_roundVect[roundIdx], indices[roundIdx], beta, eta ); } } return vect; } simrisc-16.02.00/screening/writeparameters.cc0000664000175000017500000000065214665030471020112 0ustar frankfrank//#define XERR #include "screening.ih" void Screening::writeParameters(ostream &out) const { //Globals::setPrecision(out, 3) << out << "Screening:\n" " attendanceRate: " << d_rate << "\n" " rounds: " << d_roundVect.size() << '\n'; for (auto const &round: d_roundVect) out << " " << round << '\n'; // Globals::setPrecision(out, 3).put('\n'); out.put('\n'); } simrisc-16.02.00/screening/screening1.cc0000664000175000017500000000075514665030471016736 0ustar frankfrank#define XERR #include "screening.ih" Screening::Screening(Modalities &modalities) : d_modalities(modalities), d_base{ "" }, // option -e is deprecated and is only available for reasons of // backward compatibility. d_errRiskVector(Arg::instance().option('e') ? errRisk1404 : errRisk1405), d_lungCancer(not Globals::isBreast()) { setAttendanceRate(); // from the config file setRounds(); // from the config file } simrisc-16.02.00/screening/beir7err2.cc0000664000175000017500000000122514665030471016474 0ustar frankfrank//#define XERR #include "screening.ih" // called from errRisk1405.cc // index is the biRad column index to use with BC // and 0 when used with LC, as LC has no dose variation. // static double Screening::beir7Err(uint16_t age, Round const &round, uint16_t index, double beta, double eta, Modalities const &modalities) { double risk = 1; double factor = beta * pow(age / 60.0, eta) / 1000; //g_log << age << ' ' << index << ' ' << factor << '\n'; for (ModBase const *modBase: modalities.use(round.modalityIndices())) risk *= (1 + factor * modBase->dose(index)); return risk; } simrisc-16.02.00/screening/errrisk1405.cc0000664000175000017500000000137014665030471016665 0ustar frankfrank//#define XERR #include "screening.ih" // called from radiationrisk.cc // index is the biRad column index to use with BC // and 0 when used with LC, as LC has no dose variation. // static void Screening::errRisk1405(DoubleVect &vect, Modalities const &modalities, Round const &round, uint16_t index, double beta, double eta) { // visit all subsequent ages, and compute // beir7Err separately for each age // (beir7err2.cc) for (uint16_t age = round.rndAge() + 1; age != END_AGE; ++age) vect[age] *= beir7Err(age, round, index, beta, eta, modalities); } simrisc-16.02.00/screening/frame0000664000175000017500000000007014665030471015374 0ustar frankfrank//#define XERR #include "screening.ih" Screening:: { } simrisc-16.02.00/screening/beir7err1.cc0000664000175000017500000000127014665030471016473 0ustar frankfrank//#define XERR #include "screening.ih" // called from (deprecated) errRisk1404.cc // index is the biRad column index to use with BC // and 0 when used with LC, as LC has no dose variation. // static double Screening::beir7Err(Round const &round, uint16_t index, double beta, double eta, Modalities const &modalities) { double risk = 1; double factor = beta * pow(round.age() / 60, eta) / 1000; // for modalities not defining 'dose' (MRI) // 0 is returned for (ModBase const *modBase: modalities.use(round.modalityIndices())) risk *= (1 + factor * modBase->dose(index)); return risk; } simrisc-16.02.00/screening/increasingage.cc0000664000175000017500000000044114665030471017467 0ustar frankfrank//#define XERR #include "screening.ih" bool Screening::increasingAge(Round const &round) const { return d_roundVect.empty() or Globals::weakCompare(d_roundVect.back().age() + 1, round.age()) != 1; // new age must be at least last age + 1 ; } simrisc-16.02.00/screening/setrounds.cc0000664000175000017500000000121414665030471016715 0ustar frankfrank#define XERR #include "screening.ih" void Screening::setRounds() { d_base.back() = "round:"; auto lines = Parser::any(d_base); // obtain the 'round:' lines bool allOK = true; LineInfo noneLine; while (true) { LineInfo const *line = lines.get(); if (line == 0) break; // add a round specification allOK = addRound(&noneLine, *line) and allOK; } if (d_roundVect.size() and not allOK) // not all rounds were OK { Err::reset(noneLine); Err::msg(Err::ROUND_NONE) << noneLine.txt << endl; } } simrisc-16.02.00/screening/screening.ih0000664000175000017500000000054614665030471016666 0ustar frankfrank#include "screening.h" #include "../xerr/xerr.ih" #include //#include "../options/options.h" #include "../random/random.h" #include "../modbase/modbase.h" #include "../globals/globals.h" #include "../modalities/modalities.h" #include "../parser/parser.h" #include "../log/log.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/simrisc0000777000175000017500000000000014630012742015361 2simriscustar frankfranksimrisc-16.02.00/simrisc.xref0000664000175000017500000064254614665030471014765 0ustar frankfrankoxref by Frank B. Brokken (f.b.brokken@rug.nl) oxref V 2.01.00 2012-2023 CREATED Sun, 07 Apr 2024 09:20:23 +0000 OXREF ARGUMENTS: -t main -r replacements -fxs tmp/main.o tmp/libofiles.a ---------------------------------------------------------------------- CROSS REFERENCE LISTING: accept(double&) Full name: VSD::accept(double&) Source: accept.cc Used By: data.cc: GLOBALS data.cc 20data.o accept(double) const Full name: Distribution::accept(double) const Source: accept.cc Used By: distribution1.cc: Distribution::Distribution(VaryType) activate() Full name: Options::activate() Source: activate.cc Used By: actualize.cc: Analysis::actualize(std::vector const&) active() Full name: Modalities::active() Source: active.cc Used By: iterate.cc: Loop::iterate() actualize() Full name: Options::actualize() Source: actualize.cc Used By: actualize.cc: Analysis::actualize(std::vector const&) actualize(std::vector const&) Full name: Analysis::actualize(std::vector const&) Source: actualize.cc Used By: analysis1.cc: Analysis::Analysis(std::istream&&, unsigned short) add(bool*, LineInfo const&) Full name: Densities::add(bool*, LineInfo const&) Source: add.cc Used By: densities1.cc: Densities::Densities() add(bool*, LineInfo const&) Full name: CT::add(bool*, LineInfo const&) Source: add.cc Used By: setsensitivity.cc: CT::setSensitivity() add(unsigned short) Full name: Round::add(unsigned short) Source: add.cc Used By: addmodality.cc: Screening::addModality(std::istream&, Round&) addConfigLine(std::vector*>&, ConfigLines&, ParamsSrc) Full name: Parser::addConfigLine(std::vector*>&, ConfigLines&, ParamsSrc) Source: addconfigline.cc Used By: load1.cc: Parser::load(std::istream&, unsigned short, std::vector&, std::vector&) load2.cc: Parser::load(std::string const&) addCost(double) Full name: Loop::addCost(double) Source: addcost.cc Used By: intervalcancer.cc: Loop::intervalCancer() maybefalsepositive.cc: Loop::maybeFalsePositive(ModBase*, double) screen.cc: Loop::screen(double) tumordetected.cc: Loop::tumorDetected(ModBase*, double) addMod(ModBase*) Full name: Modalities::addMod(ModBase*) Source: addmod.cc Used By: modalities1.cc: Modalities::Modalities(Tumor const&) addModality(std::istream&, Round&) Full name: Screening::addModality(std::istream&, Round&) Source: addmodality.cc Used By: addround.cc: Screening::addRound(LineInfo*, LineInfo const&) addRound(LineInfo*, LineInfo const&) Full name: Screening::addRound(LineInfo*, LineInfo const&) Source: addround.cc Used By: setrounds.cc: Screening::setRounds() AgeGroupVSD(VaryType, bool, bool) Full name: AgeGroupVSD::AgeGroupVSD(VaryType, bool, bool) Source: agegroupvsd1.cc Used By: specificitybase.cc: ModBase::specificityBase(std::vector&) setdoublingtime.cc: Growth::setDoublingTime() ageGroupVSDbreast(unsigned short) const Full name: Growth::ageGroupVSDbreast(unsigned short) const Source: agegroupvsdbreast.cc Used By: setdoublingtime.cc: Growth::setDoublingTime() ageGroupVSDlung(unsigned short) const Full name: Growth::ageGroupVSDlung(unsigned short) const Source: agegroupvsdlung.cc Used By: setdoublingtime.cc: Growth::setDoublingTime() ages() const Full name: Screening::ages() const Source: ages.cc Used By: cptindices.cc: Loop::cptIndices() const alter(int, std::string const&) Full name: Options::alter(int, std::string const&) Source: alter.cc Used By: actualize.cc: Analysis::actualize(std::vector const&) Analysis(std::istream&&, unsigned short) Full name: Analysis::Analysis(std::istream&&, unsigned short) Source: analysis1.cc Used By: run.cc: Simulator::run() any(std::vector const&) Full name: Parser::any(std::vector const&) Source: any.cc Used By: fillrisktable.cc: TableParams::fillRiskTable(std::vector&) setrounds.cc: Screening::setRounds() densities1.cc: Densities::Densities() setsensitivity.cc: CT::setSensitivity() one.cc: Parser::one(std::vector const&) vsdparameters1.cc: Parser::VSDparameters(VaryType, std::vector const&, std::initializer_list const&) setdeath.cc: Scenario::setDeath() setdoublingtime.cc: Growth::setDoublingTime() loads3.cc: Survival::loadS3() appendCumDeath(std::string const&) Full name: Scenario::appendCumDeath(std::string const&) Source: appendcumdeath.cc Used By: readcumdeath.cc: Scenario::readCumDeath(std::string const&) setdeath.cc: Scenario::setDeath() appendPair(std::string const&) Full name: TableParams::appendPair(std::string const&) Source: appendpair.cc Used By: fillrisktable.cc: TableParams::fillRiskTable(std::vector&) atLeast(double) Full name: Err::atLeast(double) Source: atleast.cc Used By: setlungcancer.cc: Costs::setLungCancer() atleast.cc: Parser::atLeast(double, std::vector const&, double&) setstart.cc: Growth::setStart() atLeast(double, std::vector const&, double&) Full name: Parser::atLeast(double, std::vector const&, double&) Source: atleast.cc Used By: setage.cc: Costs::setAge() setvariables.cc: Costs::setVariables(bool) modbase1.cc: ModBase::ModBase(std::string const&) setncases.cc: Scenario::setNcases() setniterations.cc: Scenario::setNiterations() setseed.cc: Scenario::setSeed() author Full name: Icmake::author Source: version.cc Used By: usage.cc: usage(std::string const&) baseOption() Full name: Options::baseOption() Source: baseoption.cc Used By: options1.cc: Options::Options() Beir7() Full name: Beir7::Beir7() Source: beir71.cc Used By: loop1.cc: Loop::Loop(std::vector const&) beir7Err(Round const&, unsigned short, double, double, Modalities const&) Full name: Screening::beir7Err(Round const&, unsigned short, double, double, Modalities const&) Source: beir7err1.cc Used By: errrisk1404.cc: Screening::errRisk1404(std::vector&, Modalities const&, Round const&, unsigned short, double, double) beir7Err(unsigned short, Round const&, unsigned short, double, double, Modalities const&) Full name: Screening::beir7Err(unsigned short, Round const&, unsigned short, double, double, Modalities const&) Source: beir7err2.cc Used By: errrisk1405.cc: Screening::errRisk1405(std::vector&, Modalities const&, Round const&, unsigned short, double, double) BetaDist(std::istream&) Full name: BetaDist::BetaDist(std::istream&) Source: betadist1.cc Used By: preparebeta.cc: Random::prepareBeta(std::istream&) betaVary() Full name: Random::betaVary() Source: betavary.cc Used By: varybeta.cc: Distribution::varyBeta(double) const caseIdx(unsigned long) Full name: Log::caseIdx(unsigned long) Source: caseidx.cc Used By: gencases.cc: Loop::genCases(unsigned long, unsigned long) caseInit() Full name: Loop::caseInit() Source: caseinit.cc Used By: gencases.cc: Loop::genCases(unsigned long, unsigned long) cases() const Full name: Loop::cases() const Source: cases.cc Used By: iterate.cc: Loop::iterate() characteristicsAt(double) Full name: Tumor::characteristicsAt(double) Source: characteristicsat.cc Used By: leaving.cc: Loop::leaving(double) postscreen.cc: Loop::postScreen() tumordetected.cc: Loop::tumorDetected(ModBase*, double) checkCumDeath(std::string const&, LineInfo const*) const Full name: Scenario::checkCumDeath(std::string const&, LineInfo const*) const Source: checkcumdeath.cc Used By: setdeath.cc: Scenario::setDeath() checkIncreasing() Full name: TableParams::checkIncreasing() Source: checkincreasing.cc Used By: checktable.cc: TableParams::checkTable() checkRedo(ConfigLines&) Full name: Parser::checkRedo(ConfigLines&) Source: checkredo.cc Used By: addconfigline.cc: Parser::addConfigLine(std::vector*>&, ConfigLines&, ParamsSrc) checkTable() Full name: TableParams::checkTable() Source: checktable.cc Used By: fillrisktable.cc: TableParams::fillRiskTable(std::vector&) cmdLineAnalysis() Full name: Simulator::cmdLineAnalysis() Source: cmdlineanalysis.cc Used By: setanalysissource.cc: Simulator::setAnalysisSource() ConfigLines(std::istream&, unsigned short) Full name: ConfigLines::ConfigLines(std::istream&, unsigned short) Source: configlines2.cc Used By: load1.cc: Parser::load(std::istream&, unsigned short, std::vector&, std::vector&) ConfigLines(std::string const&) Full name: ConfigLines::ConfigLines(std::string const&) Source: configlines1.cc Used By: load2.cc: Parser::load(std::string const&) configOption() Full name: Options::configOption() Source: configoption.cc Used By: options1.cc: Options::Options() conflictCheck() const Full name: Options::conflictCheck() const Source: conflictcheck.cc Used By: actualize.cc: Options::actualize() connects(Group const&) const Full name: Group::connects(Group const&) const Source: connects.cc Used By: add.cc: Densities::add(bool*, LineInfo const&) specificitybase.cc: ModBase::specificityBase(std::vector&) setdoublingtime.cc: Growth::setDoublingTime() loads3.cc: Survival::loadS3() contains(double) const Full name: Group::contains(double) const Source: contains.cc Used By: vsensitivity.cc: CT::vSensitivity(unsigned long) const probindexof.cc: ProbGroup::probIndexOf(std::vector const&, double, double) cost(double) const Full name: Costs::cost(double) const Source: cost.cc Used By: othertreatment.cc: Costs::otherTreatment(double, double, bool) const Costs() Full name: Costs::Costs() Source: costs1.cc Used By: loop1.cc: Loop::Loop(std::vector const&) cptIndices() const Full name: Loop::cptIndices() const Source: cptindices.cc Used By: caseinit.cc: Loop::caseInit() cptTNM(double) Full name: Survival::cptTNM(double) Source: cpttnm.cc Used By: survival1.cc: Survival::Survival() cptTumorRisk() Full name: Incidence::cptTumorRisk() Source: cpttumorrisk.cc Used By: incidence1.cc: Incidence::Incidence() vary.cc: Incidence::vary(std::ostream&) cptVSDrow(double) Full name: Survival::cptVSDrow(double) Source: cptvsdrow.cc Used By: survival1.cc: Survival::Survival() CT(Tumor const&) Full name: CT::CT(Tumor const&) Source: ct1.cc Used By: modalities1.cc: Modalities::Modalities(Tumor const&) cumDeathOption(std::string const&) Full name: Options::cumDeathOption(std::string const&) Source: cumdeathoption.cc Used By: options1.cc: Options::Options() cumTotalRisk(std::vector const&) Full name: TumorInfo::cumTotalRisk(std::vector const&) Source: cumtotalrisk.cc Used By: caseinit.cc: Loop::caseInit() deathAge(std::string const&) Full name: Options::deathAge(std::string const&) Source: deathage.cc Used By: alter.cc: Options::alter(int, std::string const&) deathageoption.cc: Options::deathAgeOption(std::string const&) deathAgeOption(std::string const&) Full name: Options::deathAgeOption(std::string const&) Source: deathageoption.cc Used By: options1.cc: Options::Options() Densities() Full name: Densities::Densities() Source: densities1.cc Used By: loop1.cc: Loop::Loop(std::vector const&) discount(double, unsigned long) const Full name: Costs::discount(double, unsigned long) const Source: discount.cc Used By: lctreatment.cc: Costs::lcTreatment(double, double, bool) const othertreatment.cc: Costs::otherTreatment(double, double, bool) const maybefalsepositive.cc: Loop::maybeFalsePositive(ModBase*, double) screen.cc: Loop::screen(double) Distribution(VaryType) Full name: Distribution::Distribution(VaryType) Source: distribution1.cc Used By: vsd1.cc: VSD::VSD(VaryType) doseBase(std::vector&) Full name: ModBase::doseBase(std::vector&) Source: dosebase.cc Used By: tomo1.cc: Tomo::Tomo() mammo1.cc: Mammo::Mammo(Tumor const&) endPoint(std::pair const&) Full name: Parser::endPoint(std::pair const&) Source: endpoint.cc Used By: addconfigline.cc: Parser::addConfigLine(std::vector*>&, ConfigLines&, ParamsSrc) initlineinfovects.cc: Parser::initLineInfoVects(std::unordered_map&) rmlineinfovectors.cc: Parser::rmLineInfoVectors(std::unordered_map&) errRisk1404(std::vector&, Modalities const&, Round const&, unsigned short, double, double) Full name: Screening::errRisk1404(std::vector&, Modalities const&, Round const&, unsigned short, double, double) Source: errrisk1404.cc Used By: screening1.cc: Screening::Screening(Modalities&) errRisk1405(std::vector&, Modalities const&, Round const&, unsigned short, double, double) Full name: Screening::errRisk1405(std::vector&, Modalities const&, Round const&, unsigned short, double, double) Source: errrisk1405.cc Used By: radiationrisk.cc: Screening::radiationRisk(Modalities const&, std::vector const&, double, double) screening1.cc: Screening::Screening(Modalities&) extract(char const*, VSD&) Full name: CT::extract(char const*, VSD&) Source: extract.cc Used By: setspecificity.cc: CT::setSpecificity() extract(char const*, VSD&) Full name: MRI::extract(char const*, VSD&) Source: extract.cc Used By: setsensitivity.cc: MRI::setSensitivity() setspecificity.cc: MRI::setSpecificity() extract(std::istream&) Full name: Distribution::extract(std::istream&) Source: extract.cc Used By: extract.cc: VSD::extract(std::istream&) extract(std::istream&) Full name: AgeGroupVSD::extract(std::istream&) Source: extract.cc Used By: specificitybase.cc: ModBase::specificityBase(std::vector&) setdoublingtime.cc: GLOBALS setdoublingtime.cc 7setdoublingtime.o extract(std::istream&) Full name: ProbGroup::extract(std::istream&) Source: extract.cc Used By: add.cc: Densities::add(bool*, LineInfo const&) loads3.cc: Survival::loadS3() extract(std::istream&) Full name: VSD::extract(std::istream&) Source: extract.cc Used By: vsdparams1.cc: GLOBALS vsdparams1.cc 10vsdparams1.o beir71.cc: GLOBALS beir71.cc 13beir71.o extractbase.cc: ModBase::extractBase(VSD&) extract.cc: AgeGroupVSD::extract(std::istream&) vsdparameters1.cc: Parser::VSDparameters(VaryType, std::vector const&, std::initializer_list const&) vsdparameters2.cc: Parser::VSDparameters(VaryType, std::vector const&, unsigned long) setselfdetect.cc: Growth::setSelfDetect() extract(std::istream&) Full name: Group::extract(std::istream&) Source: extract.cc Used By: add.cc: CT::add(bool*, LineInfo const&) extract.cc: ProbGroup::extract(std::istream&) extract.cc: AgeGroupVSD::extract(std::istream&) extractBase(VSD&) Full name: ModBase::extractBase(VSD&) Source: extractbase.cc Used By: extract.cc: CT::extract(char const*, VSD&) extract.cc: MRI::extract(char const*, VSD&) extractDiameters(Parser::Lines&&) Full name: Costs::extractDiameters(Parser::Lines&&) Source: extractdiameters.cc Used By: setdiameters.cc: Costs::setDiameters() falseNegative(ModBase*) Full name: Loop::falseNegative(ModBase*) Source: falsenegative.cc Used By: maybefalsenegative.cc: Loop::maybeFalseNegative(ModBase*, double) fileAnalysis() Full name: Simulator::fileAnalysis() Source: fileanalysis.cc Used By: setanalysissource.cc: Simulator::setAnalysisSource() fileOption(std::string*, int) Full name: Options::fileOption(std::string*, int) Source: fileoption.cc Used By: options1.cc: Options::Options() fillRiskTable(std::vector&) Full name: TableParams::fillRiskTable(std::vector&) Source: fillrisktable.cc Used By: tableparams1.cc: TableParams::TableParams(std::vector&, unsigned long, bool) fillTNM(std::ostream&) Full name: Loop::fillTNM(std::ostream&) Source: filltnm.cc Used By: loop1.cc: Loop::Loop(std::vector const&) find(std::string const&) Full name: Distribution::find(std::string const&) Source: find.cc Used By: extract.cc: Distribution::extract(std::istream&) xlat.cc: Distribution::xlat(LineInfo const&, std::string const&) find(std::string const&) const Full name: Modalities::find(std::string const&) const Source: find.cc Used By: active.cc: Modalities::active() addmodality.cc: Screening::addModality(std::istream&, Round&) find(std::vector const&, std::string const&) Full name: Scenario::find(std::vector const&, std::string const&) Source: find.cc Used By: setgeneratortype.cc: Scenario::setGeneratorType() setvary.cc: Scenario::setVary() findAge(std::vector const&, double) Full name: Globals::findAge(std::vector const&, double) Source: findage.cc Used By: naturaldeathage.cc: Loop::naturalDeathAge() tumorage.cc: Tumor::tumorAge() findSimType(std::string const&) Full name: Globals::findSimType(std::string const&) Source: findsimtype.cc Used By: setsimulationtype.cc: Options::setSimulationType() fixedNaturalDeathAge(double&) const Full name: Options::fixedNaturalDeathAge(double&) const Source: fixednaturaldeathage.cc Used By: caseinit.cc: Loop::caseInit() fixedTumorAge(double&) const Full name: Options::fixedTumorAge(double&) const Source: fixedtumorage.cc Used By: tumorage.cc: Tumor::tumorAge() fmt(unsigned int, char const*, char, unsigned int, unsigned int, unsigned int, unsigned int) Full name: VSD::fmt(unsigned int, char const*, char, unsigned int, unsigned int, unsigned int, unsigned int) Source: fmt2.cc Used By: vinsert.cc: Tomo::vInsert(std::ostream&) const vinsert.cc: Mammo::vInsert(std::ostream&) const lungparameters.cc: Survival::lungParameters(std::ostream&) const writebreast.cc: Survival::writeBreast(std::ostream&) const fmt(unsigned int, unsigned int) Full name: Distribution::fmt(unsigned int, unsigned int) Source: fmt.cc Used By: fmt1.cc: VSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int) fmt(unsigned int, unsigned int, unsigned int, unsigned int) Full name: VSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int) Source: fmt1.cc Used By: vwriteparameters.cc: VSDParams::v_writeParameters(std::ostream&) const writeparameters.cc: Beir7::writeParameters(std::ostream&) const fmt2.cc: VSD::fmt(unsigned int, char const*, char, unsigned int, unsigned int, unsigned int, unsigned int) vinsert.cc: CT::vInsert(std::ostream&) const vinsert.cc: MRI::vInsert(std::ostream&) const fmt.cc: AgeGroupVSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int, unsigned int) writeparameters.cc: Growth::writeParameters(std::ostream&) const fmt(unsigned int, unsigned int, unsigned int, unsigned int, unsigned int) Full name: AgeGroupVSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int, unsigned int) Source: fmt.cc Used By: vinsert.cc: Tomo::vInsert(std::ostream&) const vinsert.cc: Mammo::vInsert(std::ostream&) const writeparameters.cc: Growth::writeParameters(std::ostream&) const functionF(double) const Full name: Tumor::functionF(double) const Source: functionf.cc Used By: setdeathage.cc: Tumor::setDeathAge(double) functionQ(double) const Full name: Tumor::functionQ(double) const Source: functionq.cc Used By: functionf.cc: Tumor::functionF(double) const functionZ(double) const Full name: Tumor::functionZ(double) const Source: functionz.cc Used By: functionf.cc: Tumor::functionF(double) const g_log Full name: g_log Source: data.cc Used By: radiationrisk.cc: Screening::radiationRisk(Modalities const&, std::vector const&, double, double) logoption.cc: Options::logOption(std::string const&) lognormal.cc: Random::logNormal(double, double) uniform.cc: Random::uniform() uniformcase.cc: Random::uniformCase() uniformvsd.cc: Random::uniformVSD() caseinit.cc: Loop::caseInit() falsenegative.cc: Loop::falseNegative(ModBase*) gencases.cc: Loop::genCases(unsigned long, unsigned long) left.cc: Loop::left(Loop::Status, double) maybefalsepositive.cc: Loop::maybeFalsePositive(ModBase*, double) naturaldeathage.cc: Loop::naturalDeathAge() postscreen.cc: Loop::postScreen() screen.cc: Loop::screen(double) screening.cc: Loop::screening() characteristicsat.cc: Tumor::characteristicsAt(double) reset.cc: Tumor::reset() setdeathage.cc: Tumor::setDeathAge(double) tumorage.cc: Tumor::tumorAge() cptvsdrow.cc: Survival::cptVSDrow(double) g_longEnd Full name: g_longEnd Source: main.cc Used By: actualize.cc: Analysis::actualize(std::vector const&) g_longOpts Full name: g_longOpts Source: main.cc Used By: actualize.cc: Analysis::actualize(std::vector const&) genCases(unsigned long, unsigned long) Full name: Loop::genCases(unsigned long, unsigned long) Source: gencases.cc Used By: iterate.cc: Loop::iterate() get() Full name: Parser::Lines::get() Source: linesget.cc Used By: vsdparams1.cc: GLOBALS vsdparams1.cc 10vsdparams1.o fillrisktable.cc: TableParams::fillRiskTable(std::vector&) beir71.cc: GLOBALS beir71.cc 13beir71.o extractdiameters.cc: Costs::extractDiameters(Parser::Lines&&) setlungcancer.cc: Costs::setLungCancer() setproportion.cc: Costs::setProportion(bool) setrounds.cc: Screening::setRounds() densities1.cc: Densities::Densities() setdose.cc: GLOBALS setdose.cc 26setdose.o setsensitivity.cc: CT::setSensitivity() extractbase.cc: ModBase::extractBase(VSD&) specificitybase.cc: ModBase::specificityBase(std::vector&) atleast.cc: Parser::atLeast(double, std::vector const&, double&) proportion.cc: Parser::proportion(std::vector const&, double&) vsdparameters1.cc: Parser::VSDparameters(VaryType, std::vector const&, std::initializer_list const&) vsdparameters2.cc: GLOBALS vsdparameters2.cc 34vsdparameters2.o setdeath.cc: Scenario::setDeath() setgeneratortype.cc: GLOBALS setgeneratortype.cc 4setgeneratortype.o setvary.cc: GLOBALS setvary.cc 4setvary.o setdoublingtime.cc: Growth::setDoublingTime() setselfdetect.cc: Growth::setSelfDetect() setstart.cc: Growth::setStart() loadbc.cc: Survival::loadBC() loads3.cc: Survival::loadS3() get() Full name: ConfigLines::get() Source: get.cc Used By: load1.cc: Parser::load(std::istream&, unsigned short, std::vector&, std::vector&) load2.cc: Parser::load(std::string const&) setlabels.cc: Parser::setLabels(ConfigLines&, std::vector&) setoptions.cc: Parser::setOptions(ConfigLines&, std::vector&) Growth() Full name: Growth::Growth() Source: growth1.cc Used By: loop1.cc: Loop::Loop(std::vector const&) handleException() Full name: handleException() Source: handleexception.cc Used By: main.cc: main hasSection(std::vector const&) Full name: Parser::hasSection(std::vector const&) Source: hassection.cc Used By: setincidence2.cc: Incidence::setIncidence(std::vector&, unsigned long, bool) modbase1.cc: ModBase::ModBase(std::string const&) headerData(unsigned long) const Full name: Loop::headerData(unsigned long) const Source: headerdata.cc Used By: gencases.cc: Loop::genCases(unsigned long, unsigned long) headerRounds(unsigned long) const Full name: Loop::headerRounds(unsigned long) const Source: headerrounds.cc Used By: iterate.cc: Loop::iterate() headerSensitivity() const Full name: Loop::headerSensitivity() const Source: headersensitivity.cc Used By: iterate.cc: Loop::iterate() Incidence() Full name: Incidence::Incidence() Source: incidence1.cc Used By: loop1.cc: Loop::Loop(std::vector const&) increasingAge(Round const&) const Full name: Screening::increasingAge(Round const&) const Source: increasingage.cc Used By: addround.cc: Screening::addRound(LineInfo*, LineInfo const&) index() const Full name: Incidence::index() const Source: index.cc Used By: cumtotalrisk.cc: TumorInfo::cumTotalRisk(std::vector const&) indexOf(double) const Full name: ProbGroup::indexOf(double) const Source: indexof.cc Used By: probindexof.cc: ProbGroup::probIndexOf(std::vector const&, double, double) initialize() Full name: Random::initialize() Source: initialize.cc Used By: setvary.cc: Scenario::setVary() initLineInfoVects(std::unordered_map&) Full name: Parser::initLineInfoVects(std::unordered_map&) Source: initlineinfovects.cc Used By: parser1.cc: Parser::Parser() insert(std::ostream&) const Full name: AgeGroupVSD::insert(std::ostream&) const Source: insert1.cc Used By: insert2.cc: AgeGroupVSD::insert(std::ostream&, std::vector const&) insert(std::ostream&) const Full name: Tumor::insert(std::ostream&) const Source: insert.cc Used By: caseinit.cc: Loop::caseInit() insert(std::ostream&) const Full name: ProbGroup::insert(std::ostream&) const Source: insert.cc Used By: writeparameters.cc: Densities::writeParameters(std::ostream&) const s3parameters.cc: Survival::s3parameters(std::ostream&) const insert(std::ostream&) const Full name: Round::insert(std::ostream&) const Source: insert.cc Used By: writeparameters.cc: Screening::writeParameters(std::ostream&) const insert(std::ostream&) const Full name: Distribution::insert(std::ostream&) const Source: insert.cc Used By: insert1.cc: VSD::insert(std::ostream&) const insert(std::ostream&) const Full name: VSD::insert(std::ostream&) const Source: insert1.cc Used By: vwriteparameters.cc: VSDParams::v_writeParameters(std::ostream&) const writeparameters.cc: Beir7::writeParameters(std::ostream&) const insert2.cc: VSD::insert(std::ostream&, std::vector const&) vinsert.cc: CT::vInsert(std::ostream&) const vinsert.cc: MRI::vInsert(std::ostream&) const insert1.cc: AgeGroupVSD::insert(std::ostream&) const writeparameters.cc: Growth::writeParameters(std::ostream&) const insert(std::ostream&, std::vector const&) Full name: AgeGroupVSD::insert(std::ostream&, std::vector const&) Source: insert2.cc Used By: vinsert.cc: Tomo::vInsert(std::ostream&) const vinsert.cc: Mammo::vInsert(std::ostream&) const writeparameters.cc: Growth::writeParameters(std::ostream&) const insert(std::ostream&, std::vector const&) Full name: VSD::insert(std::ostream&, std::vector const&) Source: insert2.cc Used By: vinsert.cc: Tomo::vInsert(std::ostream&) const vinsert.cc: Mammo::vInsert(std::ostream&) const lungparameters.cc: Survival::lungParameters(std::ostream&) const writebreast.cc: Survival::writeBreast(std::ostream&) const instance() Full name: Options::instance() Source: instance.cc Used By: main.cc: main actualize.cc: Analysis::actualize(std::vector const&) analysis1.cc: Analysis::Analysis(std::istream&&, unsigned short) requirebase.cc: Analysis::requireBase() const loop1.cc: Loop::Loop(std::vector const&) setdeath.cc: Scenario::setDeath() tumorage.cc: Tumor::tumorAge() instance() Full name: Random::instance() Source: instance.cc Used By: index.cc: Incidence::index() const radiationrisk.cc: Screening::radiationRisk(Modalities const&, std::vector const&, double, double) extract.cc: Distribution::extract(std::istream&) insert.cc: Distribution::insert(std::ostream&) const varybeta.cc: Distribution::varyBeta(double) const varymean.cc: Distribution::varyMean(double) const cptindices.cc: Loop::cptIndices() const falsenegative.cc: Loop::falseNegative(ModBase*) iterate.cc: Loop::iterate() maybefalsepositive.cc: Loop::maybeFalsePositive(ModBase*, double) naturaldeathage.cc: Loop::naturalDeathAge() reset.cc: Tumor::reset() tumorage.cc: Tumor::tumorAge() cptvsdrow.cc: Survival::cptVSDrow(double) intervalCancer() Full name: Loop::intervalCancer() Source: intervalcancer.cc Used By: leaving.cc: Loop::leaving(double) isZero(double) Full name: Globals::isZero(double) Source: iszero.cc Used By: addround.cc: Screening::addRound(LineInfo*, LineInfo const&) add.cc: Densities::add(bool*, LineInfo const&) outspec.cc: ModBase::outSpec(std::ostream&, char const*, unsigned int, AgeGroupVSD const&) opinsert.cc: operator<<(std::ostream&, Group const&) writedata.cc: Loop::writeData(FBB::CSVTable&, unsigned long) const writeparameters.cc: Params::writeParameters(std::ostream&) iterate() Full name: Loop::iterate() Source: iterate.cc Used By: run.cc: Analysis::run() key(std::string const&) Full name: ConfigLines::key(std::string const&) Source: key1.cc Used By: checkredo.cc: Parser::checkRedo(ConfigLines&) keywordsLines(std::vector const&) Full name: Parser::keywordsLines(std::vector const&) Source: keywordslines.cc Used By: hassection.cc: Parser::hasSection(std::vector const&) lines.cc: Parser::lines(std::vector const&) labels(std::ostream&) const Full name: Loop::labels(std::ostream&) const Source: labels.cc Used By: headerdata.cc: Loop::headerData(unsigned long) const headerrounds.cc: Loop::headerRounds(unsigned long) const headersensitivity.cc: Loop::headerSensitivity() const iterate.cc: Loop::iterate() writeparameters.cc: Loop::writeParameters(unsigned long) const lastCase(std::string const&) Full name: Options::lastCase(std::string const&) Source: lastcase.cc Used By: alter.cc: Options::alter(int, std::string const&) lastcaseoption.cc: Options::lastCaseOption(std::string const&) lastCaseOption(std::string const&) Full name: Options::lastCaseOption(std::string const&) Source: lastcaseoption.cc Used By: options1.cc: Options::Options() lcTreatment(double, double, bool) const Full name: Costs::lcTreatment(double, double, bool) const Source: lctreatment.cc Used By: setvariables.cc: Costs::setVariables(bool) leaving(double) Full name: Loop::leaving(double) Source: leaving.cc Used By: screening.cc: Loop::screening() left(Loop::Status, double) Full name: Loop::left(Loop::Status, double) Source: left.cc Used By: intervalcancer.cc: Loop::intervalCancer() leaving.cc: Loop::leaving(double) postscreen.cc: Loop::postScreen() tumordetected.cc: Loop::tumorDetected(ModBase*, double) linear(double, std::pair const&, std::pair const&) Full name: TableParams::linear(double, std::pair const&, std::pair const&) Source: linear.cc Used By: checktable.cc: TableParams::checkTable() Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) Full name: Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) Source: lineslines2.cc Used By: lines.cc: Parser::lines(std::vector const&) Lines(std::vector const&) Full name: Parser::Lines::Lines(std::vector const&) Source: lineslines1.cc Used By: lines.cc: Parser::lines(std::vector const&) lines(std::vector const&) Full name: Parser::lines(std::vector const&) Source: lines.cc Used By: any.cc: Parser::any(std::vector const&) ln() Full name: VSD::ln() Source: ln.cc Used By: ln.cc: AgeGroupVSD::ln() setselfdetect.cc: Growth::setSelfDetect() ln() Full name: Distribution::ln() Source: ln.cc Used By: ln.cc: VSD::ln() ln() Full name: AgeGroupVSD::ln() Source: ln.cc Used By: setdoublingtime.cc: Growth::setDoublingTime() load(std::istream&, unsigned short, std::vector&, std::vector&) Full name: Parser::load(std::istream&, unsigned short, std::vector&, std::vector&) Source: load1.cc Used By: analysis1.cc: Analysis::Analysis(std::istream&&, unsigned short) load(std::string const&) Full name: Parser::load(std::string const&) Source: load2.cc Used By: analysis1.cc: Analysis::Analysis(std::istream&&, unsigned short) loadBC() Full name: Survival::loadBC() Source: loadbc.cc Used By: survival1.cc: Survival::Survival() loadS3() Full name: Survival::loadS3() Source: loads3.cc Used By: survival1.cc: Survival::Survival() loadS4() Full name: Survival::loadS4() Source: loads4.cc Used By: survival1.cc: Survival::Survival() locateError(std::vector*>&, ConfigLines&, ParamsSrc) Full name: Parser::locateError(std::vector*>&, ConfigLines&, ParamsSrc) Source: locateerror.cc Used By: addconfigline.cc: Parser::addConfigLine(std::vector*>&, ConfigLines&, ParamsSrc) Log() Full name: Log::Log() Source: log1.cc Used By: data.cc: GLOBALS data.cc 36data.o logNormal(double, double) Full name: Random::logNormal(double, double) Source: lognormal.cc Used By: reset.cc: Tumor::reset() tumorage.cc: Tumor::tumorAge() logNormalVary(double, double) Full name: Random::logNormalVary(double, double) Source: lognormalvary.cc Used By: varymean.cc: Distribution::varyMean(double) const logOption(std::string const&) Full name: Options::logOption(std::string const&) Source: logoption.cc Used By: options1.cc: Options::Options() Loop(std::vector const&) Full name: Loop::Loop(std::vector const&) Source: loop1.cc Used By: run.cc: Analysis::run() lungParameters(std::ostream&) const Full name: Survival::lungParameters(std::ostream&) const Source: lungparameters.cc Used By: writelung.cc: Survival::writeLung(std::ostream&) const Mammo(Tumor const&) Full name: Mammo::Mammo(Tumor const&) Source: mammo1.cc Used By: modalities1.cc: Modalities::Modalities(Tumor const&) maxEnd() Full name: Group::maxEnd() Source: maxend.cc Used By: setsensitivity.cc: CT::setSensitivity() maybeFalseNegative(ModBase*, double) Full name: Loop::maybeFalseNegative(ModBase*, double) Source: maybefalsenegative.cc Used By: screen.cc: Loop::screen(double) maybeFalsePositive(ModBase*, double) Full name: Loop::maybeFalsePositive(ModBase*, double) Source: maybefalsepositive.cc Used By: screen.cc: Loop::screen(double) Modalities(Tumor const&) Full name: Modalities::Modalities(Tumor const&) Source: modalities1.cc Used By: loop1.cc: Loop::Loop(std::vector const&) ModBase(std::string const&) Full name: ModBase::ModBase(std::string const&) Source: modbase1.cc Used By: ct1.cc: CT::CT(Tumor const&) tomo1.cc: Tomo::Tomo() mammo1.cc: Mammo::Mammo(Tumor const&) mri1.cc: MRI::MRI() MRI() Full name: MRI::MRI() Source: mri1.cc Used By: modalities1.cc: Modalities::Modalities(Tumor const&) msg(Err::Context) Full name: Err::msg(Err::Context) Source: msg2.cc Used By: checktable.cc: TableParams::checkTable() setproportion.cc: Costs::setProportion(bool) addmodality.cc: Screening::addModality(std::istream&, Round&) addround.cc: Screening::addRound(LineInfo*, LineInfo const&) setrounds.cc: Screening::setRounds() add.cc: Densities::add(bool*, LineInfo const&) poscheck.cc: VSD::posCheck(double&) extract.cc: Distribution::extract(std::istream&) xlat.cc: Distribution::xlat(LineInfo const&, std::string const&) atleast.cc: Err::atLeast(double) negative.cc: Err::negative() range.cc: Err::range() specification.cc: Err::specification() add.cc: CT::add(bool*, LineInfo const&) setdose.cc: CT::setDose() setsensitivity.cc: CT::setSensitivity() connects.cc: Group::connects(Group const&) const extract.cc: Group::extract(std::istream&) extract.cc: AgeGroupVSD::extract(std::istream&) vsdparameters1.cc: Parser::VSDparameters(VaryType, std::vector const&, std::initializer_list const&) vsdparameters2.cc: Parser::VSDparameters(VaryType, std::vector const&, unsigned long) betadist1.cc: BetaDist::BetaDist(std::istream&) setstart.cc: Growth::setStart() loadbc.cc: Survival::loadBC() msg(Err::Plain) Full name: Err::msg(Err::Plain) Source: msg1.cc Used By: setincidence1.cc: Incidence::setIncidence() multiplyspecified.cc: Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) vsensitivity.cc: CT::vSensitivity(unsigned long) const any.cc: Parser::any(std::vector const&) locateerror.cc: Parser::locateError(std::vector*>&, ConfigLines&, ParamsSrc) checkcumdeath.cc: Scenario::checkCumDeath(std::string const&, LineInfo const*) const readcumdeath.cc: Scenario::readCumDeath(std::string const&) multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) Full name: Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) Source: multiplyspecified.cc Used By: one.cc: Parser::one(std::vector const&) naturalDeathAge() Full name: Loop::naturalDeathAge() Source: naturaldeathage.cc Used By: caseinit.cc: Loop::caseInit() negative() Full name: Err::negative() Source: negative.cc Used By: setselfdetect.cc: Growth::setSelfDetect() nl(Log&) Full name: nl(Log&) Source: nl.cc Used By: lognormal.cc: Random::logNormal(double, double) uniform.cc: Random::uniform() uniformcase.cc: Random::uniformCase() uniformvsd.cc: Random::uniformVSD() normalVary() Full name: Random::normalVary() Source: normalvary.cc Used By: varymean.cc: Distribution::varyMean(double) const noTNM(std::ostream&) Full name: Loop::noTNM(std::ostream&) Source: notnm.cc Used By: loop1.cc: Loop::Loop(std::vector const&) one(std::vector const&) Full name: Parser::one(std::vector const&) Source: one.cc Used By: vsdparams1.cc: GLOBALS vsdparams1.cc 10vsdparams1.o beir71.cc: Beir7::Beir7() setdiameters.cc: Costs::setDiameters() setlungcancer.cc: Costs::setLungCancer() setproportion.cc: Costs::setProportion(bool) setdose.cc: GLOBALS setdose.cc 26setdose.o extractbase.cc: ModBase::extractBase(VSD&) specificitybase.cc: ModBase::specificityBase(std::vector&) atleast.cc: Parser::atLeast(double, std::vector const&, double&) proportion.cc: Parser::proportion(std::vector const&, double&) vsdparameters2.cc: Parser::VSDparameters(VaryType, std::vector const&, unsigned long) setgeneratortype.cc: GLOBALS setgeneratortype.cc 4setgeneratortype.o setvary.cc: GLOBALS setvary.cc 4setvary.o setdoublingtime.cc: Growth::setDoublingTime() setselfdetect.cc: Growth::setSelfDetect() setstart.cc: Growth::setStart() loadbc.cc: Survival::loadBC() open(std::string const&) Full name: Loop::open(std::string const&) Source: open.cc Used By: outstream.cc: Loop::outStream(std::string const&, unsigned long) operator()(int) Full name: Log::operator()(int) Source: operatorfun.cc Used By: lognormal.cc: Random::logNormal(double, double) uniform.cc: Random::uniform() uniformcase.cc: Random::uniformCase() uniformvsd.cc: Random::uniformVSD() operator()(std::mersenne_twister_engine&) Full name: BetaDist::operator()(std::mersenne_twister_engine&) Source: operatorfun.cc Used By: betavary.cc: Random::betaVary() operator<<(std::ostream&, Group const&) Full name: operator<<(std::ostream&, Group const&) Source: opinsert.cc Used By: vinsert.cc: CT::vInsert(std::ostream&) const insert.cc: ProbGroup::insert(std::ostream&) const insert1.cc: AgeGroupVSD::insert(std::ostream&) const vary2.cc: AgeGroupVSD::vary(std::ostream&, unsigned int, char const*, std::vector&) operator<<(std::ostream&, ModBase const&) Full name: operator<<(std::ostream&, ModBase const&) Source: opinsert.cc Used By: writeparameters.cc: Modalities::writeParameters(std::ostream&) const operator>>(std::istream&, Round&) Full name: operator>>(std::istream&, Round&) Source: opextract.cc Used By: addround.cc: Screening::addRound(LineInfo*, LineInfo const&) Options() Full name: Options::Options() Source: options1.cc Used By: instance.cc: Options::instance() otherTreatment(double, double, bool) const Full name: Costs::otherTreatment(double, double, bool) const Source: othertreatment.cc Used By: setvariables.cc: Costs::setVariables(bool) outStream(std::string const&, unsigned long) Full name: Loop::outStream(std::string const&, unsigned long) Source: outstream.cc Used By: headerdata.cc: Loop::headerData(unsigned long) const headerrounds.cc: Loop::headerRounds(unsigned long) const headersensitivity.cc: Loop::headerSensitivity() const iterate.cc: Loop::iterate() writeparameters.cc: Loop::writeParameters(unsigned long) const Params(std::vector&, unsigned long, bool) Full name: Params::Params(std::vector&, unsigned long, bool) Source: params1.cc Used By: vsdparams1.cc: VSDParams::VSDParams(std::vector&, unsigned long, bool) tableparams1.cc: TableParams::TableParams(std::vector&, unsigned long, bool) Parser() Full name: Parser::Parser() Source: parser1.cc Used By: analysis1.cc: Analysis::Analysis(std::istream&&, unsigned short) data.cc: GLOBALS data.cc 34data.o Parser(std::unordered_map&&) Full name: Parser::Parser(std::unordered_map&&) Source: parser2.cc Used By: data.cc: GLOBALS data.cc 34data.o percentages(std::vector const&) Full name: Densities::percentages(std::vector const&) Source: proportions.cc Used By: add.cc: Densities::add(bool*, LineInfo const&) posCheck(double&) Full name: VSD::posCheck(double&) Source: poscheck.cc Used By: data.cc: GLOBALS data.cc 20data.o postScreen() Full name: Loop::postScreen() Source: postscreen.cc Used By: gencases.cc: Loop::genCases(unsigned long, unsigned long) prepareBeta(std::istream&) Full name: Random::prepareBeta(std::istream&) Source: preparebeta.cc Used By: extract.cc: Distribution::extract(std::istream&) prepareVary(std::istream&) Full name: Distribution::prepareVary(std::istream&) Source: preparevary.cc Used By: extract.cc: Distribution::extract(std::istream&) probCheck(double&) Full name: VSD::probCheck(double&) Source: probcheck.cc Used By: data.cc: GLOBALS data.cc 20data.o ProbGroup(Series) Full name: ProbGroup::ProbGroup(Series) Source: probgroup1.cc Used By: add.cc: Densities::add(bool*, LineInfo const&) loads3.cc: Survival::loadS3() probIndexOf(std::vector const&, double, double) Full name: ProbGroup::probIndexOf(std::vector const&, double, double) Source: probindexof.cc Used By: cptindices.cc: Loop::cptIndices() const cptvsdrow.cc: Survival::cptVSDrow(double) proportion(std::vector const&, double&) Full name: Parser::proportion(std::vector const&, double&) Source: proportion.cc Used By: setattendancerate.cc: Screening::setAttendanceRate() setsystematicerror.cc: Mammo::setSystematicError() params1.cc: Params::Params(std::vector&, unsigned long, bool) radiationRisk(Modalities const&, std::vector const&, double, double) Full name: Screening::radiationRisk(Modalities const&, std::vector const&, double, double) Source: radiationrisk.cc Used By: caseinit.cc: Loop::caseInit() Random() Full name: Random::Random() Source: random1.cc Used By: initialize.cc: Random::initialize() range() Full name: Err::range() Source: range.cc Used By: setproportion.cc: Costs::setProportion(bool) probcheck.cc: VSD::probCheck(double&) proportion.cc: Parser::proportion(std::vector const&, double&) readCumDeath(std::string const&) Full name: Scenario::readCumDeath(std::string const&) Source: readcumdeath.cc Used By: setdeath.cc: Scenario::setDeath() reinit(unsigned long, GeneratorType) Full name: Random::reinit(unsigned long, GeneratorType) Source: reinit.cc Used By: iterate.cc: Loop::iterate() replaceDollar(std::string const&, unsigned long) Full name: Loop::replaceDollar(std::string const&, unsigned long) Source: replacedollar.cc Used By: outstream.cc: Loop::outStream(std::string const&, unsigned long) replaceHome(std::string&) Full name: Options::replaceHome(std::string&) Source: replacehome.cc Used By: actualize.cc: Options::actualize() setbase.cc: Options::setBase() replacePlus(std::string&) Full name: Options::replacePlus(std::string&) Source: replaceplus.cc Used By: actualize.cc: Options::actualize() requireBase() const Full name: Analysis::requireBase() const Source: requirebase.cc Used By: run.cc: Analysis::run() requireTumor(char const*) const Full name: Tumor::requireTumor(char const*) const Source: check.cc Used By: characteristicsat.cc: Tumor::characteristicsAt(double) setdeathage.cc: Tumor::setDeathAge(double) volume.cc: Tumor::volume() const reset() Full name: Tumor::reset() Source: reset.cc Used By: caseinit.cc: Loop::caseInit() reset() Full name: Random::reset() Source: reset.cc Used By: reinit.cc: Random::reinit(unsigned long, GeneratorType) reset() Full name: BetaDist::reset() Source: reset.cc Used By: reset.cc: Random::reset() reset(LineInfo const&) Full name: Err::reset(LineInfo const&) Source: reset.cc Used By: setrounds.cc: Screening::setRounds() linesget.cc: Parser::Lines::get() lineslines2.cc: Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) resetCounters() Full name: Loop::resetCounters() Source: resetcounters.cc Used By: iterate.cc: Loop::iterate() resetCounters(unsigned long) Full name: ModBase::resetCounters(unsigned long) Source: resetcounters.cc Used By: resetcounters.cc: Modalities::resetCounters(unsigned long) resetCounters(unsigned long) Full name: Modalities::resetCounters(unsigned long) Source: resetcounters.cc Used By: resetcounters.cc: Loop::resetCounters() rmLineInfoVectors(std::unordered_map&) Full name: Parser::rmLineInfoVectors(std::unordered_map&) Source: rmlineinfovectors.cc Used By: destructor.cc: Parser::~Parser() roundAge(unsigned long) const Full name: Screening::roundAge(unsigned long) const Source: roundage.cc Used By: loop1.cc: Loop::Loop(std::vector const&) screening.cc: Loop::screening() roundFmt(FBB::CSVTable&) const Full name: Modalities::roundFmt(FBB::CSVTable&) const Source: roundfmt.cc Used By: headerrounds.cc: Loop::headerRounds(unsigned long) const roundHeaders(FBB::CSVTable&) const Full name: Modalities::roundHeaders(FBB::CSVTable&) const Source: roundheaders.cc Used By: headerrounds.cc: Loop::headerRounds(unsigned long) const run() Full name: Simulator::run() Source: run.cc Used By: main.cc: main run() Full name: Analysis::run() Source: run.cc Used By: run.cc: Simulator::run() s3parameters(std::ostream&) const Full name: Survival::s3parameters(std::ostream&) const Source: s3parameters.cc Used By: writelung.cc: Survival::writeLung(std::ostream&) const s_availableFiles Full name: Loop::s_availableFiles Source: data.cc Used By: open.cc: Loop::open(std::string const&) s_base Full name: Options::s_base Source: data.cc Used By: baseoption.cc: Options::baseOption() s_bool Full name: Scenario::s_bool Source: data.cc Used By: setvary.cc: Scenario::setVary() writeparameters.cc: Scenario::writeParameters(std::ostream&, unsigned long) const s_ch Full name: VSD::s_ch Source: data.cc Used By: fmt2.cc: VSD::fmt(unsigned int, char const*, char, unsigned int, unsigned int, unsigned int, unsigned int) insert2.cc: VSD::insert(std::ostream&, std::vector const&) s_config Full name: Options::s_config Source: data.cc Used By: configoption.cc: Options::configOption() s_context Full name: Err::s_context Source: data.cc Used By: msg2.cc: Err::msg(Err::Context) s_fileName Full name: Options::s_fileName Source: data.cc Used By: fileoption.cc: Options::fileOption(std::string*, int) s_generatorType Full name: Scenario::s_generatorType Source: data.cc Used By: setgeneratortype.cc: Scenario::setGeneratorType() writeparameters.cc: Scenario::writeParameters(std::ostream&, unsigned long) const s_handle Full name: Err::s_handle Source: data.cc Used By: msg2.cc: Err::msg(Err::Context) reset.cc: Err::reset(LineInfo const&) s_indent Full name: AgeGroupVSD::s_indent Source: data.cc Used By: fmt.cc: AgeGroupVSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int, unsigned int) insert2.cc: AgeGroupVSD::insert(std::ostream&, std::vector const&) s_indent Full name: VSD::s_indent Source: data.cc Used By: fmt2.cc: VSD::fmt(unsigned int, char const*, char, unsigned int, unsigned int, unsigned int, unsigned int) insert2.cc: VSD::insert(std::ostream&, std::vector const&) s_label Full name: Globals::s_label Source: data.cc Used By: vvary.cc: VSDParams::v_vary(std::ostream&) vvary.cc: TableParams::v_vary(std::ostream&) setincidence1.cc: Incidence::setIncidence() writeparameters.cc: Incidence::writeParameters(std::ostream&) const vary.cc: Beir7::vary(std::ostream&) writeparameters.cc: Beir7::writeParameters(std::ostream&) const setsimulationtype.cc: Options::setSimulationType() findsimtype.cc: Globals::findSimType(std::string const&) setsimtype.cc: Globals::setSimType(std::string const&) data.cc: GLOBALS data.cc 34data.o data.cc: GLOBALS data.cc 9data.o s_label Full name: Params::s_label Source: data.cc Used By: vvary.cc: VSDParams::v_vary(std::ostream&) vvary.cc: TableParams::v_vary(std::ostream&) setincidence1.cc: Incidence::setIncidence() writeparameters.cc: Incidence::writeParameters(std::ostream&) const writeparameters.cc: Params::writeParameters(std::ostream&) s_labels Full name: ProbGroup::s_labels Source: data.cc Used By: insert.cc: ProbGroup::insert(std::ostream&) const s_lineInfo Full name: Err::s_lineInfo Source: data.cc Used By: add.cc: Densities::add(bool*, LineInfo const&) poscheck.cc: VSD::posCheck(double&) extract.cc: Distribution::extract(std::istream&) atleast.cc: Err::atLeast(double) msg2.cc: Err::msg(Err::Context) negative.cc: Err::negative() range.cc: Err::range() reset.cc: Err::reset(LineInfo const&) specification.cc: Err::specification() add.cc: CT::add(bool*, LineInfo const&) setsensitivity.cc: CT::setSensitivity() extract.cc: Group::extract(std::istream&) betadist1.cc: BetaDist::BetaDist(std::istream&) s_lungColumn Full name: Survival::s_lungColumn Source: data.cc Used By: loads4.cc: Survival::loadS4() lungparameters.cc: Survival::lungParameters(std::ostream&) const s_map Full name: Parser::s_map Source: data.cc Used By: destructor.cc: Parser::~Parser() keywordslines.cc: Parser::keywordsLines(std::vector const&) load1.cc: Parser::load(std::istream&, unsigned short, std::vector&, std::vector&) load2.cc: Parser::load(std::string const&) parser1.cc: Parser::Parser() setoptions.cc: Parser::setOptions(ConfigLines&, std::vector&) s_name Full name: Distribution::s_name Source: data.cc Used By: find.cc: Distribution::find(std::string const&) insert.cc: Distribution::insert(std::ostream&) const varynonneg.cc: Distribution::varyNonNeg(double) const varyprob.cc: Distribution::varyProb(double) const s_noColon Full name: Survival::s_noColon Source: data.cc Used By: varylung.cc: Survival::varyLung(std::ostream&) s_noYes Full name: Tumor::s_noYes Source: data.cc Used By: writedata.cc: Tumor::writeData(FBB::CSVTable&) const s_options Full name: Options::s_options Source: data.cc Used By: instance.cc: Options::instance() s_plain Full name: Err::s_plain Source: data.cc Used By: msg1.cc: Err::msg(Err::Plain) s_prec Full name: VSD::s_prec Source: data.cc Used By: fmt1.cc: VSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int) s_precision Full name: Distribution::s_precision Source: data.cc Used By: fmt.cc: Distribution::fmt(unsigned int, unsigned int) insert.cc: Distribution::insert(std::ostream&) const s_random Full name: Random::s_random Source: data.cc Used By: initialize.cc: Random::initialize() instance.cc: Random::instance() s_simType Full name: Globals::s_simType Source: data.cc Used By: vvary.cc: VSDParams::v_vary(std::ostream&) vvary.cc: TableParams::v_vary(std::ostream&) setincidence1.cc: Incidence::setIncidence() writeparameters.cc: Incidence::writeParameters(std::ostream&) const beir71.cc: Beir7::Beir7() vary.cc: Beir7::vary(std::ostream&) writeparameters.cc: Beir7::writeParameters(std::ostream&) const costs1.cc: Costs::Costs() modalities1.cc: Modalities::Modalities(Tumor const&) screening1.cc: Screening::Screening(Modalities&) densities1.cc: Densities::Densities() setsimtype.cc: Globals::setSimType(std::string const&) probgroup1.cc: ProbGroup::ProbGroup(Series) cptindices.cc: Loop::cptIndices() const loop1.cc: Loop::Loop(std::vector const&) writeparameters.cc: Loop::writeParameters(unsigned long) const growth1.cc: Growth::Growth() setdoublingtime.cc: Growth::setDoublingTime() setselfdetect.cc: Growth::setSelfDetect() setstart.cc: Growth::setStart() survival1.cc: Survival::Survival() s_sqrt2PI Full name: Globals::s_sqrt2PI Source: data.cc Used By: vcpttumorrisk.cc: VSDParams::v_cptTumorRisk(std::vector&) s_src Full name: Err::s_src Source: data.cc Used By: msg2.cc: Err::msg(Err::Context) locateerror.cc: Parser::locateError(std::vector*>&, ConfigLines&, ParamsSrc) s_status Full name: Loop::s_status Source: data.cc Used By: headerdata.cc: Loop::headerData(unsigned long) const left.cc: Loop::left(Loop::Status, double) s_type Full name: VSD::s_type Source: data.cc Used By: fmt2.cc: VSD::fmt(unsigned int, char const*, char, unsigned int, unsigned int, unsigned int, unsigned int) insert2.cc: VSD::insert(std::ostream&, std::vector const&) s_valueCheck Full name: VSD::s_valueCheck Source: data.cc Used By: vsd1.cc: VSD::VSD(VaryType) s_vary Full name: Globals::s_vary Source: data.cc Used By: extract.cc: VSD::extract(std::istream&) ln.cc: VSD::ln() distribution1.cc: Distribution::Distribution(VaryType) extract.cc: Distribution::extract(std::istream&) preparevary.cc: Distribution::prepareVary(std::istream&) random1.cc: Random::Random() reinit.cc: Random::reinit(unsigned long, GeneratorType) reset.cc: Random::reset() iterate.cc: Loop::iterate() setvary.cc: Scenario::setVary() writeparameters.cc: Scenario::writeParameters(std::ostream&, unsigned long) const s_varyParam Full name: Distribution::s_varyParam Source: data.cc Used By: distribution1.cc: Distribution::Distribution(VaryType) s_width Full name: Distribution::s_width Source: data.cc Used By: fmt.cc: Distribution::fmt(unsigned int, unsigned int) insert.cc: Distribution::insert(std::ostream&) const s_width Full name: VSD::s_width Source: data.cc Used By: fmt1.cc: VSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int) Scenario() Full name: Scenario::Scenario() Source: scenario1.cc Used By: loop1.cc: Loop::Loop(std::vector const&) screen(double) Full name: Loop::screen(double) Source: screen.cc Used By: screening.cc: Loop::screening() screening() Full name: Loop::screening() Source: screening.cc Used By: gencases.cc: Loop::genCases(unsigned long, unsigned long) Screening(Modalities&) Full name: Screening::Screening(Modalities&) Source: screening1.cc Used By: loop1.cc: Loop::Loop(std::vector const&) sectionList(std::vector const&) Full name: Parser::sectionList(std::vector const&) Source: sectionlist.cc Used By: any.cc: Parser::any(std::vector const&) one.cc: Parser::one(std::vector const&) sensitivity(ModBase*) const Full name: Loop::sensitivity(ModBase*) const Source: sensitivity1.cc Used By: falsenegative.cc: Loop::falseNegative(ModBase*) set(unsigned int, unsigned int, std::string const&, std::string const&) Full name: Log::set(unsigned int, unsigned int, std::string const&, std::string const&) Source: set.cc Used By: logoption.cc: Options::logOption(std::string const&) setAge() Full name: Costs::setAge() Source: setage.cc Used By: setdiscount.cc: Costs::setDiscount(bool) setAnalysisSource() Full name: Simulator::setAnalysisSource() Source: setanalysissource.cc Used By: simulator1.cc: Simulator::Simulator() setAttendanceRate() Full name: Screening::setAttendanceRate() Source: setattendancerate.cc Used By: screening1.cc: Screening::Screening(Modalities&) setBase() Full name: Options::setBase() Source: setbase.cc Used By: actualize.cc: Options::actualize() setBeta() Full name: Mammo::setBeta() Source: setbeta.cc Used By: mammo1.cc: Mammo::Mammo(Tumor const&) setDeath() Full name: Scenario::setDeath() Source: setdeath.cc Used By: scenario1.cc: Scenario::Scenario() setDeathAge(double) Full name: Tumor::setDeathAge(double) Source: setdeathage.cc Used By: tumordetected.cc: Loop::tumorDetected(ModBase*, double) setDiameters() Full name: Costs::setDiameters() Source: setdiameters.cc Used By: costs1.cc: Costs::Costs() setDiscount(bool) Full name: Costs::setDiscount(bool) Source: setdiscount.cc Used By: costs1.cc: Costs::Costs() setDose() Full name: CT::setDose() Source: setdose.cc Used By: ct1.cc: CT::CT(Tumor const&) setDoublingTime() Full name: Growth::setDoublingTime() Source: setdoublingtime.cc Used By: growth1.cc: Growth::Growth() setGeneratorType() Full name: Scenario::setGeneratorType() Source: setgeneratortype.cc Used By: scenario1.cc: Scenario::Scenario() setIncidence() Full name: Incidence::setIncidence() Source: setincidence1.cc Used By: incidence1.cc: Incidence::Incidence() setIncidence(std::vector&, unsigned long, bool) Full name: Incidence::setIncidence(std::vector&, unsigned long, bool) Source: setincidence2.cc Used By: setincidence1.cc: Incidence::setIncidence() setLabels(ConfigLines&, std::vector&) Full name: Parser::setLabels(ConfigLines&, std::vector&) Source: setlabels.cc Used By: load1.cc: Parser::load(std::istream&, unsigned short, std::vector&, std::vector&) setLungCancer() Full name: Costs::setLungCancer() Source: setlungcancer.cc Used By: setvariables.cc: Costs::setVariables(bool) setM() Full name: Mammo::setM() Source: setm.cc Used By: mammo1.cc: Mammo::Mammo(Tumor const&) setNcases() Full name: Scenario::setNcases() Source: setncases.cc Used By: scenario1.cc: Scenario::Scenario() setNiterations() Full name: Scenario::setNiterations() Source: setniterations.cc Used By: scenario1.cc: Scenario::Scenario() setOptions(ConfigLines&, std::vector&) Full name: Parser::setOptions(ConfigLines&, std::vector&) Source: setoptions.cc Used By: load1.cc: Parser::load(std::istream&, unsigned short, std::vector&, std::vector&) setPrecision(std::ostream&, unsigned short) Full name: Globals::setPrecision(std::ostream&, unsigned short) Source: setprecision.cc Used By: vwriteparameters.cc: VSDParams::v_writeParameters(std::ostream&) const vwriteparameters.cc: TableParams::v_writeParameters(std::ostream&) const insert.cc: Distribution::insert(std::ostream&) const setwidthprec.cc: Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) insert1.cc: AgeGroupVSD::insert(std::ostream&) const writeparameters.cc: Loop::writeParameters(unsigned long) const writeparameters.cc: Params::writeParameters(std::ostream&) setProportion(bool) Full name: Costs::setProportion(bool) Source: setproportion.cc Used By: setdiscount.cc: Costs::setDiscount(bool) setRounds() Full name: Screening::setRounds() Source: setrounds.cc Used By: screening1.cc: Screening::Screening(Modalities&) setSeed() Full name: Scenario::setSeed() Source: setseed.cc Used By: scenario1.cc: Scenario::Scenario() setSelfDetect() Full name: Growth::setSelfDetect() Source: setselfdetect.cc Used By: growth1.cc: Growth::Growth() setSensitivity() Full name: CT::setSensitivity() Source: setsensitivity.cc Used By: ct1.cc: CT::CT(Tumor const&) setSensitivity() Full name: Tomo::setSensitivity() Source: setsensitivity.cc Used By: tomo1.cc: Tomo::Tomo() setSensitivity() Full name: MRI::setSensitivity() Source: setsensitivity.cc Used By: mri1.cc: MRI::MRI() setSimType(std::string const&) Full name: Globals::setSimType(std::string const&) Source: setsimtype.cc Used By: actualize.cc: Options::actualize() setSimulationType() Full name: Options::setSimulationType() Source: setsimulationtype.cc Used By: options1.cc: Options::Options() setSpecificity() Full name: MRI::setSpecificity() Source: setspecificity.cc Used By: mri1.cc: MRI::MRI() setSpecificity() Full name: CT::setSpecificity() Source: setspecificity.cc Used By: ct1.cc: CT::CT(Tumor const&) setStart() Full name: Growth::setStart() Source: setstart.cc Used By: growth1.cc: Growth::Growth() setSystematicError() Full name: Mammo::setSystematicError() Source: setsystematicerror.cc Used By: mammo1.cc: Mammo::Mammo(Tumor const&) setVariables(bool) Full name: Costs::setVariables(bool) Source: setvariables.cc Used By: costs1.cc: Costs::Costs() setVary() Full name: Scenario::setVary() Source: setvary.cc Used By: scenario1.cc: Scenario::Scenario() setWidthPrec(std::ostream&, unsigned int, unsigned int) Full name: Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) Source: setwidthprec.cc Used By: writeparameters.cc: Beir7::writeParameters(std::ostream&) const writeparameters.cc: Costs::writeParameters(std::ostream&) const writeparameters.cc: Densities::writeParameters(std::ostream&) const insert1.cc: VSD::insert(std::ostream&) const insert.cc: Distribution::insert(std::ostream&) const vinsert.cc: Mammo::vInsert(std::ostream&) const insert.cc: ProbGroup::insert(std::ostream&) const showLineInfo(LineInfo const*) Full name: Scenario::showLineInfo(LineInfo const*) Source: showlineinfo.cc Used By: checkcumdeath.cc: Scenario::checkCumDeath(std::string const&, LineInfo const*) const showRound() const Full name: Loop::showRound() const Source: showround.cc Used By: writedata.cc: Loop::writeData(FBB::CSVTable&, unsigned long) const showVary(std::ostream&) const Full name: VSD::showVary(std::ostream&) const Source: showvary.cc Used By: vvary.cc: VSDParams::v_vary(std::ostream&) vary.cc: Beir7::vary(std::ostream&) vary3.cc: VSD::vary(std::ostream&, unsigned int, char const*, char, std::vector&) vvary.cc: CT::vVary(std::ostream&) vvary.cc: MRI::vVary(std::ostream&) vary2.cc: AgeGroupVSD::vary(std::ostream&, unsigned int, char const*, std::vector&) vary.cc: Growth::vary(std::ostream&) Simulator() Full name: Simulator::Simulator() Source: simulator1.cc Used By: main.cc: main specification() Full name: Err::specification() Source: specification.cc Used By: vsdparams1.cc: GLOBALS vsdparams1.cc 10vsdparams1.o appendpair.cc: TableParams::appendPair(std::string const&) beir71.cc: GLOBALS beir71.cc 13beir71.o setdiameters.cc: Costs::setDiameters() setlungcancer.cc: Costs::setLungCancer() addround.cc: Screening::addRound(LineInfo*, LineInfo const&) add.cc: Densities::add(bool*, LineInfo const&) add.cc: CT::add(bool*, LineInfo const&) setdose.cc: GLOBALS setdose.cc 26setdose.o extractbase.cc: ModBase::extractBase(VSD&) specificitybase.cc: ModBase::specificityBase(std::vector&) atleast.cc: Parser::atLeast(double, std::vector const&, double&) proportion.cc: Parser::proportion(std::vector const&, double&) vsdparameters1.cc: Parser::VSDparameters(VaryType, std::vector const&, std::initializer_list const&) vsdparameters2.cc: GLOBALS vsdparameters2.cc 34vsdparameters2.o find.cc: Scenario::find(std::vector const&, std::string const&) setgeneratortype.cc: GLOBALS setgeneratortype.cc 4setgeneratortype.o setvary.cc: GLOBALS setvary.cc 4setvary.o setdoublingtime.cc: GLOBALS setdoublingtime.cc 7setdoublingtime.o setselfdetect.cc: Growth::setSelfDetect() loads3.cc: Survival::loadS3() specificityBase(std::vector&) Full name: ModBase::specificityBase(std::vector&) Source: specificitybase.cc Used By: tomo1.cc: Tomo::Tomo() mammo1.cc: Mammo::Mammo(Tumor const&) sumProbs() Full name: Incidence::sumProbs() Source: sumprobs.cc Used By: setincidence1.cc: Incidence::setIncidence() Survival() Full name: Survival::Survival() Source: survival1.cc Used By: loop1.cc: Loop::Loop(std::vector const&) TableParams(std::vector&, unsigned long, bool) Full name: TableParams::TableParams(std::vector&, unsigned long, bool) Source: tableparams1.cc Used By: setincidence2.cc: Incidence::setIncidence(std::vector&, unsigned long, bool) tnm() const Full name: Options::tnm() const Source: tnm.cc Used By: loop1.cc: Loop::Loop(std::vector const&) Tomo() Full name: Tomo::Tomo() Source: tomo1.cc Used By: modalities1.cc: Modalities::Modalities(Tumor const&) Tumor(TumorInfo&) Full name: Tumor::Tumor(TumorInfo&) Source: tumor1.cc Used By: loop1.cc: Loop::Loop(std::vector const&) tumorAge() Full name: Tumor::tumorAge() Source: tumorage.cc Used By: reset.cc: Tumor::reset() tumorAge(std::string const&) Full name: Options::tumorAge(std::string const&) Source: tumorage.cc Used By: alter.cc: Options::alter(int, std::string const&) tumorageoption.cc: Options::tumorAgeOption(std::string const&) tumorAgeOption(std::string const&) Full name: Options::tumorAgeOption(std::string const&) Source: tumorageoption.cc Used By: options1.cc: Options::Options() tumorDetected(ModBase*, double) Full name: Loop::tumorDetected(ModBase*, double) Source: tumordetected.cc Used By: maybefalsenegative.cc: Loop::maybeFalseNegative(ModBase*, double) uint16_max Full name: Globals::uint16_max Source: data.cc Used By: extract.cc: Group::extract(std::istream&) maxend.cc: Group::maxEnd() opinsert.cc: operator<<(std::ostream&, Group const&) loadbc.cc: Survival::loadBC() writebreast.cc: Survival::writeBreast(std::ostream&) const uniform() Full name: Random::uniform() Source: uniform.cc Used By: index.cc: Incidence::index() const radiationrisk.cc: Screening::radiationRisk(Modalities const&, std::vector const&, double, double) cptindices.cc: Loop::cptIndices() const falsenegative.cc: Loop::falseNegative(ModBase*) maybefalsepositive.cc: Loop::maybeFalsePositive(ModBase*, double) uniformCase() Full name: Random::uniformCase() Source: uniformcase.cc Used By: naturaldeathage.cc: Loop::naturalDeathAge() reset.cc: Tumor::reset() tumorage.cc: Tumor::tumorAge() uniformVary() Full name: Random::uniformVary() Source: uniformvary.cc Used By: varymean.cc: Distribution::varyMean(double) const uniformVSD() Full name: Random::uniformVSD() Source: uniformvsd.cc Used By: cptvsdrow.cc: Survival::cptVSDrow(double) usage(std::string const&) Full name: usage(std::string const&) Source: usage.cc Used By: main.cc: main use(ModBase*) Full name: Loop::use(ModBase*) Source: use.cc Used By: screen.cc: Loop::screen(double) use(std::vector const&) const Full name: Modalities::use(std::vector const&) const Source: use.cc Used By: beir7err1.cc: Screening::beir7Err(Round const&, unsigned short, double, double, Modalities const&) beir7err2.cc: Screening::beir7Err(unsigned short, Round const&, unsigned short, double, double, Modalities const&) screen.cc: Loop::screen(double) v_cptTumorRisk(std::vector&) Full name: VSDParams::v_cptTumorRisk(std::vector&) Source: vcpttumorrisk.cc Used By: destructor.cc: VSDParams::~VSDParams() v_vary(std::ostream&) Full name: VSDParams::v_vary(std::ostream&) Source: vvary.cc Used By: destructor.cc: VSDParams::~VSDParams() v_vary(std::ostream&) Full name: TableParams::v_vary(std::ostream&) Source: vvary.cc Used By: vcpttumorrisk.cc: TableParams::v_cptTumorRisk(std::vector&) v_writeParameters(std::ostream&) const Full name: VSDParams::v_writeParameters(std::ostream&) const Source: vwriteparameters.cc Used By: destructor.cc: VSDParams::~VSDParams() v_writeParameters(std::ostream&) const Full name: TableParams::v_writeParameters(std::ostream&) const Source: vwriteparameters.cc Used By: vcpttumorrisk.cc: TableParams::v_cptTumorRisk(std::vector&) vary() Full name: AgeGroupVSD::vary() Source: vary1.cc Used By: vary2.cc: AgeGroupVSD::vary(std::ostream&, unsigned int, char const*, std::vector&) vary(std::ostream&) Full name: Beir7::vary(std::ostream&) Source: vary.cc Used By: vary.cc: TumorInfo::vary(std::ostream&) vary(std::ostream&) Full name: Growth::vary(std::ostream&) Source: vary.cc Used By: vary.cc: TumorInfo::vary(std::ostream&) vary(std::ostream&) Full name: TumorInfo::vary(std::ostream&) Source: vary.cc Used By: iterate.cc: Loop::iterate() vary(std::ostream&) Full name: Incidence::vary(std::ostream&) Source: vary.cc Used By: vary.cc: TumorInfo::vary(std::ostream&) vary(std::ostream&) Full name: Modalities::vary(std::ostream&) Source: vary.cc Used By: iterate.cc: Loop::iterate() vary(std::ostream&, unsigned int, char const*, char const*, char, std::vector&) Full name: VSD::vary(std::ostream&, unsigned int, char const*, char const*, char, std::vector&) Source: vary2.cc Used By: vvary.cc: Tomo::vVary(std::ostream&) vvary.cc: Mammo::vVary(std::ostream&) varybreast.cc: Survival::varyBreast(std::ostream&) varylung.cc: Survival::varyLung(std::ostream&) vary(std::ostream&, unsigned int, char const*, char, std::vector&) Full name: VSD::vary(std::ostream&, unsigned int, char const*, char, std::vector&) Source: vary3.cc Used By: vary2.cc: VSD::vary(std::ostream&, unsigned int, char const*, char const*, char, std::vector&) varylung.cc: Survival::varyLung(std::ostream&) vary(std::ostream&, unsigned int, char const*, std::vector&) Full name: AgeGroupVSD::vary(std::ostream&, unsigned int, char const*, std::vector&) Source: vary2.cc Used By: vvary.cc: Tomo::vVary(std::ostream&) vvary.cc: Mammo::vVary(std::ostream&) vary.cc: Growth::vary(std::ostream&) varyBeta(double) const Full name: Distribution::varyBeta(double) const Source: varybeta.cc Used By: data.cc: GLOBALS data.cc 21data.o extract.cc: Distribution::extract(std::istream&) varyBreast(std::ostream&) Full name: Survival::varyBreast(std::ostream&) Source: varybreast.cc Used By: survival1.cc: Survival::Survival() varyLung(std::ostream&) Full name: Survival::varyLung(std::ostream&) Source: varylung.cc Used By: survival1.cc: Survival::Survival() varyMean(double) const Full name: Distribution::varyMean(double) const Source: varymean.cc Used By: data.cc: GLOBALS data.cc 21data.o varynonneg.cc: Distribution::varyNonNeg(double) const varyprob.cc: Distribution::varyProb(double) const varyNonNeg(double) const Full name: Distribution::varyNonNeg(double) const Source: varynonneg.cc Used By: data.cc: GLOBALS data.cc 21data.o varyProb(double) const Full name: Distribution::varyProb(double) const Source: varyprob.cc Used By: data.cc: GLOBALS data.cc 21data.o vDose() const Full name: Mammo::vDose() const Source: vdose1.cc Used By: destructor.cc: Mammo::~Mammo() vDose() const Full name: ModBase::vDose() const Source: vdose1.cc Used By: destructor.cc: CT::~CT() destructor.cc: MRI::~MRI() destructor.cc: ModBase::~ModBase() vDose() const Full name: Tomo::vDose() const Source: vdose1.cc Used By: destructor.cc: Tomo::~Tomo() vDose(unsigned short) const Full name: Mammo::vDose(unsigned short) const Source: vdose2.cc Used By: destructor.cc: Mammo::~Mammo() vDose(unsigned short) const Full name: CT::vDose(unsigned short) const Source: vdose.cc Used By: destructor.cc: CT::~CT() vDose(unsigned short) const Full name: ModBase::vDose(unsigned short) const Source: vdose2.cc Used By: destructor.cc: MRI::~MRI() destructor.cc: ModBase::~ModBase() vDose(unsigned short) const Full name: Tomo::vDose(unsigned short) const Source: vdose2.cc Used By: destructor.cc: Tomo::~Tomo() version Full name: Icmake::version Source: version.cc Used By: main.cc: main usage.cc: usage(std::string const&) labels.cc: Loop::labels(std::ostream&) const vInsert(std::ostream&) const Full name: MRI::vInsert(std::ostream&) const Source: vinsert.cc Used By: destructor.cc: MRI::~MRI() vInsert(std::ostream&) const Full name: Tomo::vInsert(std::ostream&) const Source: vinsert.cc Used By: destructor.cc: Tomo::~Tomo() vInsert(std::ostream&) const Full name: Mammo::vInsert(std::ostream&) const Source: vinsert.cc Used By: destructor.cc: Mammo::~Mammo() vInsert(std::ostream&) const Full name: CT::vInsert(std::ostream&) const Source: vinsert.cc Used By: destructor.cc: CT::~CT() VSD(VaryType) Full name: VSD::VSD(VaryType) Source: vsd1.cc Used By: vsdparams1.cc: VSDParams::VSDParams(std::vector&, unsigned long, bool) beir71.cc: Beir7::Beir7() ct1.cc: CT::CT(Tumor const&) mri1.cc: MRI::MRI() agegroupvsd1.cc: AgeGroupVSD::AgeGroupVSD(VaryType, bool, bool) vsdparameters1.cc: Parser::VSDparameters(VaryType, std::vector const&, std::initializer_list const&) vsdparameters2.cc: Parser::VSDparameters(VaryType, std::vector const&, unsigned long) growth1.cc: Growth::Growth() VSDparameters(VaryType, std::vector const&, std::initializer_list const&) Full name: Parser::VSDparameters(VaryType, std::vector const&, std::initializer_list const&) Source: vsdparameters1.cc Used By: loads4.cc: Survival::loadS4() survival1.cc: Survival::Survival() VSDparameters(VaryType, std::vector const&, unsigned long) Full name: Parser::VSDparameters(VaryType, std::vector const&, unsigned long) Source: vsdparameters2.cc Used By: setsensitivity.cc: Tomo::setSensitivity() setbeta.cc: Mammo::setBeta() setm.cc: Mammo::setM() dosebase.cc: ModBase::doseBase(std::vector&) VSDParams(std::vector&, unsigned long, bool) Full name: VSDParams::VSDParams(std::vector&, unsigned long, bool) Source: vsdparams1.cc Used By: setincidence2.cc: Incidence::setIncidence(std::vector&, unsigned long, bool) vSensitivity(unsigned long) const Full name: CT::vSensitivity(unsigned long) const Source: vsensitivity.cc Used By: destructor.cc: CT::~CT() vSensitivity(unsigned long) const Full name: MRI::vSensitivity(unsigned long) const Source: vsensitivity.cc Used By: destructor.cc: MRI::~MRI() vSensitivity(unsigned long) const Full name: Tomo::vSensitivity(unsigned long) const Source: vsensitivity.cc Used By: destructor.cc: Tomo::~Tomo() vSensitivity(unsigned long) const Full name: Mammo::vSensitivity(unsigned long) const Source: vsensitivity.cc Used By: destructor.cc: Mammo::~Mammo() vSpecificity(double) const Full name: MRI::vSpecificity(double) const Source: vspecificity.cc Used By: destructor.cc: MRI::~MRI() vSpecificity(double) const Full name: CT::vSpecificity(double) const Source: vspecificity.cc Used By: destructor.cc: CT::~CT() vSpecificity(double) const Full name: Tomo::vSpecificity(double) const Source: vspecificity.cc Used By: destructor.cc: Tomo::~Tomo() vSpecificity(double) const Full name: Mammo::vSpecificity(double) const Source: vspecificity.cc Used By: destructor.cc: Mammo::~Mammo() vVary(std::ostream&) Full name: CT::vVary(std::ostream&) Source: vvary.cc Used By: destructor.cc: CT::~CT() vVary(std::ostream&) Full name: Tomo::vVary(std::ostream&) Source: vvary.cc Used By: destructor.cc: Tomo::~Tomo() vVary(std::ostream&) Full name: Mammo::vVary(std::ostream&) Source: vvary.cc Used By: destructor.cc: Mammo::~Mammo() vVary(std::ostream&) Full name: MRI::vVary(std::ostream&) Source: vvary.cc Used By: destructor.cc: MRI::~MRI() weakCompare(double, double) Full name: Globals::weakCompare(double, double) Source: weakcompare.cc Used By: increasingage.cc: Screening::increasingAge(Round const&) const setdeathage.cc: Tumor::setDeathAge(double) writeBreast(std::ostream&) const Full name: Survival::writeBreast(std::ostream&) const Source: writebreast.cc Used By: survival1.cc: Survival::Survival() writeData(FBB::CSVTable&) const Full name: Tumor::writeData(FBB::CSVTable&) const Source: writedata.cc Used By: writedata.cc: Loop::writeData(FBB::CSVTable&, unsigned long) const writeData(FBB::CSVTable&, unsigned long) const Full name: Loop::writeData(FBB::CSVTable&, unsigned long) const Source: writedata.cc Used By: gencases.cc: Loop::genCases(unsigned long, unsigned long) writeLung(std::ostream&) const Full name: Survival::writeLung(std::ostream&) const Source: writelung.cc Used By: survival1.cc: Survival::Survival() writeParameters(std::ostream&) Full name: Params::writeParameters(std::ostream&) Source: writeparameters.cc Used By: writeparameters.cc: Incidence::writeParameters(std::ostream&) const writeParameters(std::ostream&) const Full name: Modalities::writeParameters(std::ostream&) const Source: writeparameters.cc Used By: writeparameters.cc: Loop::writeParameters(unsigned long) const writeParameters(std::ostream&) const Full name: Growth::writeParameters(std::ostream&) const Source: writeparameters.cc Used By: writeparameters.cc: TumorInfo::writeParameters(std::ostream&) const writeParameters(std::ostream&) const Full name: TumorInfo::writeParameters(std::ostream&) const Source: writeparameters.cc Used By: writeparameters.cc: Loop::writeParameters(unsigned long) const writeParameters(std::ostream&) const Full name: Incidence::writeParameters(std::ostream&) const Source: writeparameters.cc Used By: writeparameters.cc: TumorInfo::writeParameters(std::ostream&) const writeParameters(std::ostream&) const Full name: Beir7::writeParameters(std::ostream&) const Source: writeparameters.cc Used By: writeparameters.cc: TumorInfo::writeParameters(std::ostream&) const writeParameters(std::ostream&) const Full name: Costs::writeParameters(std::ostream&) const Source: writeparameters.cc Used By: writeparameters.cc: Loop::writeParameters(unsigned long) const writeParameters(std::ostream&) const Full name: Screening::writeParameters(std::ostream&) const Source: writeparameters.cc Used By: writeparameters.cc: Loop::writeParameters(unsigned long) const writeParameters(std::ostream&) const Full name: Densities::writeParameters(std::ostream&) const Source: writeparameters.cc Used By: writeparameters.cc: Loop::writeParameters(unsigned long) const writeParameters(std::ostream&, unsigned long) const Full name: Scenario::writeParameters(std::ostream&, unsigned long) const Source: writeparameters.cc Used By: writeparameters.cc: Loop::writeParameters(unsigned long) const writeParameters(unsigned long) const Full name: Loop::writeParameters(unsigned long) const Source: writeparameters.cc Used By: iterate.cc: Loop::iterate() writeRounds(FBB::CSVTable&) const Full name: Loop::writeRounds(FBB::CSVTable&) const Source: writerounds.cc Used By: iterate.cc: Loop::iterate() writeRounds(FBB::CSVTable&, unsigned long) const Full name: Modalities::writeRounds(FBB::CSVTable&, unsigned long) const Source: writerounds.cc Used By: writerounds.cc: Loop::writeRounds(FBB::CSVTable&) const writeSensitivity(FBB::CSVTable&, unsigned long) const Full name: Loop::writeSensitivity(FBB::CSVTable&, unsigned long) const Source: writesensitivity.cc Used By: iterate.cc: Loop::iterate() years Full name: Icmake::years Source: version.cc Used By: usage.cc: usage(std::string const&) ~Modalities() Full name: Modalities::~Modalities() Source: destructor.cc Used By: run.cc: GLOBALS run.cc 2run.o loop1.cc: Loop::Loop(std::vector const&) ~ModBase() Full name: ModBase::~ModBase() Source: destructor.cc Used By: ct1.cc: CT::CT(Tumor const&) destructor.cc: CT::~CT() destructor.cc: Tomo::~Tomo() tomo1.cc: Tomo::Tomo() destructor.cc: Mammo::~Mammo() mammo1.cc: Mammo::Mammo(Tumor const&) destructor.cc: MRI::~MRI() mri1.cc: MRI::MRI() ~Params() Full name: Params::~Params() Source: destructor.cc Used By: destructor.cc: VSDParams::~VSDParams() vsdparams1.cc: VSDParams::VSDParams(std::vector&, unsigned long, bool) tableparams1.cc: TableParams::TableParams(std::vector&, unsigned long, bool) vcpttumorrisk.cc: TableParams::v_cptTumorRisk(std::vector&) ~Parser() Full name: Parser::~Parser() Source: destructor.cc Used By: run.cc: Simulator::run() analysis1.cc: Analysis::Analysis(std::istream&&, unsigned short) ---------------------------------------------------------------------- CALL TREE FOR: main main +-usage(std::string const&) | +-Icmake::version | +-Icmake::author | +-Icmake::years +-Icmake::version +-Options::instance() | +-Options::s_options | +-Options::Options() | +-Options::baseOption() | | +-Options::s_base | +-Options::configOption() | | +-Options::s_config | +-Options::cumDeathOption(std::string const&) | +-Options::deathAgeOption(std::string const&) | | +-Options::deathAge(std::string const&) | +-Options::fileOption(std::string*, int) | | +-Options::s_fileName | +-Options::lastCaseOption(std::string const&) | | +-Options::lastCase(std::string const&) | +-Options::logOption(std::string const&) | | +-g_log | | +-Log::set(unsigned int, unsigned int, std::string const&, std::string const&) | +-Options::setSimulationType() | | +-Globals::s_label | | +-Globals::findSimType(std::string const&) | | +-Globals::s_label | +-Options::tumorAgeOption(std::string const&) | +-Options::tumorAge(std::string const&) +-Simulator::Simulator() | +-Simulator::setAnalysisSource() | +-Simulator::cmdLineAnalysis() | +-Simulator::fileAnalysis() +-Simulator::run() | +-Analysis::Analysis(std::istream&&, unsigned short) | | +-Options::instance() | | | +-Options::s_options | | | +-Options::Options() | | | +-Options::baseOption() | | | | +-Options::s_base | | | +-Options::configOption() | | | | +-Options::s_config | | | +-Options::cumDeathOption(std::string const&) | | | +-Options::deathAgeOption(std::string const&) | | | | +-Options::deathAge(std::string const&) | | | +-Options::fileOption(std::string*, int) | | | | +-Options::s_fileName | | | +-Options::lastCaseOption(std::string const&) | | | | +-Options::lastCase(std::string const&) | | | +-Options::logOption(std::string const&) | | | | +-g_log | | | | +-Log::set(unsigned int, unsigned int, std::string const&, std::string const&) | | | +-Options::setSimulationType() | | | | +-Globals::s_label | | | | +-Globals::findSimType(std::string const&) | | | | +-Globals::s_label | | | +-Options::tumorAgeOption(std::string const&) | | | +-Options::tumorAge(std::string const&) | | +-Parser::~Parser() | | | +-Parser::s_map | | | +-Parser::rmLineInfoVectors(std::unordered_map&) | | | +-Parser::endPoint(std::pair const&) | | +-Analysis::actualize(std::vector const&) | | | +-g_longOpts | | | +-g_longEnd | | | +-Options::instance() | | | | +-Options::s_options | | | | +-Options::Options() | | | | +-Options::baseOption() | | | | | +-Options::s_base | | | | +-Options::configOption() | | | | | +-Options::s_config | | | | +-Options::cumDeathOption(std::string const&) | | | | +-Options::deathAgeOption(std::string const&) | | | | | +-Options::deathAge(std::string const&) | | | | +-Options::fileOption(std::string*, int) | | | | | +-Options::s_fileName | | | | +-Options::lastCaseOption(std::string const&) | | | | | +-Options::lastCase(std::string const&) | | | | +-Options::logOption(std::string const&) | | | | | +-g_log | | | | | +-Log::set(unsigned int, unsigned int, std::string const&, std::string const&) | | | | +-Options::setSimulationType() | | | | | +-Globals::s_label | | | | | +-Globals::findSimType(std::string const&) | | | | | +-Globals::s_label | | | | +-Options::tumorAgeOption(std::string const&) | | | | +-Options::tumorAge(std::string const&) | | | +-Options::activate() | | | +-Options::actualize() | | | | +-Options::replaceHome(std::string&) | | | | +-Options::setBase() | | | | | +-Options::replaceHome(std::string&) | | | | +-Options::replacePlus(std::string&) | | | | +-Globals::setSimType(std::string const&) | | | | | +-Globals::s_simType | | | | | +-Globals::s_label | | | | +-Options::conflictCheck() const | | | +-Options::alter(int, std::string const&) | | | +-Options::tumorAge(std::string const&) | | | +-Options::deathAge(std::string const&) | | | +-Options::lastCase(std::string const&) | | +-Parser::Parser() | | | +-Parser::s_map | | | +-Parser::initLineInfoVects(std::unordered_map&) | | | +-Parser::endPoint(std::pair const&) | | +-Parser::load(std::istream&, unsigned short, std::vector&, std::vector&) | | | +-ConfigLines::ConfigLines(std::istream&, unsigned short) | | | +-ConfigLines::get() | | | +-Parser::addConfigLine(std::vector*>&, ConfigLines&, ParamsSrc) | | | | +-Parser::checkRedo(ConfigLines&) | | | | | +-ConfigLines::key(std::string const&) | | | | +-Parser::endPoint(std::pair const&) | | | | +-Parser::locateError(std::vector*>&, ConfigLines&, ParamsSrc) | | | | +-Err::msg(Err::Plain) | | | | | +-Err::s_plain | | | | +-Err::s_src | | | +-Parser::s_map | | | +-Parser::setLabels(ConfigLines&, std::vector&) | | | | +-ConfigLines::get() | | | +-Parser::setOptions(ConfigLines&, std::vector&) | | | +-ConfigLines::get() | | | +-Parser::s_map | | +-Parser::load(std::string const&) | | +-ConfigLines::ConfigLines(std::string const&) | | +-ConfigLines::get() | | +-Parser::addConfigLine(std::vector*>&, ConfigLines&, ParamsSrc) | | | +-Parser::checkRedo(ConfigLines&) | | | | +-ConfigLines::key(std::string const&) | | | +-Parser::endPoint(std::pair const&) | | | +-Parser::locateError(std::vector*>&, ConfigLines&, ParamsSrc) | | | +-Err::msg(Err::Plain) | | | | +-Err::s_plain | | | +-Err::s_src | | +-Parser::s_map | +-Analysis::run() | | +-Analysis::requireBase() const | | | +-Options::instance() | | | +-Options::s_options | | | +-Options::Options() | | | +-Options::baseOption() | | | | +-Options::s_base | | | +-Options::configOption() | | | | +-Options::s_config | | | +-Options::cumDeathOption(std::string const&) | | | +-Options::deathAgeOption(std::string const&) | | | | +-Options::deathAge(std::string const&) | | | +-Options::fileOption(std::string*, int) | | | | +-Options::s_fileName | | | +-Options::lastCaseOption(std::string const&) | | | | +-Options::lastCase(std::string const&) | | | +-Options::logOption(std::string const&) | | | | +-g_log | | | | +-Log::set(unsigned int, unsigned int, std::string const&, std::string const&) | | | +-Options::setSimulationType() | | | | +-Globals::s_label | | | | +-Globals::findSimType(std::string const&) | | | | +-Globals::s_label | | | +-Options::tumorAgeOption(std::string const&) | | | +-Options::tumorAge(std::string const&) | | +-Loop::Loop(std::vector const&) | | | +-Options::instance() | | | | +-Options::s_options | | | | +-Options::Options() | | | | +-Options::baseOption() | | | | | +-Options::s_base | | | | +-Options::configOption() | | | | | +-Options::s_config | | | | +-Options::cumDeathOption(std::string const&) | | | | +-Options::deathAgeOption(std::string const&) | | | | | +-Options::deathAge(std::string const&) | | | | +-Options::fileOption(std::string*, int) | | | | | +-Options::s_fileName | | | | +-Options::lastCaseOption(std::string const&) | | | | | +-Options::lastCase(std::string const&) | | | | +-Options::logOption(std::string const&) | | | | | +-g_log | | | | | +-Log::set(unsigned int, unsigned int, std::string const&, std::string const&) | | | | +-Options::setSimulationType() | | | | | +-Globals::s_label | | | | | +-Globals::findSimType(std::string const&) | | | | | +-Globals::s_label | | | | +-Options::tumorAgeOption(std::string const&) | | | | +-Options::tumorAge(std::string const&) | | | +-Globals::s_simType | | | +-Incidence::Incidence() | | | | +-Incidence::cptTumorRisk() | | | | +-Incidence::setIncidence() | | | | +-Globals::s_simType | | | | +-Globals::s_label | | | | +-Params::s_label | | | | +-Incidence::sumProbs() | | | | +-Err::msg(Err::Plain) | | | | | +-Err::s_plain | | | | +-Incidence::setIncidence(std::vector&, unsigned long, bool) | | | | +-VSDParams::VSDParams(std::vector&, unsigned long, bool) | | | | | +-Params::~Params() | | | | | +-Params::Params(std::vector&, unsigned long, bool) | | | | | | +-Parser::proportion(std::vector const&, double&) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Err::specification() | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Err::range() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-VSD::VSD(VaryType) | | | | | +-VSD::s_valueCheck | | | | | +-Distribution::Distribution(VaryType) | | | | | +-Globals::s_vary | | | | | +-Distribution::accept(double) const | | | | | +-Distribution::s_varyParam | | | | +-TableParams::TableParams(std::vector&, unsigned long, bool) | | | | | +-Params::~Params() | | | | | +-Params::Params(std::vector&, unsigned long, bool) | | | | | | +-Parser::proportion(std::vector const&, double&) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Err::specification() | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Err::range() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-TableParams::fillRiskTable(std::vector&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-TableParams::appendPair(std::string const&) | | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-TableParams::checkTable() | | | | | | +-TableParams::checkIncreasing() | | | | | | +-TableParams::linear(double, std::pair const&, std::pair const&) | | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Parser::any(std::vector const&) | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Parser::lines(std::vector const&) | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | +-Parser::s_map | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | +-Parser::sectionList(std::vector const&) | | | | +-Parser::hasSection(std::vector const&) | | | | +-Parser::keywordsLines(std::vector const&) | | | | +-Parser::s_map | | | +-Beir7::Beir7() | | | | +-Parser::one(std::vector const&) | | | | | +-Parser::any(std::vector const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::lines(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | +-Parser::s_map | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_handle | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Parser::sectionList(std::vector const&) | | | | +-VSD::VSD(VaryType) | | | | | +-VSD::s_valueCheck | | | | | +-Distribution::Distribution(VaryType) | | | | | +-Globals::s_vary | | | | | +-Distribution::accept(double) const | | | | | +-Distribution::s_varyParam | | | | +-Globals::s_simType | | | +-Costs::Costs() | | | | +-Globals::s_simType | | | | +-Costs::setDiameters() | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Costs::extractDiameters(Parser::Lines&&) | | | | | +-Parser::Lines::get() | | | | | +-Err::reset(LineInfo const&) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_handle | | | | +-Costs::setDiscount(bool) | | | | | +-Costs::setAge() | | | | | | +-Parser::atLeast(double, std::vector const&, double&) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Err::specification() | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Err::atLeast(double) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Costs::setProportion(bool) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::range() | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Costs::setVariables(bool) | | | | +-Costs::lcTreatment(double, double, bool) const | | | | | +-Costs::discount(double, unsigned long) const | | | | +-Costs::otherTreatment(double, double, bool) const | | | | | +-Costs::cost(double) const | | | | | +-Costs::discount(double, unsigned long) const | | | | +-Parser::atLeast(double, std::vector const&, double&) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Err::atLeast(double) | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Costs::setLungCancer() | | | | +-Parser::one(std::vector const&) | | | | | +-Parser::any(std::vector const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::lines(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | +-Parser::s_map | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_handle | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Parser::sectionList(std::vector const&) | | | | +-Parser::Lines::get() | | | | | +-Err::reset(LineInfo const&) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_handle | | | | +-Err::specification() | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Err::atLeast(double) | | | | +-Err::msg(Err::Context) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_context | | | | | +-Err::s_src | | | | | +-Err::s_handle | | | | +-Err::s_lineInfo | | | +-Modalities::~Modalities() | | | +-Modalities::Modalities(Tumor const&) | | | | +-Globals::s_simType | | | | +-Modalities::addMod(ModBase*) | | | | +-CT::CT(Tumor const&) | | | | | +-VSD::VSD(VaryType) | | | | | | +-VSD::s_valueCheck | | | | | | +-Distribution::Distribution(VaryType) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::accept(double) const | | | | | | +-Distribution::s_varyParam | | | | | +-ModBase::ModBase(std::string const&) | | | | | | +-Parser::hasSection(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | +-Parser::s_map | | | | | | +-Parser::atLeast(double, std::vector const&, double&) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Err::specification() | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Err::atLeast(double) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-CT::setDose() | | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-CT::setSpecificity() | | | | | | +-CT::extract(char const*, VSD&) | | | | | | +-ModBase::extractBase(VSD&) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-VSD::extract(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::extract(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Err::s_lineInfo | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::varyBeta(double) const | | | | | | | | +-Random::instance() | | | | | | | | | +-Random::s_random | | | | | | | | +-Random::betaVary() | | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | | +-Distribution::find(std::string const&) | | | | | | | | +-Distribution::s_name | | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | | +-Err::msg(Err::Context) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_context | | | | | | | | | +-Err::s_src | | | | | | | | | +-Err::s_handle | | | | | | | | +-Err::s_lineInfo | | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-CT::setSensitivity() | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::s_lineInfo | | | | | | +-CT::add(bool*, LineInfo const&) | | | | | | | +-Err::specification() | | | | | | | | +-Err::msg(Err::Context) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_context | | | | | | | | | +-Err::s_src | | | | | | | | | +-Err::s_handle | | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | | +-Group::extract(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | | +-Globals::uint16_max | | | | | | +-Group::maxEnd() | | | | | | +-Globals::uint16_max | | | | | +-ModBase::~ModBase() | | | | | +-ModBase::vDose() const | | | | | +-ModBase::vDose(unsigned short) const | | | | +-Mammo::Mammo(Tumor const&) | | | | | +-ModBase::ModBase(std::string const&) | | | | | | +-Parser::hasSection(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | +-Parser::s_map | | | | | | +-Parser::atLeast(double, std::vector const&, double&) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Err::specification() | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Err::atLeast(double) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-ModBase::~ModBase() | | | | | | +-ModBase::vDose() const | | | | | | +-ModBase::vDose(unsigned short) const | | | | | +-ModBase::doseBase(std::vector&) | | | | | | +-Parser::VSDparameters(VaryType, std::vector const&, unsigned long) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-VSD::extract(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::extract(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Err::s_lineInfo | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::varyBeta(double) const | | | | | | | | +-Random::instance() | | | | | | | | | +-Random::s_random | | | | | | | | +-Random::betaVary() | | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | | +-Distribution::find(std::string const&) | | | | | | | | +-Distribution::s_name | | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | | +-Err::msg(Err::Context) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_context | | | | | | | | | +-Err::s_src | | | | | | | | | +-Err::s_handle | | | | | | | | +-Err::s_lineInfo | | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | +-VSD::VSD(VaryType) | | | | | | | +-VSD::s_valueCheck | | | | | | | +-Distribution::Distribution(VaryType) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::accept(double) const | | | | | | | +-Distribution::s_varyParam | | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-ModBase::specificityBase(std::vector&) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Err::specification() | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Group::connects(Group const&) const | | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-AgeGroupVSD::AgeGroupVSD(VaryType, bool, bool) | | | | | | | +-VSD::VSD(VaryType) | | | | | | | +-VSD::s_valueCheck | | | | | | | +-Distribution::Distribution(VaryType) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::accept(double) const | | | | | | | +-Distribution::s_varyParam | | | | | | +-AgeGroupVSD::extract(std::istream&) | | | | | | +-VSD::extract(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::extract(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Err::s_lineInfo | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::varyBeta(double) const | | | | | | | | +-Random::instance() | | | | | | | | | +-Random::s_random | | | | | | | | +-Random::betaVary() | | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | | +-Distribution::find(std::string const&) | | | | | | | | +-Distribution::s_name | | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | | +-Err::msg(Err::Context) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_context | | | | | | | | | +-Err::s_src | | | | | | | | | +-Err::s_handle | | | | | | | | +-Err::s_lineInfo | | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Group::extract(std::istream&) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | | +-Globals::uint16_max | | | | | +-Mammo::setSystematicError() | | | | | | +-Parser::proportion(std::vector const&, double&) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Err::specification() | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Err::range() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Mammo::setM() | | | | | | +-Parser::VSDparameters(VaryType, std::vector const&, unsigned long) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-VSD::extract(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::extract(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Err::s_lineInfo | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::varyBeta(double) const | | | | | | | | +-Random::instance() | | | | | | | | | +-Random::s_random | | | | | | | | +-Random::betaVary() | | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | | +-Distribution::find(std::string const&) | | | | | | | | +-Distribution::s_name | | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | | +-Err::msg(Err::Context) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_context | | | | | | | | | +-Err::s_src | | | | | | | | | +-Err::s_handle | | | | | | | | +-Err::s_lineInfo | | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | +-VSD::VSD(VaryType) | | | | | | | +-VSD::s_valueCheck | | | | | | | +-Distribution::Distribution(VaryType) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::accept(double) const | | | | | | | +-Distribution::s_varyParam | | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Mammo::setBeta() | | | | | +-Parser::VSDparameters(VaryType, std::vector const&, unsigned long) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-VSD::extract(std::istream&) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::extract(std::istream&) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Random::instance() | | | | | | | +-Random::s_random | | | | | | +-Err::s_lineInfo | | | | | | +-Globals::s_vary | | | | | | +-Distribution::varyBeta(double) const | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Random::betaVary() | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | +-Distribution::find(std::string const&) | | | | | | | +-Distribution::s_name | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | +-Globals::s_vary | | | | | +-VSD::VSD(VaryType) | | | | | | +-VSD::s_valueCheck | | | | | | +-Distribution::Distribution(VaryType) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::accept(double) const | | | | | | +-Distribution::s_varyParam | | | | | +-Err::msg(Err::Context) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_context | | | | | +-Err::s_src | | | | | +-Err::s_handle | | | | +-Tomo::Tomo() | | | | | +-ModBase::ModBase(std::string const&) | | | | | | +-Parser::hasSection(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | +-Parser::s_map | | | | | | +-Parser::atLeast(double, std::vector const&, double&) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Err::specification() | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Err::atLeast(double) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-ModBase::~ModBase() | | | | | | +-ModBase::vDose() const | | | | | | +-ModBase::vDose(unsigned short) const | | | | | +-Tomo::setSensitivity() | | | | | | +-Parser::VSDparameters(VaryType, std::vector const&, unsigned long) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-VSD::extract(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::extract(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Err::s_lineInfo | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::varyBeta(double) const | | | | | | | | +-Random::instance() | | | | | | | | | +-Random::s_random | | | | | | | | +-Random::betaVary() | | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | | +-Distribution::find(std::string const&) | | | | | | | | +-Distribution::s_name | | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | | +-Err::msg(Err::Context) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_context | | | | | | | | | +-Err::s_src | | | | | | | | | +-Err::s_handle | | | | | | | | +-Err::s_lineInfo | | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | +-VSD::VSD(VaryType) | | | | | | | +-VSD::s_valueCheck | | | | | | | +-Distribution::Distribution(VaryType) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::accept(double) const | | | | | | | +-Distribution::s_varyParam | | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-ModBase::doseBase(std::vector&) | | | | | | +-Parser::VSDparameters(VaryType, std::vector const&, unsigned long) | | | | | | +-Parser::one(std::vector const&) | | | | | | | +-Parser::any(std::vector const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | | +-Err::s_plain | | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | | +-Parser::s_map | | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | | +-Err::s_handle | | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-VSD::extract(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::extract(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Err::s_lineInfo | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::varyBeta(double) const | | | | | | | | +-Random::instance() | | | | | | | | | +-Random::s_random | | | | | | | | +-Random::betaVary() | | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | | +-Distribution::find(std::string const&) | | | | | | | | +-Distribution::s_name | | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | | +-Err::msg(Err::Context) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_context | | | | | | | | | +-Err::s_src | | | | | | | | | +-Err::s_handle | | | | | | | | +-Err::s_lineInfo | | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | +-VSD::VSD(VaryType) | | | | | | | +-VSD::s_valueCheck | | | | | | | +-Distribution::Distribution(VaryType) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::accept(double) const | | | | | | | +-Distribution::s_varyParam | | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-ModBase::specificityBase(std::vector&) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Group::connects(Group const&) const | | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-AgeGroupVSD::AgeGroupVSD(VaryType, bool, bool) | | | | | | +-VSD::VSD(VaryType) | | | | | | +-VSD::s_valueCheck | | | | | | +-Distribution::Distribution(VaryType) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::accept(double) const | | | | | | +-Distribution::s_varyParam | | | | | +-AgeGroupVSD::extract(std::istream&) | | | | | +-VSD::extract(std::istream&) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::extract(std::istream&) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Random::instance() | | | | | | | +-Random::s_random | | | | | | +-Err::s_lineInfo | | | | | | +-Globals::s_vary | | | | | | +-Distribution::varyBeta(double) const | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Random::betaVary() | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | +-Distribution::find(std::string const&) | | | | | | | +-Distribution::s_name | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | +-Globals::s_vary | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Group::extract(std::istream&) | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | | +-Globals::uint16_max | | | | +-MRI::MRI() | | | | +-VSD::VSD(VaryType) | | | | | +-VSD::s_valueCheck | | | | | +-Distribution::Distribution(VaryType) | | | | | +-Globals::s_vary | | | | | +-Distribution::accept(double) const | | | | | +-Distribution::s_varyParam | | | | +-ModBase::ModBase(std::string const&) | | | | | +-Parser::hasSection(std::vector const&) | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | +-Parser::s_map | | | | | +-Parser::atLeast(double, std::vector const&, double&) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Err::atLeast(double) | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-ModBase::~ModBase() | | | | | +-ModBase::vDose() const | | | | | +-ModBase::vDose(unsigned short) const | | | | +-MRI::setSpecificity() | | | | | +-MRI::extract(char const*, VSD&) | | | | | +-ModBase::extractBase(VSD&) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-VSD::extract(std::istream&) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::extract(std::istream&) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Random::instance() | | | | | | | +-Random::s_random | | | | | | +-Err::s_lineInfo | | | | | | +-Globals::s_vary | | | | | | +-Distribution::varyBeta(double) const | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Random::betaVary() | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | +-Distribution::find(std::string const&) | | | | | | | +-Distribution::s_name | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | +-Globals::s_vary | | | | | +-Err::specification() | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-MRI::setSensitivity() | | | | +-MRI::extract(char const*, VSD&) | | | | +-ModBase::extractBase(VSD&) | | | | +-Parser::one(std::vector const&) | | | | | +-Parser::any(std::vector const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::lines(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | +-Parser::s_map | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_handle | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Parser::sectionList(std::vector const&) | | | | +-Parser::Lines::get() | | | | | +-Err::reset(LineInfo const&) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_handle | | | | +-VSD::extract(std::istream&) | | | | | +-Globals::s_vary | | | | | +-Distribution::extract(std::istream&) | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-Err::s_lineInfo | | | | | +-Globals::s_vary | | | | | +-Distribution::varyBeta(double) const | | | | | | +-Random::instance() | | | | | | | +-Random::s_random | | | | | | +-Random::betaVary() | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | +-Distribution::find(std::string const&) | | | | | | +-Distribution::s_name | | | | | +-Random::prepareBeta(std::istream&) | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Distribution::prepareVary(std::istream&) | | | | | +-Globals::s_vary | | | | +-Err::specification() | | | | +-Err::msg(Err::Context) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_context | | | | | +-Err::s_src | | | | | +-Err::s_handle | | | | +-Err::s_lineInfo | | | +-Screening::roundAge(unsigned long) const | | | +-Screening::Screening(Modalities&) | | | | +-Globals::s_simType | | | | +-Screening::errRisk1404(std::vector&, Modalities const&, Round const&, unsigned short, double, double) | | | | | +-Screening::beir7Err(Round const&, unsigned short, double, double, Modalities const&) | | | | | +-Modalities::use(std::vector const&) const | | | | +-Screening::errRisk1405(std::vector&, Modalities const&, Round const&, unsigned short, double, double) | | | | | +-Screening::beir7Err(unsigned short, Round const&, unsigned short, double, double, Modalities const&) | | | | | +-Modalities::use(std::vector const&) const | | | | +-Screening::setAttendanceRate() | | | | | +-Parser::proportion(std::vector const&, double&) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Err::range() | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Screening::setRounds() | | | | +-Parser::Lines::get() | | | | | +-Err::reset(LineInfo const&) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_handle | | | | +-Err::msg(Err::Context) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_context | | | | | +-Err::s_src | | | | | +-Err::s_handle | | | | +-Parser::any(std::vector const&) | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Parser::lines(std::vector const&) | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | +-Parser::s_map | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | +-Parser::sectionList(std::vector const&) | | | | +-Screening::addRound(LineInfo*, LineInfo const&) | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Screening::addModality(std::istream&, Round&) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Modalities::find(std::string const&) const | | | | | | +-Round::add(unsigned short) | | | | | +-operator>>(std::istream&, Round&) | | | | | +-Globals::isZero(double) | | | | | +-Screening::increasingAge(Round const&) const | | | | | +-Globals::weakCompare(double, double) | | | | +-Err::reset(LineInfo const&) | | | | +-Err::s_lineInfo | | | | +-Err::s_handle | | | +-Densities::Densities() | | | | +-Parser::Lines::get() | | | | | +-Err::reset(LineInfo const&) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_handle | | | | +-Globals::s_simType | | | | +-Parser::any(std::vector const&) | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Parser::lines(std::vector const&) | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | +-Parser::s_map | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | +-Parser::sectionList(std::vector const&) | | | | +-Densities::add(bool*, LineInfo const&) | | | | +-Err::specification() | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Err::msg(Err::Context) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_context | | | | | +-Err::s_src | | | | | +-Err::s_handle | | | | +-Globals::isZero(double) | | | | +-ProbGroup::ProbGroup(Series) | | | | | +-Globals::s_simType | | | | +-ProbGroup::extract(std::istream&) | | | | | +-Group::extract(std::istream&) | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | | +-Globals::uint16_max | | | | +-Densities::percentages(std::vector const&) | | | | +-Group::connects(Group const&) const | | | | | +-Err::msg(Err::Context) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_context | | | | | +-Err::s_src | | | | | +-Err::s_handle | | | | +-Err::s_lineInfo | | | +-Options::tnm() const | | | +-Loop::fillTNM(std::ostream&) | | | +-Scenario::Scenario() | | | | +-Scenario::setNiterations() | | | | | +-Parser::atLeast(double, std::vector const&, double&) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Err::atLeast(double) | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Scenario::setNcases() | | | | | +-Parser::atLeast(double, std::vector const&, double&) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Err::atLeast(double) | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Scenario::setGeneratorType() | | | | | +-Scenario::s_generatorType | | | | | +-Scenario::find(std::vector const&, std::string const&) | | | | | +-Err::specification() | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Scenario::setSeed() | | | | | +-Parser::atLeast(double, std::vector const&, double&) | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Err::atLeast(double) | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Scenario::setVary() | | | | | +-Globals::s_vary | | | | | +-Random::initialize() | | | | | | +-Random::s_random | | | | | | +-Random::Random() | | | | | | +-Globals::s_vary | | | | | +-Scenario::s_bool | | | | | +-Scenario::find(std::vector const&, std::string const&) | | | | | +-Err::specification() | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Scenario::setDeath() | | | | +-Options::instance() | | | | | +-Options::s_options | | | | | +-Options::Options() | | | | | +-Options::baseOption() | | | | | | +-Options::s_base | | | | | +-Options::configOption() | | | | | | +-Options::s_config | | | | | +-Options::cumDeathOption(std::string const&) | | | | | +-Options::deathAgeOption(std::string const&) | | | | | | +-Options::deathAge(std::string const&) | | | | | +-Options::fileOption(std::string*, int) | | | | | | +-Options::s_fileName | | | | | +-Options::lastCaseOption(std::string const&) | | | | | | +-Options::lastCase(std::string const&) | | | | | +-Options::logOption(std::string const&) | | | | | | +-g_log | | | | | | +-Log::set(unsigned int, unsigned int, std::string const&, std::string const&) | | | | | +-Options::setSimulationType() | | | | | | +-Globals::s_label | | | | | | +-Globals::findSimType(std::string const&) | | | | | | +-Globals::s_label | | | | | +-Options::tumorAgeOption(std::string const&) | | | | | +-Options::tumorAge(std::string const&) | | | | +-Parser::Lines::get() | | | | | +-Err::reset(LineInfo const&) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_handle | | | | +-Parser::any(std::vector const&) | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Parser::lines(std::vector const&) | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | +-Parser::s_map | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | +-Parser::sectionList(std::vector const&) | | | | +-Scenario::appendCumDeath(std::string const&) | | | | +-Scenario::checkCumDeath(std::string const&, LineInfo const*) const | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Scenario::showLineInfo(LineInfo const*) | | | | +-Scenario::readCumDeath(std::string const&) | | | | +-Err::msg(Err::Plain) | | | | | +-Err::s_plain | | | | +-Scenario::appendCumDeath(std::string const&) | | | +-Growth::Growth() | | | | +-VSD::VSD(VaryType) | | | | | +-VSD::s_valueCheck | | | | | +-Distribution::Distribution(VaryType) | | | | | +-Globals::s_vary | | | | | +-Distribution::accept(double) const | | | | | +-Distribution::s_varyParam | | | | +-Globals::s_simType | | | | +-Growth::setSelfDetect() | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-VSD::extract(std::istream&) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::extract(std::istream&) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Random::instance() | | | | | | | +-Random::s_random | | | | | | +-Err::s_lineInfo | | | | | | +-Globals::s_vary | | | | | | +-Distribution::varyBeta(double) const | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Random::betaVary() | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | +-Distribution::find(std::string const&) | | | | | | | +-Distribution::s_name | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | +-Globals::s_vary | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Globals::s_simType | | | | | +-VSD::ln() | | | | | | +-Globals::s_vary | | | | | | +-Distribution::ln() | | | | | +-Err::negative() | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Err::s_lineInfo | | | | +-Growth::setDoublingTime() | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Globals::s_simType | | | | | +-Parser::any(std::vector const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::lines(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | +-Parser::s_map | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_handle | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Group::connects(Group const&) const | | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-AgeGroupVSD::AgeGroupVSD(VaryType, bool, bool) | | | | | | +-VSD::VSD(VaryType) | | | | | | +-VSD::s_valueCheck | | | | | | +-Distribution::Distribution(VaryType) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::accept(double) const | | | | | | +-Distribution::s_varyParam | | | | | +-AgeGroupVSD::ln() | | | | | | +-VSD::ln() | | | | | | +-Globals::s_vary | | | | | | +-Distribution::ln() | | | | | +-Growth::ageGroupVSDbreast(unsigned short) const | | | | | +-Growth::ageGroupVSDlung(unsigned short) const | | | | +-Growth::setStart() | | | | +-Parser::one(std::vector const&) | | | | | +-Parser::any(std::vector const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::lines(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | +-Parser::s_map | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_handle | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Parser::sectionList(std::vector const&) | | | | +-Parser::Lines::get() | | | | | +-Err::reset(LineInfo const&) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_handle | | | | +-Globals::s_simType | | | | +-Err::msg(Err::Context) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_context | | | | | +-Err::s_src | | | | | +-Err::s_handle | | | | +-Err::atLeast(double) | | | | +-Err::msg(Err::Context) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_context | | | | | +-Err::s_src | | | | | +-Err::s_handle | | | | +-Err::s_lineInfo | | | +-Survival::Survival() | | | | +-Globals::s_simType | | | | +-Parser::VSDparameters(VaryType, std::vector const&, std::initializer_list const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-VSD::extract(std::istream&) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::extract(std::istream&) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Random::instance() | | | | | | | +-Random::s_random | | | | | | +-Err::s_lineInfo | | | | | | +-Globals::s_vary | | | | | | +-Distribution::varyBeta(double) const | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Random::betaVary() | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | +-Distribution::find(std::string const&) | | | | | | | +-Distribution::s_name | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | +-Globals::s_vary | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-VSD::VSD(VaryType) | | | | | | +-VSD::s_valueCheck | | | | | | +-Distribution::Distribution(VaryType) | | | | | | +-Globals::s_vary | | | | | | +-Distribution::accept(double) const | | | | | | +-Distribution::s_varyParam | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Parser::any(std::vector const&) | | | | | +-Err::msg(Err::Plain) | | | | | | +-Err::s_plain | | | | | +-Parser::lines(std::vector const&) | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | +-Parser::s_map | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | +-Parser::sectionList(std::vector const&) | | | | +-Survival::cptTNM(double) | | | | +-Survival::cptVSDrow(double) | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-g_log | | | | | +-Random::uniformVSD() | | | | | | +-g_log | | | | | | +-Log::operator()(int) | | | | | | +-nl(Log&) | | | | | +-ProbGroup::probIndexOf(std::vector const&, double, double) | | | | | +-Group::contains(double) const | | | | | +-ProbGroup::indexOf(double) const | | | | +-Survival::loadBC() | | | | | +-Parser::one(std::vector const&) | | | | | | +-Parser::any(std::vector const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | | +-Err::s_plain | | | | | | | +-Parser::lines(std::vector const&) | | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | | +-Parser::s_map | | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_handle | | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | | +-Parser::sectionList(std::vector const&) | | | | | | +-Err::multiplySpecified(__gnu_cxx::__normal_iterator >, __gnu_cxx::__normal_iterator >, std::string const&) | | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::msg(Err::Context) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_context | | | | | | +-Err::s_src | | | | | | +-Err::s_handle | | | | | +-Globals::uint16_max | | | | +-Survival::loadS3() | | | | | +-Parser::Lines::get() | | | | | | +-Err::reset(LineInfo const&) | | | | | | +-Err::s_lineInfo | | | | | | +-Err::s_handle | | | | | +-Err::specification() | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | +-Parser::any(std::vector const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::lines(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | +-Parser::s_map | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_handle | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-ProbGroup::ProbGroup(Series) | | | | | | +-Globals::s_simType | | | | | +-ProbGroup::extract(std::istream&) | | | | | | +-Group::extract(std::istream&) | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Err::s_lineInfo | | | | | | +-Globals::uint16_max | | | | | +-Group::connects(Group const&) const | | | | | +-Err::msg(Err::Context) | | | | | +-Err::s_lineInfo | | | | | +-Err::s_context | | | | | +-Err::s_src | | | | | +-Err::s_handle | | | | +-Survival::loadS4() | | | | | +-Parser::VSDparameters(VaryType, std::vector const&, std::initializer_list const&) | | | | | | +-Parser::Lines::get() | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_handle | | | | | | +-VSD::extract(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::extract(std::istream&) | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Random::instance() | | | | | | | | +-Random::s_random | | | | | | | +-Err::s_lineInfo | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::varyBeta(double) const | | | | | | | | +-Random::instance() | | | | | | | | | +-Random::s_random | | | | | | | | +-Random::betaVary() | | | | | | | | +-BetaDist::operator()(std::mersenne_twister_engine&) | | | | | | | +-Distribution::find(std::string const&) | | | | | | | | +-Distribution::s_name | | | | | | | +-Random::prepareBeta(std::istream&) | | | | | | | | +-BetaDist::BetaDist(std::istream&) | | | | | | | | +-Err::msg(Err::Context) | | | | | | | | | +-Err::s_lineInfo | | | | | | | | | +-Err::s_context | | | | | | | | | +-Err::s_src | | | | | | | | | +-Err::s_handle | | | | | | | | +-Err::s_lineInfo | | | | | | | +-Distribution::prepareVary(std::istream&) | | | | | | | +-Globals::s_vary | | | | | | +-Err::specification() | | | | | | | +-Err::msg(Err::Context) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_context | | | | | | | | +-Err::s_src | | | | | | | | +-Err::s_handle | | | | | | | +-Err::s_lineInfo | | | | | | +-VSD::VSD(VaryType) | | | | | | | +-VSD::s_valueCheck | | | | | | | +-Distribution::Distribution(VaryType) | | | | | | | +-Globals::s_vary | | | | | | | +-Distribution::accept(double) const | | | | | | | +-Distribution::s_varyParam | | | | | | +-Err::msg(Err::Context) | | | | | | | +-Err::s_lineInfo | | | | | | | +-Err::s_context | | | | | | | +-Err::s_src | | | | | | | +-Err::s_handle | | | | | | +-Parser::any(std::vector const&) | | | | | | +-Err::msg(Err::Plain) | | | | | | | +-Err::s_plain | | | | | | +-Parser::lines(std::vector const&) | | | | | | | +-Parser::keywordsLines(std::vector const&) | | | | | | | | +-Parser::s_map | | | | | | | +-Parser::Lines::Lines(__gnu_cxx::__normal_iterator > const&, __gnu_cxx::__normal_iterator > const&) | | | | | | | | +-Err::reset(LineInfo const&) | | | | | | | | +-Err::s_lineInfo | | | | | | | | +-Err::s_handle | | | | | | | +-Parser::Lines::Lines(std::vector const&) | | | | | | +-Parser::sectionList(std::vector const&) | | | | | +-Survival::s_lungColumn | | | | +-Survival::varyLung(std::ostream&) | | | | | +-VSD::vary(std::ostream&, unsigned int, char const*, char const*, char, std::vector&) | | | | | | +-VSD::vary(std::ostream&, unsigned int, char const*, char, std::vector&) | | | | | | +-VSD::showVary(std::ostream&) const | | | | | +-VSD::vary(std::ostream&, unsigned int, char const*, char, std::vector&) | | | | | | +-VSD::showVary(std::ostream&) const | | | | | +-Survival::s_noColon | | | | +-Survival::writeLung(std::ostream&) const | | | | | +-Survival::lungParameters(std::ostream&) const | | | | | | +-VSD::fmt(unsigned int, char const*, char, unsigned int, unsigned int, unsigned int, unsigned int) | | | | | | | +-VSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int) | | | | | | | | +-VSD::s_prec | | | | | | | | +-VSD::s_width | | | | | | | | +-Distribution::fmt(unsigned int, unsigned int) | | | | | | | | +-Distribution::s_precision | | | | | | | | +-Distribution::s_width | | | | | | | +-VSD::s_ch | | | | | | | +-VSD::s_type | | | | | | | +-VSD::s_indent | | | | | | +-VSD::insert(std::ostream&, std::vector const&) | | | | | | | +-VSD::insert(std::ostream&) const | | | | | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | | | | +-Distribution::insert(std::ostream&) const | | | | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | | | | +-Random::instance() | | | | | | | | | +-Random::s_random | | | | | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | | | | +-Distribution::s_name | | | | | | | | +-Distribution::s_precision | | | | | | | | +-Distribution::s_width | | | | | | | +-VSD::s_ch | | | | | | | +-VSD::s_type | | | | | | | +-VSD::s_indent | | | | | | +-Survival::s_lungColumn | | | | | +-Survival::s3parameters(std::ostream&) const | | | | | +-ProbGroup::insert(std::ostream&) const | | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | +-operator<<(std::ostream&, Group const&) | | | | | | +-Globals::isZero(double) | | | | | | +-Globals::uint16_max | | | | | +-ProbGroup::s_labels | | | | +-Survival::varyBreast(std::ostream&) | | | | | +-VSD::vary(std::ostream&, unsigned int, char const*, char const*, char, std::vector&) | | | | | +-VSD::vary(std::ostream&, unsigned int, char const*, char, std::vector&) | | | | | +-VSD::showVary(std::ostream&) const | | | | +-Survival::writeBreast(std::ostream&) const | | | | +-VSD::fmt(unsigned int, char const*, char, unsigned int, unsigned int, unsigned int, unsigned int) | | | | | +-VSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int) | | | | | | +-VSD::s_prec | | | | | | +-VSD::s_width | | | | | | +-Distribution::fmt(unsigned int, unsigned int) | | | | | | +-Distribution::s_precision | | | | | | +-Distribution::s_width | | | | | +-VSD::s_ch | | | | | +-VSD::s_type | | | | | +-VSD::s_indent | | | | +-VSD::insert(std::ostream&, std::vector const&) | | | | | +-VSD::insert(std::ostream&) const | | | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | | +-Distribution::insert(std::ostream&) const | | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | | +-Random::instance() | | | | | | | +-Random::s_random | | | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | | +-Distribution::s_name | | | | | | +-Distribution::s_precision | | | | | | +-Distribution::s_width | | | | | +-VSD::s_ch | | | | | +-VSD::s_type | | | | | +-VSD::s_indent | | | | +-Globals::uint16_max | | | +-Tumor::Tumor(TumorInfo&) | | | +-Loop::noTNM(std::ostream&) | | +-Loop::iterate() | | +-Random::instance() | | | +-Random::s_random | | +-Modalities::active() | | | +-Modalities::find(std::string const&) const | | +-Modalities::vary(std::ostream&) | | +-Globals::s_vary | | +-Random::reinit(unsigned long, GeneratorType) | | | +-Globals::s_vary | | | +-Random::reset() | | | +-Globals::s_vary | | | +-BetaDist::reset() | | +-Loop::cases() const | | +-Loop::genCases(unsigned long, unsigned long) | | | +-g_log | | | +-Log::caseIdx(unsigned long) | | | +-Loop::caseInit() | | | | +-Screening::radiationRisk(Modalities const&, std::vector const&, double, double) | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-Random::uniform() | | | | | | +-g_log | | | | | | +-Log::operator()(int) | | | | | | +-nl(Log&) | | | | | +-Screening::errRisk1405(std::vector&, Modalities const&, Round const&, unsigned short, double, double) | | | | | | +-Screening::beir7Err(unsigned short, Round const&, unsigned short, double, double, Modalities const&) | | | | | | +-Modalities::use(std::vector const&) const | | | | | +-g_log | | | | +-g_log | | | | +-Options::fixedNaturalDeathAge(double&) const | | | | +-Loop::cptIndices() const | | | | | +-Globals::s_simType | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-Random::uniform() | | | | | | +-g_log | | | | | | +-Log::operator()(int) | | | | | | +-nl(Log&) | | | | | +-Screening::ages() const | | | | | +-ProbGroup::probIndexOf(std::vector const&, double, double) | | | | | +-Group::contains(double) const | | | | | +-ProbGroup::indexOf(double) const | | | | +-TumorInfo::cumTotalRisk(std::vector const&) | | | | | +-Incidence::index() const | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-Random::uniform() | | | | | +-g_log | | | | | +-Log::operator()(int) | | | | | +-nl(Log&) | | | | +-Loop::naturalDeathAge() | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-g_log | | | | | +-Random::uniformCase() | | | | | | +-g_log | | | | | | +-Log::operator()(int) | | | | | | +-nl(Log&) | | | | | +-Globals::findAge(std::vector const&, double) | | | | +-Tumor::reset() | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-g_log | | | | | +-Random::logNormal(double, double) | | | | | | +-g_log | | | | | | +-Log::operator()(int) | | | | | | +-nl(Log&) | | | | | +-Random::uniformCase() | | | | | | +-g_log | | | | | | +-Log::operator()(int) | | | | | | +-nl(Log&) | | | | | +-Tumor::tumorAge() | | | | | +-Options::instance() | | | | | | +-Options::s_options | | | | | | +-Options::Options() | | | | | | +-Options::baseOption() | | | | | | | +-Options::s_base | | | | | | +-Options::configOption() | | | | | | | +-Options::s_config | | | | | | +-Options::cumDeathOption(std::string const&) | | | | | | +-Options::deathAgeOption(std::string const&) | | | | | | | +-Options::deathAge(std::string const&) | | | | | | +-Options::fileOption(std::string*, int) | | | | | | | +-Options::s_fileName | | | | | | +-Options::lastCaseOption(std::string const&) | | | | | | | +-Options::lastCase(std::string const&) | | | | | | +-Options::logOption(std::string const&) | | | | | | | +-g_log | | | | | | | +-Log::set(unsigned int, unsigned int, std::string const&, std::string const&) | | | | | | +-Options::setSimulationType() | | | | | | | +-Globals::s_label | | | | | | | +-Globals::findSimType(std::string const&) | | | | | | | +-Globals::s_label | | | | | | +-Options::tumorAgeOption(std::string const&) | | | | | | +-Options::tumorAge(std::string const&) | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-g_log | | | | | +-Options::fixedTumorAge(double&) const | | | | | +-Random::logNormal(double, double) | | | | | | +-g_log | | | | | | +-Log::operator()(int) | | | | | | +-nl(Log&) | | | | | +-Random::uniformCase() | | | | | | +-g_log | | | | | | +-Log::operator()(int) | | | | | | +-nl(Log&) | | | | | +-Globals::findAge(std::vector const&, double) | | | | +-Tumor::insert(std::ostream&) const | | | +-Loop::headerData(unsigned long) const | | | | +-Loop::s_status | | | | +-Loop::outStream(std::string const&, unsigned long) | | | | | +-Loop::open(std::string const&) | | | | | | +-Loop::s_availableFiles | | | | | +-Loop::replaceDollar(std::string const&, unsigned long) | | | | +-Loop::labels(std::ostream&) const | | | | +-Icmake::version | | | +-Loop::screening() | | | | +-g_log | | | | +-Screening::roundAge(unsigned long) const | | | | +-Loop::leaving(double) | | | | | +-Loop::intervalCancer() | | | | | | +-Loop::addCost(double) | | | | | | +-Loop::left(Loop::Status, double) | | | | | | +-g_log | | | | | | +-Loop::s_status | | | | | +-Loop::left(Loop::Status, double) | | | | | | +-g_log | | | | | | +-Loop::s_status | | | | | +-Tumor::characteristicsAt(double) | | | | | +-g_log | | | | | +-Tumor::requireTumor(char const*) const | | | | +-Loop::screen(double) | | | | +-Costs::discount(double, unsigned long) const | | | | +-Modalities::use(std::vector const&) const | | | | +-g_log | | | | +-Loop::addCost(double) | | | | +-Loop::maybeFalseNegative(ModBase*, double) | | | | | +-Loop::falseNegative(ModBase*) | | | | | | +-Random::instance() | | | | | | | +-Random::s_random | | | | | | +-Random::uniform() | | | | | | | +-g_log | | | | | | | +-Log::operator()(int) | | | | | | | +-nl(Log&) | | | | | | +-g_log | | | | | | +-Loop::sensitivity(ModBase*) const | | | | | +-Loop::tumorDetected(ModBase*, double) | | | | | +-Loop::addCost(double) | | | | | +-Loop::left(Loop::Status, double) | | | | | | +-g_log | | | | | | +-Loop::s_status | | | | | +-Tumor::characteristicsAt(double) | | | | | | +-g_log | | | | | | +-Tumor::requireTumor(char const*) const | | | | | +-Tumor::setDeathAge(double) | | | | | +-Globals::weakCompare(double, double) | | | | | +-g_log | | | | | +-Tumor::requireTumor(char const*) const | | | | | +-Tumor::functionF(double) const | | | | | +-Tumor::functionQ(double) const | | | | | +-Tumor::functionZ(double) const | | | | +-Loop::maybeFalsePositive(ModBase*, double) | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-Random::uniform() | | | | | | +-g_log | | | | | | +-Log::operator()(int) | | | | | | +-nl(Log&) | | | | | +-Costs::discount(double, unsigned long) const | | | | | +-g_log | | | | | +-Loop::addCost(double) | | | | +-Loop::use(ModBase*) | | | +-Loop::postScreen() | | | | +-g_log | | | | +-Loop::left(Loop::Status, double) | | | | | +-g_log | | | | | +-Loop::s_status | | | | +-Tumor::characteristicsAt(double) | | | | +-g_log | | | | +-Tumor::requireTumor(char const*) const | | | +-Loop::writeData(FBB::CSVTable&, unsigned long) const | | | +-Globals::isZero(double) | | | +-Loop::showRound() const | | | +-Tumor::writeData(FBB::CSVTable&) const | | | +-Tumor::s_noYes | | +-Loop::outStream(std::string const&, unsigned long) | | | +-Loop::open(std::string const&) | | | | +-Loop::s_availableFiles | | | +-Loop::replaceDollar(std::string const&, unsigned long) | | +-Loop::labels(std::ostream&) const | | | +-Icmake::version | | +-Loop::headerRounds(unsigned long) const | | | +-Modalities::roundFmt(FBB::CSVTable&) const | | | +-Modalities::roundHeaders(FBB::CSVTable&) const | | | +-Loop::outStream(std::string const&, unsigned long) | | | | +-Loop::open(std::string const&) | | | | | +-Loop::s_availableFiles | | | | +-Loop::replaceDollar(std::string const&, unsigned long) | | | +-Loop::labels(std::ostream&) const | | | +-Icmake::version | | +-Loop::headerSensitivity() const | | | +-Loop::outStream(std::string const&, unsigned long) | | | | +-Loop::open(std::string const&) | | | | | +-Loop::s_availableFiles | | | | +-Loop::replaceDollar(std::string const&, unsigned long) | | | +-Loop::labels(std::ostream&) const | | | +-Icmake::version | | +-TumorInfo::vary(std::ostream&) | | | +-Incidence::vary(std::ostream&) | | | | +-Incidence::cptTumorRisk() | | | +-Beir7::vary(std::ostream&) | | | | +-Globals::s_simType | | | | +-Globals::s_label | | | | +-VSD::showVary(std::ostream&) const | | | +-Growth::vary(std::ostream&) | | | +-VSD::showVary(std::ostream&) const | | | +-AgeGroupVSD::vary(std::ostream&, unsigned int, char const*, std::vector&) | | | +-VSD::showVary(std::ostream&) const | | | +-operator<<(std::ostream&, Group const&) | | | | +-Globals::isZero(double) | | | | +-Globals::uint16_max | | | +-AgeGroupVSD::vary() | | +-Loop::writeParameters(unsigned long) const | | | +-Globals::s_simType | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | +-Costs::writeParameters(std::ostream&) const | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | +-Modalities::writeParameters(std::ostream&) const | | | | +-operator<<(std::ostream&, ModBase const&) | | | +-Screening::writeParameters(std::ostream&) const | | | | +-Round::insert(std::ostream&) const | | | +-Densities::writeParameters(std::ostream&) const | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | +-ProbGroup::insert(std::ostream&) const | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | +-operator<<(std::ostream&, Group const&) | | | | | +-Globals::isZero(double) | | | | | +-Globals::uint16_max | | | | +-ProbGroup::s_labels | | | +-Loop::outStream(std::string const&, unsigned long) | | | | +-Loop::open(std::string const&) | | | | | +-Loop::s_availableFiles | | | | +-Loop::replaceDollar(std::string const&, unsigned long) | | | +-Loop::labels(std::ostream&) const | | | | +-Icmake::version | | | +-Scenario::writeParameters(std::ostream&, unsigned long) const | | | | +-Globals::s_vary | | | | +-Scenario::s_generatorType | | | | +-Scenario::s_bool | | | +-TumorInfo::writeParameters(std::ostream&) const | | | +-Incidence::writeParameters(std::ostream&) const | | | | +-Globals::s_simType | | | | +-Globals::s_label | | | | +-Params::s_label | | | | +-Params::writeParameters(std::ostream&) | | | | +-Params::s_label | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | +-Globals::isZero(double) | | | +-Beir7::writeParameters(std::ostream&) const | | | | +-Globals::s_simType | | | | +-Globals::s_label | | | | +-VSD::insert(std::ostream&) const | | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | +-Distribution::insert(std::ostream&) const | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | +-Random::instance() | | | | | | +-Random::s_random | | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | | +-Distribution::s_name | | | | | +-Distribution::s_precision | | | | | +-Distribution::s_width | | | | +-VSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int) | | | | | +-VSD::s_prec | | | | | +-VSD::s_width | | | | | +-Distribution::fmt(unsigned int, unsigned int) | | | | | +-Distribution::s_precision | | | | | +-Distribution::s_width | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | +-Growth::writeParameters(std::ostream&) const | | | +-VSD::insert(std::ostream&) const | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | +-Distribution::insert(std::ostream&) const | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | +-Random::instance() | | | | | +-Random::s_random | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | +-Distribution::s_name | | | | +-Distribution::s_precision | | | | +-Distribution::s_width | | | +-VSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int) | | | | +-VSD::s_prec | | | | +-VSD::s_width | | | | +-Distribution::fmt(unsigned int, unsigned int) | | | | +-Distribution::s_precision | | | | +-Distribution::s_width | | | +-AgeGroupVSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int, unsigned int) | | | | +-VSD::fmt(unsigned int, unsigned int, unsigned int, unsigned int) | | | | | +-VSD::s_prec | | | | | +-VSD::s_width | | | | | +-Distribution::fmt(unsigned int, unsigned int) | | | | | +-Distribution::s_precision | | | | | +-Distribution::s_width | | | | +-AgeGroupVSD::s_indent | | | +-AgeGroupVSD::insert(std::ostream&, std::vector const&) | | | +-AgeGroupVSD::s_indent | | | +-AgeGroupVSD::insert(std::ostream&) const | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | +-VSD::insert(std::ostream&) const | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | +-Distribution::insert(std::ostream&) const | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | +-Random::instance() | | | | | +-Random::s_random | | | | +-Globals::setWidthPrec(std::ostream&, unsigned int, unsigned int) | | | | | +-Globals::setPrecision(std::ostream&, unsigned short) | | | | +-Distribution::s_name | | | | +-Distribution::s_precision | | | | +-Distribution::s_width | | | +-operator<<(std::ostream&, Group const&) | | | +-Globals::isZero(double) | | | +-Globals::uint16_max | | +-Loop::resetCounters() | | | +-Modalities::resetCounters(unsigned long) | | | +-ModBase::resetCounters(unsigned long) | | +-Loop::writeRounds(FBB::CSVTable&) const | | | +-Modalities::writeRounds(FBB::CSVTable&, unsigned long) const | | +-Loop::writeSensitivity(FBB::CSVTable&, unsigned long) const | +-Parser::~Parser() | +-Parser::s_map | +-Parser::rmLineInfoVectors(std::unordered_map&) | +-Parser::endPoint(std::pair const&) +-handleException() simrisc-16.02.00/simulator/0000775000175000017500000000000014665030471014424 5ustar frankfranksimrisc-16.02.00/simulator/endofspecs.cc0000664000175000017500000000014014665030471017057 0ustar frankfrank//#define XERR #include "simulator.ih" string Simulator::endOfSpecs() { return string{}; } simrisc-16.02.00/simulator/run.cc0000664000175000017500000000077714665030471015552 0ustar frankfrank#define XERR #include "simulator.ih" //code void Simulator::run() { while (d_next) { uint16_t lineNr = d_lineNr; // read the next analysis specs string spec = (this->*d_nextSpecs)(); // cmdLineAnalysis() or // fileAnalysis() emsg.setCount(0); Analysis analysis{ istringstream{ spec }, lineNr }; analysis.run(); // run the simulation } } //= simrisc-16.02.00/simulator/fileanalysis.cc0000664000175000017500000000157014665030471017421 0ustar frankfrank#define XERR #include "simulator.ih" string Simulator::fileAnalysis() { d_next = false; string specs; string line; while (getline(d_ifstream, line)) { ++d_lineNr; // process all lines until the next // analysis: specification is found if ( size_t pos = line.find_first_not_of(" \t\r"); pos != string::npos // found non-blanks and // and 'analysis:' as 1st word line.find("Analysis:", pos) == pos ) { d_next = true; break; // the next analysis is ready } specs += line + '\n'; // append the line to the } // specs return specs; } simrisc-16.02.00/simulator/setanalysissource.cc0000664000175000017500000000211114665030471020506 0ustar frankfrank#define XERR #include "simulator.ih" void Simulator::setAnalysisSource() { Arg const &arg = Arg::instance(); if (arg.option('o')) // -o -> specs from { d_next = true; d_nextSpecs = &Simulator::cmdLineAnalysis; // cmd line args } else { // otherwise find the (next) Analysis: // line in the analysis file d_ifstream = Exception::factory(arg[0]); string line; while (getline(d_ifstream, line)) { ++d_lineNr; size_t pos = line.find_first_not_of(" \t\r"); if (pos == string::npos) continue; if (line.find("Analysis:", pos) == pos) // analysis up to EOF of { d_next = true; break; // the next analysis } } if (d_next == 0) wmsg << "No Analysis: specification found" << endl; d_nextSpecs = &Simulator::fileAnalysis; } } simrisc-16.02.00/simulator/simulator.ih0000664000175000017500000000037314665030471016770 0ustar frankfrank#include "simulator.h" #include "../xerr/xerr.ih" #include #include #include #include #include "../analysis/analysis.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/simulator/simulator1.cc0000664000175000017500000000022414665030471017031 0ustar frankfrank#define XERR #include "simulator.ih" Simulator::Simulator() { imsg.off(); setAnalysisSource(); // maybe one analysis (-o) or more } simrisc-16.02.00/simulator/cmdlineanalysis.cc0000664000175000017500000000065414665030471020117 0ustar frankfrank#define XERR #include "simulator.ih" string Simulator::cmdLineAnalysis() { string specs; Arg const &arg = Arg::instance(); for (size_t idx = 0, end = arg.nArgs(); idx != end; ++idx) { specs += arg[idx]; if (specs.back() == ',') // commas end specifications specs.back() = '\n'; else specs += ' '; } d_next = false; return specs; } simrisc-16.02.00/simulator/icmconf0000664000175000017500000000010014665030471015754 0ustar frankfrank#define LIBRARY "simulator" #include "../icmconf.lib" simrisc-16.02.00/simulator/simulator.h0000664000175000017500000000211314665030471016611 0ustar frankfrank#ifndef INCLUDED_SIMULATOR_ #define INCLUDED_SIMULATOR_ #include #include // analyses specfy different parameters, like screeningRound, iterations, // nWomen class Simulator { //data bool d_next = false; // true if 'run()' should run // an analysis uint16_t d_lineNr = 1; // updated by 'fileAnalysis' std::ifstream d_ifstream; // multiple analysis specs std::string (Simulator::*d_nextSpecs)(); // ptr to function handling // the (next) analysis spec. //= public: Simulator(); void run(); private: bool nextAnalysis(); void setAnalysisSource(); // extra specifications either on the // cmd line or the next 'analysis:' // specification from file std::string cmdLineAnalysis(); std::string fileAnalysis(); std::string endOfSpecs(); }; #endif simrisc-16.02.00/simulator/frame0000664000175000017500000000007014665030471015436 0ustar frankfrank//#define XERR #include "simulator.ih" Simulator:: { } simrisc-16.02.00/spch0000664000175000017500000000217314632623016013265 0ustar frankfrank#define SPCH_ #include "main.ih" #include "log/log.ih" #include "betadist/betadist.ih" #include "agegroupvsd/agegroupvsd.ih" #include "probgroup/probgroup.ih" #include "group/group.ih" #include "incidence/incidence.ih" #include "simulator/simulator.ih" #include "modbase/modbase.ih" #include "mammo/mammo.ih" #include "survival/survival.ih" #include "tumorinfo/tumorinfo.ih" #include "tumor/tumor.ih" #include "modalities/modalities.ih" #include "random/random.ih" #include "scenario/scenario.ih" #include "beir7/beir7.ih" #include "costs/costs.ih" #include "loop/loop.ih" #include "err/err.ih" #include "analysis/analysis.ih" #include "tableparams/tableparams.ih" #include "params/params.ih" #include "round/round.ih" #include "densities/densities.ih" #include "vsdparams/vsdparams.ih" #include "globals/globals.ih" #include "configlines/configlines.ih" #include "parser/parser.ih" #include "vsd/vsd.ih" #include "screening/screening.ih" #include "distribution/distribution.ih" #include "growth/growth.ih" #include "options/options.ih" #include "mri/mri.ih" #include "ct/ct.ih" #include "tomo/tomo.ih" using namespace std; using namespace FBB; simrisc-16.02.00/stdconfig/0000755000175000017500000000000014665030471014363 5ustar frankfranksimrisc-16.02.00/stdconfig/simrisc0000777000175000017500000000000014665030471021615 2../dot.config/simriscustar frankfranksimrisc-16.02.00/stdconfig/lung0000664000175000017500000001575214665030471015267 0ustar frankfrank# supported distribution names are: Normal, LogNormal, Uniform, Beta # Modalities are: Mammo, Tomo, MRI, CT Scenario: # use true for variable spreading # spread: true spread: false iterations: 1 # random generator behavior: # random, fixed, increasing generator: fixed # initial seed unless using generator: random seed: 1 # n cases to simulate cases: 1000 # Used for all modalities except for CT: # ref.age proportion biop specs (first diameter must be 0) # Lungcancer costs: configured at Modalities: CT: costs: Costs: biop: 176 diameters: 0: 6438 20: 7128 50: 7701 Discount: # breast lung proportion: 0 .04 age: 50 BreastDensities: # bi-rad: a b c d ageGroup: 0 - 40: .05 .30 .48 .17 ageGroup: 40 - 50: .06 .34 .47 .13 ageGroup: 50 - 60: .08 .50 .37 .05 ageGroup: 60 - 70: .15 .53 .29 .03 ageGroup: 70 - * : .18 .54 .26 .02 Modalities: CT: # screening diagnosis M0 M1 (M0, M1: Table S3) costs: 176 1908 37909 56556 dose: 1 # diam. value (must be integral 0..100 or -1) sensitivity: 0 - 3: 0 sensitivity: 3 - 5: -1 # formula: (.5 * diam - 1.5) * 100 sensitivity: 5 - *: 100 # mean stddev dist specificity: 99.2 .076 Normal Mammo: costs: 64 # bi-rad: a b c d dose: 3 3 3 3 m: .136 .136 .136 .136 # ageGroup specificity: 0 - 40: .961 40 - *: .965 # 1 2 3 4 beta: -4.38 .49 -1.34 -7.18 systematicError: 0.1 Tomo: costs: 64 # bi-rad: a b c d dose: 3 3 3 3 sensitivity: .87 .84 .73 .65 # ageGroup specificity: 0 - 40: .961 40 - *: .965 MRI: costs: 280 sensitivity: .94 specificity: .95 Screening: # round: age space separated modalities. # subsequent ages must exceed the last age by at least 1 # with lung cancer simulations only CT can be specified, # with breast cancer simulations CT cannot be specified, round: 50 CT round: 52 CT round: 54 CT round: 56 CT round: 58 CT round: 60 CT round: 62 CT round: 64 CT round: 66 CT round: 68 CT round: 70 CT round: 72 CT round: 74 CT # proportion: attendanceRate: .8 Tumor: Beir7: # eta beta spread dist. breast: -2.0 0.51 0.32 Normal # Beta-distribution parameters: # LC: eta beta dist constant factor aParam bParam male: -1.4 .32 Beta .234091 1.72727 2.664237 5.184883 female: -1.4 1.40 Beta .744828 .818966 3.366115 4.813548 Growth: # breast lung start: 5 3 #selfDetect: # stdev mean spread dist breast: .70 2.92 .084 Normal lung: .014 3.037 .061 Normal DoublingTime: # stdev mean spread dist. ageGroup: 1 - 50: .61 4.38 .43 Normal ageGroup: 50 - 70: .26 5.06 .17 Normal ageGroup: 70 - * : .45 5.24 .23 Normal # all ages stdev mean spread dist. lung: .21 4.59 .74 Normal Incidence: Male: # value spread distr. lifetimeRisk: .22 .005 Normal meanAge: 72.48 1.08 Normal stdDev: 9.28 1.62 Normal Female: # value spread distr. lifetimeRisk: .20 .004 Normal meanAge: 69.62 1.49 Normal stdDev: 9.73 1.83 Normal Breast: probability: 1 # value spread distr. lifetimeRisk: .226 .0053 Normal meanAge: 72.9 .552 Normal stdDev: 21.1 BRCA1: probability: 0 # value spread distr. lifetimeRisk: .96 meanAge: 53.9 stdDev: 16.51 BRCA2: probability: 0 # value spread distr. lifetimeRisk: .96 meanAge: 53.9 stdDev: 16.51 Survival: # value spread dist: type: a .00004475 .000004392 Normal type: b 1.85867 .0420 Normal type: c -.271 .0101 Normal type: d 2.0167 .0366 Normal # table S4: 4 columns per a..d parameter # lungX: X is table S4's column index lung0: a .00143 .00095 Normal lung0: b 1.84559 .33748 Normal lung0: c -.22794 .07823 Normal lung0: d 1.06799 .16226 Normal lung1: a .01530 .00381 Normal lung1: b 1.69434 .10979 Normal lung1: c -.19358 .02105 Normal lung1: d .66690 .03869 Normal lung2: a .78600 .29815 Normal lung2: b .69791 .05425 Normal lung2: c .0 .0 Normal lung2: d .0 .0 Normal lung3: a 1.25148 .32305 Normal lung3: b .77852 .34149 Normal lung3: c .0 .0 Normal lung3: d .0 .0 Normal S3: # T-row range N0,M0 N1-3,M0 N1-3,M1a-b N0-3M1c prob: 0 - 11: .756 .157 .048 .039 # T1a,b prob: 11 - 21: .703 .197 .055 .045 # T1b prob: 21 - 31: .559 .267 .095 .078 # T1c prob: 31 - 51: .345 .351 .167 .137 # T2a,b prob: 51 - 71: .196 .408 .218 .178 # T3 prob: 71 - * : .187 .347 .256 .210 # T4 simrisc-16.02.00/survival/0000775000175000017500000000000014665030471014260 5ustar frankfranksimrisc-16.02.00/survival/survival.ih0000664000175000017500000000051114665030471016452 0ustar frankfrank#include "survival.h" #include "../xerr/xerr.ih" #include #include #include "../globals/globals.h" #include "../random/random.h" #include "../options/options.h" #include "../parser/parser.h" #include "../log/log.h" extern size_t g_caseIdx; extern size_t g_err; #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/survival/data.cc0000664000175000017500000000035014665030471015476 0ustar frankfrank//#define XERR #include "survival.ih" char const *Survival::s_lungColumn[] = { "lung0:", "lung1:", "lung2:", "lung3:", }; char const *Survival::s_noColon[] = { "lung0", "lung1", "lung2", "lung3" }; simrisc-16.02.00/survival/s3parameters.cc0000664000175000017500000000033614665030471017202 0ustar frankfrank//#define XERR #include "survival.ih" void Survival::s3parameters(ostream &out) const { out << "S3:\n"; for (unsigned idx = 0, end = d_s3.size(); idx != end; ++idx) out << " " << d_s3[idx] << '\n'; } simrisc-16.02.00/survival/varylung.cc0000664000175000017500000000043714665030471016442 0ustar frankfrank#define XERR #include "survival.ih" void Survival::varyLung(ostream &out) { VSD::vary(out, 2, "Survival:", s_noColon[0], 'a', d_vsdMatrix[0]); for (size_t idx = 1, end = d_vsdMatrix.size(); idx != end; ++idx) VSD::vary(out, 4, s_noColon[idx], 'a', d_vsdMatrix[idx]); } simrisc-16.02.00/survival/varybreast.cc0000664000175000017500000000023114665030471016745 0ustar frankfrank//#define XERR #include "survival.ih" void Survival::varyBreast(ostream &out) { VSD::vary(out, 2, "Survival:", "type", 'a', d_vsdMatrix.front()); } simrisc-16.02.00/survival/vsdrow.cc0000664000175000017500000000061214665030471016112 0ustar frankfrank//#define XERR //#include "survival.ih" // //void Survival::vsdRow() const //{ ////xerr(d_vsdRow << ' ' << d_vsdMatrix[d_vsdRow].size() << ' ' <<\x ////d_vsdMatrix[d_vsdRow][0].value() << ' ' <<\x ////d_vsdMatrix[d_vsdRow][1].value() << ' ' <<\x ////d_vsdMatrix[d_vsdRow][2].value() << ' ' <<\x ////d_vsdMatrix[d_vsdRow][3].value() << ' ' <<\x ////d_vsdMatrix[d_vsdRow][4].value() ); // //} // simrisc-16.02.00/survival/survival1.cc0000664000175000017500000000167214665030471016531 0ustar frankfrank#define XERR #include "survival.ih" Survival::Survival() { if (not Globals::isBreast()) // LC simulation { d_vary = &Survival::varyLung; d_write = &Survival::writeLung; d_cptVSDrow = &Survival::cptVSDrow; loadS3(); loadS4(); // loads "lung[0-4]" } else // BC simulation: only { // type: must be specified d_vary = &Survival::varyBreast; d_write = &Survival::writeBreast; d_cptVSDrow = &Survival::cptTNM; d_vsdMatrix.push_back( // load the BC 'type' params Parser::VSDparameters( VARY_MEAN, { "type:" }, { 'a', 'b', 'c', 'd', 'e' } ) ); loadBC(); } } simrisc-16.02.00/survival/cptvsdrow.cc0000664000175000017500000000220614665030471016622 0ustar frankfrank#define XERR #include "survival.ih" // determine the row of d_vsdMatrix to use by locating the row in s3 // containing 'diameter' in its ProbGrooup.end() value. Then compute // the lowest column index in that row exceeding a random proportion // value. That index becomes d_vsdRow. RowCol Survival::cptVSDrow(double diameter) { // if diameter > 100 the last line in S3 must be used. probIndexOf uses // 101 as end-value because that's an end-age and probGroups are normally // based on ages. // Therefore, if diameter > 100 100 is passed to probIndexOf // resulting in the last line of S3 being used. // S3's row (first) and S3's column (second) RowCol rowCol = ProbGroup::probIndexOf( d_s3, diameter > 100 ? 100 : diameter, Random::instance().uniformVSD() ); d_vsdRow = rowCol.second; g_log << " Survival::cptVSDRow: S3 row = " << d_vsdRow << " for diameter " << diameter << '\n'; return rowCol; } simrisc-16.02.00/survival/survival.f0000664000175000017500000000073014665030471016302 0ustar frankfrankinline RowCol Survival::setVSD(double diameter) { return (this->*d_cptVSDrow)(diameter); } inline bool Survival::metastatis() const { return d_vsdRow >= 2; } inline VSD const &Survival::operator[](size_t idx) const { return d_vsdMatrix[d_vsdRow][idx]; } inline void Survival::vary(std::ostream &out) { (this->*d_vary)(out); } inline void Survival::writeParameters(std::ostream &out) const { (this->*d_write)(out); // writeBreast / writeLung } simrisc-16.02.00/survival/loads4.cc0000664000175000017500000000115214665030471015754 0ustar frankfrank#define XERR #include "survival.ih" void Survival::loadS4() { for (char const *column: s_lungColumn) { d_vsdMatrix.push_back( // read 4 VSD values in a Parser::VSDparameters( // VSDvector and push that vector VARY_MEAN, // to the vsdMatrix { column }, { 'a', 'b', 'c', 'd', 'e' } ) ); // xerr("d_vsdMatrix " << column); // for (auto value: d_vsdMatrix.back()) // cerr << value.value() << ' '; // cerr << '\n'; } } simrisc-16.02.00/survival/writelung.cc0000664000175000017500000000020614665030471016605 0ustar frankfrank#define XERR #include "survival.ih" void Survival::writeLung(ostream &out) const { lungParameters(out); s3parameters(out); } simrisc-16.02.00/survival/icmconf0000664000175000017500000000007714665030471015625 0ustar frankfrank#define LIBRARY "survival" #include "../icmconf.lib" simrisc-16.02.00/survival/lungparameters.cc0000664000175000017500000000045414665030471017623 0ustar frankfrank#define XERR #include "survival.ih" void Survival::lungParameters(ostream &out) const { out << "Survival:\n"; for (unsigned idx = 0, end = d_vsdMatrix.size(); idx != end; ++idx) { VSD::fmt(4, s_lungColumn[idx], 'a', 2, 8, 0, 9); out << d_vsdMatrix[idx] << '\n'; } } simrisc-16.02.00/survival/cpttnm.cc0000664000175000017500000000041514665030471016074 0ustar frankfrank//#define XERR #include "survival.ih" RowCol Survival::cptTNM(double diameter) { auto iter = find_if(d_bc.begin(), d_bc.end(), [&](uint16_t max) { return diameter <= max; } ); return RowCol{ iter - d_bc.begin(), 0 }; } simrisc-16.02.00/survival/writebreast.cc0000664000175000017500000000065514665030471017130 0ustar frankfrank//#define XERR #include "survival.ih" void Survival::writeBreast(ostream &out) const { VSD::fmt(4, "type:", 'a', 2, 8, 0, 9); out << "Survival:\n" << d_vsdMatrix.front() << '\n' << " bc: "; for (size_t idx = 0, end = d_bc.size() - 1; idx != end; ++idx) out << d_bc[idx] << ", "; if (d_bc.back() == Globals::uint16_max) out << "*\n"; else out << d_bc.back() << '\n'; } simrisc-16.02.00/survival/loads3.cc0000664000175000017500000000153314665030471015756 0ustar frankfrank#define XERR #include "survival.ih" void Survival::loadS3() { auto lines = Parser::any({ "prob:" }); bool push = true; while (true) { LineInfo const *line = lines.get(); // load the lines of S3 if (line == 0) // no (more) lines break; ProbGroup group{ SINGLE }; if (not Parser::extract(*line, group)) push = false; if (not push) continue; // continue for syntax-check // purposes if (group.group().nextRange(d_s3)) // add the next range { // (0 - 11 thru 71 - *) d_s3.push_back(move(group)); // add the info to d_s3 continue; } push = false; } } simrisc-16.02.00/survival/survival.h0000664000175000017500000001162514665030471016311 0ustar frankfrank#ifndef INCLUDED_SURVIVAL_ #define INCLUDED_SURVIVAL_ // Tumor: // Survival: // # value spread dist: // type: a .00004475 .000004392 Normal // b 1.85867 .0420 Normal // c - .271 .0101 Normal // d 2.0167 .0366 Normal // e 1.00 .01 Normal // // # 4 columns per a..d parameter, according to table S4: // # lungX: X is the table S4 column index // lung0: a .00143 .00095 Normal // b 1.84559 .33748 Normal // c -.22794 .07823 Normal // d 1.06799 .16226 Normal // e 1.00 .01 Normal // // lung1: a .01530 .00381 Normal // b 1.69434 .10979 Normal // c -.19358 .02105 Normal // d .66690 .03869 Normal // e 1.00 .01 Normal // // lung2: a .78600 .29815 Normal // b .69791 .05425 Normal // c .0 .0 Normal // d .0 .0 Normal // e 1.00 .01 Normal // // lung3: a 1.25148 .32305 Normal // b .77852 .34149 Normal // c .0 .0 Normal // d .0 .0 Normal // e 1.00 .01 Normal // // S3: // # T-row range N0,M0 N1-3,M0 N1-3,M1a-b N0-3M1c // prob: 0 - 11: .756 .157 .048 .039 # T1a,b // prob: 11 - 21: .703 .197 .055 .045 # T1b // prob: 21 - 31: .559 .267 .095 .078 # T1c // prob: 31 - 51: .345 .351 .167 .137 # T2a,b // prob: 51 - 71: .196 .408 .218 .178 # T3 // prob: 71 - * : .187 .347 .256 .210 # T4 // // # BC TNM categories up to (<=) diameters (mm): // BC: 20 50 * // # TNM: 1 2 3 #include "../typedefs/typedefs.h" #include "../vsd/vsd.h" #include "../probgroup/probgroup.h" class Survival { // d_vsdMatrix is a [][4] matrix. // with BC simulations only row 0 is filled and used, and d_vsdRow is // set to 0, its default value. The member pointer 'd_cptVSDrow' // performs no action (cals cptTNM()). // // with LC simulations 4 rows are filled with, resp. the // lung0 thru lung3 VSD values, and the member pointer d_cptVSDrow // computes d_vsdRow using S3, S4 and the tumor diameter (calls // cptVSDrow()). // 1st idx: BC: always 0 // LC: 0..3 for lung0..lung4 // 2nd idx: elements contain the BC/LC VSDmatrix d_vsdMatrix; // a..d VSD params (0: a, thru 3: d) ProbGroup::Vector d_s3; // contains the lines of S3 Uint16Vect d_bc; // contains the BC: specifications size_t d_vsdRow = 0; void (Survival::*d_vary)(std::ostream &out); void (Survival::*d_write)(std::ostream &out) const; // LC: cptVSDrow, BC: cptTNM RowCol (Survival::*d_cptVSDrow)(double diameter); static char const *s_lungColumn[4]; // cf. data.cc static char const *s_noColon[4]; // cf. data.cc public: Survival(); bool metastatis() const; // .f VSD const &operator[](size_t idx) const; // .f // determine random vsd-value(s) RowCol setVSD(double diameter); // with LC: cpt the row of // .f // d_vsdMatrix to use (cptVSDRow) // with BC: cptTNM. void vary(std::ostream &out); // and write to 'out' // .f void writeParameters(std::ostream &out) const; // .f // OBS: void vsdRow() const; (was called in tumor/functionf.cc) private: RowCol cptVSDrow(double diameter); RowCol cptTNM(double diameter); void loadBC(); void loadS3(); void loadS4(); void lungParameters(std::ostream &out) const; void s3parameters(std::ostream &out) const; void varyBreast(std::ostream &out); void varyLung(std::ostream &out); void writeBreast(std::ostream &out) const; void writeLung(std::ostream &out) const; }; #include "survival.f" // ProbGroup::Vector const &s3() const; // .f #endif simrisc-16.02.00/survival/loadbc.cc0000664000175000017500000000144014665030471016012 0ustar frankfrank#define XERR #include "survival.ih" // load the BC TNM category boundaries void Survival::loadBC() { auto lines = Parser::one({ "bc:" }); LineInfo const *lineInfo = lines.get(); istringstream in{ lineInfo->tail }; char sep; uint16_t value; while (in >> sep) { if (sep == '*') value = Globals::uint16_max; else { in.unget(); in >> value; } d_bc.push_back(value); } bool err = false; for (size_t idx = 1, end = d_bc.size(); idx < end; ++idx) { if (d_bc[idx - 1] >= d_bc[idx]) { err = true; break; } } if (err or d_bc.back() != Globals::uint16_max) Err::msg(Err::NOT_CONSECUTIVE) << lineInfo->txt << endl; } simrisc-16.02.00/survival/frame0000664000175000017500000000006614665030471015277 0ustar frankfrank//#define XERR #include "survival.ih" Survival:: { } simrisc-16.02.00/tableparams/0000775000175000017500000000000014665030471014700 5ustar frankfranksimrisc-16.02.00/tableparams/appendpair.cc0000664000175000017500000000075414665030471017340 0ustar frankfrank#define XERR #include "tableparams.ih" bool TableParams::appendPair(string const &line) { size_t age; double prob; istringstream in{ line }; while (in >> age) { if (not (in >> prob)) // 2nd pair value not available { d_error = true; Err::specification(); return false; } d_riskTable.push_back(DoublePair{ age, prob }); } return true; // all pairs were read from line } simrisc-16.02.00/tableparams/linear.cc0000664000175000017500000000136514665030471016466 0ustar frankfrank#define XERR #include "tableparams.ih" //linear interpolation: for a = d_riskTable[idx].first // p = d_riskTable[idx].second // b = d_riskTable[idx + 1].first // q = d_riskTable[idx + 1].second // x = age, a is searched for a <= x // compute f(x), where a <= x <= b as // p + (q - p) / b - a) * (x - a) // = p + (q - p) * (x - a) / b - a) // static double TableParams::linear(double age, DoublePair const &from, DoublePair const &to) { return from.second + (to.second - from.second) * (age - from.first) / (to.first - from.first); } simrisc-16.02.00/tableparams/vwriteparameters.cc0000664000175000017500000000116714665030471020620 0ustar frankfrank#define XERR #include "tableparams.ih" // override void TableParams::v_writeParameters(ostream &out) const { Globals::setPrecision(out, 3) << setw(8) << ' ' << "riskTable:\n" << setw(9) << ' '; for (size_t idx = 0, end = d_riskTable.size(); idx != end; ) { out << setw(3) << static_cast(d_riskTable[idx].first + .5) << ": " << d_riskTable[idx].second; if (++idx == end) { out << "\n\n"; return; } if (idx % 6 != 0) out << ", "; else out << '\n' << setw(9) << ' '; } } simrisc-16.02.00/tableparams/tableparams.ih0000664000175000017500000000034514665030471017517 0ustar frankfrank#include "tableparams.h" #include "../xerr/xerr.ih" #include #include "../globals/globals.h" #include "../err/err.h" #include "../parser/parser.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/tableparams/checktable.cc0000664000175000017500000000226014665030471017274 0ustar frankfrank#define XERR #include "tableparams.ih" void TableParams::checkTable() try { if (d_error) return; if (d_riskTable.size() < 2) // at least 2 pairs must be specified throw "at least 2 pairs must be specified"; if (d_riskTable.front().first != 0) // ensure a first {0, ..} is available d_riskTable.insert(d_riskTable.begin(), DoublePair{0, 0}); checkIncreasing(); // if no MAX_AGE at the end: if (d_riskTable.back().first < MAX_AGE) // add a final end-age value { d_riskTable.push_back( DoublePair{ MAX_AGE, linear(MAX_AGE, *(d_riskTable.rbegin() + 1), d_riskTable.back() ) } ); // ensure the last value is <= 1 if (DoublePair &last = d_riskTable.back(); last.second > 1.0) last.second = 1; } } catch (char const *txt) { d_error = true; Err::msg(Err::TABLEPARAMS) << txt << '\n'; return; } simrisc-16.02.00/tableparams/tableparams1.cc0000664000175000017500000000042614665030471017565 0ustar frankfrank#define XERR #include "tableparams.ih" TableParams::TableParams(StringVect &base, size_t idx, bool setProb) : Params(base, idx, setProb), d_error(false) { if (prob() < 0) // invalid probability setting return; fillRiskTable(base); } simrisc-16.02.00/tableparams/icmconf0000664000175000017500000000016314665030471016241 0ustar frankfrank#define LIBRARY "tableparams" //#define SPCH "-k xerr/xerr.ih" #include "../icmconf.lib" simrisc-16.02.00/tableparams/risktable.cc0000664000175000017500000000101114665030471017160 0ustar frankfrank////#define XERR //#include "incidence.ih" // //void Incidence::riskTable() //{ // for (auto const &str: base) // cerr << str << ' '; // // Parser::Lines lines = Parser::any(base); // size_t age; // double value; // cerr << "got " << lines.size() << " lines\n"; // // LineInfo const *ptr; // while ((ptr = lines.get())) // { // istringstream tail{ ptr->tail }; // while (tail >> age >> value) // cerr << "age: " << age << ", value: " << value << '\n'; // } //} // simrisc-16.02.00/tableparams/checkincreasing.cc0000664000175000017500000000071514665030471020332 0ustar frankfrank#define XERR #include "tableparams.ih" void TableParams::checkIncreasing() { // check increasing ages DoublePair saw{ 0, 0 }; // and increasing probabilities for (DoublePair &pair: Ranger(d_riskTable.begin() + 1, d_riskTable.end())) { if (pair.first <= saw.first or pair.second < saw.second) throw "ages and probabilities must increase"; saw = pair; } } simrisc-16.02.00/tableparams/vcpttumorrisk.cc0000664000175000017500000000375314665030471020153 0ustar frankfrank//#define XERR #include "tableparams.ih" // virtual void TableParams::v_cptTumorRisk(DoubleVect &ageValues) { DoublePair const *from = &d_riskTable.front(); // assign the 1st prob.: ageValues.front() = from->second; // cum.prob for age 0 double *begin = &ageValues.front() + 1; // next value to assign // visit all pairs of // riskTable elems for (size_t idx = 1, end = d_riskTable.size(); idx != end; ++idx) { DoublePair const *to = &d_riskTable[idx]; // eventually the last elem. // points beyond the ageValues double *beyond = &ageValues[ // elem. beyond to's index static_cast(to->first + 1.5) ]; fill(begin, beyond, // assign [begin..beyond) (to->second - from->second) / (to->first - from->first) ); begin = beyond; // the begin of the next range from = to; } } // void TableParams::v_cptTumorRisk(DoubleVect &ageValues) // { // DoublePair from = &d_riskTable.front(); // // visit pairs of d_simriskTable elements // // (elements idx and idx + 1) // for (size_t idx = 0, end = d_riskTable.size() - 1; idx != end; ++idx) // { // DoublePair to = d_riskTable[idx + 1]; // // to.second -= d_riskTable[idx].second; // convert cumprobs to probs // // for ( // set the age-range [age..endAge) // size_t age = from->first + .5, endAge = to.first + .5; // age != endAge; // ++age // ) // ageValues[age] = linear(age, from, to); // // from = to; // } // // ageValues.back() = d_riskTable.back().second - from.second; // } simrisc-16.02.00/tableparams/frame0000664000175000017500000000007214665030471015714 0ustar frankfrank#define XERR #include "tableparams.ih" TableParams:: { } simrisc-16.02.00/tableparams/tableparams.h0000664000175000017500000000161214665030471017344 0ustar frankfrank#ifndef INCLUDED_TABLEPARAMS_ #define INCLUDED_TABLEPARAMS_ // the Parser has already confirmed that 'riskTable:' was used // (cf. incidence/setincidence2.cc) #include "../params/params.h" #include "../typedefs/typedefs.h" class TableParams: public Params { bool d_error; Double2Vect d_riskTable; // first: age, second: cumprob for age public: TableParams(StringVect &base, size_t idx, bool setProb); private: void fillRiskTable(StringVect &base); bool appendPair(std::string const &line); void checkTable(); void checkIncreasing(); static double linear(double age, DoublePair const &from, DoublePair const &to); void v_cptTumorRisk(DoubleVect &ageValues) override; void v_vary(std::ostream &out) override; void v_writeParameters(std::ostream &out) const; }; #endif simrisc-16.02.00/tableparams/fillrisktable.cc0000664000175000017500000000056514665030471020044 0ustar frankfrank#define XERR #include "tableparams.ih" void TableParams::fillRiskTable(StringVect &base) { base.back() = "riskTable:"; Parser::Lines lines = Parser::any(base); DoublePair next; LineInfo const *ptr; do ptr = lines.get(); while (ptr != 0 and appendPair(ptr->tail)); checkTable(); // ensure values are incrementing and complete } simrisc-16.02.00/tableparams/vvary.cc0000664000175000017500000000055014665030471016356 0ustar frankfrank//#define XERR #include "tableparams.ih" // overrides void TableParams::v_vary(ostream &out) { out << " " << ( not Globals::isBreast() ? Globals::simTypeLabel(LC) : label() ) << "\n" " tableParams: no spread\n"; } simrisc-16.02.00/tomo/0000775000175000017500000000000014665030471013363 5ustar frankfranksimrisc-16.02.00/tomo/vspecificity.cc0000664000175000017500000000111614665030471016372 0ustar frankfrank//#define XERR #include "tomo.ih" // E.g., age groups: // 0-40 // 40-100 // then by searching from the last to the first: find the agegroup // where the begin-age is < specified age. // Examples: age 50: the last group, // age 40: the first group // 'age' may not be negative double Tomo::vSpecificity(double age) const { return find_if(d_specVect.rbegin(), d_specVect.rend(), [&](AgeGroupVSD const &spec) { return spec.beginAge() < age; } )->value(); } simrisc-16.02.00/tomo/vdose1.cc0000664000175000017500000000013614665030471015073 0ustar frankfrank//#define XERR #include "tomo.ih" VSDvect const *Tomo::vDose() const { return &d_dose; } simrisc-16.02.00/tomo/setsensitivity.cc0000664000175000017500000000024214665030471016776 0ustar frankfrank//#define XERR #include "tomo.ih" void Tomo::setSensitivity() { base().back() = "sensitivity:"; d_sens = Parser::VSDparameters(VARY_PROB, base(), 4); } simrisc-16.02.00/tomo/tomo.h0000664000175000017500000000176114665030471014517 0ustar frankfrank#ifndef INCLUDED_TOMO_ #define INCLUDED_TOMO_ #include "../enums/enums.h" #include "../modbase/modbase.h" #include "../agegroupvsd/agegroupvsd.h" // Tomo: // costs: 64 // // # bi-rad: a b c d // dose: 3 3 3 3 // sensitivity: .87 .84 .73 .65 // // # ageGroup // specificity: 0 - 40: .961 40 - *: .965 class Tomo: public ModBase { VSDvect d_dose; VSDvect d_sens; AgeGroupVSDvect d_specVect; // was: d_specificity; public: Tomo(); ~Tomo() override; private: void setSensitivity(); VSDvect const *vDose() const override; // 1 double vDose(uint16_t) const override; // 2 void vInsert(std::ostream &out) const override; double vSensitivity(size_t idx) const override; double vSpecificity(double age) const override; void vVary(std::ostream &out) override; }; #endif simrisc-16.02.00/tomo/vdose2.cc0000664000175000017500000000015614665030471015076 0ustar frankfrank//#define XERR #include "tomo.ih" double Tomo::vDose(uint16_t idx) const { return d_dose[idx].value(); } simrisc-16.02.00/tomo/icmconf0000664000175000017500000000007314665030471014724 0ustar frankfrank#define LIBRARY "tomo" #include "../icmconf.lib" simrisc-16.02.00/tomo/destructor.cc0000664000175000017500000000006414665030471016070 0ustar frankfrank//#define XERR #include "tomo.ih" Tomo::~Tomo() {} simrisc-16.02.00/tomo/tomo.ih0000664000175000017500000000025514665030471014665 0ustar frankfrank#include "tomo.h" #include "../xerr/xerr.ih" #include #include "../globals/globals.h" #include "../parser/parser.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/tomo/tomo1.cc0000664000175000017500000000077514665030471014742 0ustar frankfrank#define XERR #include "tomo.ih" // Tomo: // costs: 64 // // # bi-rad: a b c d // dose: 3 3 3 3 // sensitivity: .87 .84 .73 .65 // // # ageGroup // specificity: 0 - 40: .961 40 - *: .965 Tomo::Tomo() : ModBase("Tomo") { if (not defined()) return; doseBase(d_dose); // using ModBase's member setSensitivity(); specificityBase(d_specVect); } simrisc-16.02.00/tomo/vinsert.cc0000664000175000017500000000063014665030471015363 0ustar frankfrank//#define XERR #include "tomo.ih" void Tomo::vInsert(ostream &out) const { VSD::fmt(6, "bi-rad:", 'a', 1, 0, 1, 0); out << setw(4) << ' ' << "Dose:\n" << d_dose; VSD::fmt(6, "bi-rad:", 'a', 0, 2, 0, 2); out << setw(4) << ' ' << "Sensitivity:\n" << d_sens; AgeGroupVSD::fmt(6, 0, 3, 0, 4); out << setw(4) << ' ' << "Specificity:\n" << d_specVect; } simrisc-16.02.00/tomo/frame0000664000175000017500000000005614665030471014401 0ustar frankfrank//#define XERR #include "tomo.ih" Tomo:: { } simrisc-16.02.00/tomo/vsensitivity.cc0000664000175000017500000000016314665030471016452 0ustar frankfrank//#define XERR #include "tomo.ih" double Tomo::vSensitivity(size_t idx) const { return d_sens[idx].value(); } simrisc-16.02.00/tomo/vvary.cc0000664000175000017500000000044314665030471015042 0ustar frankfrank//#define XERR #include "tomo.ih" // override void Tomo::vVary(ostream &out) { out << " Tomo:\n"; VSD::vary(out, 4, "Dose:", "bi-rad", 'a', d_dose); VSD::vary(out, 4, "Sensitivity:", "bi-rad", 'a', d_sens); AgeGroupVSD::vary(out, 4, "Specificity:", d_specVect); } simrisc-16.02.00/tumor/0000775000175000017500000000000014665030471013553 5ustar frankfranksimrisc-16.02.00/tumor/unused0000664000175000017500000000077514665030471015012 0ustar frankfrank// use diameter() // double diameterValue() const; //+ // no need for repeated computation of the diameter index, instead // return the diameter and let using functions find the category that's // appropriate to them. // uint16_t diameterCheck() const; //+ .h //inline uint16_t Tumor::diameterCheck() const //{ // return d_diameter < 20 ? 0 : // d_diameter < 50 ? 1 : // 2; //} simrisc-16.02.00/tumor/checkdeath.cc0000664000175000017500000000037114665030471016146 0ustar frankfrank//#define XERR #include "tumor.ih" void Tumor::checkDeath(double naturalDeathAge) { if (naturalDeathAge < d_onset) // death before tumor { d_present = false; d_found = false; d_interval = false; } } simrisc-16.02.00/tumor/insert.cc0000664000175000017500000000124114665030471015364 0ustar frankfrank//#define XERR #include "tumor.ih" ostream &Tumor::insert(ostream &out) const { return out << " detectable age: " << d_selfDetectAge << "\n" " pre-period: " << d_prePeriod << "\n" " onset: " << d_onset << "\n" " doubling days: " << d_doublingDays << "\n" " doubling years: " << d_doublingYears << "\n" " p(survival): " << d_pSurvival << "\n" " start volume: " << d_startVolume; } // " self detect Diam: " << selfDetectDiam << "\n" simrisc-16.02.00/tumor/data.cc0000664000175000017500000000013214665030471014767 0ustar frankfrank//#define XERR #include "tumor.ih" char const *Tumor::s_noYes[] { "No", "Yes" }; simrisc-16.02.00/tumor/check.cc0000664000175000017500000000037214665030471015141 0ustar frankfrank//#define XERR #include "tumor.ih" void Tumor::requireTumor(char const *type) const { if (d_selfDetectAge == NO_TUMOR) throw Exception{} << "cannot determine tumor " << type << " for a non-existing tumor"; } simrisc-16.02.00/tumor/functionf.cc0000664000175000017500000000077414665030471016065 0ustar frankfrank#define XERR #include "tumor.ih" extern size_t g_caseIdx; extern size_t g_err; double Tumor::functionF(double years) const { // d_survival.vsdRow(); //if (g_caseIdx == 3) //xerr(d_survival[4].value() << ", " << -functionQ(years) << ", " << //d_diameter << ", " << functionZ(years)); return years <= 0 ? 1 : d_survival[4].value() * exp(-functionQ(years) * pow(d_diameter, functionZ(years))); } simrisc-16.02.00/tumor/tumor.h0000664000175000017500000001124314665030471015073 0ustar frankfrank#ifndef INCLUDED_TUMOR_ #define INCLUDED_TUMOR_ #include #include #include "../typedefs/typedefs.h" #include "../globals/globals.h" #include "../survival/survival.h" class TumorInfo; class Growth; namespace FBB { class CSVTable; } class Tumor: public Globals { friend std::ostream &operator<<(std::ostream &out, Tumor const &tumor); enum { // max iterations when determining N_ITER_AGE = 15, // deathAge }; static unsigned const N_YEARDAYS = 365; // initialized tumor age at an // impossible age, so always // age < tumor age unless there // is a tumor (was: -1) static constexpr double NO_TUMOR = END_AGE + END_AGE; TumorInfo const &d_tumorInfo; Growth const &d_growth; Survival &d_survival; bool d_found; // tumor has been detected by screening bool d_interval; // an interval cancer bool d_present; // true: tumor is present double d_selfDetectAge; // the age at which the tumor willl go clinical // i.e., self-detected // (selfDetectable(): true) or // NO_TUMOR (selfDetectable(): false) double d_deathAge; // death age because of the tumor double d_prePeriod; // _preclin... #years before d_selfDetectAge // the age where a tumor starts to grow and is // potentially detectable on mammographic // screening. From this age onward it'll // grow. (originally called _preclinAge) double d_onset; // (d_selfDetectAge - d_prePeriod) double d_pSurvival; // p(Survival) after treatment double d_doublingDays; // doubling time in days double d_doublingYears; // doubling time in years double d_startVolume; double d_volume; // actual tumor volume double d_diameter; // actual diameter (mm.) RowCol d_rowCol; static constexpr double s_log2YearInv = 1 / (365 * log(2)); static char const *s_noYes[]; public: Tumor(TumorInfo &tumorInfo); void reset(); // reassign the modifiable members //operator bool() const; // true: tumor is active .f bool at(double age) const; // true: tumor exists at 'age' .f // true: selfDetect <= 'age' .f bool selfDetectBefore(double age) const; double selfDetectAge() const; // self-detect age .f double deathAge() const; // tumor-caused death age .f double onset() const; // .f double volume() const; double diameter() const; // .f bool metastasis() const; // only with lung cancer .f // cpt the tumor's diameter and volume at 'age' if // d_onset <= age void characteristicsAt(double age); // .cc void intervalCancer(); // .f // tumor found during void found(); // the screening // .f bool present() const; // .f void setDeathAge(); // wrt d_selfDetectAge // .f void setDeathAge(double refAge); // wrt reference age void checkDeath(double naturalDeathAge); void writeData(FBB::CSVTable &tab) const; RowCol const &rowCol() const; // .f private: std::ostream &insert(std::ostream &out) const; bool tumorAge(); // false: no tumor void requireTumor(char const *type) const; uint16_t ageGroup() const; // .ih double functionF(double years) const; double functionQ(double years) const; double functionZ(double years) const; static double volume(double diameter); // .ih static double diameter(double volume); // .ih static double checkNot(double value); // -1 at NO_TUMOR .ih }; // only used in reset: no needed as data member // double d_selfDetect; // self-detect diameter (mm.) //OBS: // bool selfDetectable() const; // true: tumor selfDetectable .f #include "tumor.f" #endif simrisc-16.02.00/tumor/reset.cc0000664000175000017500000000403714665030471015210 0ustar frankfrank#define XERR #include "tumor.ih" void Tumor::reset() { g_log << " Tumor::reset\n"; d_found = false; d_interval = false; d_present = false; // see 'characteristics()' d_volume = 0; d_diameter = 0; d_deathAge = 0; if (not tumorAge()) { d_pSurvival = 1; d_startVolume = 0; // see modifications (7) d_doublingDays = NO_TUMOR; d_doublingYears = NO_TUMOR; // d_selfDetect = 0; d_prePeriod = NO_TUMOR; d_onset = NO_TUMOR; return; } uint16_t idx = ageGroup(); Random &random = Random::instance(); d_pSurvival = random.uniformCase(); d_startVolume = volume(d_growth.start()); AgeGroupVSD const &group = d_growth.ageGroupVSD(idx); d_doublingDays = random.logNormal(group.value(), group.stdDev()); d_doublingYears = d_doublingDays / N_YEARDAYS; double selfDetectDiam; while (true) { selfDetectDiam = random.logNormal(d_growth.selfMu().value(), d_growth.selfSigma()); g_log << "try selfDetectDiam = " << selfDetectDiam << '\n'; if (selfDetectDiam > d_growth.start()) break; } d_prePeriod = d_doublingDays * log( volume(selfDetectDiam) / volume(d_growth.start()) ) * s_log2YearInv; d_onset = d_selfDetectAge - d_prePeriod; g_log << "\nTUMOR RESET:\n" " selfDetectAge = " << d_selfDetectAge << "\n" " preperiod = " << d_prePeriod << "\n" " onset = " << d_onset << "\n" " doubingDays = " << d_doublingDays << "\n" " selfDetectDiam = " << selfDetectDiam << "\n" " volume(..) = " << volume(selfDetectDiam) << "\n" " growth start = " << d_growth.start() << "\n" " volume(..) = " << volume(d_growth.start()) << "\n" " p(survival) = " << d_pSurvival << '\n'; } simrisc-16.02.00/tumor/tumor1.cc0000664000175000017500000000054514665030471015315 0ustar frankfrank#define XERR #include "tumor.ih" Tumor::Tumor(TumorInfo &tumorInfo) : d_tumorInfo(tumorInfo), d_growth(tumorInfo.growth()), d_survival(tumorInfo.survival()) //d_selfDetectAge(-1) { // xerr("d_vsdMatrix"); // for (size_t idx = 0; idx != 4; ++idx) // cerr << d_survival[idx].value() << ' '; // cerr << '\n'; } simrisc-16.02.00/tumor/tumor.ih0000664000175000017500000000164414665030471015250 0ustar frankfrank#include "tumor.h" #include "../xerr/xerr.ih" #include #include #include #include "../options/options.h" #include "../tumorinfo/tumorinfo.h" #include "../growth/growth.h" #include "../random/random.h" #include "../log/log.h" inline uint16_t Tumor::ageGroup() const { return d_selfDetectAge < 50 ? 0 : d_selfDetectAge < 70 ? 1 : 2; } // volume = 1/6 pi * diam^3 // diam = pow(6 / pi * volume, 1/3) // static inline double Tumor::volume(double diameter) { return M_PI / 6 * pow(diameter, 3); } // static inline double Tumor::diameter(double volume) { return pow(6 / M_PI * volume, 1 / 3.); } // static inline double Tumor::checkNot(double value) { return value == NO_TUMOR ? -1 : std::max(0.0, value); } extern size_t g_caseIdx; extern size_t g_err; #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/tumor/sciencedirect.pdf0000664000175000017500000203616414665030471017066 0ustar frankfrank%PDF-1.7 %âãÏÓ 651 0 obj <> endobj xref 651 137 0000000016 00000 n 0000003781 00000 n 0000004018 00000 n 0000004060 00000 n 0000004096 00000 n 0000004530 00000 n 0000004645 00000 n 0000004759 00000 n 0000004873 00000 n 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<> endobj 617 0 obj <> endobj 618 0 obj <> endobj 619 0 obj <> endobj 620 0 obj <> endobj 621 0 obj <> endobj 622 0 obj <> endobj 623 0 obj <> endobj 624 0 obj <> endobj 625 0 obj <> endobj 626 0 obj <> endobj 627 0 obj <> endobj 628 0 obj <> endobj 629 0 obj <> endobj 630 0 obj <> endobj 631 0 obj <> endobj 632 0 obj <> endobj 633 0 obj <> endobj 634 0 obj <> endobj 635 0 obj <> endobj 636 0 obj <> endobj 637 0 obj <> endobj 638 0 obj <> endobj 639 0 obj <> endobj 640 0 obj <> endobj 641 0 obj <> endobj 642 0 obj <> endobj 643 0 obj <> endobj 644 0 obj <> endobj 645 0 obj <> endobj 646 0 obj <> endobj 647 0 obj <> endobj 648 0 obj <> endobj 649 0 obj <>stream application/pdf doi:10.1016/j.ejca.2020.05.004 Cost-effectiveness of lung cancer screening with low-dose computed tomography in heavy smokers: a microsimulation modelling study Yihui Du Grigory Sidorenkov Marjolein A. Heuvelmans Harry J.M. Groen Karin M. Vermeulen Marcel J.W. Greuter Geertruida H. de Bock Cost-effectiveness Low-dose computed tomography Lung neoplasm Mass screening Microsimulation model European Journal of Cancer, 135 (2020) 121-129. doi:10.1016/j.ejca.2020.05.004 Elsevier Ltd journal European Journal of Cancer © 2020 The Authors. Published by Elsevier Ltd. 0959-8049 135 August 2020 121-129 121 129 10.1016/j.ejca.2020.05.004 https://doi.org/10.1016/j.ejca.2020.05.004 2010-04-23 true 10.1016/j.ejca.2020.05.004 elsevier.com sciencedirect.com VoR 10.1016/j.ejca.2020.05.004 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2020-07-15T07:08:11+05:30 2020-07-17T00:02:13+05:30 2020-07-17T00:02:13+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:86c99f4a-b81a-4abb-a9a5-aa9d34757397 uuid:48070db5-e692-4808-bca3-33adc3030937 http://creativecommons.org/licenses/by/4.0/ endstream endobj 650 0 obj <> endobj xref 0 651 0000000000 65535 f 0000221385 00000 n 0000221745 00000 n 0000221850 00000 n 0000221963 00000 n 0000222075 00000 n 0000222187 00000 n 0000222300 00000 n 0000222412 00000 n 0000222524 00000 n 0000222637 00000 n 0000222751 00000 n 0000222864 00000 n 0000222977 00000 n 0000223091 00000 n 0000223205 00000 n 0000223317 00000 n 0000223430 00000 n 0000223541 00000 n 0000223652 00000 n 0000223766 00000 n 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trailer <> startxref 116 %%EOF simrisc-16.02.00/tumor/tumorage.cc0000664000175000017500000000254214665030471015710 0ustar frankfrank#define XERR #include "tumor.ih" // if (0.120662 < rndTumor and rndTumor < 0.120664) // { // cerr.setf(ios::fixed, ios::floatfield); // // for (double value: d_tumorInfo.cumTotalRisk()) // cerr << setw(6) << value << '\n'; // } bool Tumor::tumorAge() { Random &random = Random::instance(); double rnd; d_selfDetectAge = findAge( d_tumorInfo.cumTotalRisk(), rnd = random.uniformCase()); g_log << " tumorAge: self detect age: " << d_selfDetectAge << '\n'; Options::instance().fixedTumorAge(d_selfDetectAge); if (d_selfDetectAge <= MAX_AGE) return true; d_selfDetectAge = NO_TUMOR; random.uniformCase(); // extra calls to synchronize the random.logNormal(0, 0); // random generator between random.logNormal(0, 0); // tumor and no tumor states g_log << " no tumor, generated 3 synchronization random numbers\n"; return false; } //xerr("random tumor prob: " << rnd << ", age " << d_selfDetectAge); // g_log << " cum total risk:\n"; // for (size_t idx = 0, end = d_tumorInfo.cumTotalRisk().size(); // idx != end; // ++idx) // g_log << d_tumorInfo.cumTotalRisk()[idx] << // ((idx + 1) % 10 == 0 ? "\n" : ", "); // g_log << '\n'; simrisc-16.02.00/tumor/icmconf0000664000175000017500000000007414665030471015115 0ustar frankfrank#define LIBRARY "tumor" #include "../icmconf.lib" simrisc-16.02.00/tumor/functionq.cc0000664000175000017500000000072514665030471016074 0ustar frankfrank#define XERR #include "tumor.ih" // For the std. simulations survival[0] and survival[1] are returning the // a..d values of Survival: type: // For LC: // "Supplementary's" tables S3 and S4 are loaded by Survival. and the table // S4's a..d values are obtained from Survival::op[0..3], see survival.h extern size_t g_caseIdx; extern size_t g_err; double Tumor::functionQ(double years) const { return d_survival[0].value() * pow(years, d_survival[1].value()); } simrisc-16.02.00/tumor/volume.cc0000664000175000017500000000016614665030471015374 0ustar frankfrank//#define XERR #include "tumor.ih" double Tumor::volume() const { requireTumor("volume"); return d_volume; } simrisc-16.02.00/tumor/requireTumor.cc0000664000175000017500000000037214665030471016567 0ustar frankfrank//#define XERR #include "tumor.ih" void Tumor::requireTumor(char const *type) const { if (d_selfDetectAge == NO_TUMOR) throw Exception{} << "cannot determine tumor " << type << " for a non-existing tumor"; } simrisc-16.02.00/tumor/setdeathage.cc0000664000175000017500000000416114665030471016342 0ustar frankfrank#define XERR #include "tumor.ih" extern size_t g_caseIdx; extern size_t g_err; // this function computes the estimated death age using the function // published in // Cancer. 2002 Aug 15;95(4):713-23. Predicting the survival of patients // with breast carcinoma using tumor size. Michaelson JS, Silverstein M, // Wyatt J, Weber G, Moore R, Halpern E, Kopans DB, Hughes K. void Tumor::setDeathAge(double detectionAge) { requireTumor("death age"); // interval halving: search between 0 and 100 double low = 0; double high = 100; double mid; for (size_t iter = 0; iter != N_ITER_AGE; ++iter) { mid = (low + high) / 2; // if (g_caseIdx == 21) //if (g_caseIdx == 3) //xerr(mid << ", " << functionF(mid) << ", " << d_pSurvival); switch (weakCompare(functionF(mid), d_pSurvival)) { case -1: // use the lhs half: low..mid high = mid; continue; case 1: // use the rhs half: mid::high low = mid; continue; default: // equal within WEAK_TOLERANCE break; } break; // convergence } d_deathAge = std::min(detectionAge + mid, 100.); // if (g_caseIdx == 3) // xerr("case: " << setw(4) << g_caseIdx << ", self-detection. " // "Onset: " << d_onset << ", selfDet.age: " << d_selfDetectAge << // ", extension: " << mid << ", deathAge: " << d_deathAge); g_log << " Tumor::setDeathAge(" << detectionAge << ") = " << d_deathAge << '\n'; } // if (g_caseIdx == 21) // xerr("diameter: " << d_diameter); // if (g_caseIdx == 21) // xerr(mid << ", " << functionF(mid) << ", " << d_pSurvival); //////////////////////////////////////////////////////////////////////// // if (d_deathAge != 100.) // xerr("case: " << setw(4) << g_caseIdx << ", self-detection. " // "Onset: " << d_onset << ", selfDet.age: " << d_selfDetectAge << // ", extension: " << mid << ", deathAge: " << d_deathAge); simrisc-16.02.00/tumor/characteristicsat.cc0000664000175000017500000000240714665030471017565 0ustar frankfrank#define XERR #include "tumor.ih" // if a tumor is present at 'age' then cpt the tumor's diameter and volume at // 'age', using the age - d_onset time interval void Tumor::characteristicsAt(double age) { requireTumor("size"); if ((d_present = (d_onset <= age))) // if the tumor exists at { // 'age' compute its diam. d_diameter = diameter( d_volume = d_startVolume * // exp. growth of volume pow(2, (age - d_onset) / d_doublingYears) ); g_log << __FILE__ " " << age << "\n" " diameter: " << d_diameter << "\n" " volume: " << d_volume << "\n" " onset : " << d_onset << "\n" " tumor lifetime: " << (age - d_onset) << '\n'; } else // no tumor yet at 'age' { g_log << __FILE__ " No tumor at age " << age << "\n"; d_volume = 0; d_diameter = 0; g_log << " tumor::characteristics: no tumor yet at " << age << '\n'; } d_rowCol = d_survival.setVSD(d_diameter); } simrisc-16.02.00/tumor/frame0000664000175000017500000000006014665030471014564 0ustar frankfrank//#define XERR #include "tumor.ih" Tumor:: { } simrisc-16.02.00/tumor/functionz.cc0000664000175000017500000000023314665030471016077 0ustar frankfrank//#define XERR #include "tumor.ih" double Tumor::functionZ(double years) const { return d_survival[2].value() * log(years) + d_survival[3].value(); } simrisc-16.02.00/tumor/writedata.cc0000664000175000017500000000155014665030471016047 0ustar frankfrank//#define XERR #include "tumor.ih" void Tumor::writeData(CSVTable &tab) const { tab.more() << s_noYes[d_present] << // 6 s_noYes[d_found] << // 7 s_noYes[d_interval]; // 8 // see modifications (8) if (d_diameter > 1000) // 9 tab.more() << "1001"; // was: 'inf' else tab.more() << d_diameter; // see also modifications (7) // //setw(6) << d_selfDetectAge == NO_TUMOR ? 0 : age << '\t' << tab.more() << checkNot(d_doublingDays) << // 10 checkNot(d_prePeriod) << checkNot(d_onset) << // 11 - 12 checkNot(d_selfDetectAge) << d_deathAge; // 13 - 14 } simrisc-16.02.00/tumor/tumor.f0000664000175000017500000000215414665030471015072 0ustar frankfrankinline double Tumor::selfDetectAge() const { return d_selfDetectAge; } inline double Tumor::onset() const { return d_onset; } inline bool Tumor::at(double age) const { return d_onset <= age; } inline bool Tumor::selfDetectBefore(double age) const { return d_selfDetectAge <= age; } // inline bool Tumor::selfDetectable() const // { // return d_selfDetectAge != NO_TUMOR; // } // // inline void Tumor::characteristics() // { // characteristics(d_selfDetectAge); // } inline void Tumor::intervalCancer() { d_interval = true; } inline void Tumor::found() { d_found = true; } inline void Tumor::setDeathAge() { setDeathAge(d_selfDetectAge); } inline double Tumor::deathAge() const { return d_deathAge; } inline double Tumor::diameter() const { return d_diameter; } inline bool Tumor::metastasis() const { return d_survival.metastatis(); } inline bool Tumor::present() const { return d_present; } inline std::ostream &operator<<(std::ostream &out, Tumor const &tumor) { return tumor.insert(out); } inline RowCol const &Tumor::rowCol() const { return d_rowCol; } simrisc-16.02.00/tumorinfo/0000775000175000017500000000000014665030471014427 5ustar frankfranksimrisc-16.02.00/tumorinfo/tumorinfo.ih0000664000175000017500000000030114665030471016765 0ustar frankfrank#include "tumorinfo.h" #include "../xerr/xerr.ih" #include #include #include "../log/log.h" #ifndef SPCH_ using namespace std; using namespace FBB; #endif simrisc-16.02.00/tumorinfo/vary.cc0000664000175000017500000000033714665030471015722 0ustar frankfrank//#define XERR #include "tumorinfo.ih" void TumorInfo::vary(ostream &out) { out << "Tumor:\n"; d_beir7.vary(out); out.put('\n'); d_growth.vary(out); d_incidence.vary(out); d_survival.vary(out); } simrisc-16.02.00/tumorinfo/data.cc0000664000175000017500000000015114665030471015644 0ustar frankfrank////#define XERR //#include "tumorinfo.ih" // ////char const TumorInfo::s_id[] = "tumorInduction"; // // simrisc-16.02.00/tumorinfo/icmconf0000664000175000017500000000010014665030471015757 0ustar frankfrank#define LIBRARY "tumorinfo" #include "../icmconf.lib" simrisc-16.02.00/tumorinfo/cumtotalrisk.cc0000664000175000017500000000143014665030471017455 0ustar frankfrank//#define XERR #include "tumorinfo.ih" // see void calcTotalRisk(int carrierIndex) void TumorInfo::cumTotalRisk(DoubleVect const &radiationRisk) { double sum = 0; d_cumRisk.clear(); uint16_t idx = d_incidence.index(); auto iter = radiationRisk.begin(); for (double risk: d_incidence.tumorRisk(idx)) { //g_log << risk << ' ' << *iter << '\n'; d_cumRisk.push_back(sum += risk * *iter++); } } //void calcTotalRisk(int carrierIndex) { // float totRisk; // for (int T = 0; T < 101; T++) { // totRisk = radRisk[T] * tumorRisk[carrierIndex][T]; <<------ !!! // if (T == 0) { // cumTotRisk[T] = totRisk; // } // else { // cumTotRisk[T] = cumTotRisk[T-1] + totRisk; // } // } // simrisc-16.02.00/tumorinfo/writeparameters.cc0000664000175000017500000000041114665030471020150 0ustar frankfrank//#define XERR #include "tumorinfo.ih" void TumorInfo::writeParameters(ostream &out) const { out << "Tumor:\n"; d_beir7.writeParameters(out); d_incidence.writeParameters(out); d_growth.writeParameters(out); d_survival.writeParameters(out); } simrisc-16.02.00/tumorinfo/tumorinfo.h0000664000175000017500000000255714665030471016633 0ustar frankfrank#ifndef INCLUDED_TUMORINFO_ #define INCLUDED_TUMORINFO_ #include #include "../globals/globals.h" #include "../incidence/incidence.h" #include "../beir7/beir7.h" #include "../growth/growth.h" #include "../survival/survival.h" class Scenario; class TumorInfo: public Globals { Incidence d_incidence; Beir7 d_beir7; // initialized by Beir7's constructor Growth d_growth; Survival d_survival; DoubleVect d_cumRisk; public: void vary(std::ostream &out); // vary parameters // Incidence const &incidence() const; uint16_t induction() const; // beir model to use Beir7 const &beir7() const; Growth const &growth() const; Survival &survival(); void cumTotalRisk(DoubleVect const &radiationRisk); DoubleVect const &cumTotalRisk() const; void writeParameters(std::ostream &out) const; private: void totalRiskFile() const; }; //inline Incidence const &TumorInfo::incidence() const //{ // return d_incidence; //} inline Beir7 const &TumorInfo::beir7() const { return d_beir7; } inline Growth const &TumorInfo::growth() const { return d_growth; } inline Survival &TumorInfo::survival() { return d_survival; } inline DoubleVect const &TumorInfo::cumTotalRisk() const { return d_cumRisk; } #endif simrisc-16.02.00/tumorinfo/frame0000664000175000017500000000007014665030471015441 0ustar frankfrank//#define XERR #include "tumorinfo.ih" TumorInfo:: { } simrisc-16.02.00/typedefs/0000775000175000017500000000000014665030471014230 5ustar frankfranksimrisc-16.02.00/typedefs/typedefs.h0000664000175000017500000000225014665030471016223 0ustar frankfrank#ifndef INCLUDED_TYPEDEFS_ #define INCLUDED_TYPEDEFS_ #include #include #include #include #include #include "../enums/enums.h" //struct struct LineInfo { ParamsSrc src; uint16_t lineNr; std::string txt; std::string tail; }; //= //types using SizePair = std::pair; using DoublePair = std::pair; using DoublesStringTuple = std::tuple; using SizesDoubleTuple = std::tuple; using StringSet = std::unordered_set; using BoolVect = std::vector; using DoubleVect = std::vector; using DoubleVect2 = std::vector; using Double2Vect = std::vector; using LineInfoVect = std::vector; using SizeVect = std::vector; using StringVect = std::vector; using Uint16Vect = std::vector; using SizesDoubleVect = std::vector; using SizeStrVectPair = std::pair; using SizeStrVect2 = std::vector; using RowCol = std::pair; //= #endif simrisc-16.02.00/typedefs/typedefs.ih0000664000175000017500000000010114665030471016365 0ustar frankfrank#include "typedefs.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/typedefs/frame0000664000175000017500000000006614665030471015247 0ustar frankfrank//#define XERR #include "typedefs.ih" typedefs:: { } simrisc-16.02.00/unsignedcastable/0000775000175000017500000000000014665030471015720 5ustar frankfranksimrisc-16.02.00/unsignedcastable/unsignedcastable.h0000664000175000017500000000051514665030471021405 0ustar frankfrank#ifndef INCLUDED_UNSIGNEDCASTABLE_ #define INCLUDED_UNSIGNEDCASTABLE_ // concept used by Parser's unsignedcast templates to ensure that // the arguments can be static_cast to an unsigned template concept UnsignedCastable = requires(Type value) { static_cast(value); }; #endif simrisc-16.02.00/usage.cc0000664000175000017500000001302414665030471014020 0ustar frankfrank// usage.cc #include "main.ih" // Vervallend: // --totalrisk (-T) path - path name of the file containing the // cumulative total risk percentages (default: // '/totalrisk-$.txt', use ! to // suppress) // --id-base (-i) nr - Use the IDPoool, starting with value 'nr' // (specify 0 to use the std. RandomPool, // 1 is used by default) // // --test (-t) specs - run one simulation using the following // comma-separated values: // natural death age, tumor start age, // tumor self-detect age, tumor death-age, // screening testresult: // 0: incorrect (false positive/negative) // 1: correct test // Use tumor start age 0 to indicate no tumor namespace { char const info[] = R"_( [options] analyses Where: [options] - optional arguments (short options between parentheses): --base (-B) dirname - base directory (by default './', below referred to as '/') --cancer (-c) type - cancer type to simulate. 'type' can be breast (default): breast cancer simulation female: female lung cancer simulation male: male lung cancer simulation --config (-C) path - path name to the config file (by default '~/.config/simrisc') --cum-death (-d) path - path name of the file containing the 101 cumulative death proportions --data (-D) path - path name of the file containing the data generated by the simulation (default: '/data-$.txt', use ! to suppress) --death-age (-a) age - run one simulation using a specific natural death-age (also requires --tumor-age) --err (-e) - use the previously used Beir7 ERR function (excess relative risk) instead of the excess absolute risk function, using the cases' subsequent simulated ages; --help (-h) - provide this help --last-case (-l) nCases - perform simulations until 'nCases' have been analyzed and only write the data for the final case to the data file; --log "begin end file [set]" - begin: 1st case index to start logging end: last case index being logged file: path to the file to receive the logs [set]: optional set of logs to skip: C: uniform case random values L: log-normal random values U: uniform random values V: uniform VSD random values --one-analysis (-o) - run a single scenario analysis. The program's arguments may be used to specify comma-separated configuration parameters --parameters (-P) path - path name of the parameters-file (default: not used) --rounds (-R) path - path name of the file containing the summary info of the simulation rounds (default: '/rounds-$.txt', use ! to suppress) --sensitivity (-S) path - path name of the sensitivity-file (default: '/sensitivity.txt', use ! to suppress) --spread (-s) path - path name of the file showing the actual 'spread' values when 'spread: true' is specified (default: ' #include #include #include #include "../err/err.h" #include "../globals/globals.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/vsd/probcheck.cc0000664000175000017500000000026014665030471015446 0ustar frankfrank//#define XERR #include "vsd.ih" // static void VSD::probCheck(double &value) { if (not Globals::proportion(value)) { Err::range(); value = 0; } } simrisc-16.02.00/vsd/data.cc0000664000175000017500000000074714665030471014431 0ustar frankfrank//#define XERR #include "vsd.ih" // static void (*VSD::s_valueCheck[])(double &) = { &accept, // VARY_MEAN &posCheck, &probCheck, &accept, // VARY_BETA_... &accept, }; // static VaryType VSD::s_varyType[] = { VARY_MEAN, VARY_NONNEG, VARY_PROB, VARY_BETA_MALE, VARY_BETA_FEMALE, }; unsigned VSD::s_indent = 0; char const *VSD::s_type = 0; char VSD::s_ch = 0; unsigned VSD::s_width = 0; unsigned VSD::s_prec = -1; simrisc-16.02.00/vsd/vsd1.cc0000664000175000017500000000022214665030471014361 0ustar frankfrank#define XERR #include "vsd.ih" VSD::VSD(VaryType varyType) : d_dist(varyType), d_valueCheck(s_valueCheck[varyType]), d_exp(false) {} simrisc-16.02.00/vsd/fmt2.cc0000664000175000017500000000050514665030471014360 0ustar frankfrank//#define XERR #include "vsd.ih" // static void VSD::fmt(unsigned indent, char const *type, char ch, unsigned valueWidth, unsigned valuePrec, unsigned distWidth, unsigned distPrec) { s_indent = indent; s_type = type; s_ch = ch; fmt(valueWidth, valuePrec, distWidth, distPrec); } simrisc-16.02.00/vsd/vsd.h0000664000175000017500000001116614665030471014153 0ustar frankfrank#ifndef INCLUDED_VSD_ #define INCLUDED_VSD_ #include #include #include "../distribution/distribution.h" class VSD { friend std::istream &operator>>(std::istream &in, VSD &vsd); friend std::ostream &operator<<(std::ostream &out, VSD const &vsd); friend std::ostream &operator<<(std::ostream &out, std::vector const &vect); double d_value = 0; double d_orgValue = 0; // initial config. value, used by vary(), // extracted from the config file Distribution d_dist; // distribution used for spreading d_value. // The distribution may receive the 'spread' and // receives the name of the distribution. // For LC BETA_MALE or BETA_FEMALE is used // meanCheck (VARY_MEAN), posCheck (VARY_NONNEG) // probCheck (VARY_PROB). No checks for BETA_*, void (*d_valueCheck)(double &value); bool d_exp; // addresses of the static void (*s_valueCheck[])(double &value); // ..Check functions static VaryType s_varyType[]; static unsigned s_indent; static char const *s_type; static char s_ch; static unsigned s_width; static unsigned s_prec; public: VSD(VaryType varyType); // vary() modifies d_value by calling d_dist.vary(d_orgValue) // this modifies d_value, after which value() returns the modified // value. The modified value is called using the variation // computing function set by Distribution::d_vary, e.g. varyMean, // varyNonNeg, etc. The Distribution::vary* functions call the // appropriate random-variation functions, which are active // because of the 'spread: true' configuration. void vary(); // was: refresh/spread .f // sets d_value as a varied // value through d_dist.value() void showVary(std::ostream &out) const; // the actually used and orig. // values double value() const; // mean or percentage .f // values obtained from d_dist DistType distType() const; // was: dist .f std::string const &distName() const; // was: name .f Distribution const &distribution() const; static void fmt(unsigned valueIntWidth, unsigned valuePrec, // 1 unsigned distValueWdith, unsigned distPrec); static void fmt(unsigned indent, char const *type, char ch, // 2 unsigned valueIntWidth, unsigned valuePrec, unsigned distValueWidth, unsigned distPrec); void ln(); // change // write vary info to 'out' static void vary(std::ostream &out, // hdr should end in ':' // 2 unsigned indent, char const *hdr, char const *type, char ch, std::vector &vect); static void vary(std::ostream &out, // same, no hdr line 3 unsigned indent, char const *type, char ch, std::vector &vect); private: std::ostream &insert(std::ostream &out) const; // 1 static std::ostream &insert(std::ostream &out, // 2 std::vector const &vect); std::istream &extract(std::istream &in); static void accept(double &value); static void posCheck(double &value); static void probCheck(double &value); }; using VSDvect = std::vector; using VSDmatrix = std::vector>; #include "vsd.f" // // charShift != 0 then idx is converted to char // // indent: initial indentation // static std::ostream &insert(std::ostream &out, char const *label, // 1 // char const *type, // std::vector const &vect, // unsigned indent, unsigned mPrecision, // unsigned sdPrecision, char ch = 0); // // std::ostream &insert(std::ostream &out, // 2 // unsigned mPrec, unsigned sdPrec) const; // #endif simrisc-16.02.00/vsd/accept.cc0000664000175000017500000000020014665030471014737 0ustar frankfrank//#define XERR #include "vsd.ih" // static void VSD::accept(double &value) { // no checks needed for Modes MEAN and BETA } simrisc-16.02.00/vsd/ln.cc0000664000175000017500000000025414665030471014122 0ustar frankfrank//#define XERR #include "vsd.ih" void VSD::ln() { d_value = log(d_value); d_orgValue = d_value; d_exp = true; if (Globals::vary()) d_dist.ln(); } simrisc-16.02.00/vsd/vary2.cc0000664000175000017500000000051514665030471014554 0ustar frankfrank//#define XERR #include "vsd.ih" // static hdr should end in ':' void VSD::vary(ostream &out, unsigned indent, char const *hdr, char const *type, char ch, VSDvect &vect) { out << setw(indent) << ' ' << hdr << '\n'; vary(out, indent + 2, type, ch, vect); } simrisc-16.02.00/vsd/insert1.cc0000664000175000017500000000031114665030471015070 0ustar frankfrank#define XERR #include "vsd.ih" std::ostream &VSD::insert(std::ostream &out) const { return Globals::setWidthPrec(out, 6, 3) << (d_exp ? exp(d_orgValue) : d_orgValue) << ", " << d_dist; } simrisc-16.02.00/vsd/vary3.cc0000664000175000017500000000053514665030471014557 0ustar frankfrank//#define XERR #include "vsd.ih" // static void VSD::vary(ostream &out, unsigned indent, char const *type, char ch, VSDvect &vect) { for (VSD &vsd: vect) { vsd.vary(); out << setw(indent) << ' ' << type << ": " << ch << " "; vsd.showVary(out); ++ch; } out.put('\n'); } simrisc-16.02.00/vsd/insert2.cc0000664000175000017500000000062614665030471015102 0ustar frankfrank#define XERR #include "vsd.ih" // static ostream &VSD::insert(ostream &out, VSDvect const &vect) { for (unsigned idx = 0, end = vect.size(); idx != end; ++idx) { out << setw(s_indent) << ' ' << s_type << ' '; if (s_ch == 0) out << idx; else out << static_cast(s_ch + idx); out << " " << vect[idx] << '\n'; } return out; } simrisc-16.02.00/vsd/vsd.f0000664000175000017500000000135614665030471014151 0ustar frankfrankinline Distribution const &VSD::distribution() const { return d_dist; } inline void VSD::vary() { d_value = d_dist.value(d_orgValue); } inline double VSD::value() const { return d_value; } inline DistType VSD::distType() const { return d_dist.type(); } inline std::string const &VSD::distName() const { return Distribution::name(d_dist.type()); } inline std::ostream &operator<<(std::ostream &out, VSD const &vsd) { return vsd.insert(out); } inline std::ostream &operator<<(std::ostream &out, VSDvect const &vect) { return VSD::insert(out, vect); } inline std::istream &operator>>(std::istream &in, VSD &vsd) { return vsd.extract(in); } //inline double VSD::spread() const //{ // return d_dist.value(); //} simrisc-16.02.00/vsd/fmt1.cc0000664000175000017500000000043114665030471014355 0ustar frankfrank//#define XERR #include "vsd.ih" // static void VSD::fmt(unsigned valueWidth, unsigned valuePrec, unsigned distWidth, unsigned distPrec) { s_width = valueWidth + valuePrec + (valuePrec > 0); s_prec = valuePrec; Distribution::fmt(distWidth, distPrec); } simrisc-16.02.00/vsd/icmconf0000664000175000017500000000007214665030471014541 0ustar frankfrank#define LIBRARY "vsd" #include "../icmconf.lib" simrisc-16.02.00/vsd/extract.cc0000664000175000017500000000131414665030471015161 0ustar frankfrank#define XERR #include "vsd.ih" // value spread dist. // 21.1 0.048 Normal // 16.51 // implies spread = false // // beta -> d_value // // # LC: eta beta dist constant factor aParam bParam // male: -1.4 .32 Beta .234091 1.72727 2.664237 5.184883 // female: -1.4 1.40 Beta .744828 .818966 3.366115 4.813548 istream &VSD::extract(istream &in) { string v1; string v2; in >> d_value; // the beta parameter of distributions d_orgValue = d_value; if (Globals::vary()) { in >> d_dist; (*d_valueCheck)(d_value); // check valid SD / Prob. values } return in; } simrisc-16.02.00/vsd/frame0000664000175000017500000000005414665030471014215 0ustar frankfrank//#define XERR #include "vsd.ih" VSD:: { } simrisc-16.02.00/vsd/poscheck.cc0000664000175000017500000000025014665030471015304 0ustar frankfrank//#define XERR #include "vsd.ih" // static void VSD::posCheck(double &value) { if (value < 0) { Err::msgTxt(Err::NEGATIVE); value = 0; } } simrisc-16.02.00/vsdparams/0000775000175000017500000000000014665030471014405 5ustar frankfranksimrisc-16.02.00/vsdparams/vwriteparameters.cc0000664000175000017500000000063314665030471020322 0ustar frankfrank#define XERR #include "vsdparams.ih" // override void VSDParams::v_writeParameters(ostream &out) const { Globals::setPrecision(out, 2) << setw(8) << ' ' << "std. dev.: " << d_vsd[SDEV] << '\n'; VSD::fmt(2, 3, 0, 4); out << setw(8) << ' ' << "lifetimeRisk: " << d_vsd[RISK] << '\n'; VSD::fmt(2, 1, 3, 3); out << setw(8) << ' ' << "mean age: " << d_vsd[MEAN] << "\n\n"; } simrisc-16.02.00/vsdparams/vsdparams.h0000664000175000017500000000132714665030471016561 0ustar frankfrank#ifndef INCLUDED_VSDPARAMS_ #define INCLUDED_VSDPARAMS_ #include "../params/params.h" #include "../vsd/vsd.h" class VSDParams: public Params { enum Indices { RISK, // lifetimeRisk MEAN, SDEV }; VSD d_vsd[3] = { VSD{ VARY_PROB }, // lifetimeRisk VSD{ VARY_NONNEG }, // meanAge VSD{ VARY_NONNEG } }; // stdDev public: VSDParams(StringVect &base, size_t idx, bool setProb); ~VSDParams() override; private: void v_cptTumorRisk(DoubleVect &ageValues) override; void v_vary(std::ostream &out) override; void v_writeParameters(std::ostream &out) const; }; #endif simrisc-16.02.00/vsdparams/icmconf0000664000175000017500000000016114665030471015744 0ustar frankfrank#define LIBRARY "vsdparams" //#define SPCH "-k xerr/xerr.ih" #include "../icmconf.lib" simrisc-16.02.00/vsdparams/vsdparams1.cc0000664000175000017500000000106014665030471016772 0ustar frankfrank#define XERR #include "vsdparams.ih" VSDParams::VSDParams(StringVect &base, size_t idx, bool setProb) : Params(base, idx, setProb) { if (prob() < 0) // invalid probability setting return; base.back() = "lifetimeRisk:"; bool ok = Parser::one(base, d_vsd[RISK]); base.back() = "meanAge:"; ok = Parser::one(base, d_vsd[MEAN]) and ok; base.back() = "stdDev:"; ok = Parser::one(base, d_vsd[SDEV]) and ok; if (not ok) invalid(); // error in the param. specs: prob = -1 } simrisc-16.02.00/vsdparams/destructor.cc0000664000175000017500000000010114665030471017102 0ustar frankfrank#define XERR #include "vsdparams.ih" VSDParams::~VSDParams() {} simrisc-16.02.00/vsdparams/vsdparams.ih0000664000175000017500000000023414665030471016726 0ustar frankfrank#include "vsdparams.h" #include "../xerr/xerr.ih" #include "../globals/globals.h" #include "../parser/parser.h" #ifndef SPCH_ using namespace std; #endif simrisc-16.02.00/vsdparams/vcpttumorrisk.cc0000664000175000017500000000100714665030471017646 0ustar frankfrank//#define XERR #include "vsdparams.ih" // see calcTumorRisk in SimRisc.cpp // override void VSDParams::v_cptTumorRisk(DoubleVect &ageValues) { size_t age = 0; double mean = d_vsd[MEAN].value(); double stdDev = d_vsd[SDEV].value(); double factor1 = d_vsd[RISK].value() / (stdDev * Globals::s_sqrt2PI); for (double &risk: ageValues) // compute the risks per age value { double factor2 = (age++ - mean) / stdDev; risk = factor1 * exp(-(factor2 * factor2 / 2)); } } simrisc-16.02.00/vsdparams/frame0000664000175000017500000000006614665030471015424 0ustar frankfrank#define XERR #include "vsdparams.ih" VSDParams:: { } simrisc-16.02.00/vsdparams/vvary.cc0000664000175000017500000000075714665030471016074 0ustar frankfrank//#define XERR #include "vsdparams.ih" // overrides void VSDParams::v_vary(ostream &out) { for (auto &vsd: d_vsd) vsd.vary(); out << " " << ( not Globals::isBreast() ? Globals::simTypeLabel(LC) : label() ) << "\n" " lifetimeRisk: "; d_vsd[RISK].showVary(out); out << " meanAge: "; d_vsd[MEAN].showVary(out); } simrisc-16.02.00/xerr/0000775000175000017500000000000014665030471013365 5ustar frankfranksimrisc-16.02.00/xerr/xerr.ih0000664000175000017500000000130414665030471014665 0ustar frankfrank// define X to activate the xerr/xerr2 macros: // xerr(insertion) // inserts the '<<' concatenated elements into std::cerr // preceded by the name of the source file, and ended by '\n' // xerr2(insertion, code) // performs the insertion if X is defined, and (unconditionally) // executes the statement(s) in `code'. `code' must be valid // C(++) code. // #ifdef XERR #include #define xerr(insertion) std::cerr << __FILE__": " << insertion << '\n' #define xerr2(insertion, b) \ { std::cerr << __FILE__": " << insertion << '\n'; b; } #else #define xerr(insertion) #define xerr2(insertion, b) b #endif